IL-7 Signaling Pathway (Homo sapiens)
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Description
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DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | 207 (Entrez Gene) ![]() | |
BAD | GeneProduct | 572 (Entrez Gene) ![]() | |
BCL2L1 | GeneProduct | 598 (Entrez Gene) ![]() | |
CCND1 | Rna | 595 (Entrez Gene) ![]() | |
CDKN1B | GeneProduct | 1027 (Entrez Gene) ![]() | |
FYN | GeneProduct | 2534 (Entrez Gene) ![]() | |
GSK3B | GeneProduct | 2932 (Entrez Gene) ![]() | |
IL2RA | GeneProduct | 3559 (Entrez Gene) ![]() | |
IL2RG | GeneProduct | 3561 | [pubmed:15786731] has shown that IL6 induced dephosphorylation of phospho-Serine-782 in gp130 in HepG2 cells. |
IL7 | GeneProduct | 3574 (Entrez Gene) ![]() | |
IL7R | GeneProduct | 3575 (Entrez Gene) ![]() | The common gamma chain augments IL-7 binding affinity and internalization of IL-7, which may explain the defects in X-linked severe combined immunodeficiency. |
JAK1 | GeneProduct | 3716 (Entrez Gene) ![]() | IL-7 stimulation induces tyrosine phosphorylation of the kinase JAK1 in human thymocytes |
JAK3 | GeneProduct | 3718 (Entrez Gene) ![]() | IL7 stimulation induces increased phosphorylation of JAK3 in normal human chondrocytes and thymocytes. |
Ligand | GeneProduct | 7040 (Entrez Gene) ![]() | |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) ![]() | |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) ![]() | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) ![]() | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) ![]() | |
MYC | Rna | 4609 (Entrez Gene) ![]() | |
PIK3R1 | GeneProduct | 5295 (Entrez Gene) ![]() | |
PIK3R2 | GeneProduct | 5296 (Entrez Gene) ![]() | |
PTK2B | GeneProduct | 2185 (Entrez Gene) ![]() | IL-7 stimulation induces the phosphorylation of PTK2B in human chondrocytes. |
Protein | Protein | 5894 (Entrez Gene) ![]() | |
Protein | Protein | ||
Receptor | GeneProduct | 7040 (Entrez Gene) ![]() | |
STAT1 | GeneProduct | 6772 (Entrez Gene) ![]() | IL-7 stimulation leads to tyrosine phosphorylation of STAT1 in human CD4 T cells and murine YT-5 cells |
STAT3 | GeneProduct | 6774 (Entrez Gene) ![]() | IL7 stimulation induces increased phosphorylation of STAT3 in normal human chondrocytes and T lymphoblasts. |
STAT5A | GeneProduct | 6776 (Entrez Gene) ![]() | IL-7 stimulation induces phosphorylation and nuclear transport of STAT5A in human peripheral blood T lymphoblasts. |
STAT5A | GeneProduct | STAT5A (Entrez Gene) ![]() | |
STAT5B | GeneProduct | 6777 (Entrez Gene) ![]() | IL-7 stimulation leads to phosphorylation of STAT5B in CD8 T cells and human peripheral blood T lymphoblasts respectively. |
STAT5B | GeneProduct | STAT5B (Entrez Gene) ![]() | |
mRNA | Protein |
Annotated Interactions
No annotated interactions