One Carbon Metabolism (Homo sapiens)
From WikiPathways
(Difference between revisions)
(Modified description) |
(HMDB identifier normalization) |
||
Line 11: | Line 11: | ||
</Comment> | </Comment> | ||
<Comment Source="WikiPathways-category">Metabolic Process</Comment> | <Comment Source="WikiPathways-category">Metabolic Process</Comment> | ||
- | <Graphics BoardWidth=" | + | <Graphics BoardWidth="1678.261878109454" BoardHeight="789.0" /> |
<DataNode TextLabel="Deoxyuridine monophosphate" GraphId="a47" Type="Metabolite"> | <DataNode TextLabel="Deoxyuridine monophosphate" GraphId="a47" Type="Metabolite"> | ||
- | <Graphics CenterX="146.0" CenterY="366.0" Width="189.0" Height="20.0" ZOrder="28672" FontSize="11" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="146.0" CenterY="366.0" Width="189.0" Height="20.0" ZOrder="28672" FontSize="11" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="PubChem-compound" ID="65063"/> | + | <Xref Database="PubChem-compound" ID="65063" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Deoxythymidine monophosphate" GraphId="c8c" Type="Metabolite"> | <DataNode TextLabel="Deoxythymidine monophosphate" GraphId="c8c" Type="Metabolite"> | ||
- | <Graphics CenterX="142.5" CenterY="260.0" Width="193.0" Height="20.0" ZOrder="28672" FontSize="11" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="142.5" CenterY="260.0" Width="193.0" Height="20.0" ZOrder="28672" FontSize="11" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="PubChem-compound" ID="9700"/> | + | <Xref Database="PubChem-compound" ID="9700" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MAT1A" GraphId="a0b" Type="GeneProduct" GroupRef="b93bd"> | <DataNode TextLabel="MAT1A" GraphId="a0b" Type="GeneProduct" GroupRef="b93bd"> | ||
<Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="1334.3979788557228" CenterY="213.42792288557226" Width="80.0" Height="27.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1334.3979788557228" CenterY="213.42792288557226" Width="80.0" Height="27.333333333333332" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4143"/> | + | <Xref Database="Entrez Gene" ID="4143" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="BHMT" GraphId="a0c" Type="GeneProduct"> | <DataNode TextLabel="BHMT" GraphId="a0c" Type="GeneProduct"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1149.3410447761185" CenterY="494.36100746268653" Width="49.175000000001546" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1149.3410447761185" CenterY="494.36100746268653" Width="49.175000000001546" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="635"/> | + | <Xref Database="Entrez Gene" ID="635" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Tetrahydrofolate" GraphId="a19" Type="Metabolite"> | <DataNode TextLabel="Tetrahydrofolate" GraphId="a19" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="646.4916666666667" CenterY="241.5" Width="221.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="646.4916666666667" CenterY="241.5" Width="221.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="135-16-0"/> | + | <Xref Database="CAS" ID="135-16-0" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="5-Methyl Tetrahydrofolate" GraphId="a42" Type="Metabolite"> | <DataNode TextLabel="5-Methyl Tetrahydrofolate" GraphId="a42" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="638.4916666666667" CenterY="743.5" Width="129.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="638.4916666666667" CenterY="743.5" Width="129.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="134-35-0"/> | + | <Xref Database="CAS" ID="134-35-0" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="GRX1" GraphId="a4e12" Type="GeneProduct"> | <DataNode TextLabel="GRX1" GraphId="a4e12" Type="GeneProduct"> | ||
Line 44: | Line 44: | ||
<BiopaxRef>ecf</BiopaxRef> | <BiopaxRef>ecf</BiopaxRef> | ||
<BiopaxRef>a48</BiopaxRef> | <BiopaxRef>a48</BiopaxRef> | ||
- | <Graphics CenterX="1138.5535447761192" CenterY="610.1110074626865" Width="47.25" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1138.5535447761192" CenterY="610.1110074626865" Width="47.25" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="2745"/> | + | <Xref Database="Entrez Gene" ID="2745" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFS" GraphId="a74" Type="GeneProduct"> | <DataNode TextLabel="MTHFS" GraphId="a74" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="641.5" CenterY="584.2789802789804" Width="41.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="641.5" CenterY="584.2789802789804" Width="41.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="10588"/> | + | <Xref Database="Entrez Gene" ID="10588" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DHFR" GraphId="a74c2" Type="GeneProduct"> | <DataNode TextLabel="DHFR" GraphId="a74c2" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="490.3562021355778" CenterY="102.45290673774387" Width="46.01666310628252" Height="20.03333333333333" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="490.3562021355778" CenterY="102.45290673774387" Width="46.01666310628252" Height="20.03333333333333" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="1719"/> | + | <Xref Database="Entrez Gene" ID="1719" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD2" GraphId="a7b" Type="GeneProduct" GroupRef="f96c6"> | <DataNode TextLabel="MTHFD2" GraphId="a7b" Type="GeneProduct" GroupRef="f96c6"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="911.4776315789475" CenterY="574.0618421052632" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="911.4776315789475" CenterY="574.0618421052632" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="10797"/> | + | <Xref Database="Entrez Gene" ID="10797" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD1" GraphId="a92" Type="GeneProduct" GroupRef="f96c6"> | <DataNode TextLabel="MTHFD1" GraphId="a92" Type="GeneProduct" GroupRef="f96c6"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="911.4776315789475" CenterY="534.0618421052632" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="911.4776315789475" CenterY="534.0618421052632" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4522"/> | + | <Xref Database="Entrez Gene" ID="4522" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD1L" GraphId="aa1" Type="GeneProduct" GroupRef="b5249"> | <DataNode TextLabel="MTHFD1L" GraphId="aa1" Type="GeneProduct" GroupRef="b5249"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="251.30749999999998" CenterY="491.97729011194076" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="251.30749999999998" CenterY="491.97729011194076" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="25902"/> | + | <Xref Database="Entrez Gene" ID="25902" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Alcohol" GraphId="abd76" Type="Metabolite"> | <DataNode TextLabel="Alcohol" GraphId="abd76" Type="Metabolite"> | ||
- | <Graphics CenterX="698.0" CenterY="66.22142857142859" Width="56.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="698.0" CenterY="66.22142857142859" Width="56.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="PubChem-compound" ID="702"/> | + | <Xref Database="PubChem-compound" ID="702" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FOLH1" GraphId="adf" Type="GeneProduct"> | <DataNode TextLabel="FOLH1" GraphId="adf" Type="GeneProduct"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="486.3011904761905" CenterY="66.22142857142859" Width="66.03333333333333" Height="20.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="486.3011904761905" CenterY="66.22142857142859" Width="66.03333333333333" Height="20.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="2346"/> | + | <Xref Database="Entrez Gene" ID="2346" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Betaine" GraphId="aeb" Type="Metabolite"> | <DataNode TextLabel="Betaine" GraphId="aeb" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1211.9285447761192" CenterY="446.86100746268653" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1211.9285447761192" CenterY="446.86100746268653" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="107-43-7"/> | + | <Xref Database="CAS" ID="107-43-7" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="glycine" GraphId="b1439" Type="Metabolite"> | <DataNode TextLabel="glycine" GraphId="b1439" Type="Metabolite"> | ||
- | <Graphics CenterX="431.40945365254754" CenterY="223.54327808471479" Width="50.62492326580731" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="431.40945365254754" CenterY="223.54327808471479" Width="50.62492326580731" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0000123" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTFMT" GraphId="b1b" Type="GeneProduct" GroupRef="f4484"> | <DataNode TextLabel="MTFMT" GraphId="b1b" Type="GeneProduct" GroupRef="f4484"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="829.856388535319" CenterY="191.55677076999763" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="829.856388535319" CenterY="191.55677076999763" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="123263"/> | + | <Xref Database="Entrez Gene" ID="123263" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DNMT1" GraphId="b3b" Type="GeneProduct" GroupRef="c9cb9"> | <DataNode TextLabel="DNMT1" GraphId="b3b" Type="GeneProduct" GroupRef="c9cb9"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1335.417898552147" CenterY="399.84463017525934" Width="58.07059545733731" Height="20.000000000000025" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1335.417898552147" CenterY="399.84463017525934" Width="58.07059545733731" Height="20.000000000000025" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="1786"/> | + | <Xref Database="Entrez Gene" ID="1786" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD1" GraphId="ba6" Type="GeneProduct" GroupRef="b5249"> | <DataNode TextLabel="MTHFD1" GraphId="ba6" Type="GeneProduct" GroupRef="b5249"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="251.30749999999998" CenterY="471.97729011194076" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="251.30749999999998" CenterY="471.97729011194076" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4522"/> | + | <Xref Database="Entrez Gene" ID="4522" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Thymidylate Synthesis" GraphId="bb282" Type="Pathway"> | <DataNode TextLabel="Thymidylate Synthesis" GraphId="bb282" Type="Pathway"> | ||
