Oncostatin M Signaling Pathway (Homo sapiens)

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JUNDKRASGTPMAPK9MAPK8Y185T183MAP2K1S218LIFRPJAK2Y1007Y1007PRKCHPPRKCEPPRKCBPPRKCAPIL6STY759MAP2K2S222S226STAT3Y705STAT1Y701IL6STY782MEKdependentIn astrocytes,adipose tissues,VSMCs, and inlung carcinomaAdrenocortical Y-1 cells Mammary epithelial cells Sensitization of osteosarcoma cellsto apoptosisDissociationOncostatin M Signaling PathwayApoptosis in JAK1HIF1AVEGFAY1022Y1023MAPK14Y182Y180JAK3Y980TYK2Y1055Y1054RELAPMAPK3Y204Y202SOCS3OSMRY861PTPN11Y542Y580MAPK1Y185Y187STAT1Y701PIAS3STAT5BSTAT5BY699CASP3OSMSOS1GRB2SHC1PIRS1PSRCY419STAT3S727Y705RAF1S338HRASGTPPIK3R1AKT1T308S473OSMSTAT3Y705STAT1Y701FOSPXNPTK2BPCDK2CDKN1BCEBPBPRPS6S235S236JUNBPSTAT3PRKCDPMTORMMP13TP53STAT1STAT5BRICTORCREB1S133CYR61EGR1LDLREGR1CCL2MMP1MMP3NFKB1NFKBIAUbPRELANFKB1SERPINE1TIMP3CYNUCYNUCYNUCYNUCYNUCYNUCYNUIncrease in proliferationRegulation ofblood cholesterolIncrease in proliferationRegulation of osteoblastdifferentiationand activityCytoskeletonreorganizationSTAT5BY699STAT3Y705STAT1Y701MAPK3Y202Y204MAPK1Y185Y187Plaqueangiogenesis and destabilization incoronary arteryand arotic smoothmuscle cellsIn humanosteoblasts andU2OS cellsCartilagedegradationGrowthinhibitionin MCF-7cellsCASP7ProteinReceptorProteinProteinmRNALigandInduced activationEnzyme complexInhibitionTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation Induced catalysisProtein-protein interaction (PPI)LEGENDPhosphorylationNucleusCytoplasmCYNUActivationCASP9Dissociation of PPI


Description

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Ontology Terms

 

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History

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54194view13:29, 23 November 2012NetPathDeleted pathway: legend not visible
54193view13:26, 23 November 2012NetPathNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
CASP3Protein836 (Entrez Gene)
CASP7Protein840 (Entrez Gene)
CASP9Protein840 (Entrez Gene)
CCL2Rna6347 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CEBPBProtein1051 (Entrez Gene)
CREB1Protein1385 (Entrez Gene)
CYR61Rna3491 (Entrez Gene)
EGR1Rna1958 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HIF1ARna
HRASProtein3265 (Entrez Gene)
IL6STProtein3572 (Entrez Gene)
IRS1Protein3667 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK2Protein3717 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
JUNBProtein3726 (Entrez Gene)
JUNDProtein3727 (Entrez Gene)
KRASProtein3845 (Entrez Gene)
LDLRRna3949 (Entrez Gene)
LIFRProtein3977 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MMP13Rna4322 (Entrez Gene)
MMP1Rna4312 (Entrez Gene)
MMP3Rna4314 (Entrez Gene)
MTORProtein2475 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NFKBIAProtein4792 (Entrez Gene)
OSMProtein5008 (Entrez Gene)
OSMRProtein9180 (Entrez Gene)
PIAS3Protein10401 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCBProtein5579 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PRKCEProtein5581 (Entrez Gene)
PRKCHProtein5583 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
PXNProtein5829 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RELAProtein5970 (Entrez Gene)
RICTORProtein253260 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
SERPINE1Rna5054 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOCS3Protein9021 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
TIMP3Rna7078 (Entrez Gene)
TP53Rna7157 (Entrez Gene)
TYK2Protein7297 (Entrez Gene)
VEGFARna

Annotated Interactions

No annotated interactions

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