Retinoblastoma Gene in Cancer (Homo sapiens)

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6215374Examples of RB-E2F Complexes inhibiting E2F-driven gene expressionRb-E2F complexCDKN1BORC1regulation of cyclin-dependent protein kinase activityPRMT2mitotic cell cycleCDT1STMN1RB1RBP1CDKN1ACCNB1CDK2POLE2MCM6CDC25AABL1FANCGHLTFMSH6RABIFCDK1TFDP1TYMSCCNB2RRM1SMC1ARPA1PRKDCCCNE1CDC7DCKCCND1SMARCA2DNA damage response, signal transduction resulting in induction of apoptosisPOLEPRIM1CCNE2MCM7G1/S transition of mitotic cell cycleTTKG1/S transition of mitotic cell cyclecell cycle checkpointSUV39H1E2F1RPA1MAP kinase activityMDM2DNMT1DNA repairMCM3FAF1PCNACCNA2HDAC1RBBP4DNA replicationCDC45MCM4ABL1RPA2G2/M transition of mitotic cell cycleSIN3AMIR29B2HMGB1RFC3KIF4AANLNPLK4MIR21TP53POLA1MCM7MAPK13WEE1TOP2AMIR29B1JNK cascadeSMC3RFC4CDK1SMC2NPATSAP30CDC25BPOLD3histone H3-K9 methylationgrowth factor activitySKP2RBBP7CCNE1HMGB2RPA3BARD1CDKN1BCCND3RFC5CCDC6M/G1 transition of mitotic cell cycleDNA replication checkpointDHFRH2AFZMYCCDK4RAF1CHEK1RRM2RB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F2ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1TP53E2F1E2F3TFDP1G1/S transition of mitotic cell cycleTFDP1E2F1TFDP1E2F2TFDP1E2F3regulation of cyclin-dependent protein kinase activitymitotic spindle organizationTFDP2E2F1TFDP2E2F2TFDP2E2F3RBP1HDAC1TFDP1E2F2RB1RBP1HDAC1TFDP1E2F3RB1RBP1HDAC1TFDP2E2F1RB1RBP1HDAC1TFDP2E2F2RB1RBP1HDAC1TFDP2E2F3RB1RBP1HDAC1TFDP2E2F1RB1E2F2TFDP1RB1E2F3TFDP1RB1CDK6CCND1Examples of RB-E2F Complexes promoting E2F-driven gene expressionRb-E2F complex


Description

Describes the role of retinoblastoma (RB) gene in cancer.

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Ontology Terms

 

Bibliography

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  1. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed
  2. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed
  3. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed
  6. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed
  7. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed

History

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CompareRevisionActionTimeUserComment
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ANLNGeneProduct54443 (Entrez Gene)
BARD1GeneProduct580 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC45GeneProduct8318 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
DCKGeneProduct1633 (Entrez Gene)
DHFRGeneProduct1719 (Entrez Gene)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayWP707 (WikiPathways)
DNA repairPathwayWP1805 (WikiPathways)
DNA replication checkpointPathway
DNA replicationPathwayWP466 (WikiPathways)
DNMT1GeneProduct1786 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1869 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
FAF1GeneProduct11124 (Entrez Gene)
FANCGGeneProduct2189 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayWP45 (WikiPathways)
G2/M transition of mitotic cell cyclePathwayWP1859 (WikiPathways)
H2AFZGeneProduct3015 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HLTFGeneProduct6596 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
JNK cascadePathway
KIF4AGeneProduct24137 (Entrez Gene)
M/G1 transition of mitotic cell cyclePathway
MAP kinase activityPathwayWP382 (WikiPathways)
MAPK13GeneProduct5603 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MIR21RnaENSG00000284190 (Ensembl)
MIR29B1GeneProductENSG00000274250 (Ensembl)
MIR29B2GeneProductENSG00000276752 (Ensembl)
MSH6GeneProduct2956 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
ORC1GeneProduct4998 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
POLA1GeneProduct5422 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
RABIFGeneProduct5877 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBBP7GeneProduct5931 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2Protein6118 (Entrez Gene)
RPA3Protein6119 (Entrez Gene)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
SAP30GeneProduct8819 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SKP2GeneProduct6502 (Entrez Gene)
SMARCA2GeneProduct6595 (Entrez Gene)
SMC1AGeneProduct8243 (Entrez Gene)
SMC2GeneProduct10592 (Entrez Gene)
SMC3GeneProduct9126 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TOP2AGeneProduct7153 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TTKGeneProduct7272 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)
ZNF655Protein79027 (Entrez Gene)
cell cycle checkpointPathway
growth factor activityPathway
histone H3-K9 methylationPathway
mitotic cell cyclePathwayWP179 (WikiPathways)
mitotic spindle organizationPathway
regulation of cyclin-dependent protein kinase activityPathway

Annotated Interactions

No annotated interactions

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