- | <Graphics CenterX="97.0" CenterY="136.0" Width="146.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/> | + | <Graphics CenterX="97.0" CenterY="136.0" Width="146.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> |
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="CHDH" GraphId="bc738" Type="GeneProduct"> | <DataNode TextLabel="CHDH" GraphId="bc738" Type="GeneProduct"> | ||
<BiopaxRef>d81</BiopaxRef> | <BiopaxRef>d81</BiopaxRef> | ||
- | <Graphics CenterX="1272.5952114427866" CenterY="382.36100746268653" Width="40.66666666666515" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1272.5952114427866" CenterY="382.36100746268653" Width="40.66666666666515" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Uniprot-TrEMBL" ID="Q8NE62"/> | + | <Xref Database="Uniprot-TrEMBL" ID="Q8NE62" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="5-Formyl Tetrahydrofolate" GraphId="bce0f" Type="Metabolite"> | <DataNode TextLabel="5-Formyl Tetrahydrofolate" GraphId="bce0f" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="652.2439365671643" CenterY="521.5" Width="162.4130597014925" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="652.2439365671643" CenterY="521.5" Width="162.4130597014925" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="135-16-0"/> | + | <Xref Database="CAS" ID="135-16-0" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Zn" GraphId="be5fb" Type="Metabolite"> | <DataNode TextLabel="Zn" GraphId="be5fb" Type="Metabolite"> | ||
- | <Graphics CenterX="1000.6355768349788" CenterY="384.3224885013238" Width="28.499999999999986" Height="24.49999999999997" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1000.6355768349788" CenterY="384.3224885013238" Width="28.499999999999986" Height="24.49999999999997" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0001303" /> |
</DataNode> | </DataNode> | ||
- | <DataNode TextLabel="Riboflavin&# | + | <DataNode TextLabel="Riboflavin
Vitamin B2" GraphId="bed71" Type="Metabolite" GroupRef="cffba"> |
- | <Graphics CenterX="253.795" CenterY="581.0000000000003" Width="80.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="253.795" CenterY="581.0000000000003" Width="80.0" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0000244" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="10-Formyl Tetrahydrofolate" GraphId="c01" Type="Metabolite"> | <DataNode TextLabel="10-Formyl Tetrahydrofolate" GraphId="c01" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="852.0" CenterY="470.5" Width="132.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="852.0" CenterY="470.5" Width="132.0" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="2800-34-2"/> | + | <Xref Database="CAS" ID="2800-34-2" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTR" GraphId="c04" Type="GeneProduct"> | <DataNode TextLabel="MTR" GraphId="c04" Type="GeneProduct"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
<BiopaxRef>fd6</BiopaxRef> | <BiopaxRef>fd6</BiopaxRef> | ||
- | <Graphics CenterX="998.3137446400597" CenterY="421.86663677469016" Width="35.57618330996903" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="998.3137446400597" CenterY="421.86663677469016" Width="35.57618330996903" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4548"/> | + | <Xref Database="Entrez Gene" ID="4548" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="5,10-Methenyl Tetrahydrofolate" GraphId="c07" Type="Metabolite"> | <DataNode TextLabel="5,10-Methenyl Tetrahydrofolate" GraphId="c07" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="652.2439365671644" CenterY="672.6858115671641" Width="162.41305970149247" Height="30.99999999999998" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="652.2439365671644" CenterY="672.6858115671641" Width="162.41305970149247" Height="30.99999999999998" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="7444-29-3"/> | + | <Xref Database="CAS" ID="7444-29-3" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFR" GraphId="c0a" Type="GeneProduct" GroupRef="cffba"> | <DataNode TextLabel="MTHFR" GraphId="c0a" Type="GeneProduct" GroupRef="cffba"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="253.795" CenterY="557.0000000000003" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="253.795" CenterY="557.0000000000003" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4524"/> | + | <Xref Database="Entrez Gene" ID="4524" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD1L" GraphId="c1d" Type="GeneProduct" GroupRef="f4484"> | <DataNode TextLabel="MTHFD1L" GraphId="c1d" Type="GeneProduct" GroupRef="f4484"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="829.856388535319" CenterY="171.5567707699975" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="829.856388535319" CenterY="171.5567707699975" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="25902"/> | + | <Xref Database="Entrez Gene" ID="25902" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FTCD" GraphId="c5a" Type="GeneProduct"> | <DataNode TextLabel="FTCD" GraphId="c5a" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="614.6769736842105" CenterY="363.52236842105265" Width="38.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="614.6769736842105" CenterY="363.52236842105265" Width="38.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="10841"/> | + | <Xref Database="Entrez Gene" ID="10841" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Choline" GraphId="c6261" Type="Metabolite"> | <DataNode TextLabel="Choline" GraphId="c6261" Type="Metabolite"> | ||
<BiopaxRef>c4c</BiopaxRef> | <BiopaxRef>c4c</BiopaxRef> | ||
- | <Graphics CenterX="1211.9285447761192" CenterY="339.7111455842336" Width="80.0" Height="27.75" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1211.9285447761192" CenterY="339.7111455842336" Width="80.0" Height="27.75" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="62-49-7"/> | + | <Xref Database="CAS" ID="62-49-7" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="5-Formimino Tetrahydrofolate" GraphId="c6a43" Type="Metabolite"> | <DataNode TextLabel="5-Formimino Tetrahydrofolate" GraphId="c6a43" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="546.9916666666667" CenterY="437.5" Width="158.01666666666665" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="546.9916666666667" CenterY="437.5" Width="158.01666666666665" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="135-16-0"/> | + | <Xref Database="CAS" ID="135-16-0" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DNMT3b" GraphId="c78" Type="GeneProduct" GroupRef="c9cb9"> | <DataNode TextLabel="DNMT3b" GraphId="c78" Type="GeneProduct" GroupRef="c9cb9"> | ||
<Comment>KEGG database: Methionine metabolism - Homo sapiens (human)</Comment> | <Comment>KEGG database: Methionine metabolism - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="1335.417898552147" CenterY="439.84463017525934" Width="58.07059545733731" Height="20.000000000000025" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1335.417898552147" CenterY="439.84463017525934" Width="58.07059545733731" Height="20.000000000000025" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="1789"/> | + | <Xref Database="Entrez Gene" ID="1789" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Non-homologous end joining" GraphId="c9047" Type="Pathway" GroupRef="ebfa0"> | <DataNode TextLabel="Non-homologous end joining" GraphId="c9047" Type="Pathway" GroupRef="ebfa0"> | ||
- | <Graphics CenterX="246.5" CenterY="96.0" Width="173.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/> | + | <Graphics CenterX="246.5" CenterY="96.0" Width="173.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> |
- | <Xref Database="WikiPathways" ID="WP438"/> | + | <Xref Database="WikiPathways" ID="WP438" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="KIAA0828" GraphId="ca3" Type="GeneProduct" GroupRef="c1374"> | <DataNode TextLabel="KIAA0828" GraphId="ca3" Type="GeneProduct" GroupRef="c1374"> | ||
<Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="1392.261878109454" CenterY="644.3610074626865" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1392.261878109454" CenterY="644.3610074626865" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="23382"/> | + | <Xref Database="Entrez Gene" ID="23382" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ALDH1L1" GraphId="cb2" Type="GeneProduct" GroupRef="f4484"> | <DataNode TextLabel="ALDH1L1" GraphId="cb2" Type="GeneProduct" GroupRef="f4484"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="829.856388535319" CenterY="91.5567707699976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="829.856388535319" CenterY="91.5567707699976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="10840"/> | + | <Xref Database="Entrez Gene" ID="10840" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="AMT" GraphId="cc5" Type="GeneProduct" GroupRef="e81fe"> | <DataNode TextLabel="AMT" GraphId="cc5" Type="GeneProduct" GroupRef="e81fe"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="381.4290976058927" CenterY="305.74340085942214" Width="50.76488643339439" Height="19.99999999999999" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="381.4290976058927" CenterY="305.74340085942214" Width="50.76488643339439" Height="19.99999999999999" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="275"/> | + | <Xref Database="Entrez Gene" ID="275" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTRR" GraphId="ccb" Type="GeneProduct"> | <DataNode TextLabel="MTRR" GraphId="ccb" Type="GeneProduct"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1141.6903618418005" CenterY="404.97488100473686" Width="74.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1141.6903618418005" CenterY="404.97488100473686" Width="74.0" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4552"/> | + | <Xref Database="Entrez Gene" ID="4552" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Folate" GraphId="ccf" Type="Metabolite"> | <DataNode TextLabel="Folate" GraphId="ccf" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="585.9916666666667" CenterY="135.98333333333332" Width="56.01666666666665" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="585.9916666666667" CenterY="135.98333333333332" Width="56.01666666666665" Height="28.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="59-30-3"/> | + | <Xref Database="CAS" ID="59-30-3" /> |
