Iron metabolism in placenta (Homo sapiens)

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5, 1113, 22, 231mitochondrionclathrin-coated early endosome foetal liversignal ? Ferritintransporter ? 114, 196, 16, 18basolateralunknown interactionsstimulate??ApicalinhibitpH 6-7?FeIIIIREB2STEAP3foetal HAMP?TFTfR1 RNAHAMPHEPHL1TFR1SLC40A1IRP1FeII3, 2120, 2411268, 15TFR126TFTFR1TF25STEAP3late endosome TFR1TFSTEAP3lysosome2TFR1TFpH 5-6H+?SLC11A2MCOLN110H+FeIIMCOLN110SLC11A26, 14?7foetal TFTFR212TFmaternal liverTF9, 17??FTH1RNAFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIIFeIIFeIIFeIIFeII


During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. This description of Iron pathway through the placenta, and its regulation is purposed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus.

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106626view20:53, 12 September 2019Khanspersfixed unconnected
106625view20:51, 12 September 2019KhanspersModified description
105632view05:04, 10 August 2019KhanspersModified description
97386view04:23, 14 May 2018Khansperswork on interactions
97317view14:18, 9 May 2018AMTanRectified interactions where possible, converted some lines to graphical lines if they were between a target and the actual interaction line.
69751view10:40, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67414view10:58, 26 June 2013DdiglesOntology Term : 'iron homeostasis pathway' added !
63226view21:03, 8 May 2013MaintBotUpdating gpml version
59188view18:57, 22 February 2013MaintBotUpdated Ensembl data source
58506view19:06, 14 February 2013MaintBotModified title
45568view07:39, 17 October 2011Evelotype in mitochondrion
44879view10:03, 6 October 2011MartijnVanIerselOntology Term : 'PW:0000590' removed !
44878view10:03, 6 October 2011MartijnVanIerselOntology Term : 'iron transport pathway' added !
44877view10:03, 6 October 2011MartijnVanIerselOntology Term : 'iron homeostasis pathway' added !
44272view18:02, 30 August 2011KhanspersModified categories
44268view14:37, 30 August 2011JcompaiPeriodical save, work in progress
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44254view11:11, 30 August 2011JcompaiIRP1/ferritin interaction
44237view09:02, 29 August 2011JcompaiWIP
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External references


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NameTypeDatabase referenceComment
FTH1RNARnaENSG00000167996 (Ensembl)
FeIIMetabolite15438-31-0 (CAS)
FeIIIMetabolite20074-52-6 (CAS)
HAMPProteinENSG00000105697 (Ensembl)
HEPHL1GeneProductENSG00000181333 (Ensembl)
IREB2GeneProductENSG00000136381 (Ensembl)
IRP1GeneProductENSG00000122729 (Ensembl)
MCOLN1GeneProductENSG00000090674 (Ensembl)
SLC11A2GeneProductENSG00000110911 (Ensembl)
SLC40A1GeneProductENSG00000138449 (Ensembl)
STEAP3GeneProductENSG00000115107 (Ensembl)
TFProteinENSG00000091513 (Ensembl) Transferrin
TFR1ProteinENSG00000072274 (Ensembl) Transferrin receptor
TFR2GeneProductENSG00000106327 (Ensembl) Transferrin receptor
TfR1 RNARnaENSG00000072274 (Ensembl)
foetal HAMP?ProteinENSG00000105697 (Ensembl) HAMP
foetal TFProteinENSG00000091513 (Ensembl) Transferrin

Annotated Interactions

No annotated interactions

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