TNF alpha Signaling Pathway (Homo sapiens)

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(Protein-protein interaction)CY ->NUAutophosphorylationMolecular associationCYLigandGolgi apparatusUbiquitinationControlPlasma membraneCY ->NUReceptorSumoylationERMTReaction through unknown mechanisms/moleculesECNucleusCY ->NUAccession Number: NetPath 9; cellmap:9NUCY ->NUMethylationENPMPalmitoylationGORecruitmentDemethylationDephosphorylationPhosphorylationEndosomeAcetylationGlycosylationTranslocationExtracellularDMitochondrionProteins in a complex interactionActivationDeubiquitinationDesumoylationInhibitionProteolytic cleavageCY ->NUCytoplasmMolecule in the pathwayEndoplasmic reticulumEnzyme complexDeacetylationUSP11BTRCMAP3K7IP2CASP10AZI2NSMAFYWHAGPSMD1CYLDHSPB1TRAF3CAV1POLR1CBAG4CSNK2A1UBCH5CYWHABTRAIPTRAF4RELBNR2C2LRPPRCRELABCL3PKN1NFKBIZIKBKGTNFRSF1BCOPS3YWHAQGAB1RELASMARCE1PEBP1TRAF2PTPN11TRADDACTL6ASRCRIPK1YWHAHSMARCC2SMARCB1PRKACAPRKCZTNFGeneKPNA2AKT2MTIF2FBXW11TNFRSF1ATNFTNIP1BIRC3GSK3BFBLTNFTRAF4PEG3HDAC2TRAF2RELATRAF6TNIP2TNFRSF1BPOLRY2HRPS13MAP3K1CREBBPTNFRSF1ACUL1KPNA3FLNATXLNAWDR68RIPK2CASP3ALPLAKAP8CRADDPFDN2DDX3CDC34GeneIQGAP2NFKB1PPP2CABIRC2NFKBIBCASP7MEKK2TBKBP1MAP3K3TRAF1CSNK2BMCM5TRAF5TAB3COMMD1ASE1TRIAD3PSMB5MCM7KCNQ1RPL4RNF25GTF2INFKBIEIKBKGDAPNKIRAS2GeneTANKTNFUNC5CLRELBNFKB1MAP3K8GeneTRAF1RPL8CASP2KTN1Gene SymbolMAP2K5TNFYWHAZHIST3H3PTK2YWHAEPSMC3GLG1FANCD2RELUBCH5BUBE2IHDAC6PSMD13RELDPF2HSP90AB1FADDTRPC4APSUMO1NFKB1CDC37RELAPPP1R13LTBK1RPS6KB1SKP1AHDAC1ZA20D2RPL30POLR1BRPS6KA5PSMD6PSMD3TNFRSF8TNFRSF1AHSP90AA1T2BPRPL6RIPK3FKBP5BIRC3AKT1RPS11MARK2PRAF1NR2C2MAP3K3DBC1MCCPSMC2STAT1SMARCC1TNFPSMC1IKBKAPRASAL2BCL7APDCD2RIPK1POLR1DCASP8AP2PAPOLABIRC2TNFAIP3G3BP2TBK1NFKBIAFAF1IKBKBPSMD12POLR2LNFKB2PMLNFKBIACHUKCSNK2A2TNFRSF11ANKIRAS1NALP4KPNA6CAPN3IKBKEPOLR1ANFKBIAUSP2TRAF2TNFRSF1BMAP3K14TRADDCHUKCASP8PIAS3GNB2L1PSMD7SMARCA4MAP3K7IP1CFLAR


Description

"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor superfamily. Activation by the homotrimeric ligand results in receptor trimerization. TNFRSF1A trimers result in the activation of NF-kB through MAPK and caspase pathways leading to apoptosis, whereas a heterocomplex of both TNFRSF1A and TNFRSF1B recruits proteins such as BIRC2 and BIRC3, which are apoptotic inhibitors. As both TNF alpha and IL-1 stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity." Source: http://www.netpath.org/pathways?path_id=NetPath_9

Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
111053view14:57, 3 July 2020L DupuisConverted interactions to graphical lines in legend
105836view23:09, 15 August 2019KhanspersModified description
89895view13:10, 6 October 2016EgonwModified description
81070view19:14, 19 July 2015EgonwAdded three missing ChEBI metabolite IDs.
79942view08:40, 28 April 2015Zariadded annotation for RAS
79280view22:53, 19 March 2015ZariAdded Identifier for SELE,CCL2 and NOXO1
78500view10:28, 7 January 2015MaintBotadded missing graphIds
72093view21:34, 24 October 2013Mkutmonadded datasource to "TNF"
71708view20:00, 17 October 2013MaintBotremoved data source from nodes without identifier
70103view18:53, 12 July 2013MaintBotupdated to 2013 schema
67700view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
47978view14:38, 23 April 2012NetPathModified description
44640view18:30, 22 September 2011Khanspersadded description
44639view18:29, 22 September 2011KhanspersModified categories
44638view18:29, 22 September 2011KhanspersUpdating content to NetSlim
41210view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
36762view19:39, 29 April 2010Khansperstest
35303view23:33, 11 February 2010NsalomonisModified description
32365view13:44, 15 August 2009MaintBotFixed text labels
32004view13:18, 14 August 2009MaintBotFixed group labels
28972view11:00, 19 March 2009EveloSpecify description
28971view10:54, 19 March 2009EveloJus alignments
28970view10:42, 19 March 2009Evelocleaned up a bit
28911view08:09, 12 March 2009AlexanderPicoconnecting edges
28908view07:04, 12 March 2009AlexanderPicoconnecting edges
28907view06:23, 12 March 2009AlexanderPicoconnecting edges
28906view05:04, 12 March 2009Burakconnected the edges
28905view04:54, 12 March 2009BurakPeriodical save, work in progress
21163view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP231]]: Moved to stable identifier
8446view13:46, 7 January 2008MaintBot[[Pathway:Human:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Homo sapiens:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7839view16:21, 18 December 2007MaintBotfixed category names
7307view12:42, 4 November 2007MaintBotAdded categories to GPML
6399view22:18, 22 May 2007A.Pandeygpml file for [[Human:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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Annotated Interactions

No annotated interactions
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