</DataNode> | </DataNode> | ||
- | <DataNode TextLabel="Dihydrofolate&# | + | <DataNode TextLabel="Dihydrofolate
Vitamin B9" GraphId="d00" Type="Metabolite"> |
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="447.9916666666667" CenterY="171.0" Width="84.01666666666667" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="447.9916666666667" CenterY="171.0" Width="84.01666666666667" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="4033-27-6"/> | + | <Xref Database="CAS" ID="4033-27-6" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MAT2B" GraphId="d10" Type="GeneProduct" GroupRef="b93bd"> | <DataNode TextLabel="MAT2B" GraphId="d10" Type="GeneProduct" GroupRef="b93bd"> | ||
<Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="1334.3979788557228" CenterY="237.09458955223886" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1334.3979788557228" CenterY="237.09458955223886" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="27430"/> | + | <Xref Database="Entrez Gene" ID="27430" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="5,10-Methylene Tetrahydrofolate" GraphId="d13" Type="Metabolite"> | <DataNode TextLabel="5,10-Methylene Tetrahydrofolate" GraphId="d13" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="414.9916666666667" CenterY="396.0" Width="162.01666666666668" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="414.9916666666667" CenterY="396.0" Width="162.01666666666668" Height="22.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="ChEBI" ID="12071"/> | + | <Xref Database="ChEBI" ID="12071" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Methionine" GraphId="d31" Type="Metabolite"> | <DataNode TextLabel="Methionine" GraphId="d31" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1211.928544776119" CenterY="283.86100746268653" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1211.928544776119" CenterY="283.86100746268653" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="63-68-3"/> | + | <Xref Database="CAS" ID="63-68-3" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="FTCD" GraphId="d37" Type="GeneProduct"> | <DataNode TextLabel="FTCD" GraphId="d37" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="491.59290578358207" CenterY="508.2567537313433" Width="47.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="491.59290578358207" CenterY="508.2567537313433" Width="47.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="10841"/> | + | <Xref Database="Entrez Gene" ID="10841" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SHMT1" GraphId="d3d" Type="GeneProduct" GroupRef="e81fe"> | <DataNode TextLabel="SHMT1" GraphId="d3d" Type="GeneProduct" GroupRef="e81fe"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="381.4290976058927" CenterY="265.74340085942265" Width="50.764886433394395" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="381.4290976058927" CenterY="265.74340085942265" Width="50.764886433394395" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="6470"/> | + | <Xref Database="Entrez Gene" ID="6470" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="AMT" GraphId="d76" Type="GeneProduct"> | <DataNode TextLabel="AMT" GraphId="d76" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="571.7469937469938" CenterY="597.4550264550263" Width="28.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="571.7469937469938" CenterY="597.4550264550263" Width="28.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="275"/> | + | <Xref Database="Entrez Gene" ID="275" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MIsmatch repair" GraphId="d833e" Type="Pathway" GroupRef="ebfa0"> | <DataNode TextLabel="MIsmatch repair" GraphId="d833e" Type="Pathway" GroupRef="ebfa0"> | ||
- | <Graphics CenterX="244.0" CenterY="79.0" Width="126.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/> | + | <Graphics CenterX="244.0" CenterY="79.0" Width="126.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" /> |
- | <Xref Database="WikiPathways" ID="WP531"/> | + | <Xref Database="WikiPathways" ID="WP531" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="S-adenosylhomocysteine" GraphId="d97" Type="Metabolite"> | <DataNode TextLabel="S-adenosylhomocysteine" GraphId="d97" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1407.2535447761206" CenterY="519.8610074626865" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1407.2535447761206" CenterY="519.8610074626865" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="979-92-0"/> | + | <Xref Database="CAS" ID="979-92-0" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="S-Adenosylmethionine" GraphId="dd1" Type="Metabolite"> | <DataNode TextLabel="S-Adenosylmethionine" GraphId="dd1" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1407.9202114427874" CenterY="348.86100746268653" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1407.9202114427874" CenterY="348.86100746268653" Width="162.01666666666668" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="29908-03-0"/> | + | <Xref Database="CAS" ID="29908-03-0" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TYMS" GraphId="df4" Type="GeneProduct"> | <DataNode TextLabel="TYMS" GraphId="df4" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="242.08150470219442" CenterY="309.94670846394996" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="242.08150470219442" CenterY="309.94670846394996" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="7298"/> | + | <Xref Database="Entrez Gene" ID="7298" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD1" GraphId="e02" Type="GeneProduct" GroupRef="f4484"> | <DataNode TextLabel="MTHFD1" GraphId="e02" Type="GeneProduct" GroupRef="f4484"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="829.856388535319" CenterY="151.5567707699976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="829.856388535319" CenterY="151.5567707699976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="4522"/> | + | <Xref Database="Entrez Gene" ID="4522" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Cobalamin" GraphId="e31b6" Type="Metabolite"> | <DataNode TextLabel="Cobalamin" GraphId="e31b6" Type="Metabolite"> | ||
- | <Graphics CenterX="1105.5952114427857" CenterY="368.6943407960199" Width="80.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1105.5952114427857" CenterY="368.6943407960199" Width="80.0" Height="34.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0002174" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="serine" GraphId="e3cdb" Type="Metabolite"> | <DataNode TextLabel="serine" GraphId="e3cdb" Type="Metabolite"> | ||
- | <Graphics CenterX="539.0" CenterY="314.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="539.0" CenterY="314.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="PubChem-compound" ID="617"/> | + | <Xref Database="PubChem-compound" ID="617" /> |
</DataNode> | </DataNode> | ||
- | <DataNode TextLabel="Methylcobalamin&# | + | <DataNode TextLabel="Methylcobalamin
B12" GraphId="e3df5" Type="Metabolite"> |
- | <Graphics CenterX="1102.4563839412558" CenterY="442.1165937119191" Width="81.36666666666666" Height="34.03333333333333" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1102.4563839412558" CenterY="442.1165937119191" Width="81.36666666666666" Height="34.03333333333333" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0002274" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="GART" GraphId="e4e" Type="GeneProduct"> | <DataNode TextLabel="GART" GraphId="e4e" Type="GeneProduct"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="678.2310781618219" CenterY="416.4063481932442" Width="39.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="678.2310781618219" CenterY="416.4063481932442" Width="39.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="2618"/> | + | <Xref Database="Entrez Gene" ID="2618" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="SHMT2" GraphId="e55" Type="GeneProduct" GroupRef="e81fe"> | <DataNode TextLabel="SHMT2" GraphId="e55" Type="GeneProduct" GroupRef="e81fe"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="381.4290976058927" CenterY="285.7434008594225" Width="50.76488643339439" Height="19.99999999999999" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="381.4290976058927" CenterY="285.7434008594225" Width="50.76488643339439" Height="19.99999999999999" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="6472"/> | + | <Xref Database="Entrez Gene" ID="6472" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD1L" GraphId="e94" Type="GeneProduct" GroupRef="f96c6"> | <DataNode TextLabel="MTHFD1L" GraphId="e94" Type="GeneProduct" GroupRef="f96c6"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="911.4776315789475" CenterY="554.0618421052632" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="911.4776315789475" CenterY="554.0618421052632" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="25902"/> | + | <Xref Database="Entrez Gene" ID="25902" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DNMT3a" GraphId="eb3" Type="GeneProduct" GroupRef="c9cb9"> | <DataNode TextLabel="DNMT3a" GraphId="eb3" Type="GeneProduct" GroupRef="c9cb9"> | ||
<Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="1335.4178985521473" CenterY="419.84463017525934" Width="58.07059545733737" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1335.4178985521473" CenterY="419.84463017525934" Width="58.07059545733737" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="1788"/> | + | <Xref Database="Entrez Gene" ID="1788" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Homocystine" GraphId="ecab7" Type="Metabolite"> | <DataNode TextLabel="Homocystine" GraphId="ecab7" Type="Metabolite"> | ||
- | <Graphics CenterX="1211.9285447761192" CenterY="675.3610074626865" Width="80.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1211.9285447761192" CenterY="675.3610074626865" Width="80.0" Height="26.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="ChEBI" ID="CHEBI:17485"/> | + | <Xref Database="ChEBI" ID="CHEBI:17485" /> |
