Ptf1a related regulatory pathway (Mus musculus)

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TrypsinElastaseChymotrypsinogenCarboxypeptidase 4246, 11945, 7110428Acinar-specific genes8312414Symbols:Documented interaction, positiveDocumented interaction, not in mouseProved interaction from our study, negativeEndocrine pancreasPancreas specificationExocrine pancreasHigh levelLowlevelPdx1RbpjmiR-495Nkx6-1Ctnnb1Hes1Prox1RbpjNotch1Pdx1Fgf10Kat2bmiR-145RbpjlmiR-18aPtf1a


Description

By summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated together to generate a whole sight in early mouse development centered around Ptf1a, although there are some hypothetical relationships and the distinct development of dorsal and ventral pancreas in very early stage is neglected.

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Bibliography

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  1. Ghosh, B, Leach, S D; ''Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex''; Biochem J, 2006 PubMed Europe PMC
  2. Fujikura, J, Hosoda, K, Kawaguchi, Y, Noguchi, M, Iwakura, H, Odori, S, Mori, E, Tomita, T, Hirata, M, Ebihara, K, Masuzaki, H, Fukuda, A, Furuyama, K, Tanigaki, K, Yabe, D, Nakao, K; ''Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development''; Dev Dyn, 2007 PubMed Europe PMC
  3. Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI; ''Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)''; J Histochem Cytochem, 1998 PubMed Europe PMC
  4. Miyatsuka, T, Matsuoka, T A, Shiraiwa, T, Yamamoto, T, Kojima, I, Kaneto, H; ''Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC
  5. Wiebe, P O, Kormish, J D, Roper, V T, Fujitani, Y, Alston, N I, Zaret, K S, Wright, C V, Stein, R W, Gannon, M; ''Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression''; Mol Cell Biol, 2007 PubMed Europe PMC
  6. Watada H, Mirmira RG, Leung J, German MS; ''Transcriptional and Translational Regulation of -Cell Differentiation Factor Nkx6.1''; J Biol Chem, 2000 PubMed Europe PMC
  7. Junfeng Wang, Gamze Kilic, Muge Aydin, Zoe Burke, Guillermo Oliver, Beatriz Sosa-Pineda; ''Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells''; Developmental Biology, 2005 PubMed Europe PMC
  8. Masui, T, Long, Q, Beres, T M, Magnuson, M A, MacDonald, R J; ''Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex''; Genes Dev, 2007 PubMed Europe PMC
  9. Jacquemin, P, Yoshitomi, H, Kashima, Y, Rousseau, G G, Lemaigre, F P, Zaret, K S; ''An endothelial-mesenchymal relay pathway regulates early phases of pancreas development''; Dev Biol, 2006 PubMed Europe PMC
  10. Dong, P D, Provost, E, Leach, S D, Stainier, D Y; ''Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas''; Genes Dev, 2008 PubMed Europe PMC
  11. Rodolosse, A, Campos, M L, Rooman, I, Lichtenstein, M, Real, F X; ''P/CAF modulates the activity of the transcription factor p48/PTF1a involved in pancreatic acinar differentiation''; Biochem J, 2008 PubMed Europe PMC
  12. Wells, J M, Esni, F, Boivin, G P, Aronow, B J, Stuart, W, Combs, C, Sklenka, A, Leach, S D, Lowy, A M; ''Wnt/beta-catenin signaling is required for development of the exocrine pancreas''; BMC Dev Biol, 2007 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
69113view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
68391view06:25, 5 July 2013EgonwConverted a node with an Ensemble identifier to a GeneProduct.
67617view11:33, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
59034view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41299view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
35872view15:51, 19 February 2010Godevil.
34753view23:17, 13 January 2010KhanspersModified categories
