Peptide GPCRs (Homo sapiens)

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Current revision (12:07, 16 August 2019) (view source)
(HMDB identifier normalization)
 
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<?xml version="1.0" encoding="UTF-8"?>
<?xml version="1.0" encoding="UTF-8"?>
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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Peptide GPCRs" Organism="Homo sapiens" License="CC BY 2.0"><Comment Source="WikiPathways-description">G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor Wikipedia]
+
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Peptide GPCRs" Organism="Homo sapiens" License="CC BY 2.0">
 +
  <Comment Source="WikiPathways-description">G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor Wikipedia]
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP24 CPTAC Assay Portal].</Comment>
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP24 CPTAC Assay Portal].</Comment>
-
   <Comment Source="GenMAPP notes"/>
+
   <Comment Source="GenMAPP notes"></Comment>
-
   <Comment Source="GenMAPP remarks"/>
+
   <Comment Source="GenMAPP remarks"></Comment>
   <Comment Source="WikiPathways-category">Molecular Function</Comment>
   <Comment Source="WikiPathways-category">Molecular Function</Comment>
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   <DataNode TextLabel="SSTR2" GraphId="a0e" Type="GeneProduct" GroupRef="c41ec">
-
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   <DataNode TextLabel="IL8RA" GraphId="a14" Type="GeneProduct" GroupRef="fff98">
   <DataNode TextLabel="IL8RA" GraphId="a14" Type="GeneProduct" GroupRef="fff98">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL8RA | interleukin 8 receptor alpha"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL8RA | interleukin 8 receptor alpha" />
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   <DataNode TextLabel="NPY2R" GraphId="a33" Type="GeneProduct" GroupRef="e72b6">
   <DataNode TextLabel="NPY2R" GraphId="a33" Type="GeneProduct" GroupRef="e72b6">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY2R | neuropeptide Y receptor Y2"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY2R | neuropeptide Y receptor Y2" />
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   <DataNode TextLabel="CXCR3" GraphId="a37" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CXCR3" GraphId="a37" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CXCR3 | chemokine (C-X-C motif) receptor 3"/>
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   <DataNode TextLabel="CCR5" GraphId="a4e" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR5 | chemokine (C-C motif) receptor 5"/>
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   <DataNode TextLabel="GALR3" GraphId="a55" Type="GeneProduct" GroupRef="b5877">
   <DataNode TextLabel="GALR3" GraphId="a55" Type="GeneProduct" GroupRef="b5877">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GALR3 | galanin receptor 3"/>
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   <DataNode TextLabel="TACR1" GraphId="a6e" Type="GeneProduct" GroupRef="a62f0">
   <DataNode TextLabel="TACR1" GraphId="a6e" Type="GeneProduct" GroupRef="a62f0">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TACR1 | tachykinin receptor 1"/>
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   <DataNode TextLabel="BDKRB2" GraphId="a6f" Type="GeneProduct" GroupRef="f20a0">
   <DataNode TextLabel="BDKRB2" GraphId="a6f" Type="GeneProduct" GroupRef="f20a0">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDKRB2 | bradykinin receptor B2"/>
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   <DataNode TextLabel="FPR1" GraphId="a71" Type="GeneProduct" GroupRef="fff98">
   <DataNode TextLabel="FPR1" GraphId="a71" Type="GeneProduct" GroupRef="fff98">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FPR1 | formyl peptide receptor 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FPR1 | formyl peptide receptor 1" />
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   <DataNode TextLabel="Gi/Go Pathway" GraphId="a8d32" Type="Pathway">
   <DataNode TextLabel="Gi/Go Pathway" GraphId="a8d32" Type="Pathway">
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   <DataNode TextLabel="AGTR2" GraphId="acd" Type="GeneProduct" GroupRef="ce0fd">
   <DataNode TextLabel="AGTR2" GraphId="acd" Type="GeneProduct" GroupRef="ce0fd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AGTR2 | angiotensin II receptor type 2"/>
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   <DataNode TextLabel="NMBR" GraphId="ad2" Type="GeneProduct" GroupRef="f1db1">
   <DataNode TextLabel="NMBR" GraphId="ad2" Type="GeneProduct" GroupRef="f1db1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NMBR | neuromedin B receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NMBR | neuromedin B receptor" />
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   <DataNode TextLabel="AVPR2" GraphId="ad5" Type="GeneProduct" GroupRef="d0d28">
