Oncostatin M Signaling Pathway (Homo sapiens)

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JUNDKRASGTPMAPK9MAPK8Y185T183MAP2K1S218LIFRPJAK2Y1007Y1007PRKCHPPRKCEPPRKCBPPRKCAPIL6STY759MAP2K2S222S226STAT3Y705STAT1Y701IL6STY782Sensitization of osteosarcoma cellsto apoptosisDissociationMEKdependentAdrenocortical Y-1 cells Mammary epithelial cells In astrocytes,adipose tissues,VSMCs, and inlung carcinomaOncostatin M Signaling PathwayApoptosis in JAK1HIF1AVEGFAY1022Y1023MAPK14Y182Y180JAK3Y980TYK2Y1055Y1054RELAPMAPK3Y202Y204SOCS3OSMRY861PTPN11Y580Y542MAPK1Y187Y185STAT1Y701PIAS3STAT5BSTAT5BY699CASP3OSMSOS1GRB2SHC1PIRS1PSRCY419STAT3Y705S727RAF1S338HRASGTPPIK3R1AKT1S473T308OSMSTAT3Y705STAT1Y701FOSPXNPTK2BPCDK2CDKN1BCEBPBPRPS6S235S236JUNBPSTAT3PRKCDPMTORMMP13TP53STAT1STAT5BRICTORCREB1S133CYR61EGR1LDLREGR1CCL2MMP1MMP3NFKB1NFKBIAPUbRELANFKB1SERPINE1TIMP3CYNUCYNUCYNUCYNUCYNUCYNUCYNUIncrease in proliferationRegulation ofblood cholesterolIncrease in proliferationRegulation of osteoblastdifferentiationand activityCytoskeletonreorganizationSTAT5BY699STAT3Y705STAT1Y701MAPK3Y204Y202MAPK1Y187Y185Plaqueangiogenesis and destabilization incoronary arteryand arotic smoothmuscle cellsIn humanosteoblasts andU2OS cellsCartilagedegradationGrowthinhibitionin MCF-7cellsCASP7ProteinReceptorProteinProteinmRNALigandInduced activationEnzyme complexInhibitionTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation Induced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUActivationCASP9Dissociation of PPI


Description

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Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
98073view17:40, 16 July 2018AlexanderPicoReverted edits by [[Special:Contributions/Mechebek maghnaui|Mechebek maghnaui]] ([[User talk:Mechebek maghnaui|Talk]]) to last version by [[User:AlexanderPico|AlexanderPico]]
98061view15:16, 13 July 2018Mechebek maghnauiModified title
92557view00:09, 16 June 2017AlexanderPicoFixed 0 widths and heights by removing "hidden" elements
92556view00:08, 16 June 2017AlexanderPicoFixed 0 widths and heights
73668view20:34, 13 February 2014MaintBotFixing labels with red fill color
72050view17:00, 24 October 2013Mkutmonupdated annotations for HIF1A and VEGFA
71378view18:39, 17 October 2013MaintBotAutomated update of data sources
67549view11:24, 26 June 2013DdiglesOntology Term : 'oncostatin M signaling pathway' added !
61293view22:00, 6 April 2013MaintBotremoved old publication references
61234view17:35, 5 April 2013MaintBotupdated pathway elements from provided gpml
57683view20:52, 31 January 2013KhanspersModified categories
54418view11:10, 29 November 2012MaintBotOntology Term : 'osteosarcoma' added !
54417view11:09, 29 November 2012MaintBotOntology Term : 'lymphocyte' added !
54416view11:08, 29 November 2012MaintBotOntology Term : 'cytokine mediated signaling pathway' added !
54197view13:32, 23 November 2012NetPathModified description
54196view13:30, 23 November 2012NetPathModified description
54195view13:29, 23 November 2012NetPathNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP7Protein840 (Entrez Gene)
CASP9Protein840 (Entrez Gene)
CCL2Rna6347 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CEBPBProtein1051 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CYR61Rna3491 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HIF1ARna
HRASProtein3265 (Entrez Gene)
IL6STProtein3572 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
JUNBProtein3726 (Entrez Gene)
JUNDProtein3727 (Entrez Gene)
KRASProtein3845 (Entrez Gene)
LDLRRna3949 (Entrez Gene)
LIFRProtein3977 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP13Rna4322 (Entrez Gene)
MMP1Rna4312 (Entrez Gene)
MMP3Rna4314 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
OSMProtein5008 (Entrez Gene)
OSMRProtein9180 (Entrez Gene)
PIAS3Protein10401 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCHProtein5583 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RICTORProtein253260 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
SERPINE1Rna5054 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOCS3Protein9021 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TIMP3Rna7078 (Entrez Gene)
TP53Rna7157 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
VEGFARna

Annotated Interactions

No annotated interactions

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