Human Thyroid Stimulating Hormone (TSH) signaling pathway (Homo sapiens)
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Description
Human thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-thyroid by stimulating production and secretion of the thyroid hormone from the thyroid gland. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.
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Bibliography
- Telikicherla D, Ambekar A, Palapetta SM, Dwivedi SB, Raju R, Sharma J, Prasad TsK, Ramachandra Y, Mohan SS, Maharudraiah J, Mukherjee S, Pandey A; ''A comprehensive curated resource for follicle stimulating hormone signaling.''; BMC Res Notes, 2011 PubMed Europe PMC
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