   <DataNode TextLabel="AVPR2" GraphId="ad5" Type="GeneProduct" GroupRef="d0d28">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AVPR2 | arginine vasopressin receptor 2 (nephro..."/>
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   </DataNode>
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   <DataNode TextLabel="TAC4" GraphId="ad8" Type="GeneProduct" GroupRef="a62f0">
   <DataNode TextLabel="TAC4" GraphId="ad8" Type="GeneProduct" GroupRef="a62f0">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAC4 | tachykinin 4 (hemokinin)"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TAC4 | tachykinin 4 (hemokinin)" />
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     <Xref Database="Entrez Gene" ID="255061" />
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   <DataNode TextLabel="BLR1" GraphId="aec" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BLR1 | Burkitt lymphoma receptor 1 GTP binding..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BLR1 | Burkitt lymphoma receptor 1 GTP binding..." />
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   <DataNode TextLabel="AGTR1" GraphId="b10" Type="GeneProduct" GroupRef="ce0fd">
   <DataNode TextLabel="AGTR1" GraphId="b10" Type="GeneProduct" GroupRef="ce0fd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AGTR1 | angiotensin II receptor type 1"/>
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     <Xref Database="Entrez Gene" ID="185"/>
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   <DataNode TextLabel="SSTR4" GraphId="b12" Type="GeneProduct" GroupRef="c41ec">
   <DataNode TextLabel="SSTR4" GraphId="b12" Type="GeneProduct" GroupRef="c41ec">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR4 | somatostatin receptor 4"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR4 | somatostatin receptor 4" />
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   <DataNode TextLabel="BDKRB1" GraphId="b2a" Type="GeneProduct" GroupRef="f20a0">
   <DataNode TextLabel="BDKRB1" GraphId="b2a" Type="GeneProduct" GroupRef="f20a0">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDKRB1 | bradykinin receptor B1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDKRB1 | bradykinin receptor B1" />
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     <Xref Database="Entrez Gene" ID="623" />
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   <DataNode TextLabel="NTSR2" GraphId="b37" Type="GeneProduct" GroupRef="d216c">
   <DataNode TextLabel="NTSR2" GraphId="b37" Type="GeneProduct" GroupRef="d216c">
     <Comment Source="GenMAPP remarks">CAA71233 - human AA#
     <Comment Source="GenMAPP remarks">CAA71233 - human AA#
</Comment>
</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NTSR2 | neurotensin receptor 2"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NTSR2 | neurotensin receptor 2" />
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     <Xref Database="Entrez Gene" ID="23620" />
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   <DataNode TextLabel="CXCR4" GraphId="b54" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CXCR4" GraphId="b54" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CXCR4 | chemokine (C-X-C motif) receptor 4"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CXCR4 | chemokine (C-X-C motif) receptor 4" />
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   </DataNode>
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   <DataNode TextLabel="NPY5R" GraphId="b61" Type="GeneProduct" GroupRef="e72b6">
   <DataNode TextLabel="NPY5R" GraphId="b61" Type="GeneProduct" GroupRef="e72b6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY5R | neuropeptide Y receptor Y5"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY5R | neuropeptide Y receptor Y5" />
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     <Xref Database="Entrez Gene" ID="4889"/>
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   </DataNode>
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   <DataNode TextLabel="CCR7" GraphId="ba1" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CCR7" GraphId="ba1" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR7 | chemokine (C-C motif) receptor 7"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR7 | chemokine (C-C motif) receptor 7" />
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   <DataNode TextLabel="FPRL1" GraphId="bac" Type="GeneProduct" GroupRef="fff98">
   <DataNode TextLabel="FPRL1" GraphId="bac" Type="GeneProduct" GroupRef="fff98">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FPRL1 | formyl peptide receptor-like 1"/>
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   <DataNode TextLabel="ATP8A1" GraphId="bb0" Type="GeneProduct" GroupRef="ce0fd">
   <DataNode TextLabel="ATP8A1" GraphId="bb0" Type="GeneProduct" GroupRef="ce0fd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ATP8A1 | ATPase aminophospholipid transporter ..."/>
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   <DataNode TextLabel="FPRL2" GraphId="bb5" Type="GeneProduct" GroupRef="fff98">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FPRL2 | formyl peptide receptor-like 2"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FPRL2 | formyl peptide receptor-like 2" />