</DataNode> | </DataNode> | ||
- | <DataNode TextLabel="Pyridoxal 5'-phosphate&# | + | <DataNode TextLabel="Pyridoxal 5'-phosphate
Vitamin B6" GraphId="edfe5" Type="Metabolite"> |
- | <Graphics CenterX="508.4329343155308" CenterY="351.26373542050334" Width="105.87753222836054" Height="26.75" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="508.4329343155308" CenterY="351.26373542050334" Width="105.87753222836054" Height="26.75" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0001491" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="ATIC" GraphId="ef6" Type="GeneProduct" GroupRef="f4484"> | <DataNode TextLabel="ATIC" GraphId="ef6" Type="GeneProduct" GroupRef="f4484"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="829.856388535319" CenterY="131.55677076999763" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="829.856388535319" CenterY="131.55677076999763" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="471"/> | + | <Xref Database="Entrez Gene" ID="471" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Homocysteine" GraphId="f77" Type="Metabolite"> | <DataNode TextLabel="Homocysteine" GraphId="f77" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="1211.9285447761192" CenterY="559.8610074626865" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1211.9285447761192" CenterY="559.8610074626865" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="HMDB" ID=" | + | <Xref Database="HMDB" ID="HMDB0000742" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="MTHFD2" GraphId="f83" Type="GeneProduct" GroupRef="b5249"> | <DataNode TextLabel="MTHFD2" GraphId="f83" Type="GeneProduct" GroupRef="b5249"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="251.30749999999998" CenterY="511.97729011194076" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="251.30749999999998" CenterY="511.97729011194076" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="10797"/> | + | <Xref Database="Entrez Gene" ID="10797" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="AHCY" GraphId="fa9" Type="GeneProduct" GroupRef="c1374"> | <DataNode TextLabel="AHCY" GraphId="fa9" Type="GeneProduct" GroupRef="c1374"> | ||
<Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | <Comment>KEGG Database Methionine metabolism - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="1392.261878109454" CenterY="624.3610074626865" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="1392.261878109454" CenterY="624.3610074626865" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="191"/> | + | <Xref Database="Entrez Gene" ID="191" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="TCN II" GraphId="fc6" Type="GeneProduct"> | <DataNode TextLabel="TCN II" GraphId="fc6" Type="GeneProduct"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="817.7346082089548" CenterY="579.0840485074621" Width="50.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="817.7346082089548" CenterY="579.0840485074621" Width="50.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="6948"/> | + | <Xref Database="Entrez Gene" ID="6948" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="GART" GraphId="fd1" Type="GeneProduct" GroupRef="f4484"> | <DataNode TextLabel="GART" GraphId="fd1" Type="GeneProduct" GroupRef="f4484"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="829.856388535319" CenterY="111.5567707699976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="829.856388535319" CenterY="111.5567707699976" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="2618"/> | + | <Xref Database="Entrez Gene" ID="2618" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DHFR" GraphId="fe0c8" Type="GeneProduct"> | <DataNode TextLabel="DHFR" GraphId="fe0c8" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="534.9916684468587" CenterY="175.98333333333332" Width="46.01666310628252" Height="20.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="534.9916684468587" CenterY="175.98333333333332" Width="46.01666310628252" Height="20.033333333333335" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="1719"/> | + | <Xref Database="Entrez Gene" ID="1719" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="DHFR" GraphId="fea" Type="GeneProduct"> | <DataNode TextLabel="DHFR" GraphId="fea" Type="GeneProduct"> | ||
<Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | <Comment>KEGG database: One carbon pool by folate - Homo sapiens (human)</Comment> | ||
- | <Graphics CenterX="697.9916684468587" CenterY="172.5" Width="46.01666310628252" Height="17.0" ZOrder="32768" FontSize="10" Valign="Middle"/> | + | <Graphics CenterX="697.9916684468587" CenterY="172.5" Width="46.01666310628252" Height="17.0" ZOrder="32768" FontSize="10" Valign="Middle" /> |
- | <Xref Database="Entrez Gene" ID="1719"/> | + | <Xref Database="Entrez Gene" ID="1719" /> |
</DataNode> | </DataNode> | ||
<DataNode TextLabel="Polyglutamate" GraphId="fed" Type="Metabolite"> | <DataNode TextLabel="Polyglutamate" GraphId="fed" Type="Metabolite"> | ||
<BiopaxRef>cf5</BiopaxRef> | <BiopaxRef>cf5</BiopaxRef> | ||
- | <Graphics CenterX="585.4916666666667" CenterY="19.5" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="585.4916666666667" CenterY="19.5" Width="81.01666666666667" Height="31.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> |
- | <Xref Database="CAS" ID="25513-46-6"/> | + | <Xref Database="CAS" ID="25513-46-6" /> |
</DataNode> | </DataNode> | ||
<Interaction GraphId="a1142"> | <Interaction GraphId="a1142"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="585.4916666666667" Y="35.0" GraphRef="fed" RelX="0.0" RelY="1.0"/> | + | <Point X="585.4916666666667" Y="35.0" GraphRef="fed" RelX="0.0" RelY="1.0" /> |
- | <Point X="585.9916666666667" Y="121.98333333333332" GraphRef="ccf" RelX="0.0" RelY="-1.0000000000000004" ArrowHead="Arrow"/> | + | <Point X="585.9916666666667" Y="121.98333333333332" GraphRef="ccf" RelX="0.0" RelY="-1.0000000000000004" ArrowHead="Arrow" /> |
- | <Anchor Position="0.35562141137247644" Shape="None" GraphId="bfef1"/> | + | <Anchor Position="0.35562141137247644" Shape="None" GraphId="bfef1" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="a2acf"> | <Interaction GraphId="a2acf"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="611.6406716417913" Y="657.1858115671641" GraphRef="c07" RelX="-0.5" RelY="-1.0"/> | + | <Point X="611.6406716417913" Y="657.1858115671641" GraphRef="c07" RelX="-0.5" RelY="-1.0" /> |
- | <Point X="611.6406716417912" Y="537.0" GraphRef="bce0f" RelX="-0.5" RelY="1.0" ArrowHead="Arrow"/> | + | <Point X="611.6406716417912" Y="537.0" GraphRef="bce0f" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4857698961937715" Shape="None" GraphId="a444a"/> | + | <Anchor Position="0.4857698961937715" Shape="None" GraphId="a444a" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="a9b29"> | <Interaction GraphId="a9b29"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="757.0" Y="241.5" GraphRef="a19" RelX="1.0" RelY="0.0"/> | + | <Point X="757.0" Y="241.5" GraphRef="a19" RelX="1.0" RelY="0.0" /> |
- | <Point X="852.0" Y="455.0" GraphRef="c01" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="852.0" Y="455.0" GraphRef="c01" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.23169978712595904" Shape="None" GraphId="b64ca"/> | + | <Anchor Position="0.23169978712595904" Shape="None" GraphId="b64ca" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="a9d7b"> | <Interaction GraphId="a9d7b"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1407.6535447761205" Y="420.36100746268653" GraphRef="bf619" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1407.6535447761205" Y="420.36100746268653" GraphRef="bf619" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="1372.453196280816" Y="419.84463017525934" GraphRef="c4413" RelX="1.0" RelY="0.0"/> | + | <Point X="1372.453196280816" Y="419.84463017525934" GraphRef="c4413" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="a9e5b"> | <Interaction GraphId="a9e5b"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="611.1642669425042" Y="315.5831251707217" GraphRef="a15fa" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="611.1642669425042" Y="315.5831251707217" GraphRef="a15fa" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="614.6769736842105" Y="353.52236842105265" GraphRef="c5a" RelX="0.0" RelY="-1.0"/> | + | <Point X="614.6769736842105" Y="353.52236842105265" GraphRef="c5a" RelX="0.0" RelY="-1.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="aaa13"> | <Interaction GraphId="aaa13"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1392.6055970149257" Y="559.8610074626865" GraphRef="c241c" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1392.6055970149257" Y="559.8610074626865" GraphRef="c241c" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="1392.261878109454" Y="606.3610074626865" GraphRef="ff813" RelX="0.0" RelY="-1.0"/> | + | <Point X="1392.261878109454" Y="606.3610074626865" GraphRef="ff813" RelX="0.0" RelY="-1.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ab125"> | <Interaction GraphId="ab125"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="490.35620213557786" Y="112.46957340441054" GraphRef="a74c2" RelX="0.0" RelY="1.0"/> | + | <Point X="490.35620213557786" Y="112.46957340441054" GraphRef="a74c2" RelX="0.0" RelY="1.0" /> |
- | <Point X="490.4761904761905" Y="135.98333333333332" GraphRef="c19fb" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="490.4761904761905" Y="135.98333333333332" GraphRef="c19fb" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="b0a38"> | <Interaction GraphId="b0a38"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="828.4793843283584" Y="241.5" GraphRef="b64ca" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="828.4793843283584" Y="241.5" GraphRef="b64ca" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="829.856388535319" Y="209.55677076999763" GraphRef="cbe1d" RelX="0.0" RelY="1.0"/> | + | <Point X="829.856388535319" Y="209.55677076999763" GraphRef="cbe1d" RelX="0.0" RelY="1.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="b2f2f"> | <Interaction GraphId="b2f2f"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="374.4875" Y="407.0" GraphRef="d13" RelX="-0.5" RelY="1.0"/> | + | <Point X="374.4875" Y="407.0" GraphRef="d13" RelX="-0.5" RelY="1.0" /> |
