IL-7 Signaling Pathway (Homo sapiens)
From WikiPathways
Description
Please access this pathway at NetSlim database.
If you use this pathway, you must cite following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.
This pathway is part the CPTAC Assay Portal.Quality Tags
Ontology Terms
Bibliography
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | Protein | 207 (Entrez Gene) ![]() | |
BAD | Protein | 572 (Entrez Gene) ![]() | |
BCL2L1 | Rna | 598 (Entrez Gene) ![]() | |
CCND1 | Rna | 595 (Entrez Gene) ![]() | |
CDKN1B | Rna | 1027 (Entrez Gene) ![]() | |
FYN | Protein | 2534 (Entrez Gene) ![]() | |
GSK3B | Protein | 2932 (Entrez Gene) ![]() | |
IL2RA | Rna | 3559 (Entrez Gene) ![]() | |
IL2RG | Protein | 3561 (Entrez Gene) ![]() | |
IL7 | Protein | 3574 (Entrez Gene) ![]() | |
IL7R | Protein | 3575 (Entrez Gene) ![]() | The common gamma chain augments IL-7 binding affinity and internalization of IL-7, which may explain the defects in X-linked severe combined immunodeficiency. |
JAK1 | Protein | 3716 (Entrez Gene) ![]() | IL-7 stimulation induces tyrosine phosphorylation of the kinase JAK1 in human thymocytes |
JAK3 | Protein | 3718 (Entrez Gene) ![]() | IL7 stimulation induces increased phosphorylation of JAK3 in normal human chondrocytes and thymocytes. |
MAP2K1 | Protein | 5604 (Entrez Gene) ![]() | |
MAP2K2 | Protein | 5605 (Entrez Gene) ![]() | |
MAPK1 | Protein | 5594 (Entrez Gene) ![]() | |
MAPK3 | Protein | 5595 (Entrez Gene) ![]() | |
MYC | Rna | 4609 (Entrez Gene) ![]() | |
PIK3R1 | Protein | 5295 (Entrez Gene) ![]() | |
PIK3R2 | Protein | 5296 (Entrez Gene) ![]() | |
PTK2B | Protein | 2185 (Entrez Gene) ![]() | IL-7 stimulation induces the phosphorylation of PTK2B in human chondrocytes. |
STAT1 | Protein | 6772 (Entrez Gene) ![]() | IL-7 stimulation leads to tyrosine phosphorylation of STAT1 in human CD4 T cells and murine YT-5 cells |
STAT3 | Protein | 6774 (Entrez Gene) ![]() | IL7 stimulation induces increased phosphorylation of STAT3 in normal human chondrocytes and T lymphoblasts. |
STAT5A | Protein | 6776 (Entrez Gene) ![]() | |
STAT5B | Protein | 6777 (Entrez Gene) ![]() |
Annotated Interactions
No annotated interactions