Retinoblastoma Gene in Cancer (Homo sapiens)

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213Examples of RB-E2F Complexes inhibiting E2F-driven gene expressionANLNRb-E2F complexPRIM1JNK cascadeBRCA1M/G1 transition of mitotic cell cyclePLK4RBBP7JUNHMGB2SMC1AMDM2WEE1SAP30G1/S transition of mitotic cell cycleRBP1DNA repairTOP2ACDC45PathwayCDC25BRPA3DNA replicationCCND3FANCGCDC25ARPA2CDKN1Acell cycle checkpointPRKDCSUV39H1MAPK13RB1CDK1CDK2DNA replication checkpointSKP2CDKN1BSIN3ARABIFMCM7ABL1STMN1CDK1CCNB1CCNB2G1/S transition of mitotic cell cycleG2/M transition of mitotic cell cyclePOLD3PRMT2TTKBARD1mitotic cell cycleCCNE1SMC3CDT1CCNA2regulation of cyclin-dependent protein kinase activitySP1NPATRBBP4CCNE1HLTFCCDC6POLE2POLEMYCCDKN1BRRM2DNMT1CHEK1CDC7MSH6ORC1DNA damage response, signal transduction resulting in induction of apoptosisRFC5MCM7RAF1POLA1PCNADHFRRRM1SMARCA2CCNE2E2F1KIF4ATFDP1HMGB1RPA1DCKTP53RFC4SMC2ABL1RFC3MCM4TYMSFAF1MCM6histone H3-K9 methylationHDAC1H2AFZMCM3RPA1RB1RB1TFDP1E2F1RB1SKP2RB1TFDP1E2F2ZNF655RB1RB1MDM2TFDP1E2F1MDM2RBP1HDAC1TFDP1E2F1RB1RB1TFDP1E2F1RB1RB1RB1RB1SP1RB1RB1JUNTP53E2F1E2F3TFDP1G1/S transition of mitotic cell cycleG1/S transition of mitotic cell cycleTFDP1E2F1Rb-E2F complexTFDP1E2F2TFDP1E2F3regulation of cyclin-dependent protein kinase activitymitotic spindle organizationTFDP2E2F1TFDP2E2F2TFDP2E2F3RBP1HDAC1TFDP1E2F2RB1RBP1HDAC1TFDP1E2F3RB1RBP1HDAC1TFDP2E2F1RB1RBP1HDAC1TFDP2E2F2RB1RBP1HDAC1TFDP2E2F3RB1RBP1HDAC1TFDP2E2F1RB1E2F2TFDP1RB1E2F3TFDP1RB1Rb-E2F complex


