Histone Modifications (Homo sapiens)

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Revision as of 17:13, 18 November 2012 by Egonw (Talk | contribs)
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Histones can undergo many modifications involved in transcriptiong regulation. This pathway provides an overview of the various known modifications and which catalysts are involved in that modification.

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  1. Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T; ''Regulation of chromatin structure by site-specific histone H3 methyltransferases.''; Nature, 2000 PubMed Europe PMC
  2. Wikipedians; ''''; http://en.wikipedia.org/wiki/Histone_methyltransferase,
  3. Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, Shilatifard A; ''COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.''; J Biol Chem, 2002 PubMed Europe PMC
  4. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T; ''A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.''; Genes Dev, 2004 PubMed Europe PMC
  5. Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, Mollah S, Cook RG, Shabanowitz J, Hunt DF, Allis CD; ''Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.''; Mol Cell Biol, 2002 PubMed Europe PMC
  6. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D; ''Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.''; Genes Dev, 2002 PubMed Europe PMC


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106592view19:33, 10 September 2019KhanspersModified description
105616view04:56, 10 August 2019KhanspersModified description
102995view14:38, 31 January 2019Mkutmonupdated outdated ensembl identifier
102992view14:23, 31 January 2019Mkutmonupdated outdated ensembl id
87373view09:56, 22 July 2016MaintBotadded missing graphids
83012view09:44, 17 November 2015LindarieswijkPeriodical save, work in progress
83011view09:37, 17 November 2015LindarieswijkSpecify description
83010view09:35, 17 November 2015LindarieswijkSpecify description
83008view09:33, 17 November 2015LindarieswijkPeriodical save, work in progress
83007view09:26, 17 November 2015LindarieswijkSpecify description
83006view09:25, 17 November 2015LindarieswijkSpecify description
83004view09:24, 17 November 2015LindarieswijkSpecify description
83003view09:23, 17 November 2015LindarieswijkPeriodical save, work in progress
69927view19:51, 11 July 2013AlexanderPicoModified title
62439view23:49, 28 April 2013AlexanderPicoModified description
62438view23:44, 28 April 2013AlexanderPicoModified categories
62437view23:43, 28 April 2013AlexanderPicoOntology Term : 'altered transcription pathway' added !
62436view23:38, 28 April 2013AlexanderPicoRe-added lit refs
62435view23:31, 28 April 2013AlexanderPicoHistone 3 and 4 complete
62434view23:17, 28 April 2013AlexanderPicoH3 done... now H4
62433view22:49, 28 April 2013AlexanderPicoStill working...
62432view22:07, 28 April 2013AlexanderPicoStill working on adding proper datanodes
62431view21:37, 28 April 2013AlexanderPicoModified title
62430view21:36, 28 April 2013AlexanderPicoUpdating datanodes to represent genes and states
62374view00:56, 28 April 2013MaintBotModified title
62373view00:55, 28 April 2013MaintBotModified categories
58693view18:34, 19 February 2013MaintBotModified categories
57673view20:24, 31 January 2013KhanspersModified description
57672view20:24, 31 January 2013KhanspersRemoved comment
54033view20:31, 18 November 2012EgonwAdded some phosphorylation and citrullination.
54024view18:35, 18 November 2012EgonwAdded more observed acetylations
54023view17:23, 18 November 2012EgonwIt all happens in the nucleus. Well, I'm a chemist... :)
54022view17:21, 18 November 2012EgonwAnother useful reference.
54021view17:13, 18 November 2012EgonwAdded a description of this pathway.
54020view17:10, 18 November 2012EgonwAdded a demo catalyst; haven't figured out which does this trimethylation.
54019view17:08, 18 November 2012EgonwOK, one more to the front :(
54018view17:07, 18 November 2012EgonwHopefully fixed the z-order.
54017view17:04, 18 November 2012EgonwAdded a few more possible acetylation sites.
54016view16:56, 18 November 2012EgonwThis reference is general, and not the primary citation for that methylation.
54015view16:54, 18 November 2012EgonwNew pathway

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