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     <Xref Database="Entrez Gene" ID="2359"/>
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     <Xref Database="Entrez Gene" ID="2359" />
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   <DataNode TextLabel="OPRM1" GraphId="be4" Type="GeneProduct" GroupRef="a2b4a">
   <DataNode TextLabel="OPRM1" GraphId="be4" Type="GeneProduct" GroupRef="a2b4a">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRM1 | opioid receptor mu 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRM1 | opioid receptor mu 1" />
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     <Graphics CenterX="453.3333333333333" CenterY="540.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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   <DataNode TextLabel="AVPR1A" GraphId="bf1" Type="GeneProduct" GroupRef="d0d28">
   <DataNode TextLabel="AVPR1A" GraphId="bf1" Type="GeneProduct" GroupRef="d0d28">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AVPR1A | arginine vasopressin receptor 1A"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AVPR1A | arginine vasopressin receptor 1A" />
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     <Graphics CenterX="289.6666666666667" CenterY="162.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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   <DataNode TextLabel="GALR1" GraphId="c1a" Type="GeneProduct" GroupRef="b5877">
   <DataNode TextLabel="GALR1" GraphId="c1a" Type="GeneProduct" GroupRef="b5877">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GALR1 | galanin receptor 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GALR1 | galanin receptor 1" />
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     <Graphics CenterX="453.3333333333333" CenterY="398.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Entrez Gene" ID="2587" />
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   <DataNode TextLabel="CCKAR" GraphId="c1c" Type="GeneProduct" GroupRef="f2223">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCKAR | cholecystokinin A receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCKAR | cholecystokinin A receptor" />
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     <Graphics CenterX="114.66666666666667" CenterY="360.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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   <DataNode TextLabel="MC3R" GraphId="c36" Type="GeneProduct" GroupRef="a7117">
   <DataNode TextLabel="MC3R" GraphId="c36" Type="GeneProduct" GroupRef="a7117">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC3R | melanocortin 3 receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC3R | melanocortin 3 receptor" />
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     <Graphics CenterX="454.3333333333333" CenterY="301.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="454.3333333333333" CenterY="301.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Entrez Gene" ID="4159"/>
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     <Xref Database="Entrez Gene" ID="4159" />
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   <DataNode TextLabel="LHCGR" GraphId="c43" Type="GeneProduct" GroupRef="ef214">
   <DataNode TextLabel="LHCGR" GraphId="c43" Type="GeneProduct" GroupRef="ef214">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="LHCGR | luteinizing hormone/choriogonadotropin ..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="LHCGR | luteinizing hormone/choriogonadotropin ..." />
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     <Graphics CenterX="454.3333333333333" CenterY="172.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Entrez Gene" ID="3973" />
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   <DataNode TextLabel="CCKBR" GraphId="c48" Type="GeneProduct" GroupRef="f2223">
   <DataNode TextLabel="CCKBR" GraphId="c48" Type="GeneProduct" GroupRef="f2223">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCKBR | cholecystokinin B receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCKBR | cholecystokinin B receptor" />
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     <Graphics CenterX="114.66666666666667" CenterY="380.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Entrez Gene" ID="887" />
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   <DataNode TextLabel="EDNRA" GraphId="c53" Type="GeneProduct" GroupRef="a6b50">
   <DataNode TextLabel="EDNRA" GraphId="c53" Type="GeneProduct" GroupRef="a6b50">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDNRA | endothelin receptor type A"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDNRA | endothelin receptor type A" />
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     <Xref Database="Entrez Gene" ID="1909" />
