S1P pathways and spinal cord injury (Mus musculus)

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53121151NucleusMIGRATIONNeural Stem CellVASCULARPERMEABILITYCERS1PFTY720FTY720FTY720-PApoptosisSPLABC-TSphSphK1BCL-2S1PR1SMCaspasesSphK2DH-CERCatalystFTY720-PFTY720DH-SphABC-TFTY720S1PDe novo synthesisLymphocytesLYMPHOPENIAREACTIVITYGLIAL SCARAstrocytesSPNS2ABC-T4BCL-XLS1PR15?5OlidodendrocytesREMYELINATIONS1PR3S1PR555


Description

No description

Comments

 
Preliminary pathway, we are working on it (31 03 2012)

Quality Tags

Ontology Terms

 

Bibliography

  1. Kimura A, Ohmori T, Ohkawa R, Madoiwa S, Mimuro J, Murakami T, Kobayashi E, Hoshino Y, Yatomi Y, Sakata Y; ''Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.''; Stem Cells, 2007 PubMed Europe PMC
  2. Norimatsu Y, Ohmori T, Kimura A, Madoiwa S, Mimuro J, Seichi A, Yatomi Y, Hoshino Y, Sakata Y; ''FTY720 improves functional recovery after spinal cord injury by primarily nonimmunomodulatory mechanisms.''; Am J Pathol, 2012 PubMed Europe PMC
  3. Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T; ''The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.''; J Biol Chem, 2011 PubMed Europe PMC
  4. Bandhuvula P, Tam YY, Oskouian B, Saba JD; ''The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.''; J Biol Chem, 2005 PubMed Europe PMC
  5. Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N; ''Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation.''; Cancer Res, 2009 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106869view13:34, 17 September 2019MaintBotHMDB identifier normalization
87646view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
87644view08:54, 25 July 2016LindarieswijkOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
78423view10:26, 7 January 2015MaintBotadded missing graphIds
72023view12:45, 24 October 2013Mkutmonfixed unconnected lines
71760view20:25, 17 October 2013MaintBot
71738view20:18, 17 October 2013MaintBotUpdated data sources
59059view20:58, 21 February 2013MaintBotUpdated Ensembl data source
58145view21:53, 8 February 2013MaintBotModified categories
48030view09:25, 27 April 2012MNietoDiazPeriodical save, work in progress
48029view07:21, 27 April 2012MNietoDiazPeriodical save, work in progress
48017view12:22, 26 April 2012MNietoDiazPeriodical save, work in progress
48016view11:56, 26 April 2012MNietoDiazPeriodical save, work in progress
48015view10:22, 26 April 2012MNietoDiazPeriodical save, work in progress
48014view10:11, 26 April 2012MNietoDiazPeriodical save, work in progress
48011view09:40, 26 April 2012MNietoDiazPeriodical save, work in progress
48010view08:28, 26 April 2012MNietoDiazPeriodical save, work in progress
48009view08:17, 26 April 2012MNietoDiazPeriodical save, work in progress
48008view08:07, 26 April 2012MNietoDiazPeriodical save, work in progress
48007view07:37, 26 April 2012MNietoDiazPeriodical save, work in progress
47637view20:33, 31 March 2012MNietoDiazNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?
ABC-TProteinABC transporters
ApoptosisPathway
BCL-2Protein
BCL-XLProtein
CERMetabolite
CaspasesProtein
CatalystGeneProduct
DH-CERMetabolite
DH-SphMetabolite
FTY720-PMetabolite
FTY720-PMetabolite
FTY720MetaboliteCHEMBL314854 (ChEMBL compound)
S1PMetaboliteCHEMBL225155 (ChEMBL compound)
S1PR1ProteinO08530 (Uniprot/TrEMBL)
S1PR3ProteinQ9Z0U9 (Uniprot/TrEMBL)
S1PR5ProteinQ91X56 (Uniprot/TrEMBL)
SMMetaboliteHMDB01348 (HMDB) Sphingomyelin
SPLProteinENSMUSG00000020097 (Ensembl Mouse)
SPNS2 Protein
SphMetaboliteCHEMBL67166 (ChEMBL compound)
SphK1ProteinENSMUSG00000061878 (Ensembl Mouse)
SphK2ProteinENSMUSG00000057342 (Ensembl Mouse)

Annotated Interactions

No annotated interactions
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