Peptide GPCRs (Homo sapiens)

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Chemotactic ReceptorsBradykinin ReceptorsCholecystokinin/ Gastrin ReceptorsReleasing Hormone ReceptorsAngiotensin ReceptorsEndothelin ReceptorsGlycoprotein Hormone ReceptorsMelanocortin ReceptorsVasopressin and Oxytocin ReceptorsSomatostatin ReceptorsChemokine ReceptorsNeuropeptide Y ReceptorsNeurotensin ReceptorsGalanin ReceptorsOpioid ReceptorsBombesin ReceptorsTachykinin ReceptorsIL8RBCCR8CCR3SSTR4SSTR3CCR6BRS3CCKBREDNRBCXCR6MC4RSSTR2CCR5Gq/G11 PathwayAGTR1AVPR2GNRHRNMBRMC3RCCR1GHSRNPY2RCX3CR1NPY1RGRPRCCR7OPRK1CXCR3CXCR4OPRL1Gi/Go PathwayMC5RSSTR5ATP8A1TSHRTAC4CCR2CCR1OxytocinCCR4NPY5ROPRD1BLR1TACR3TRHRGs PathwayAGTR1FPRL1IL8RATACR2NPY6RBDKRB2NTSR2CCKARMC1RAVPR1AFSHRGALR1GALR2GALR3SSTR1C3AR1BradykininNTSR1FPR1FYMC2ROPRM1C5R1OXTRFPRL2LHCGRTACR1CCR10CCR-9AVPR1BAGTR2BDKRB1PPYR1EDNRAHCRTR1HCRTR2Orexin Receptors1


G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Wikipedia This pathway is part the CPTAC Assay Portal.

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  1. Kukkonen JP; ''G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.''; Biochem Biophys Res Commun, 2016 PubMed Europe PMC Scholia


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106544view00:09, 6 September 2019KhanspersModified description
106176view12:07, 16 August 2019MaintBotHMDB identifier normalization
105783view19:45, 15 August 2019KhanspersModified description
95856view17:59, 26 January 2018KhanspersModified description
95855view17:57, 26 January 2018KhanspersModified description
95511view01:04, 19 December 2017Khanspersfixed missing xref
90195view21:13, 21 October 2016Khanspersfixed unconnected
88894view01:14, 17 August 2016AlexanderPicoQuick edit to datanode annotation or property
88893view01:12, 17 August 2016AlexanderPicoAdded orexin receptors and literature reference
79999view08:09, 30 April 2015ZariChanged old Entrez gene ID to new Enterz gene ID
79444view06:55, 22 March 2015EgonwReplaced a gene name with its Entrez Gene identifier.
72125view07:46, 25 October 2013Mkutmonadded datasource to pathway nodes
68988view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
45244view18:28, 7 October 2011KhanspersOntology Term : 'G protein mediated signaling pathway' added !
41166view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
38859view18:13, 24 September 2010KhanspersAdded pathway links
38858view18:09, 24 September 2010Khanspers
34496view22:36, 16 December 2009KhanspersAdded metabolite and changed layout
34442view18:19, 10 December 2009MaintBotAutomatic update of empty xrefs
32374view16:50, 15 August 2009MaintBotFixed text labels
32009view13:19, 14 August 2009MaintBotFixed group labels
20727view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Peptide GPCRs]] moved to [[Pathway:WP24]]: Moved to stable identifier
14494view00:45, 23 May 2008AlexanderPicoConnected!
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8336view13:46, 7 January 2008MaintBot[[Pathway:Human:Peptide GPCRs]] moved to [[Pathway:Homo sapiens:Peptide GPCRs]]: Renaming species
7786view16:17, 18 December 2007MaintBotfixed category names
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External references