34569view21:59, 21 December 2009KhanspersModified categories
32362view13:42, 15 August 2009MaintBotFixed text labels
31997view13:16, 14 August 2009MaintBotFixed group labels
29652view02:15, 24 May 2009AlexanderPicoconverted to new ensembl linkout system
28187view02:31, 1 February 2009GodevilSpecify description
28186view07:30, 31 January 2009Godevilcolorful
28185view07:13, 31 January 2009GodevilPeriodical save, work in progress
28184view06:16, 31 January 2009GodevilReverted to version '2009年1月7日 (三) 09:56' by Godevil
28143view02:46, 28 January 2009GodevilCorrection
27540view09:56, 7 January 2009GodevilUpdated
27379view06:58, 25 December 2008GodevilCorrection
27377view06:47, 25 December 2008GodevilSpecify description
27297view23:48, 23 December 2008GodevilSpecify description
27295view23:43, 23 December 2008GodevilPeriodical save, work in progress
27292view23:39, 23 December 2008GodevilRenamed; Given all gene anotations and literature related
27290view23:27, 23 December 2008GodevilCorrected
27288view23:23, 23 December 2008GodevilPeriodical save, work in progress
27285view23:08, 23 December 2008GodevilSpecify description
27283view23:06, 23 December 2008GodevilPeriodical save, work in progress
27260view17:26, 23 December 2008GodevilPeriodical save, work in progress
27258view17:15, 23 December 2008GodevilPeriodical save, work in progress
27256view17:05, 23 December 2008GodevilPeriodical save, work in progress
27252view16:45, 23 December 2008GodevilPeriodical save, work in progress
27248view16:32, 23 December 2008GodevilSpecify description
27246view16:24, 23 December 2008GodevilPeriodical save, work in progress
27244view16:14, 23 December 2008GodevilPeriodical save, work in progress
27241view15:48, 23 December 2008GodevilModified categories
27239view15:45, 23 December 2008GodevilPeriodical save, work in progress
27237view15:35, 23 December 2008GodevilPeriodical save, work in progress
27235view15:16, 23 December 2008GodevilPeriodical save, work in progress
27233view14:54, 23 December 2008GodevilUpdated
27231view14:40, 23 December 2008GodevilGiven all factors and gene annotations
27229view14:35, 23 December 2008GodevilPeriodical save, work in progress
27227view14:25, 23 December 2008GodevilPeriodical save, work in progress
27225view14:15, 23 December 2008GodevilPeriodical save, work in progress
21103view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Ptf1a related regulatory network of early mouse pancreatic development]] moved to [[Pathway:WP201]]: Moved to stable identifier
17995view09:55, 6 August 2008Thomasadded gene/protein annotations
17844view09:25, 31 July 2008Godevil
17842view08:54, 31 July 2008GodevilGiven all containers
17840view08:45, 31 July 2008GodevilPeriodical save, work in progress
17838view08:35, 31 July 2008GodevilPeriodical save, work in progress
17836view08:25, 31 July 2008GodevilPeriodical save, work in progress
17834view08:14, 31 July 2008GodevilPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
Ctnnb1GeneProductENSMUSG00000006932 (Ensembl)
Fgf10GeneProductENSMUSG00000021732 (Ensembl)
Hes1GeneProductMGI:104853 (MGI)
Kat2bGeneProductENSMUSG00000000708 (Ensembl)
Nkx6-1GeneProductENSMUSG00000035187 (Ensembl)
Notch1GeneProductENSMUSG00000026923 (Ensembl)
Pdx1ProteinENSMUSG00000029644 (Ensembl)
Prox1GeneProductENSMUSG00000010175 (Ensembl)
Ptf1aGeneProductENSMUSG00000026735 (Ensembl)
RbpjGeneProductENSMUSG00000039191 (Ensembl)
RbpjlGeneProductENSMUSG00000017007 (Ensembl)
miR-145RnaMI0000169 (miRBase)
miR-18aRnaMI0000567 (miRBase)
miR-495RnaMI0004639 (miRBase)

Annotated Interactions

No annotated interactions

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