- | <Point X="573.9833333333333" Y="743.5" GraphRef="a42" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> | + | <Point X="573.9833333333333" Y="743.5" GraphRef="a42" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.3054526328380802" Shape="None" GraphId="f7edf"/> | + | <Anchor Position="0.3054526328380802" Shape="None" GraphId="f7edf" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="b4fcc"> | <Interaction GraphId="b4fcc"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="571.0374067164182" Y="672.6858115671641" GraphRef="c07" RelX="-1.0" RelY="0.0"/> | + | <Point X="571.0374067164182" Y="672.6858115671641" GraphRef="c07" RelX="-1.0" RelY="0.0" /> |
- | <Point X="414.9916666666667" Y="407.0" GraphRef="d13" RelX="0.0" RelY="1.0" ArrowHead="Arrow"/> | + | <Point X="414.9916666666667" Y="407.0" GraphRef="d13" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.7911450703894298" Shape="None" GraphId="cd89d"/> | + | <Anchor Position="0.7911450703894298" Shape="None" GraphId="cd89d" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ba53a"> | <Interaction GraphId="ba53a"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1171.4202114427858" Y="559.8610074626865" GraphRef="f77" RelX="-1.0" RelY="0.0"/> | + | <Point X="1171.4202114427858" Y="559.8610074626865" GraphRef="f77" RelX="-1.0" RelY="0.0" /> |
- | <Point X="963.2476679104481" Y="421.86100746268653"/> | + | <Point X="963.2476679104481" Y="421.86100746268653" /> |
- | <Point X="1171.4202114427858" Y="283.86100746268653" GraphRef="d31" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> | + | <Point X="1171.4202114427858" Y="283.86100746268653" GraphRef="d31" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bb8fd"> | <Interaction GraphId="bb8fd"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1211.928544776119" Y="462.36100746268653" GraphRef="aeb" RelX="0.0" RelY="1.0"/> | + | <Point X="1211.928544776119" Y="462.36100746268653" GraphRef="aeb" RelX="0.0" RelY="1.0" /> |
- | <Point X="1211.928544776119" Y="544.3610074626865" GraphRef="f77" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="1211.928544776119" Y="544.3610074626865" GraphRef="f77" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4" Shape="None" GraphId="bf7db"/> | + | <Anchor Position="0.4" Shape="None" GraphId="bf7db" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bba99"> | <Interaction GraphId="bba99"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="722.0" Y="417.17595366133054" GraphRef="a6d38" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="722.0" Y="417.17595366133054" GraphRef="a6d38" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="658.7310781618219" Y="416.4063481932442" GraphRef="e4e" RelX="-1.0" RelY="0.0"/> | + | <Point X="658.7310781618219" Y="416.4063481932442" GraphRef="e4e" RelX="-1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bcb04"> | <Interaction GraphId="bcb04"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="646.0" Y="256.0" GraphRef="a19" RelX="-0.004449136565869844" RelY="0.9354838709677419"/> | + | <Point X="646.0" Y="256.0" GraphRef="a19" RelX="-0.004449136565869844" RelY="0.9354838709677419" /> |
- | <Point X="652.2439365671643" Y="506.0" GraphRef="bce0f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="652.2439365671643" Y="506.0" GraphRef="bce0f" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.27079245283018877" Shape="None" GraphId="e62e2"/> | + | <Anchor Position="0.27079245283018877" Shape="None" GraphId="e62e2" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bdeb7"> | <Interaction GraphId="bdeb7"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="670.0" Y="66.22142857142859" GraphRef="abd76" RelX="-1.0" RelY="0.0"/> | + | <Point X="670.0" Y="66.22142857142859" GraphRef="abd76" RelX="-1.0" RelY="0.0" /> |
- | <Point X="585.669477372353" Y="65.93313576588257" GraphRef="bfef1" RelX="0.0" RelY="0.0" ArrowHead="TBar"/> | + | <Point X="585.669477372353" Y="65.93313576588257" GraphRef="bfef1" RelX="0.0" RelY="0.0" ArrowHead="TBar" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bdf2b"> | <Interaction GraphId="bdf2b"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="674.9833368937175" Y="172.5" GraphRef="fea" RelX="-1.0" RelY="0.0"/> | + | <Point X="674.9833368937175" Y="172.5" GraphRef="fea" RelX="-1.0" RelY="0.0" /> |
- | <Point X="646.4916666666667" Y="172.34790111940302" GraphRef="f4a4a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="646.4916666666667" Y="172.34790111940302" GraphRef="f4a4a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bf2ef"> | <Interaction GraphId="bf2ef"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1407.2535447761206" Y="535.3610074626865" GraphRef="d97" RelX="0.0" RelY="1.0"/> | + | <Point X="1407.2535447761206" Y="535.3610074626865" GraphRef="d97" RelX="0.0" RelY="1.0" /> |
- | <Point X="1252.4368781094522" Y="559.8610074626865" GraphRef="f77" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> | + | <Point X="1252.4368781094522" Y="559.8610074626865" GraphRef="f77" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.21831739619589857" Shape="None" GraphId="c241c"/> | + | <Anchor Position="0.21831739619589857" Shape="None" GraphId="c241c" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="bf7ea"> | <Interaction GraphId="bf7ea"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="515.0929057835821" Y="508.2567537313432" GraphRef="d37" RelX="1.0" RelY="0.0"/> | + | <Point X="515.0929057835821" Y="508.2567537313432" GraphRef="d37" RelX="1.0" RelY="0.0" /> |
- | <Point X="546.9916666666667" Y="508.1311501351232" GraphRef="e3bf2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="546.9916666666667" Y="508.1311501351232" GraphRef="e3bf2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="c200a"> | <Interaction GraphId="c200a"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="414.9916666666667" Y="495.08071352750744" GraphRef="cd89d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="414.9916666666667" Y="495.08071352750744" GraphRef="cd89d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="299.3075" Y="491.97729011194076" GraphRef="ee605" RelX="1.0" RelY="0.0"/> | + | <Point X="299.3075" Y="491.97729011194076" GraphRef="ee605" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="c3964"> | <Interaction GraphId="c3964"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="692.8472014925374" Y="585.0743246268656" GraphRef="cfb9e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="692.8472014925374" Y="585.0743246268656" GraphRef="cfb9e" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="662.0" Y="584.2789802789804" GraphRef="a74" RelX="1.0" RelY="0.0"/> | + | <Point X="662.0" Y="584.2789802789804" GraphRef="a74" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="c9467"> | <Interaction GraphId="c9467"> | ||
<Graphics ConnectorType="Curved" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> | <Graphics ConnectorType="Curved" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> | ||
- | <Point X="142.5" Y="250.0" GraphRef="c8c" RelX="0.0" RelY="-1.0"/> | + | <Point X="142.5" Y="250.0" GraphRef="c8c" RelX="0.0" RelY="-1.0" /> |
- | <Point X="119.75" Y="210.0"/> | + | <Point X="119.75" Y="210.0" /> |
- | <Point X="97.0" Y="146.0" GraphRef="bb282" RelX="0.0" RelY="1.0" ArrowHead="Arrow"/> | + | <Point X="97.0" Y="146.0" GraphRef="bb282" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ca6d9"> | <Interaction GraphId="ca6d9"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="614.0" Y="135.98333333333332" GraphRef="ccf" RelX="1.0" RelY="0.0"/> | + | <Point X="614.0" Y="135.98333333333332" GraphRef="ccf" RelX="1.0" RelY="0.0" /> |
- | <Point X="646.4916666666667" Y="226.0" GraphRef="a19" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="646.4916666666667" Y="226.0" GraphRef="a19" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.5620534748879915" Shape="None" GraphId="f4a4a"/> | + | <Anchor Position="0.5620534748879915" Shape="None" GraphId="f4a4a" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="cdd14"> | <Interaction GraphId="cdd14"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="692.8472014925374" Y="537.0" GraphRef="bce0f" RelX="0.5" RelY="1.0"/> | + | <Point X="692.8472014925374" Y="537.0" GraphRef="bce0f" RelX="0.5" RelY="1.0" /> |
- | <Point X="692.8472014925375" Y="657.1858115671641" GraphRef="c07" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="692.8472014925375" Y="657.1858115671641" GraphRef="c07" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4" Shape="None" GraphId="cfb9e"/> | + | <Anchor Position="0.4" Shape="None" GraphId="cfb9e" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ce830"> | <Interaction GraphId="ce830"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1252.4368781094522" Y="283.86100746268653" GraphRef="d31" RelX="1.0" RelY="0.0"/> | + | <Point X="1252.4368781094522" Y="283.86100746268653" GraphRef="d31" RelX="1.0" RelY="0.0" /> |
- | <Point X="1407.9202114427871" Y="333.36100746268653" GraphRef="dd1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="1407.9202114427871" Y="333.36100746268653" GraphRef="dd1" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4014349243294872" Shape="None" GraphId="dce76"/> | + | <Anchor Position="0.4014349243294872" Shape="None" GraphId="dce76" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="d660d"> | <Interaction GraphId="d660d"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="546.9916666666667" Y="453.0" GraphRef="c6a43" RelX="0.0" RelY="1.0"/> | + | <Point X="546.9916666666667" Y="453.0" GraphRef="c6a43" RelX="0.0" RelY="1.0" /> |
- | <Point X="571.0374067164182" Y="664.9358115671641" GraphRef="c07" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow"/> | + | <Point X="571.0374067164182" Y="664.9358115671641" GraphRef="c07" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow" /> |
- | <Anchor Position="0.23362483108264856" Shape="None" GraphId="e3bf2"/> | + | <Anchor Position="0.23362483108264856" Shape="None" GraphId="e3bf2" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="d8a14"> | <Interaction GraphId="d8a14"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="733.4504664179105" Y="664.9358115671641" GraphRef="c07" RelX="1.0" RelY="-0.5"/> | + | <Point X="733.4504664179105" Y="664.9358115671641" GraphRef="c07" RelX="1.0" RelY="-0.5" /> |
