Serotonin Receptor 2 and STAT3 Signaling (Mus musculus)

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14122, 6, 9, 11, 13...1, 3, 4, 7, 10...5, 8Stat3serotoninJak2GnaqHtr2a


This pathway is courtesy of Ariadne Genomics Pathway Studio.


This pathway was inferred from Homo sapiens pathway WP733(r45035) with a 50% conversion rate.

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  1. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R; ''Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils.''; Fundam Clin Pharmacol, 1995 PubMed Europe PMC Scholia
  2. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y; ''Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.''; Nat Cell Biol, 2004 PubMed Europe PMC Scholia
  3. Butts DA, Rokhsar DS; ''The information content of spontaneous retinal waves.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  4. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M; ''Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  5. Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D'Souza DN, Garcia F, Battaglia G, Muma NA; ''Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus.''; J Pharmacol Exp Ther, 2003 PubMed Europe PMC Scholia
  6. Hattori R, Maulik N, Otani H, Zhu L, Cordis G, Engelman RM, Siddiqui MA, Das DK; ''Role of STAT3 in ischemic preconditioning.''; J Mol Cell Cardiol, 2001 PubMed Europe PMC Scholia
  7. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM; ''Sexual functioning in depressed outpatients taking mirtazapine.''; Depress Anxiety, 1999 PubMed Europe PMC Scholia
  8. Li Q, Muma NA, Battaglia G, Van de Kar LD; ''Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins.''; Brain Res, 1997 PubMed Europe PMC Scholia
  9. Ni CW, Hsieh HJ, Chao YJ, Wang DL; ''Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.''; Am J Physiol Cell Physiol, 2004 PubMed Europe PMC Scholia
  10. Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia
  11. Flowers LO, Subramaniam PS, Johnson HM; ''A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.''; Oncogene, 2005 PubMed Europe PMC Scholia
  12. Guillet-Deniau I, Burnol AF, Girard J; ''Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  13. Murata S, Usuda N, Okano A, Kobayashi S, Suzuki T; ''Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain.''; Brain Res Mol Brain Res, 2000 PubMed Europe PMC Scholia
  14. Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, Pradayrol L, Fourmy D, Dufresne M, Seva C; ''A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  15. Waris G, Turkson J, Hassanein T, Siddiqui A; ''Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication.''; J Virol, 2005 PubMed Europe PMC Scholia
  16. Lo RK, Wong YH; ''Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  17. Goppelt-Struebe M, Stroebel M; ''Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.''; Naunyn Schmiedebergs Arch Pharmacol, 1997 PubMed Europe PMC Scholia
  18. Dougalis A, Lees G, Ganellin CR; ''The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro.''; Neuropharmacology, 2004 PubMed Europe PMC Scholia


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105026view10:42, 29 June 2019EgonwAnother space in a PubMed identifier removed.
105009view07:35, 28 June 2019EgonwRemoved trailing spaces in PubMed identifiers.
104959view12:56, 27 June 2019Fehrhartannotated missing nodes
102082view19:40, 28 November 2018EgonwRemoved whitespace in PubMed identifiers.
74497view15:59, 26 April 2014EgonwFixed PubMed IDs.
69173view18:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
45981view21:01, 1 December 2011MaintBotNew pathway

External references


NameTypeDatabase referenceComment
GnaqGeneProduct14682 (Entrez Gene) guanine nucleotide binding protein, alpha q polypeptide
Htr2aGeneProductENSMUSG00000034997 (Ensembl) 5-hydroxytryptamine (serotonin) receptor 2A
Jak2GeneProductENSMUSG00000024789 (Ensembl) Janus kinase 2
Stat3GeneProduct20848 (Entrez Gene) signal transducer and activator of transcription
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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