Description

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Bibliography

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  1. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC
  2. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM; ''MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC
  3. Domínguez R, Famulari A, Vila J; ''[Leukoencephalopathy: the frontier between what is reversible and what is persistent].''; Rev Neurol, 1997 PubMed Europe PMC
  4. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L; ''An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.''; Mol Cell, 2004 PubMed Europe PMC
  5. Welch PJ, Wang JY; ''Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms.''; Mol Cell Biol, 1995 PubMed Europe PMC
  6. Welch PJ, Wang JY; ''A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.''; Cell, 1993 PubMed Europe PMC
  7. Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM; ''MicroRNA 29b functions in acute myeloid leukemia.''; Blood, 2009 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106493view21:43, 4 September 2019KhanspersModified description
105447view04:57, 8 August 2019KhanspersModified description
102997view14:43, 31 January 2019Mkutmonupdated outdated ensembl ids
98748view01:20, 4 October 2018AlexanderPicoModified title
98747view01:20, 4 October 2018AlexanderPicoModified title
98354view05:35, 24 August 2018EgonwUpdated the MIR21 identifier.
87639view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
84651view22:24, 10 March 2016KhanspersQuick edit to datanode annotation or property
80443view05:49, 23 June 2015KhanspersAdded mir29b targeting of CDK6
80434view20:26, 22 June 2015KhanspersAdded mir21 targeting of MSH6
80433view20:17, 22 June 2015KhanspersAdded mir21 targetinf of E2F1
80430view20:00, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80174view11:06, 16 May 2015EveloModified title
80173view11:01, 16 May 2015EveloModified description
80172view10:44, 16 May 2015EveloModified description
80171view10:40, 16 May 2015EveloModified description
78573view14:50, 7 January 2015MaintBotadded missing graphIds
76353view18:32, 3 July 2014EgonwRemoved database names when no identifier was given.
76335view22:48, 2 July 2014MaintBotchanged pathway node Xrefs
72248view22:23, 29 October 2013MaintBotchanged xrefs from Gene Ontology to WikiPathways
71096view14:30, 4 October 2013Mkutmonconnected lines
70977view04:49, 19 September 2013JYoungrenSpecify description
70976view04:40, 19 September 2013JYoungrenPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ANLNGeneProduct54443 (Entrez Gene)
BARD1GeneProduct580 (Entrez Gene)
BRCA1GeneProduct672 (Entrez Gene)
CCDC6GeneProduct8030 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCNB2GeneProduct9133 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC45GeneProduct8318 (Entrez Gene)
CDC7GeneProduct8317 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDT1GeneProduct81620 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
DCKGeneProduct1633 (Entrez Gene)
DHFRGeneProduct1719 (Entrez Gene)
DNA damage response, signal transduction resulting in induction of apoptosisPathwayGO:0008630 (GeneOntology)
DNA repairPathwayGO:0006281 (GeneOntology)
DNA replication checkpointPathwayGO:0000076 (GeneOntology)
DNA replicationPathwayGO:0006260 (GeneOntology)
DNMT1GeneProduct1786 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1869 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
FAF1GeneProduct11124 (Entrez Gene)
FANCGGeneProduct2189 (Entrez Gene)
G1/S transition of mitotic cell cyclePathwayGO:0000082 (GeneOntology)
G2/M transition of mitotic cell cyclePathwayGO:0000086 (GeneOntology)
H2AFZGeneProduct3015 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HLTFGeneProduct6596 (Entrez Gene)
HMGB1GeneProduct3146 (Entrez Gene)
HMGB2GeneProduct3148 (Entrez Gene)
JNK cascadePathwayGO:0007254 (GeneOntology)
JUNGeneProduct3725 (Entrez Gene)
KIF4AGeneProduct24137 (Entrez Gene)
M/G1 transition of mitotic cell cyclePathwayGO:0000216 (GeneOntology)
MAPK13GeneProduct5603 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MSH6GeneProduct2956 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NPATGeneProduct4863 (Entrez Gene)
ORC1GeneProduct4998 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PLK4GeneProduct10733 (Entrez Gene)
POLA1GeneProduct5422 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRKDCGeneProduct5591 (Entrez Gene)
PRMT2GeneProduct3275 (Entrez Gene)
PathwayPathway
RABIFGeneProduct5877 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RBBP4GeneProduct5928 (Entrez Gene)
RBBP7GeneProduct5931 (Entrez Gene)
RBP1GeneProduct5947 (Entrez Gene)
RFC3GeneProduct5983 (Entrez Gene)
RFC4GeneProduct5984 (Entrez Gene)
RFC5GeneProduct5985 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2Protein6118 (Entrez Gene)
RPA3Protein6119 (Entrez Gene)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
Rb-E2F complexPathwayGO:0035189 (GeneOntology)
SAP30GeneProduct8819 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SKP2GeneProduct6502 (Entrez Gene)
SMARCA2GeneProduct6595 (Entrez Gene)
SMC1AGeneProduct8243 (Entrez Gene)
SMC2GeneProduct10592 (Entrez Gene)
SMC3GeneProduct9126 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
SUV39H1GeneProduct6839 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TOP2AGeneProduct7153 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TTKGeneProduct7272 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene)
WEE1GeneProduct7465 (Entrez Gene)
ZNF655Protein79027 (Entrez Gene)
cell cycle checkpointPathwayGO:0000075 (GeneOntology)
histone H3-K9 methylationPathwayGO:0051567 (GeneOntology)
mitotic cell cyclePathwayGO:0000278 (GeneOntology)
mitotic spindle organizationPathwayGO:0007052 (GeneOntology)
regulation of cyclin-dependent protein kinase activityPathwayGO:0000079 (GeneOntology)

Annotated Interactions

No annotated interactions

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