Iron metabolism in placenta (Homo sapiens)

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  1. Georgieff MK, Berry SA, Wobken JD, Leibold EA; ''Increased placental iron regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency.''; Placenta, 1999 PubMed Europe PMC
  2. Stys A, Galy B, Starzynski RR, Smuda E, Drapier JC, Lipinski P, Bouton C; ''Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.''; J Biol Chem, 2011 PubMed Europe PMC
  3. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA; ''Cloning and characterization of a mammalian proton-coupled metal-ion transporter.''; Nature, 1997 PubMed Europe PMC
  4. Mandò C, Tabano S, Colapietro P, Pileri P, Colleoni F, Avagliano L, Doi P, Bulfamante G, Miozzo M, Cetin I; ''Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas.''; Placenta, 2011 PubMed Europe PMC
  5. Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H; ''The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.''; Nature, 2008 PubMed Europe PMC
  6. Chen H, Attieh ZK, Syed BA, Kuo YM, Stevens V, Fuqua BK, Andersen HS, Naylor CE, Evans RW, Gambling L, Danzeisen R, Bacouri-Haidar M, Usta J, Vulpe CD, McArdle HJ; ''Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.''; J Nutr, 2010 PubMed Europe PMC
  7. Gambling L, Lang C, McArdle HJ; ''Fetal regulation of iron transport during pregnancy.''; Am J Clin Nutr, 2011 PubMed Europe PMC
  8. Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD; ''Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.''; Nat Genet, 2005 PubMed Europe PMC
  9. Ganz T; ''Hepcidin and iron regulation, 10 years later.''; Blood, 2011 PubMed Europe PMC
  10. Habtemichael EN, Brewer PD, Romenskaia I, Mastick CC; ''Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin.''; J Biol Chem, 2011 PubMed Europe PMC
  11. Baraibar MA, Muhoberac BB, Garringer HJ, Hurley TD, Vidal R; ''Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration.''; J Biol Chem, 2010 PubMed Europe PMC
  12. Bou-Abdallah F, Santambrogio P, Levi S, Arosio P, Chasteen ND; ''Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin.''; J Mol Biol, 2005 PubMed Europe PMC
  13. Steere AN, Byrne SL, Chasteen ND, Mason AB; ''Kinetics of iron release from transferrin bound to the transferrin receptor at endosomal pH.''; Biochim Biophys Acta, 2011 PubMed Europe PMC
  14. Chen J, Wang J, Meyers KR, Enns CA; ''Transferrin-directed internalization and cycling of transferrin receptor 2.''; Traffic, 2009 PubMed Europe PMC
  15. Zoller H, Theurl I, Koch R, Kaser A, Weiss G; ''Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.''; Blood Cells Mol Dis, 2002 PubMed Europe PMC
  16. Macara IG, Hoy TG, Harrison PM; ''The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake.''; Biochem J, 1972 PubMed Europe PMC
  17. Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV; ''A general map of iron metabolism and tissue-specific subnetworks.''; Mol Biosyst, 2009 PubMed Europe PMC
  18. Bergamaschi G, Bergamaschi P, Carlevati S, Cazzola M; ''Transferrin receptor expression in the human placenta.''; Haematologica, 1990 PubMed Europe PMC
  19. Bou-Abdallah F, Biasiotto G, Arosio P, Chasteen ND; ''The putative "nucleation site" in human H-chain ferritin is not required for mineralization of the iron core.''; Biochemistry, 2004 PubMed Europe PMC
  20. Anderson GJ, Frazer DM, McLaren GD; ''Iron absorption and metabolism.''; Curr Opin Gastroenterol, 2009 PubMed Europe PMC
  21. Hudson DM, Krisinger MJ, Griffiths TA, Macgillivray RT; ''Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.''; J Cell Biochem, 2008 PubMed Europe PMC
  22. Callus BA, Iacopetta BJ, Kühn LC, Morgan EH; ''Effects of overexpression of the transferrin receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron.''; Eur J Biochem, 1996 PubMed Europe PMC
  23. Zoller H, Theurl I, Koch RO, McKie AT, Vogel W, Weiss G; ''Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.''; Gastroenterology, 2003 PubMed Europe PMC
  24. Puri C; ''Loss of myosin VI no insert isoform (NoI) induces a defect in clathrin-mediated endocytosis and leads to caveolar endocytosis of transferrin receptor.''; J Biol Chem, 2009 PubMed Europe PMC
  25. Dezier JF, Vernet M, Damour O, Guillemin G, Le Treut A, Paris M, Plomteux G, Pressac M, Revenant MC, Rymer JC; ''[The coefficient of saturation of iron in transferrin].''; Ann Biol Clin (Paris), 1988 PubMed Europe PMC
  26. Griffiths TA, Mauk AG, MacGillivray RT; ''Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity.''; Biochemistry, 2005 PubMed Europe PMC


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106626view20:53, 12 September 2019Khanspersfixed unconnected
106625view20:51, 12 September 2019KhanspersModified description
105632view05:04, 10 August 2019KhanspersModified description
97386view04:23, 14 May 2018Khansperswork on interactions
97317view14:18, 9 May 2018AMTanRectified interactions where possible, converted some lines to graphical lines if they were between a target and the actual interaction line.
69751view10:40, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67414view10:58, 26 June 2013DdiglesOntology Term : 'iron homeostasis pathway' added !
63226view21:03, 8 May 2013MaintBotUpdating gpml version
59188view18:57, 22 February 2013MaintBotUpdated Ensembl data source
58506view19:06, 14 February 2013MaintBotModified title
45568view07:39, 17 October 2011Evelotype in mitochondrion
44879view10:03, 6 October 2011MartijnVanIerselOntology Term : 'PW:0000590' removed !
44878view10:03, 6 October 2011MartijnVanIerselOntology Term : 'iron transport pathway' added !
44877view10:03, 6 October 2011MartijnVanIerselOntology Term : 'iron homeostasis pathway' added !
44272view18:02, 30 August 2011KhanspersModified categories
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44254view11:11, 30 August 2011JcompaiIRP1/ferritin interaction
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43797view11:10, 28 July 2011JcompaiWIP
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43779view14:48, 27 July 2011JcompaiWIP
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External references


NameTypeDatabase referenceComment
STEAP3GeneProductENSG00000115107 (Ensembl Human)
TFProteinENSG00000091513 (Ensembl Human) Transferrin
TFR1ProteinENSG00000072274 (Ensembl Human) Transferrin receptor

Annotated Interactions

No annotated interactions

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