IL-7 Signaling Pathway (Homo sapiens)

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DemethylationDDeubiquitinationGlycosylationLigandMethylationCYExtracellularDNucleusPhosphorylationENNUD(Protein-protein interaction)GODesumoylationRecruitmentPMProteolytic cleavageSumoylationAutophosphorylationTranslocationECDeacetylationReaction through unknown mechanisms/moleculesReceptorEndosomeCytoplasmProteins in a complex interactionMTGolgi apparatusMolecular associationAccession Number: NetPath 19ActivationDephosphorylationAcetylationUbiquitinationMolecule in the pathwayPlasma membraneInhibitionMitochondrionControlPalmitoylationEnzyme complexIL7RPIK3R1STAMSTAT5AGRB2BAXPTK2BAKT1MAP2K1RAF1CBLBSTAT1STAT5BSTAM2SHC1JAK1CLTCIRS2Gene SymbolMAP2K2CDK2IL7IRS1MAPK3IRF1BADMCL1JAK3CCNA2LYNSOS1RB1MUC1MAPK1BLKSTAT3IL2RGFOXO3ACBLFYNBCL2L11FOXO1ACDK4CCND2HRASGSK3B


Interleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common gamma chain (γc) that is shared between all members of this family. IL-7 mainly activates the JAK/STAT signaling module. Source: NetPath


GenMAPP notes 
NetPath 19 – IL-7 Signaling Pathway

The annotation of immune signaling pathways ( is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use these pathways, you must cite these websites.

GenMAPP remarks

Quality Tags

Ontology Terms



No bibliography


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108328view21:11, 6 December 2019L DupuisConverted interactions to graphical lines in legend
106598view19:36, 10 September 2019KhanspersModified description
105621view04:59, 10 August 2019KhanspersModified description
89854view12:22, 6 October 2016MkutmonModified description
80223view17:41, 26 May 2015EgonwRestored the description with non-corrupted chars.
79472view12:07, 23 March 2015Zari
79279view22:36, 19 March 2015ZariAdded Identifier for STAT5A and STAT5B
78518view10:29, 7 January 2015MaintBotadded missing graphIds
70018view01:51, 12 July 2013AlexanderPicoModified title
67387view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-7 signaling pathway' added !
63214view20:59, 8 May 2013MaintBotUpdating gpml version
48440view14:42, 24 May 2012NetPathModified description
45369view21:00, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45139view01:02, 7 October 2011AlexanderPicofixed db ref
44849view09:48, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44628view18:11, 22 September 2011KhanspersUpdating content to NetSlim
44110view20:33, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44018view22:42, 22 August 2011Khanspers
44015view22:32, 22 August 2011KhanspersAdded category
44014view22:31, 22 August 2011KhanspersModified description
44013view22:28, 22 August 2011KhanspersUpdating pathway from NetSlim
41183view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35646view21:36, 12 February 2010KhanspersModified description
21111view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-7 NetPath 19]] moved to [[Pathway:WP205]]: Moved to stable identifier
8194view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-7 NetPath 19]] moved to [[Pathway:Homo sapiens:IL-7 NetPath 19]]: Renaming species
7717view16:12, 18 December 2007MaintBotfixed category names
7256view12:41, 4 November 2007MaintBotAdded categories to GPML
6340view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-7_NetPath_19]]

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
BLKGeneProduct640 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CCNA2GeneProduct890 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK4GeneProduct1019 (Entrez Gene)
CLTCGeneProduct1213 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
Gene SymbolGeneProduct
HRASGeneProduct3265 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IL7GeneProduct5295 (Entrez Gene)
IL7RGeneProduct3575 (Entrez Gene)
IRF1GeneProduct3659 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MCL1GeneProduct4170 (Entrez Gene)
MUC1GeneProduct4582 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
STAM2GeneProduct10254 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)

Annotated Interactions

No annotated interactions
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