Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis (Homo sapiens)

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Current revision (12:10, 16 August 2019) (view source)
(HMDB identifier normalization)
 
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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis" Author="Chris Boye" Last-Modified="10/16/2013" Organism="Homo sapiens"><Comment Source="WikiPathways-description">Quercetin is a flavonoid that is widely distributed in nature. In this pathway, its dual nature is depicted. On the one hand, it is capable of exerting anti-oxidant and anti-inflammatory effects by inhibiting the PLA2-induced conversion of cell membrane phospholipids to arachidonic acid, reducing the downstream synthesis of pro-inflammatory prostaglandins; furthermore, inhibition of NF-kB and AP-1 transcription factor activation also contribute to these effects.
+
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis" Author="Chris Boye" Last-Modified="10/16/2013" Organism="Homo sapiens">
 +
  <Comment Source="WikiPathways-description">Quercetin is a flavonoid that is widely distributed in nature. In this pathway, its dual nature is depicted. On the one hand, it is capable of exerting anti-oxidant and anti-inflammatory effects by inhibiting the PLA2-induced conversion of cell membrane phospholipids to arachidonic acid, reducing the downstream synthesis of pro-inflammatory prostaglandins; furthermore, inhibition of NF-kB and AP-1 transcription factor activation also contribute to these effects.
On the other hand, quercetin itself may - paraxodically - generate ROS, as well as facilitate the activation of NFE2L2, which results in the production of CYP2A6. This isotype of CYP450 was found to be involved in the formation of carcinogenic metabolites. Both of these effects culminate in DNA damage.  It has been observed, however, that these pro-oxidant effects are dominant at higher concentrations, whereas anti-oxidant effects are dominant at lower concentrations. Based on this, it has been suggested that quercetin may have a scavenging effect. </Comment>
On the other hand, quercetin itself may - paraxodically - generate ROS, as well as facilitate the activation of NFE2L2, which results in the production of CYP2A6. This isotype of CYP450 was found to be involved in the formation of carcinogenic metabolites. Both of these effects culminate in DNA damage.  It has been observed, however, that these pro-oxidant effects are dominant at higher concentrations, whereas anti-oxidant effects are dominant at lower concentrations. Based on this, it has been suggested that quercetin may have a scavenging effect. </Comment>
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+
     <Graphics CenterX="1415.187248581094" CenterY="454.44947633168294" Width="72.69999999999992" Height="24.249999999999545" ZOrder="32791" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
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   <Shape TextLabel="ARE" GraphId="e66b3">
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     <Graphics CenterX="1959.6394216429933" CenterY="639.6416355502578" Width="200.50000000000034" Height="24.761904761904738" ZOrder="32815" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/>
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     <Graphics CenterX="1959.6394216429933" CenterY="639.6416355502578" Width="200.50000000000034" Height="24.761904761904738" ZOrder="32815" FontSize="10" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
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   <Shape TextLabel="ROS" GraphId="d907f">
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     <Graphics CenterX="2189.801886628987" CenterY="58.02243659300284" Width="108.11904761904839" Height="25.61374805456508" ZOrder="32816" FontSize="10" Valign="Middle" ShapeType="Rectangle" Color="0033ff" Rotation="0.0" />
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   <Group GroupId="a5732" GraphId="f57a5" Style="Complex" />
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   <InfoBox CenterX="0.0" CenterY="0.0"/>
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   <InfoBox CenterX="0.0" CenterY="0.0" />
   <Biopax>
   <Biopax>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ac2">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ac2">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives</bp:TITLE>
Line 652: Line 653:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suresh R. Volatea</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suresh R. Volatea</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Michael J. Wargovich</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Michael J. Wargovich</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f35">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11729303</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and leukotrienes: advances in eicosanoid biology.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Funk CD</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca2">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca2">
Line 665: Line 674:
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">apoptotic cell death pathway</bp:TERM>
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">apoptotic cell death pathway</bp:TERM>
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000009</bp:ID>
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000009</bp:ID>
 +
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 +
    </bp:openControlledVocabulary>
 +
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 +
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulatory pathway</bp:TERM>
 +
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000004</bp:ID>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
Line 676: Line 690:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fujii M</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fujii M</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hou DX</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hou DX</bp:AUTHORS>
-
    </bp:PublicationXref>
 
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">regulatory pathway</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000004</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f35">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11729303</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Prostaglandins and leukotrienes: advances in eicosanoid biology.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Science</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Funk CD</bp:AUTHORS>
 
     </bp:PublicationXref>
     </bp:PublicationXref>
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106204view12:10, 16 August 2019MaintBotHMDB identifier normalization
97772view13:34, 7 June 2018AMTanModified description
94228view08:53, 27 August 2017DeSlConnected which lines I could. There are some (from "gene box") where I do not know the meaning...
88907view08:51, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
87626view08:54, 25 July 2016LindarieswijkOntology Term : 'apoptotic cell death pathway' added !
87375view09:56, 22 July 2016MaintBotadded missing graphids
80008view12:38, 30 April 2015Zariannotated small MAF
79692view20:20, 4 April 2015AlexanderPicoModified title
79583view08:35, 26 March 2015Zariadded ID for COX2 gene
72165view12:38, 25 October 2013Nuno
71259view21:20, 16 October 2013MaintBotAutomated update of data sources
62392view02:31, 28 April 2013AlexanderPicoRestored references
62391view02:26, 28 April 2013AlexanderPicoFixed datanodes, labels, lines and states
59177view18:43, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57886view19:35, 4 February 2013MaintBotModified categories
56385view22:51, 6 January 2013Cboye21New pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/0/02/WP2435_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/0/02/WP2435_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106204)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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