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   <DataNode TextLabel="CX3CR1" GraphId="c67" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CX3CR1" GraphId="c67" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CX3CR1 | chemokine (C-X3-C motif) receptor 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CX3CR1 | chemokine (C-X3-C motif) receptor 1" />
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     <Graphics CenterX="716.0" CenterY="236.66666666666663" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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   <DataNode TextLabel="GHSR" GraphId="c69" Type="GeneProduct" GroupRef="a4a31">
   <DataNode TextLabel="GHSR" GraphId="c69" Type="GeneProduct" GroupRef="a4a31">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GHSR | growth hormone secretagogue receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GHSR | growth hormone secretagogue receptor" />
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     <Xref Database="Entrez Gene" ID="2693"/>
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     <Xref Database="Entrez Gene" ID="2693" />
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   <DataNode TextLabel="CCR8" GraphId="c6e" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CCR8" GraphId="c6e" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR8 | chemokine (C-C motif) receptor 8"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR8 | chemokine (C-C motif) receptor 8" />
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     <Xref Database="Entrez Gene" ID="1237" />
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   <DataNode TextLabel="CCR-9" GraphId="ca8" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CCR-9" GraphId="ca8" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR9 | chemokine (C-C motif) receptor 9"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR9 | chemokine (C-C motif) receptor 9" />
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     <Xref Database="Entrez Gene" ID="10803"/>
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     <Xref Database="Entrez Gene" ID="10803" />
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   <DataNode TextLabel="SSTR3" GraphId="cca" Type="GeneProduct" GroupRef="c41ec">
   <DataNode TextLabel="SSTR3" GraphId="cca" Type="GeneProduct" GroupRef="c41ec">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR3 | somatostatin receptor 3"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR3 | somatostatin receptor 3" />
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     <Xref Database="Entrez Gene" ID="6753"/>
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   <DataNode TextLabel="GRPR" GraphId="cd6" Type="GeneProduct" GroupRef="f1db1">
   <DataNode TextLabel="GRPR" GraphId="cd6" Type="GeneProduct" GroupRef="f1db1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRPR | gastrin-releasing peptide receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRPR | gastrin-releasing peptide receptor" />
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     <Graphics CenterX="289.6666666666667" CenterY="292.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="289.6666666666667" CenterY="292.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Entrez Gene" ID="2925"/>
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     <Xref Database="Entrez Gene" ID="2925" />
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   <DataNode TextLabel="EDNRB" GraphId="cdb" Type="GeneProduct" GroupRef="a6b50">
   <DataNode TextLabel="EDNRB" GraphId="cdb" Type="GeneProduct" GroupRef="a6b50">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDNRB | endothelin receptor type B"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="EDNRB | endothelin receptor type B" />
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     <Xref Database="Entrez Gene" ID="1910"/>
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     <Xref Database="Entrez Gene" ID="1910" />
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   <DataNode TextLabel="MC4R" GraphId="d06" Type="GeneProduct" GroupRef="a7117">
   <DataNode TextLabel="MC4R" GraphId="d06" Type="GeneProduct" GroupRef="a7117">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC4R | melanocortin 4 receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC4R | melanocortin 4 receptor" />
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     <Xref Database="Entrez Gene" ID="4160"/>
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     <Xref Database="Entrez Gene" ID="4160" />
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   <DataNode TextLabel="FSHR" GraphId="d20" Type="GeneProduct" GroupRef="ef214">
   <DataNode TextLabel="FSHR" GraphId="d20" Type="GeneProduct" GroupRef="ef214">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FSHR | follicle stimulating hormone receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FSHR | follicle stimulating hormone receptor" />
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     <Graphics CenterX="454.3333333333333" CenterY="152.33333333333331" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Entrez Gene" ID="2492"/>
