Vitamin B5 (pantothenate) and CoA biosynthesis Pathway (Zea mays)

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Peroxisome Mitochondria1, 2long chain acyl-coA estersL-glutamatealpha-ketoisovalerateBeta-AlanineGRMZM2G055899valinepantoate transporter2.6.1.42 Plastid2.1.2.11ketopantoate1.1.1.169(R)-pantoatealpha-ketoglutarate5,10-methylene-tetrahydrofolatetetrahydrofolate (THF)NADPHNADP(R)-pantoate(R)-pantothenate6.3.2.1ATPADPPPi(R)-4'-phosphopantothenate2.7.1.33AMP(R0-4'-phosphopantothenynoyl-L-cysteine6.3.2.54'-phosphopantetheine4.1.1.36CO23'-dephospho-CoA2.7.7.3CoA2.7.1.24cysteinepantetheinepantethine1/2 GSSHGSHATPADP3'-dephospho-CoACoA2.7.1.24ATPADP3'-dephospho-CoACoA2.7.1.24CoA transporterCoACoA/dephospho-CoA transporterCoA/dephospho-CoA transporterlong chain acyl-coA ester carrier (PXA1)long chain acyl-coA estersGRMZM2G071208GRMZM2G010596GRMZM5G876146GRMZM2G104504GRMZM5G808624GRMZM2G008209GRMZM2G002173GRMZM2G127911GRMZM2G407396AC192244.3_FGP007GRMZM2G071294GRMZM2G102015GRMZM2G043819GRMZM2G060045(R)-pantothenate transporterGRMZM2G043819GRMZM2G102015GRMZM2G043819GRMZM2G102015pantethine transporterpantethine(R)-pantothenate


Pantothenate is the precursor of coenzyme A (CoA), the acyl carrier in scores of reactions. Pantothenate is made in the cytosol from pantoate and β-alanine, then converted to CoA in five steps, all probably cytosolic (Webb and Smith, 2011); the fifth step may also occur in plastids and peroxisomes. The three-step pathway to pantoate is not fully defined, but it is clear that step two, conversion of α-keto-isovalerate to ketopantoate, is mitochondrial (Ottenhof et al., 2004). Step one, α-keto-isovalerate formation from valine, is thus likely catalyzed by a mitochondrial branched chain aminotransferase (Taylor et al., 2004). The enzyme for step three (ketopantoate reduction to pantoate) is not known, so it is unclear whether this step is located in mitochondria or the cytosol. The details of the pantothenate and CoA biosynthesis (especially their compartmentalization) in plants are far from being elucidated. This diagram is an attempt to capture the current state of the field

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Ontology Terms



  1. Gerdes S, Lerma-Ortiz C, Frelin O, Seaver SM, Henry CS, de Crécy-Lagard V, Hanson AD; ''Plant B Vitamin Pathways and their Compartmentation: a Guide for the Perplexed.''; J Exp Bot, 2012 PubMed Europe PMC Scholia
  2. Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG; ''Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants.''; Plant J, 2004 PubMed Europe PMC Scholia


View all...
110989view15:01, 25 June 2020L Dupuisconnected lines
107280view14:37, 17 September 2019MaintBotChEBI identifier normalization
86882view07:49, 14 July 2016MkutmonOntology Term : 'pantothenic acid metabolic pathway' added !
86881view07:49, 14 July 2016MkutmonOntology Term : 'PW:0000167' removed !
78449view10:27, 7 January 2015MaintBotadded missing graphIds
74402view08:22, 16 April 2014EgonwRemoved a data source where no ID was given.
73530view23:39, 29 January 2014KhanspersModified title
72151view10:25, 25 October 2013Mkutmonadded datasource for AC192244.3_FGP007
71955view23:20, 23 October 2013MaintBotremoved data source from nodes without identifier
65173view19:09, 5 June 2013MaintBotadded datasource to GrameneMaize datanodes
65172view19:06, 5 June 2013MaintBotModified categories
55392view05:46, 14 December 2012SvetaGModified description
55377view00:05, 14 December 2012SvetaGSpecify description
55372view23:53, 13 December 2012SvetaGModified description
55370view23:38, 13 December 2012SvetaGSpecify description
55369view23:33, 13 December 2012SvetaGPeriodical save, work in progress
55368view23:08, 13 December 2012SvetaGPeriodical save, work in progress
55145view22:55, 12 December 2012SvetaGSpecify description
55144view22:53, 12 December 2012SvetaGSpecify description
55143view22:50, 12 December 2012SvetaGSpecify description
55142view22:43, 12 December 2012SvetaGPeriodical save, work in progress
55141view22:33, 12 December 2012SvetaGPeriodical save, work in progress
55140view22:21, 12 December 2012SvetaGSpecify description
55137view22:13, 12 December 2012SvetaGPeriodical save, work in progress
55134view21:54, 12 December 2012SvetaGSpecify description
53371view00:31, 6 November 2012PjaiswalModified title
53195view23:08, 30 October 2012PjaiswalModified categories
53194view23:07, 30 October 2012PjaiswalOntology Term : 'vitamin B5 metabolic pathway' added !
53193view23:07, 30 October 2012PjaiswalOntology Term : 'plant cell' added !
53192view23:06, 30 October 2012PjaiswalNew pathway

External references


View all...
NameTypeDatabase referenceComment
(R)-pantothenate transporterGeneProduct
1/2 GSSHMetabolite (Enzyme Nomenclature) (Enzyme Nomenclature) (Enzyme Nomenclature) (Enzyme Nomenclature) (Enzyme Nomenclature)
4'-phosphopantetheineMetabolite (Enzyme Nomenclature)
5,10-methylene-tetrahydrofolateMetabolite (Enzyme Nomenclature) (Enzyme Nomenclature)
AC192244.3_FGP007GeneProductAC192244.3_FGP007 (Gramene Maize)
Beta-AlanineMetaboliteCHEBI:16958 (ChEBI)
CoA transporterGeneProduct
CoA/dephospho-CoA transporterGeneProduct
GRMZM2G002173GeneProductGRMZM2G002173 (Gramene Maize)
GRMZM2G008209GeneProductGRMZM2G008209 (Gramene Maize)
GRMZM2G010596GeneProductGRMZM2G010596 (Gramene Maize)
GRMZM2G043819GeneProductGRMZM2G043819 (Gramene Maize)
GRMZM2G055899GeneProductGRMZM2G055899 (Gramene Maize)
GRMZM2G060045GeneProductGRMZM2G060045 (Gramene Maize)
GRMZM2G071208GeneProductGRMZM2G071208 (Gramene Maize)
GRMZM2G071294GeneProductGRMZM2G071294 (Gramene Maize)
GRMZM2G102015GeneProductGRMZM2G102015 (Gramene Maize)
GRMZM2G104504GeneProductGRMZM2G104504 (Gramene Maize)
GRMZM2G127911GeneProductGRMZM2G127911 (Gramene Maize)
GRMZM2G407396GeneProductGRMZM2G407396 (Gramene Maize)
GRMZM5G808624GeneProductGRMZM5G808624 (Gramene Maize)
GRMZM5G876146GeneProductGRMZM5G876146 (Gramene Maize)
long chain acyl-coA ester carrier (PXA1)GeneProduct
long chain acyl-coA estersMetabolite
pantethine transporterGeneProduct
pantoate transporterGeneProduct
tetrahydrofolate (THF)Metabolite

Annotated Interactions

No annotated interactions

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