Glucocorticoid and Mineralcorticoid Metabolism (Homo sapiens)

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OHCC=OCHHOHOOProgesterone Degradation11b, 21-Dihydroxy-3,20-5b-Pregnan-18-al=OOHO17a,21-Dihydroxy-5b-17a,21-Dihydroxy-5b-Pregnane-3,11,20-trioneO=OGlucocorticoids11b,17a 21-Trihydroxy-5bPregnane 3,20-dioneCOHCHOHGlucuronidesHOHO3OH3a-OH-5b-Pregnane-20-one=OOCHCCHHCChemical structures shownfor metabolites in teal=OCH3Urocortisone=OHH11-Deoxycortisol=OCH23CHO2-OH3COHHOOOHUrocortisol3a,11b,21-Trihydroxy-20-Oxo-5b-Pregnan-18-alCCH3O25b-Pregnane-3,20-dioneCHC17-OH-progesteroneHSD3B2CorticosteroneHSD3B1CortolonePregnenoloneMetabolite18-Hydroxycorticosterone(R)20-hydroxysteroid Dh3a-Hydroxysteroid DhCortisolCortisoneProgesteroneHSD3B1Cholesterol Biosynthesis3-Oxo-5b-Steroid DhCorticosterone 18-MonooxyHSD11B2CYP11B2Steroid Hormone SignalingCortisone beta-reductaseCortisol11-DeoxycorticosteroneCYP17A1AldosteroneCYP21A2PregnanediolHSD11B120b-Hydroxysteroid DhAndrogen Synthesis and MetabolismCholesterolCYP11A13a-Hydroxysteroid Dh3B-OH-delta-Steroid DhCYP17A117a-OH-pregnenolone


Description

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Ontology Terms

 

Bibliography

  1. Fardella CE, Miller WL; ''Molecular biology of mineralocorticoid metabolism.''; Annu Rev Nutr, 1996 PubMed Europe PMC Scholia
  2. Funder JW; ''Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance.''; Annu Rev Med, 1997 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
106711view13:14, 17 September 2019MaintBotHMDB identifier normalization
102525view20:03, 3 January 2019Khanspersconverted interactions to graphical lines (chemical structures)
102356view19:40, 20 December 2018Fehrhartfixed a line
98650view09:58, 26 September 2018EgonwWP496 is not about signalling. WP170 is not perfect, but better.
98649view09:30, 26 September 2018EgonwModified description
96253view15:11, 2 March 2018Fehrhartconnected lines and changed interactions to graphical lines
96038view15:54, 15 February 2018DeSlModified description
96035view15:52, 15 February 2018DeSlAdded 2 lit refs
96034view15:46, 15 February 2018DeSlOntology Term : 'glucocorticoid biosynthetic pathway' added !
95658view13:08, 16 January 2018DeSlRemoved licence number and last modified part.
95657view13:08, 16 January 2018DeSlrewrote '&' to 'and' for integration with Latex
78497view10:28, 7 January 2015MaintBotadded missing graphIds
72079view20:40, 24 October 2013EgonwRemoved a dangling "Metabolite" that accidentally sneaked in in revision 15409.
71371view18:37, 17 October 2013MaintBotAutomated update of data sources
71251view20:44, 16 October 2013MaintBotAutomated update of data sources
67282view10:31, 26 June 2013Christine ChichesterOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
63196view20:52, 8 May 2013MaintBotUpdating gpml version
62690view21:31, 1 May 2013MaintBotupated uniprot data source
54707view13:48, 7 December 2012AndraRDF Tidy
41092view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
38932view21:50, 24 September 2010AlexanderPicofixed grouping
38899view20:21, 24 September 2010Thomasadded pathway link
38827view11:45, 24 September 2010Thomasadded pathway link
34463view18:28, 10 December 2009MaintBotAutomatic update of empty xrefs
32571view13:38, 17 August 2009Thomas
32373view16:49, 15 August 2009MaintBotFixed text labels
32369view16:33, 15 August 2009Thomas
32008view13:19, 14 August 2009MaintBotFixed group labels
21175view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:WP237]]: Moved to stable identifier
15409view23:10, 27 May 2008Khanspersconnectors fix
14503view01:02, 23 May 2008KhanspersAdded connectors, groups, metabolites
14499view00:53, 23 May 2008KhanspersPeriodical save, work in progress
14492view00:43, 23 May 2008KhanspersPeriodical save, work in progress
14488view00:32, 23 May 2008KhanspersPeriodical save, work in progress
14484view00:22, 23 May 2008KhanspersPeriodical save, work in progress
13070view11:13, 17 May 2008MaintBotautomated metabolite conversion
8078view13:46, 7 January 2008MaintBot[[Pathway:Human:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:Homo sapiens:Glucocorticoid Mineralocorticoid Metabolism]]: Renaming species
7661view16:07, 18 December 2007MaintBotfixed category names
7360view12:42, 4 November 2007MaintBotAdded categories to GPML
6326view22:17, 22 May 2007M.Liebermangpml file for [[Human:Glucocorticoid_Mineralocorticoid_Metabolism]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)20-hydroxysteroid DhGeneProduct1.1.1.53, similiar SP:2BHD STREX
11-DeoxycorticosteroneMetabolite64-85-7 (CAS)
17-OH-progesteroneMetaboliteHMDB00374 (HMDB)
17a-OH-pregnenoloneMetaboliteHMDB00363 (HMDB)
18-HydroxycorticosteroneMetaboliteHMDB00319 (HMDB)
20b-Hydroxysteroid DhGeneProduct1.1.1.53, similiar SP:2BHD STREX
3-Oxo-5b-Steroid DhGeneProduct3O5B (Uniprot-TrEMBL)
3B-OH-delta-Steroid DhGeneProduct
3a-Hydroxysteroid DhGeneProductSPs:DIDH RAT
AldosteroneMetabolite52-39-1 (CAS)
Androgen Synthesis and MetabolismPathwayWP496 (WikiPathways)
CYP11A1GeneProduct1583 (Entrez Gene)
CYP11B2GeneProduct1585 (Entrez Gene)
CYP17A1GeneProduct1586 (Entrez Gene)
CYP21A2GeneProduct1589 (Entrez Gene)
Cholesterol BiosynthesisPathwayWP197 (WikiPathways)
CholesterolMetabolite57-88-5 (CAS)
Corticosterone 18-MonooxyGeneProductEC number: 1.14.15.5
CorticosteroneMetabolite50-22-6 (CAS)
CortisolMetabolite50-23-7 (CAS)
Cortisone beta-reductaseGeneProduct1.3.1.3
CortisoneMetaboliteHMDB02802 (HMDB)
CortoloneMetabolite516-42-7 (CAS)
HSD11B1GeneProduct3290 (Entrez Gene)
HSD11B2GeneProduct3291 (Entrez Gene)
HSD3B1GeneProduct3283 (Entrez Gene)
HSD3B2GeneProduct3284 (Entrez Gene)
MetaboliteMetabolite
PregnanediolMetabolite80-92-2 (CAS)
PregnenoloneMetabolite145-13-1 (CAS)
ProgesteroneMetabolite57-83-0 (CAS)
Steroid Hormone SignalingPathwayWP496 (WikiPathways)

Annotated Interactions

No annotated interactions

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