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   <DataNode TextLabel="TSHR" GraphId="d32" Type="GeneProduct" GroupRef="ef214">
   <DataNode TextLabel="TSHR" GraphId="d32" Type="GeneProduct" GroupRef="ef214">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TSHR | thyroid stimulating hormone receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TSHR | thyroid stimulating hormone receptor" />
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     <Graphics CenterX="454.3333333333333" CenterY="192.33333333333334" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Entrez Gene" ID="7253"/>
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     <Xref Database="Entrez Gene" ID="7253" />
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   <DataNode TextLabel="TACR3" GraphId="d51" Type="GeneProduct" GroupRef="a62f0">
   <DataNode TextLabel="TACR3" GraphId="d51" Type="GeneProduct" GroupRef="a62f0">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TACR3 | tachykinin receptor 3"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TACR3 | tachykinin receptor 3" />
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     <Xref Database="Entrez Gene" ID="6870" />
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   <DataNode TextLabel="GNRHR" GraphId="d93" Type="GeneProduct" GroupRef="a4a31">
   <DataNode TextLabel="GNRHR" GraphId="d93" Type="GeneProduct" GroupRef="a4a31">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNRHR | gonadotropin-releasing hormone receptor..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNRHR | gonadotropin-releasing hormone receptor..." />
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   <DataNode TextLabel="BRS3" GraphId="d9b" Type="GeneProduct" GroupRef="f1db1">
   <DataNode TextLabel="BRS3" GraphId="d9b" Type="GeneProduct" GroupRef="f1db1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BRS3 | bombesin-like receptor 3"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BRS3 | bombesin-like receptor 3" />
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     <Xref Database="Entrez Gene" ID="680"/>
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   <DataNode TextLabel="Oxytocin" GraphId="d9d" Type="Metabolite">
   <DataNode TextLabel="Oxytocin" GraphId="d9d" Type="Metabolite">
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     <Xref Database="CAS" ID="50-56-6"/>
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     <Xref Database="CAS" ID="50-56-6" />
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   <DataNode TextLabel="Gq/G11 Pathway" GraphId="da478" Type="Pathway">
   <DataNode TextLabel="Gq/G11 Pathway" GraphId="da478" Type="Pathway">
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     <Xref Database="WikiPathways" ID="WP35"/>
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   <DataNode TextLabel="TRHR" GraphId="daf" Type="GeneProduct" GroupRef="a4a31">
   <DataNode TextLabel="TRHR" GraphId="daf" Type="GeneProduct" GroupRef="a4a31">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRHR | thyrotropin-releasing hormone receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TRHR | thyrotropin-releasing hormone receptor" />
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   <DataNode TextLabel="AVPR1B" GraphId="db2" Type="GeneProduct" GroupRef="d0d28">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AVPR1B | arginine vasopressin receptor 1B"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AVPR1B | arginine vasopressin receptor 1B" />
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   <DataNode TextLabel="CXCR6" GraphId="db8" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CXCR6 | chemokine (C-X-C motif) receptor 6"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CXCR6 | chemokine (C-X-C motif) receptor 6" />
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   <DataNode TextLabel="MC2R" GraphId="dd9" Type="GeneProduct" GroupRef="a7117">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC2R | melanocortin 2 receptor (adrenocorticotr..."/>
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   <DataNode TextLabel="NPY1R" GraphId="ddc" Type="GeneProduct" GroupRef="e72b6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY1R | neuropeptide Y receptor Y1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY1R | neuropeptide Y receptor Y1" />
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   <DataNode TextLabel="SSTR5" GraphId="df7" Type="GeneProduct" GroupRef="c41ec">
   <DataNode TextLabel="SSTR5" GraphId="df7" Type="GeneProduct" GroupRef="c41ec">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR5 | somatostatin receptor 5"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR5 | somatostatin receptor 5" />
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   <DataNode TextLabel="TACR2" GraphId="e29" Type="GeneProduct" GroupRef="a62f0">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TACR2 | tachykinin receptor 2"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TACR2 | tachykinin receptor 2" />
