IL-7 Signaling Pathway (Homo sapiens)

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IL-7 Signaling PathwayEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage277, 348277, 319, 338, 340319, 340102, 297, 309, 357277, 348257, 362112, 180, 317277, 319, 340170, 463171, 277102, 297, 309, 3578, 185, 348, 432277, 319, 36254, 420336158, 244, 3578, 348144, 40714, 176NFkBpathwayFYNMAP2K1PPBCL2L1170, 186PTK2BPCDKN1B53, 396STAT5A144, 228CCND1108, 217, 237, 278PMAP2K2MYCPGSK3BSTAT5BP108, 125, 217, 237, 278PIK3R2IL2RGMAPK3JAK1PP53, 176, 476IL7STAT5AIL7R427, 441STAT3BAD105, 217PPMAPK1PAKT1JAK3PPIK3R153, 244, 4768, 348, 460PIL2RASTAT5B336336336NUCY68, 428STAT1P185, 428


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108328view21:11, 6 December 2019L DupuisConverted interactions to graphical lines in legend
106598view19:36, 10 September 2019KhanspersModified description
105621view04:59, 10 August 2019KhanspersModified description
89854view12:22, 6 October 2016MkutmonModified description
80223view17:41, 26 May 2015EgonwRestored the description with non-corrupted chars.
79472view12:07, 23 March 2015Zari
79279view22:36, 19 March 2015ZariAdded Identifier for STAT5A and STAT5B
78518view10:29, 7 January 2015MaintBotadded missing graphIds
70018view01:51, 12 July 2013AlexanderPicoModified title
67387view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-7 signaling pathway' added !
63214view20:59, 8 May 2013MaintBotUpdating gpml version
48440view14:42, 24 May 2012NetPathModified description
45369view21:00, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45139view01:02, 7 October 2011AlexanderPicofixed db ref
44849view09:48, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44628view18:11, 22 September 2011KhanspersUpdating content to NetSlim
44110view20:33, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44018view22:42, 22 August 2011Khanspers
44015view22:32, 22 August 2011KhanspersAdded category
44014view22:31, 22 August 2011KhanspersModified description
44013view22:28, 22 August 2011KhanspersUpdating pathway from NetSlim
41183view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35646view21:36, 12 February 2010KhanspersModified description
21111view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-7 NetPath 19]] moved to [[Pathway:WP205]]: Moved to stable identifier
8194view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-7 NetPath 19]] moved to [[Pathway:Homo sapiens:IL-7 NetPath 19]]: Renaming species
7717view16:12, 18 December 2007MaintBotfixed category names
7256view12:41, 4 November 2007MaintBotAdded categories to GPML
6340view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-7_NetPath_19]]

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
CCND1Rna595 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
IL2RAGeneProduct3559 (Entrez Gene)
IL2RGGeneProduct3561[pubmed:15786731] has shown that IL6 induced dephosphorylation of phospho-Serine-782 in gp130 in HepG2 cells.
IL7GeneProduct3574 (Entrez Gene)
IL7RGeneProduct3575 (Entrez Gene) The common gamma chain augments IL-7 binding affinity and internalization of IL-7, which may explain the defects in X-linked severe combined immunodeficiency.
JAK1GeneProduct3716 (Entrez Gene) IL-7 stimulation induces tyrosine phosphorylation of the kinase JAK1 in human thymocytes
JAK3GeneProduct3718 (Entrez Gene) IL7 stimulation induces increased phosphorylation of JAK3 in normal human chondrocytes and thymocytes.
LigandGeneProduct7040 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MYCRna4609 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene) IL-7 stimulation induces the phosphorylation of PTK2B in human chondrocytes.
ProteinProtein5894 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene) IL-7 stimulation leads to tyrosine phosphorylation of STAT1 in human CD4 T cells and murine YT-5 cells
STAT3GeneProduct6774 (Entrez Gene) IL7 stimulation induces increased phosphorylation of STAT3 in normal human chondrocytes and T lymphoblasts.
STAT5AGeneProduct6776 (Entrez Gene) IL-7 stimulation induces phosphorylation and nuclear transport of STAT5A in human peripheral blood T lymphoblasts.
STAT5AGeneProductSTAT5A (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene) IL-7 stimulation leads to phosphorylation of STAT5B in CD8 T cells and human peripheral blood T lymphoblasts respectively.
STAT5BGeneProductSTAT5B (Entrez Gene)

Annotated Interactions

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