- | <Point X="755.6993190298508" Y="565.0083663098978"/> | + | <Point X="755.6993190298508" Y="565.0083663098978" /> |
- | <Point X="738.8496595149254" Y="465.08092105263154"/> | + | <Point X="738.8496595149254" Y="465.08092105263154" /> |
- | <Point X="722.0" Y="257.0" GraphRef="a19" RelX="0.6832818037855365" RelY="1.0" ArrowHead="Arrow"/> | + | <Point X="722.0" Y="257.0" GraphRef="a19" RelX="0.6832818037855365" RelY="1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.6547068675376538" Shape="None" GraphId="a6d38"/> | + | <Anchor Position="0.6547068675376538" Shape="None" GraphId="a6d38" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="dfbce"> | <Interaction GraphId="dfbce"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="647.6908108983386" Y="323.6981132075472" GraphRef="e62e2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="647.6908108983386" Y="323.6981132075472" GraphRef="e62e2" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="614.6769736842105" Y="353.52236842105265" GraphRef="c5a" RelX="0.0" RelY="-1.0"/> | + | <Point X="614.6769736842105" Y="353.52236842105265" GraphRef="c5a" RelX="0.0" RelY="-1.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="e2c91"> | <Interaction GraphId="e2c91"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="374.4875" Y="570.7213384819075" GraphRef="f7edf" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="374.4875" Y="570.7213384819075" GraphRef="f7edf" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="305.79499999999996" Y="571.0000000000003" GraphRef="ea0db" RelX="1.0" RelY="0.0"/> | + | <Point X="305.79499999999996" Y="571.0000000000003" GraphRef="ea0db" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="e3b89"> | <Interaction GraphId="e3b89"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="792.7346082089548" Y="579.0840485074621" GraphRef="fc6" RelX="-1.0" RelY="0.0"/> | + | <Point X="792.7346082089548" Y="579.0840485074621" GraphRef="fc6" RelX="-1.0" RelY="0.0" /> |
- | <Point X="774.9176305970151" Y="580.3487602301739" GraphRef="a330b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="774.9176305970151" Y="580.3487602301739" GraphRef="a330b" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="e4a7c"> | <Interaction GraphId="e4a7c"> | ||
<Graphics ConnectorType="Curved" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> | <Graphics ConnectorType="Curved" ZOrder="12288" LineStyle="Broken" LineThickness="1.0"> | ||
- | <Point X="148.49717514124293" Y="255.0" GraphRef="c8c" RelX="0.062146892655367235" RelY="-0.5"/> | + | <Point X="148.49717514124293" Y="255.0" GraphRef="c8c" RelX="0.062146892655367235" RelY="-0.5" /> |
- | <Point X="197.49858757062145" Y="213.0"/> | + | <Point X="197.49858757062145" Y="213.0" /> |
- | <Point X="246.5" Y="114.0" GraphRef="e7ee4" RelX="0.0" RelY="1.0" ArrowHead="Arrow"/> | + | <Point X="246.5" Y="114.0" GraphRef="e7ee4" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="e795d"> | <Interaction GraphId="e795d"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1211.928544776119" Y="495.16100746268654" GraphRef="bf7db" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1211.928544776119" Y="495.16100746268654" GraphRef="bf7db" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="1173.9285447761192" Y="494.36100746268653" GraphRef="a0c" RelX="1.0" RelY="0.0"/> | + | <Point X="1173.9285447761192" Y="494.36100746268653" GraphRef="a0c" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="e8fdb"> | <Interaction GraphId="e8fdb"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="468.99583333333334" Y="184.0" GraphRef="d00" RelX="0.5" RelY="1.0"/> | + | <Point X="468.99583333333334" Y="184.0" GraphRef="d00" RelX="0.5" RelY="1.0" /> |
- | <Point X="535.9833333333333" Y="233.75" GraphRef="a19" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow"/> | + | <Point X="535.9833333333333" Y="233.75" GraphRef="a19" RelX="-1.0" RelY="-0.5" ArrowHead="Arrow" /> |
- | <Anchor Position="0.49282392130426794" Shape="None" GraphId="f1164"/> | + | <Anchor Position="0.49282392130426794" Shape="None" GraphId="f1164" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="e9680"> | <Interaction GraphId="e9680"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="852.0" Y="554.2548966544806" GraphRef="a36c3" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="852.0" Y="554.2548966544806" GraphRef="a36c3" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="873.4776315789475" Y="554.0618421052632" GraphRef="e013b" RelX="-1.0" RelY="0.0"/> | + | <Point X="873.4776315789475" Y="554.0618421052632" GraphRef="e013b" RelX="-1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ea837"> | <Interaction GraphId="ea837"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="852.0" Y="486.0" GraphRef="c01" RelX="0.0" RelY="1.0"/> | + | <Point X="852.0" Y="486.0" GraphRef="c01" RelX="0.0" RelY="1.0" /> |
- | <Point X="733.4504664179105" Y="680.4358115671641" GraphRef="c07" RelX="1.0" RelY="0.5" ArrowHead="Arrow"/> | + | <Point X="733.4504664179105" Y="680.4358115671641" GraphRef="c07" RelX="1.0" RelY="0.5" ArrowHead="Arrow" /> |
- | <Anchor Position="0.15995607200672132" Shape="None" GraphId="bc5d1"/> | + | <Anchor Position="0.15995607200672132" Shape="None" GraphId="bc5d1" /> |
- | <Anchor Position="0.21807697297115256" Shape="None" GraphId="a36c3"/> | + | <Anchor Position="0.21807697297115256" Shape="None" GraphId="a36c3" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ed12d"> | <Interaction GraphId="ed12d"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="585.669477372353" Y="65.93313576588257" GraphRef="bfef1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="585.669477372353" Y="65.93313576588257" GraphRef="bfef1" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="519.3178571428572" Y="66.22142857142859" GraphRef="adf" RelX="1.0" RelY="0.0"/> | + | <Point X="519.3178571428572" Y="66.22142857142859" GraphRef="adf" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ee083"> | <Interaction GraphId="ee083"> | ||
<Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1143.1397172745892" Y="442.1165937119191" GraphRef="e3df5" RelX="1.0" RelY="0.0"/> | + | <Point X="1143.1397172745892" Y="442.1165937119191" GraphRef="e3df5" RelX="1.0" RelY="0.0" /> |
- | <Point X="1215.261878109454" Y="405.4054672539695"/> | + | <Point X="1215.261878109454" Y="405.4054672539695" /> |
- | <Point X="1145.5952114427857" Y="368.6943407960199" GraphRef="e31b6" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/> | + | <Point X="1145.5952114427857" Y="368.6943407960199" GraphRef="e31b6" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4" Shape="None" GraphId="f11c5"/> | + | <Anchor Position="0.4" Shape="None" GraphId="f11c5" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="eecbe"> | <Interaction GraphId="eecbe"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="523.4875026702881" Y="185.99999999999994" GraphRef="fe0c8" RelX="-0.5" RelY="1.0"/> | + | <Point X="523.4875026702881" Y="185.99999999999994" GraphRef="fe0c8" RelX="-0.5" RelY="1.0" /> |
- | <Point X="502.008875761703" Y="208.51799008488734" GraphRef="f1164" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="502.008875761703" Y="208.51799008488734" GraphRef="f1164" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="f114b"> | <Interaction GraphId="f114b"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="646.4916666666667" Y="257.0" GraphRef="a19" RelX="0.0" RelY="1.0"/> | + | <Point X="646.4916666666667" Y="257.0" GraphRef="a19" RelX="0.0" RelY="1.0" /> |
- | <Point X="546.9916666666667" Y="422.0" GraphRef="c6a43" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="546.9916666666667" Y="422.0" GraphRef="c6a43" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.3550492434589194" Shape="None" GraphId="a15fa"/> | + | <Anchor Position="0.3550492434589194" Shape="None" GraphId="a15fa" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="f1d72"> | <Interaction GraphId="f1d72"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1061.7730506079224" Y="442.1165937119191" GraphRef="e3df5" RelX="-1.0" RelY="0.0"/> | + | <Point X="1061.7730506079224" Y="442.1165937119191" GraphRef="e3df5" RelX="-1.0" RelY="0.0" /> |
- | <Point X="1065.5952114427857" Y="368.6943407960199" GraphRef="e31b6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/> | + | <Point X="1065.5952114427857" Y="368.6943407960199" GraphRef="e31b6" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4955519838248123" Shape="None" GraphId="f9a14"/> | + | <Anchor Position="0.4955519838248123" Shape="None" GraphId="f9a14" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="f52d5"> | <Interaction GraphId="f52d5"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="703.0" Y="743.5" GraphRef="a42" RelX="1.0" RelY="0.0"/> | + | <Point X="703.0" Y="743.5" GraphRef="a42" RelX="1.0" RelY="0.0" /> |
- | <Point X="774.9176305970151" Y="488.625"/> | + | <Point X="774.9176305970151" Y="488.625" /> |
- | <Point X="757.0" Y="233.75" GraphRef="a19" RelX="1.0" RelY="-0.5" ArrowHead="Arrow"/> | + | <Point X="757.0" Y="233.75" GraphRef="a19" RelX="1.0" RelY="-0.5" ArrowHead="Arrow" /> |
- | <Anchor Position="0.3920524495527438" Shape="None" GraphId="a330b"/> | + | <Anchor Position="0.3920524495527438" Shape="None" GraphId="a330b" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="f66da"> | <Interaction GraphId="f66da"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="585.7469937469938" Y="597.4550264550263" GraphRef="d76" RelX="1.0" RelY="0.0"/> | + | <Point X="585.7469937469938" Y="597.4550264550263" GraphRef="d76" RelX="1.0" RelY="0.0" /> |
- | <Point X="611.6406716417913" Y="598.8031623582186" GraphRef="a444a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="611.6406716417913" Y="598.8031623582186" GraphRef="a444a" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="fac19"> | <Interaction GraphId="fac19"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1334.7243470149256" Y="283.86100746268653" GraphRef="dce76" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1334.7243470149256" Y="283.86100746268653" GraphRef="dce76" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="1334.3979788557228" Y="255.09458955223886" GraphRef="d6d9d" RelX="0.0" RelY="1.0"/> | + | <Point X="1334.3979788557228" Y="255.09458955223886" GraphRef="d6d9d" RelX="0.0" RelY="1.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="faff4"> | <Interaction GraphId="faff4"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="557.9833333333333" Y="135.98333333333332" GraphRef="ccf" RelX="-1.0" RelY="0.0"/> | + | <Point X="557.9833333333333" Y="135.98333333333332" GraphRef="ccf" RelX="-1.0" RelY="0.0" /> |
