Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis (Homo sapiens)

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1, 433Phosphorylated4AP-1 transcription factor complexit was not possbile to add a further article without pubmed idE-boxProstaglandin G2FOSQuercetinIKBA_HUMANACOX2IKBKBNFKB1Arachidonic acidProstaglandin H2PhosphorylatedIKBA_HUMANNf-kBNOS1VEGFAAngiogenesisCarcinogenesisNFKB1JUNAP-1MMP1MetastasisGene boxE-boxGene box22232233AREROSApoptosisinduces malformation32inhibits dimerizationinhibition of ubiquitination328DNA damageCYP2A6carcinogenic metaboliteNFE2L2KEAP1NFE2L2NFE2L2small MAFPhase 2 enzymeCell cycle arrest3Malignancy(Causes vasodilation;inhibits platelet aggregation)351, 41, 441, 44444, 74Phospholipase A2 (PLA2)1, 4Cox1/Cox2Prostaglandin I2Thromboxane A2(Causes vasoconstriction;promotes platelet aggregation)Cell membrane phospholipids(Increasesvasoconstriction)Prostaglandin F2aProstaglandin D2Prostaglandin E2(Induces vasoconstrictionand secretion of IL-1 and IL-2)INFLAMMATION444444444444


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Ontology Terms



  1. Ala Y. Issaa, Suresh R. Volatea, Michael J. Wargovich; ''The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives''; Journal of Food Composition and Analysis, 2006
  2. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia
  3. Ricciotti E, FitzGerald GA; ''Prostaglandins and inflammation.''; Arterioscler Thromb Vasc Biol, 2011 PubMed Europe PMC Scholia
  4. Tanigawa S, Fujii M, Hou DX; ''Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia


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106204view12:10, 16 August 2019MaintBotHMDB identifier normalization
97772view13:34, 7 June 2018AMTanModified description
94228view08:53, 27 August 2017DeSlConnected which lines I could. There are some (from "gene box") where I do not know the meaning...
88907view08:51, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
87626view08:54, 25 July 2016LindarieswijkOntology Term : 'apoptotic cell death pathway' added !
87375view09:56, 22 July 2016MaintBotadded missing graphids
80008view12:38, 30 April 2015Zariannotated small MAF
79692view20:20, 4 April 2015AlexanderPicoModified title
79583view08:35, 26 March 2015Zariadded ID for COX2 gene
72165view12:38, 25 October 2013Nuno
71259view21:20, 16 October 2013MaintBotAutomated update of data sources
62392view02:31, 28 April 2013AlexanderPicoRestored references
62391view02:26, 28 April 2013AlexanderPicoFixed datanodes, labels, lines and states
59177view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57886view19:35, 4 February 2013MaintBotModified categories
56385view22:51, 6 January 2013Cboye21New pathway

External references


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NameTypeDatabase referenceComment
(Causes vasoconstriction; promotes platelet aggregation)
(Causes vasodilation; inhibits platelet aggregation)
(Increases vasoconstriction)
(Induces vasoconstriction and secretion of IL-1 and IL-2)
ACOX2GeneProductENSG00000168306 (Ensembl)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
CYP2A6GeneProductENSG00000255974 (Ensembl) one of several possible phase 1 enzymes
Cell membrane phospholipids
DNA damage
FOSGeneProductENSG00000170345 (Ensembl)
IKBA_HUMANProteinP25963 (Uniprot/TrEMBL)
IKBKBGeneProductENSG00000104365 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
KEAP1GeneProductENSG00000079999 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
Phase 2 enzyme Protein
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin E2MetaboliteHMDB01220 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin G2MetaboliteHMDB03235 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
QuercetinMetaboliteHMDB05794 (HMDB)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
VEGFAGeneProductENSG00000112715 (Ensembl)
carcinogenic metaboliteMetabolite
small MAFProtein

Annotated Interactions

No annotated interactions

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