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NameTypeDatabase referenceComment
AGTR1GeneProduct185 (Entrez Gene)
AGTR2GeneProduct186 (Entrez Gene)
ATP8A1GeneProduct10396 (Entrez Gene)
AVPR1AGeneProduct552 (Entrez Gene)
AVPR1BGeneProduct553 (Entrez Gene)
AVPR2GeneProduct554 (Entrez Gene)
BDKRB1GeneProduct623 (Entrez Gene)
BDKRB2GeneProduct624 (Entrez Gene)
BLR1GeneProduct643 (Entrez Gene)
BRS3GeneProduct680 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
C3AR1GeneProduct719 (Entrez Gene)
C5R1GeneProduct728 (Entrez Gene)
CCKARGeneProduct886 (Entrez Gene)
CCKBRGeneProduct887 (Entrez Gene)
CCR-9GeneProduct10803 (Entrez Gene)
CCR10GeneProduct2826 (Entrez Gene)
CCR1GeneProduct1230 (Entrez Gene)
CCR2GeneProduct729230 (Entrez Gene)
CCR3GeneProduct1232 (Entrez Gene)
CCR4GeneProduct1233 (Entrez Gene)
CCR5GeneProduct1234 (Entrez Gene)
CCR6GeneProduct1235 (Entrez Gene)
CCR7GeneProduct1236 (Entrez Gene)
CCR8GeneProduct1237 (Entrez Gene)
CX3CR1GeneProduct1524 (Entrez Gene)
CXCR3GeneProduct2833 (Entrez Gene)
CXCR4GeneProduct7852 (Entrez Gene)
CXCR6GeneProduct10663 (Entrez Gene)
EDNRAGeneProduct1909 (Entrez Gene)
EDNRBGeneProduct1910 (Entrez Gene)
FPR1GeneProduct2357 (Entrez Gene)
FPRL1GeneProduct2358 (Entrez Gene)
FPRL2GeneProduct2359 (Entrez Gene)
FSHRGeneProduct2492 (Entrez Gene)
FYGeneProduct2532 (Entrez Gene)
GALR1GeneProduct2587 (Entrez Gene)
GALR2GeneProduct8811 (Entrez Gene)
GALR3GeneProduct8484 (Entrez Gene)
GHSRGeneProduct2693 (Entrez Gene)
GNRHRGeneProduct2798 (Entrez Gene)
GRPRGeneProduct2925 (Entrez Gene)
Gi/Go PathwayPathwayWP35 (WikiPathways)
Gq/G11 PathwayPathwayWP35 (WikiPathways)
Gs PathwayPathwayWP35 (WikiPathways)
HCRTR1GeneProduct3061 (Entrez Gene)
HCRTR2GeneProductENSG00000137252 (Ensembl) CAA71233 - human AA#
IL8RAGeneProduct3577 (Entrez Gene)
IL8RBGeneProduct3579 (Entrez Gene)
LHCGRGeneProduct3973 (Entrez Gene)
MC1RGeneProduct4157 (Entrez Gene)
MC2RGeneProduct4158 (Entrez Gene)
MC3RGeneProduct4159 (Entrez Gene)
MC4RGeneProduct4160 (Entrez Gene)
MC5RGeneProduct4161 (Entrez Gene)
NMBRGeneProduct4829 (Entrez Gene)
NPY1RGeneProduct4886 (Entrez Gene)
NPY2RGeneProduct4887 (Entrez Gene)
NPY5RGeneProduct4889 (Entrez Gene)
NPY6RGeneProduct4888 (Entrez Gene) human Acc# BAA13103
NTSR1GeneProduct4923 (Entrez Gene)
NTSR2GeneProduct23620 (Entrez Gene) CAA71233 - human AA#
OPRD1GeneProduct4985 (Entrez Gene)
OPRK1GeneProduct4986 (Entrez Gene)
OPRL1GeneProduct4987 (Entrez Gene)
OPRM1GeneProduct4988 (Entrez Gene)
OXTRGeneProduct5021 (Entrez Gene)
OxytocinMetabolite50-56-6 (CAS)
PPYR1GeneProduct5540 (Entrez Gene)
SSTR1GeneProduct6751 (Entrez Gene)
SSTR2GeneProduct6752 (Entrez Gene)
SSTR3GeneProduct6753 (Entrez Gene)
SSTR4GeneProduct6754 (Entrez Gene)
SSTR5GeneProduct6755 (Entrez Gene)
TAC4GeneProduct255061 (Entrez Gene)
TACR1GeneProduct6869 (Entrez Gene)
TACR2GeneProduct6865 (Entrez Gene)
TACR3GeneProduct6870 (Entrez Gene)
TRHRGeneProduct7201 (Entrez Gene)
TSHRGeneProduct7253 (Entrez Gene)

Annotated Interactions

No annotated interactions

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