- | <Point X="447.9916666666667" Y="158.0" GraphRef="d00" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="447.9916666666667" Y="158.0" GraphRef="d00" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.51138546448186" Shape="None" GraphId="c19fb"/> | + | <Anchor Position="0.51138546448186" Shape="None" GraphId="c19fb" /> |
- | <Anchor Position="0.338474844441228" Shape="None" GraphId="d4ce4"/> | + | <Anchor Position="0.338474844441228" Shape="None" GraphId="d4ce4" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="fc0e7"> | <Interaction GraphId="fc0e7"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="481.9635512584407" Y="295.33404029692474" GraphRef="a96b5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="481.9635512584407" Y="295.33404029692474" GraphRef="a96b5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="414.8115408225899" Y="285.7434008594224" GraphRef="a71c2" RelX="1.0" RelY="0.0"/> | + | <Point X="414.8115408225899" Y="285.7434008594224" GraphRef="a71c2" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="fc168"> | <Interaction GraphId="fc168"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="264.0815047021944" Y="309.94670846394996" GraphRef="df4" RelX="1.0" RelY="0.0"/> | + | <Point X="264.0815047021944" Y="309.94670846394996" GraphRef="df4" RelX="1.0" RelY="0.0" /> |
- | <Point X="313.4796238244514" Y="309.5611285266458" GraphRef="cba34" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="313.4796238244514" Y="309.5611285266458" GraphRef="cba34" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id28a21609"> | <Interaction GraphId="id28a21609"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1211.928544776119" Y="610.1610074626865" GraphRef="aaddb" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1211.928544776119" Y="610.1610074626865" GraphRef="aaddb" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
- | <Point X="1162.1785447761192" Y="610.1110074626865" GraphRef="a4e12" RelX="1.0" RelY="0.0"/> | + | <Point X="1162.1785447761192" Y="610.1110074626865" GraphRef="a4e12" RelX="1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id2a447c04"> | <Interaction GraphId="id2a447c04"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1211.9285447761192" Y="353.5861455842336" GraphRef="c6261" RelX="0.0" RelY="1.0"/> | + | <Point X="1211.9285447761192" Y="353.5861455842336" GraphRef="c6261" RelX="0.0" RelY="1.0" /> |
- | <Point X="1211.928544776119" Y="431.36100746268653" GraphRef="aeb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/> | + | <Point X="1211.928544776119" Y="431.36100746268653" GraphRef="aeb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> |
- | <Anchor Position="0.4" Shape="None" GraphId="cd4de"/> | + | <Anchor Position="0.4" Shape="None" GraphId="cd4de" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id2d7f0158"> | <Interaction GraphId="id2d7f0158"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="481.9635512584407" Y="295.33404029692474" GraphRef="a96b5" RelX="0.0" RelY="0.0"/> | + | <Point X="481.9635512584407" Y="295.33404029692474" GraphRef="a96b5" RelX="0.0" RelY="0.0" /> |
- | <Point X="431.40945365254754" Y="233.54327808471479" GraphRef="b1439" RelX="0.0" RelY="1.0"/> | + | <Point X="431.40945365254754" Y="233.54327808471479" GraphRef="b1439" RelX="0.0" RelY="1.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id36efcfa9"> | <Interaction GraphId="id36efcfa9"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1252.261878109454" Y="382.36100746268653" GraphRef="bc738" RelX="-1.0" RelY="0.0"/> | + | <Point X="1252.261878109454" Y="382.36100746268653" GraphRef="bc738" RelX="-1.0" RelY="0.0" /> |
- | <Point X="1211.9285447761192" Y="384.69609033561477" GraphRef="cd4de" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1211.9285447761192" Y="384.69609033561477" GraphRef="cd4de" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id3e1dd780"> | <Interaction GraphId="id3e1dd780"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="535.9833333333333" Y="249.25" GraphRef="a19" RelX="-1.0" RelY="0.5"/> | + | <Point X="535.9833333333333" Y="249.25" GraphRef="a19" RelX="-1.0" RelY="0.5" /> |
- | <Point X="481.9635512584407" Y="337.88873542050334" GraphRef="edfe5" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion"/> | + | <Point X="481.9635512584407" Y="337.88873542050334" GraphRef="edfe5" RelX="-0.5" RelY="-1.0" ArrowHead="mim-conversion" /> |
- | <Anchor Position="0.7017023878370812" Shape="None" GraphId="a96b5"/> | + | <Anchor Position="0.7017023878370812" Shape="None" GraphId="a96b5" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id5e90d8d7"> | <Interaction GraphId="id5e90d8d7"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1407.6535447761205" Y="420.36100746268653" GraphRef="bf619" RelX="0.0" RelY="0.0"/> | + | <Point X="1407.6535447761205" Y="420.36100746268653" GraphRef="bf619" RelX="0.0" RelY="0.0" /> |
- | <Point X="1526.261878109454" Y="485.36100746268653" GraphRef="a84" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion"/> | + | <Point X="1526.261878109454" Y="485.36100746268653" GraphRef="a84" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id67e7177a"> | <Interaction GraphId="id67e7177a"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="240.5" Y="366.0" GraphRef="a47" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion"/> | + | <Point X="240.5" Y="366.0" GraphRef="a47" RelX="1.0" RelY="0.0" ArrowHead="mim-conversion" /> |
- | <Point X="313.4796238244514" Y="309.5611285266458" GraphRef="cba34" RelX="0.0" RelY="0.0"/> | + | <Point X="313.4796238244514" Y="309.5611285266458" GraphRef="cba34" RelX="0.0" RelY="0.0" /> |
- | <Anchor Position="1.0" Shape="None" GraphId="a54e8"/> | + | <Anchor Position="1.0" Shape="None" GraphId="a54e8" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id6a964360"> | <Interaction GraphId="id6a964360"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1211.928544776119" Y="575.3610074626865" GraphRef="f77" RelX="0.0" RelY="1.0" ArrowHead="Arrow"/> | + | <Point X="1211.928544776119" Y="575.3610074626865" GraphRef="f77" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> |
- | <Point X="1211.9285447761192" Y="662.3610074626865" GraphRef="ecab7" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion"/> | + | <Point X="1211.9285447761192" Y="662.3610074626865" GraphRef="ecab7" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> |
- | <Anchor Position="0.4" Shape="None" GraphId="aaddb"/> | + | <Anchor Position="0.4" Shape="None" GraphId="aaddb" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id6bd6286"> | <Interaction GraphId="id6bd6286"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1407.6535447761205" Y="420.36100746268653" GraphRef="bf619" RelX="0.0" RelY="0.0"/> | + | <Point X="1407.6535447761205" Y="420.36100746268653" GraphRef="bf619" RelX="0.0" RelY="0.0" /> |
- | <Point X="1522.964763315101" Y="381.241915995529" GraphRef="c93" RelX="-1.0" RelY="0.0"/> | + | <Point X="1522.964763315101" Y="381.241915995529" GraphRef="c93" RelX="-1.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id8a932132"> | <Interaction GraphId="id8a932132"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1178.6903618418005" Y="404.97488100473686" GraphRef="ccb" RelX="1.0" RelY="0.0"/> | + | <Point X="1178.6903618418005" Y="404.97488100473686" GraphRef="ccb" RelX="1.0" RelY="0.0" /> |
- | <Point X="1208.6019710034752" Y="422.30992693972223" GraphRef="f11c5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1208.6019710034752" Y="422.30992693972223" GraphRef="f11c5" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="id97f892de"> | <Interaction GraphId="id97f892de"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1016.1018362950442" Y="421.86663677469016" GraphRef="c04" RelX="1.0" RelY="0.0"/> | + | <Point X="1016.1018362950442" Y="421.86663677469016" GraphRef="c04" RelX="1.0" RelY="0.0" /> |
- | <Point X="1041.7730506079224" Y="404.0158918853516" GraphRef="f9a14" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis"/> | + | <Point X="1041.7730506079224" Y="404.0158918853516" GraphRef="f9a14" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="ida598ea4b"> | <Interaction GraphId="ida598ea4b"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="239.0" Y="260.0" GraphRef="c8c" RelX="1.0" RelY="0.0"/> | + | <Point X="239.0" Y="260.0" GraphRef="c8c" RelX="1.0" RelY="0.0" /> |
- | <Point X="313.4796238244514" Y="309.5611285266458" GraphRef="cba34" RelX="0.0" RelY="0.0"/> | + | <Point X="313.4796238244514" Y="309.5611285266458" GraphRef="cba34" RelX="0.0" RelY="0.0" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="idabeb15"> | <Interaction GraphId="idabeb15"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="481.9635512584407" Y="295.33404029692474" GraphRef="a96b5" RelX="0.0" RelY="0.0"/> | + | <Point X="481.9635512584407" Y="295.33404029692474" GraphRef="a96b5" RelX="0.0" RelY="0.0" /> |
- | <Point X="414.9916666666667" Y="385.0" GraphRef="d13" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion"/> | + | <Point X="414.9916666666667" Y="385.0" GraphRef="d13" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="idae7d27b4"> | <Interaction GraphId="idae7d27b4"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1407.9202114427871" Y="364.36100746268653" GraphRef="dd1" RelX="0.0" RelY="1.0"/> | + | <Point X="1407.9202114427871" Y="364.36100746268653" GraphRef="dd1" RelX="0.0" RelY="1.0" /> |
- | <Point X="1407.2535447761206" Y="504.36100746268653" GraphRef="d97" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion"/> | + | <Point X="1407.2535447761206" Y="504.36100746268653" GraphRef="d97" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> |