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   <DataNode TextLabel="MC5R" GraphId="e39" Type="GeneProduct" GroupRef="a7117">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC5R | melanocortin 5 receptor"/>
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   <DataNode TextLabel="MC1R" GraphId="e42" Type="GeneProduct" GroupRef="a7117">
   <DataNode TextLabel="MC1R" GraphId="e42" Type="GeneProduct" GroupRef="a7117">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MC1R | melanocortin 1 receptor (alpha melanocyt..."/>
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   <DataNode TextLabel="PPYR1" GraphId="e4c" Type="GeneProduct" GroupRef="e72b6">
   <DataNode TextLabel="PPYR1" GraphId="e4c" Type="GeneProduct" GroupRef="e72b6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPYR1 | pancreatic polypeptide receptor 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PPYR1 | pancreatic polypeptide receptor 1" />
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   <DataNode TextLabel="CCR2" GraphId="e58" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CCR2" GraphId="e58" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR2 | chemokine (C-C motif) receptor 2"/>
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   <DataNode TextLabel="OXTR" GraphId="e64" Type="GeneProduct" GroupRef="d0d28">
   <DataNode TextLabel="OXTR" GraphId="e64" Type="GeneProduct" GroupRef="d0d28">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OXTR | oxytocin receptor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OXTR | oxytocin receptor" />
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   <DataNode TextLabel="OPRK1" GraphId="e82" Type="GeneProduct" GroupRef="a2b4a">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRK1 | opioid receptor kappa 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRK1 | opioid receptor kappa 1" />
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   <DataNode TextLabel="CCR1" GraphId="e92" Type="GeneProduct" GroupRef="f7c58">
   <DataNode TextLabel="CCR1" GraphId="e92" Type="GeneProduct" GroupRef="f7c58">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR1 | chemokine (C-C motif) receptor 1"/>
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   <DataNode TextLabel="SSTR1" GraphId="ea3" Type="GeneProduct" GroupRef="c41ec">
   <DataNode TextLabel="SSTR1" GraphId="ea3" Type="GeneProduct" GroupRef="c41ec">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR1 | somatostatin receptor 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SSTR1 | somatostatin receptor 1" />
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     <Xref Database="Entrez Gene" ID="6751"/>
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   <DataNode TextLabel="NTSR1" GraphId="eb0" Type="GeneProduct" GroupRef="d216c">
   <DataNode TextLabel="NTSR1" GraphId="eb0" Type="GeneProduct" GroupRef="d216c">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NTSR1 | neurotensin receptor 1 (high affinity)"/>
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NTSR1 | neurotensin receptor 1 (high affinity)" />
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     <Graphics CenterX="288.6666666666667" CenterY="550.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Entrez Gene" ID="4923"/>
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   <DataNode TextLabel="Gs Pathway" GraphId="ebaa0" Type="Pathway">
   <DataNode TextLabel="Gs Pathway" GraphId="ebaa0" Type="Pathway">
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     <Xref Database="WikiPathways" ID="WP35"/>
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     <Xref Database="WikiPathways" ID="WP35" />
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   <DataNode TextLabel="GALR2" GraphId="ec1" Type="GeneProduct" GroupRef="b5877">
   <DataNode TextLabel="GALR2" GraphId="ec1" Type="GeneProduct" GroupRef="b5877">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GALR2 | galanin receptor 2"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GALR2 | galanin receptor 2" />
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   <DataNode TextLabel="IL8RB" GraphId="f35" Type="GeneProduct" GroupRef="fff98">
   <DataNode TextLabel="IL8RB" GraphId="f35" Type="GeneProduct" GroupRef="fff98">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL8RB | interleukin 8 receptor beta"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IL8RB | interleukin 8 receptor beta" />
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   <DataNode TextLabel="OPRD1" GraphId="f42" Type="GeneProduct" GroupRef="a2b4a">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRD1 | opioid receptor delta 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRD1 | opioid receptor delta 1" />
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   <DataNode TextLabel="OPRL1" GraphId="f47" Type="GeneProduct" GroupRef="a2b4a">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRL1 | opiate receptor-like 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="OPRL1 | opiate receptor-like 1" />
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   <DataNode TextLabel="CCR10" GraphId="f49" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR10 | chemokine (C-C motif) receptor 10"/>
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     <Xref Database="Entrez Gene" ID="2826" />
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   <DataNode TextLabel="NPY6R" GraphId="f57" Type="GeneProduct" GroupRef="e72b6">
     <Comment Source="GenMAPP remarks">human Acc# BAA13103</Comment>
     <Comment Source="GenMAPP remarks">human Acc# BAA13103</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NPY6R | neuropeptide Y receptor Y6 (pseudogene)..."/>
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   <DataNode TextLabel="C3AR1" GraphId="f65" Type="GeneProduct" GroupRef="fff98">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="C3AR1 | complement component 3a receptor 1"/>
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   <DataNode TextLabel="AGTR1" GraphId="f70" Type="GeneProduct" GroupRef="ce0fd">
   <DataNode TextLabel="AGTR1" GraphId="f70" Type="GeneProduct" GroupRef="ce0fd">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="AGTR1 | angiotensin II receptor type 1"/>
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     <Xref Database="Entrez Gene" ID="185"/>
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   <DataNode TextLabel="Bradykinin" GraphId="f79e5" Type="Metabolite">
   <DataNode TextLabel="Bradykinin" GraphId="f79e5" Type="Metabolite">
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   <DataNode TextLabel="C5R1" GraphId="faa" Type="GeneProduct" GroupRef="fff98">
   <DataNode TextLabel="C5R1" GraphId="faa" Type="GeneProduct" GroupRef="fff98">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="C5R1 | complement component 5 receptor 1 (C5a l..."/>
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   <DataNode TextLabel="CCR3" GraphId="fb2" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR3 | chemokine (C-C motif) receptor 3"/>
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   <DataNode TextLabel="FY" GraphId="fbd" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FY | Duffy blood group"/>
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   <DataNode TextLabel="CCR1" GraphId="ff5" Type="GeneProduct" GroupRef="f7c58">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CCR1 | chemokine (C-C motif) receptor 1"/>
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CompareRevisionActionTimeUserComment
106176view12:07, 16 August 2019MaintBotHMDB identifier normalization
105783view19:45, 15 August 2019KhanspersModified description
95856view17:59, 26 January 2018KhanspersModified description
95855view17:57, 26 January 2018KhanspersModified description
95511view01:04, 19 December 2017Khanspersfixed missing xref
90195view21:13, 21 October 2016Khanspersfixed unconnected
88894view01:14, 17 August 2016AlexanderPicoQuick edit to datanode annotation or property
88893view01:12, 17 August 2016AlexanderPicoAdded orexin receptors and literature reference
79999view08:09, 30 April 2015ZariChanged old Entrez gene ID to new Enterz gene ID
79444view06:55, 22 March 2015EgonwReplaced a gene name with its Entrez Gene identifier.
72125view07:46, 25 October 2013Mkutmonadded datasource to pathway nodes
68988view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
45244view18:28, 7 October 2011KhanspersOntology Term : 'G protein mediated signaling pathway' added !
41166view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
38859view18:13, 24 September 2010KhanspersAdded pathway links
38858view18:09, 24 September 2010Khanspers
34496view22:36, 16 December 2009KhanspersAdded metabolite and changed layout
34442view18:19, 10 December 2009MaintBotAutomatic update of empty xrefs
32374view16:50, 15 August 2009MaintBotFixed text labels
32009view13:19, 14 August 2009MaintBotFixed group labels
20727view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Peptide GPCRs]] moved to [[Pathway:WP24]]: Moved to stable identifier
14494view00:45, 23 May 2008AlexanderPicoConnected!
14490view00:34, 23 May 2008AlexanderPicoGrouped and fixed labels and layout
14486view00:24, 23 May 2008AlexanderPicoPeriodical save, work in progress
13106view11:16, 17 May 2008MaintBotautomated metabolite conversion
12991view11:00, 17 May 2008MaintBotSticky edges patch by Sjoerd
8336view13:46, 7 January 2008MaintBot[[Pathway:Human:Peptide GPCRs]] moved to [[Pathway:Homo sapiens:Peptide GPCRs]]: Renaming species
7786view16:17, 18 December 2007MaintBotfixed category names
7440view12:42, 4 November 2007MaintBotAdded categories to GPML
6362view22:18, 22 May 2007Nsalomonisgpml file for [[Human:Peptide_GPCRs]]

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/c/cb/WP24_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/c/cb/WP24_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106176)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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