- | <Anchor Position="0.4" Shape="None" GraphId="bf619"/> | + | <Anchor Position="0.4" Shape="None" GraphId="bf619" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="iddb175817"> | <Interaction GraphId="iddb175817"> | ||
<Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="405.98333333333335" Y="171.0" GraphRef="d00" RelX="-1.0" RelY="0.0"/> | + | <Point X="405.98333333333335" Y="171.0" GraphRef="d00" RelX="-1.0" RelY="0.0" /> |
- | <Point X="313.4796238244514" Y="283.5"/> | + | <Point X="313.4796238244514" Y="283.5" /> |
- | <Point X="333.98333333333335" Y="396.0" GraphRef="d13" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion"/> | + | <Point X="333.98333333333335" Y="396.0" GraphRef="d13" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" /> |
- | <Anchor Position="0.6836087761238878" Shape="None" GraphId="cba34"/> | + | <Anchor Position="0.6836087761238878" Shape="None" GraphId="cba34" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Interaction GraphId="iddef44681"> | <Interaction GraphId="iddef44681"> | ||
<Graphics ZOrder="12288" LineThickness="1.0"> | <Graphics ZOrder="12288" LineThickness="1.0"> | ||
- | <Point X="1014.8855768349788" Y="384.32248850132373" GraphRef="be5fb" RelX="1.0" RelY="0.0"/> | + | <Point X="1014.8855768349788" Y="384.32248850132373" GraphRef="be5fb" RelX="1.0" RelY="0.0" /> |
- | <Point X="1041.7730506079224" Y="404.0158918853516" GraphRef="f9a14" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion"/> | + | <Point X="1041.7730506079224" Y="404.0158918853516" GraphRef="f9a14" RelX="0.0" RelY="0.0" ArrowHead="mim-conversion" /> |
</Graphics> | </Graphics> | ||
- | <Xref Database="" ID=""/> | + | <Xref Database="" ID="" /> |
</Interaction> | </Interaction> | ||
<Label TextLabel="DNA repair pathways" GraphId="a2285" GroupRef="ebfa0"> | <Label TextLabel="DNA repair pathways" GraphId="a2285" GroupRef="ebfa0"> | ||
- | <Graphics CenterX="245.5" CenterY="59.0" Width="167.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="13" Valign="Middle"/> | + | <Graphics CenterX="245.5" CenterY="59.0" Width="167.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontStyle="Italic" FontSize="13" Valign="Middle" /> |
</Label> | </Label> | ||
<Label TextLabel="DNA 5-methylcytosine" GraphId="a84"> | <Label TextLabel="DNA 5-methylcytosine" GraphId="a84"> | ||
- | <Graphics CenterX="1587.261878109454" CenterY="485.36100746268653" Width="122.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1587.261878109454" CenterY="485.36100746268653" Width="122.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="0000ff" /> |
</Label> | </Label> | ||
<Label TextLabel="DNA" GraphId="c93"> | <Label TextLabel="DNA" GraphId="c93"> | ||
- | <Graphics CenterX="1541.464763315101" CenterY="381.241915995529" Width="37.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="0000ff"/> | + | <Graphics CenterX="1541.464763315101" CenterY="381.241915995529" Width="37.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="11" Valign="Middle" Color="0000ff" /> |
</Label> | </Label> | ||
- | <Group GroupId="e81fe" GraphId="a71c2"/> | + | <Group GroupId="e81fe" GraphId="a71c2" /> |
- | <Group GroupId="c9cb9" GraphId="c4413"/> | + | <Group GroupId="c9cb9" GraphId="c4413" /> |
- | <Group GroupId="f4484" GraphId="cbe1d"/> | + | <Group GroupId="f4484" GraphId="cbe1d" /> |
- | <Group GroupId="b93bd" GraphId="d6d9d"/> | + | <Group GroupId="b93bd" GraphId="d6d9d" /> |
- | <Group GroupId="f96c6" GraphId="e013b"/> | + | <Group GroupId="f96c6" GraphId="e013b" /> |
- | <Group GroupId="ebfa0" GraphId="e7ee4" Style="Group"/> | + | <Group GroupId="ebfa0" GraphId="e7ee4" Style="Group" /> |
- | <Group GroupId="cffba" GraphId="ea0db" Style="Complex"/> | + | <Group GroupId="cffba" GraphId="ea0db" Style="Complex" /> |
- | <Group GroupId="b5249" GraphId="ee605"/> | + | <Group GroupId="b5249" GraphId="ee605" /> |
- | <Group GroupId="c1374" GraphId="ff813"/> | + | <Group GroupId="c1374" GraphId="ff813" /> |
- | <InfoBox CenterX="0.0" CenterY="0.0"/> | + | <InfoBox CenterX="0.0" CenterY="0.0" /> |
<Biopax> | <Biopax> | ||
- | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id=" | + | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c4c"> |
- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12466265</bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
- | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.</bp:TITLE> |
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> | ||
- | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2003</bp:YEAR> |
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Waditee R</bp:AUTHORS> |
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tanaka Y</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aoki K</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hibino T</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jikuya H</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takano J</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takabe T</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5"> | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17389618</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17389618</bp:ID> | ||
Line 874: | Line 856: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hunter DJ</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hunter DJ</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
+ | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ba1"> | ||
+ | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">13271447</bp:ID> | ||
+ | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
+ | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glutathione-homocystine transhydrogenase.</bp:TITLE> | ||
+ | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE> | ||
+ | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1955</bp:YEAR> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">RACKER E</bp:AUTHORS> | ||
+ | </bp:PublicationXref> | ||
+ | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
+ | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">folate mediated one-carbon metabolic pathway</bp:TERM> | ||
+ | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000189</bp:ID> | ||
+ | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> | ||
+ | </bp:openControlledVocabulary> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d81"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d81"> | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8752328</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8752328</bp:ID> | ||
Line 884: | Line 879: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schmid R</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schmid R</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bremer E</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bremer E</bp:AUTHORS> | ||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
- | |||
</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fd6"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fd6"> | ||
Line 907: | Line 888: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ludwig ML</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ludwig ML</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matthews RG</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matthews RG</bp:AUTHORS> | ||
+ | </bp:PublicationXref> | ||
+ | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ecf"> | ||
+ | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22634633</bp:ID> | ||
+ | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
+ | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.</bp:TITLE> | ||
+ | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Acta Biochim Biophys Sin (Shanghai)</bp:SOURCE> | ||
+ | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim HY</bp:AUTHORS> | ||
+ | </bp:PublicationXref> | ||
+ | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a48"> | ||
+ | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8019414</bp:ID> | ||
+ | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
+ | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The primary structure and properties of thioltransferase (glutaredoxin) from human red blood cells.</bp:TITLE> | ||
+ | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein Sci</bp:SOURCE> | ||
+ | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1994</bp:YEAR> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Papov VV</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gravina SA</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mieyal JJ</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biemann K</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
</Biopax> | </Biopax> | ||
</Pathway> | </Pathway> |
Revision as of 12:06, 16 August 2019
Error rendering pathway page
This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.
Pathway history
View all... |
Error details
exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/8/8c/WP241_prev.svg: <BR>Status:1 <BR>Message:Exception in thread "main" java.lang.NullPointerException at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source) at org.pathvisio.core.Engine.importPathway(Unknown Source) at org.pathvisio.core.util.Converter.main(Unknown Source) <BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/8/8c/WP241_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255 Stack trace: #0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...') #1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg') #2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg') #3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState)) #4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array) #5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array) #6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106172) #7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true) #8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true) #9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...') #10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision() #11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false) #12 /var/www/wikipathways/includes/Wiki.php(437): Article->view() #13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest)) #14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest)) #15 {main}