Complement Activation, Classical Pathway (Mus musculus)

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CytoplasmComplexFormationantigen/antibodycomplexPlasmaMembraneaggregated IgG,IgM-antigen complex,polyanions, RNA, DNAlipopolysaccharidesC1 complexPrevents Complement AttackProteolytic CleavageMembraneattack complexIonsC1qcC2C1sC1qbHcH2OC8aC6C4aC1rDaf1C7C1qaC8bC3C4bMasp1C9


No description


This pathway was inferred from Homo sapiens pathway WP545(r21826) with a 64% conversion rate.

Quality Tags

Ontology Terms



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106864view13:34, 17 September 2019MaintBotHMDB identifier normalization
72061view17:24, 24 October 2013Mkutmonupdated annotation for C4a
69783view12:51, 11 July 2013Mkutmonfixed unconnected lines
69205view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67121view10:09, 26 June 2013Christine ChichesterOntology Term : 'classical complement pathway' added !
47967view13:21, 23 April 2012MartijnVanIerselfont size
47966view13:19, 23 April 2012MartijnVanIersel
41395view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
32694view23:38, 31 August 2009KhanspersAdded xrefs
32361view13:42, 15 August 2009MaintBotFixed text labels
31996view13:15, 14 August 2009MaintBotFixed group labels
31408view20:52, 13 August 2009MaintBotFixed text labels
30820view23:57, 29 July 2009MaintBotConverted from Homo sapiens
21101view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:Complement Activation Classical]] moved to [[Pathway:WP200]]: Moved to stable identifier
7968view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Complement Activation Classical]] moved to [[Pathway:Mus musculus:Complement Activation Classical]]: Renaming species
7608view16:03, 18 December 2007MaintBotfixed category names
7465view12:42, 4 November 2007MaintBotAdded categories to GPML
6427view22:18, 22 May 2007Nsalomonisgpml file for [[Mouse:Complement_Activation_Classical]]

External references


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NameTypeDatabase referenceComment
C1qaGeneProduct12259 (Entrez Gene) update: C1QA HUMAN
C1qbGeneProduct12260 (Entrez Gene)
C1qcGeneProduct12262 (Entrez Gene) update C1QC HUMAN
C1rGeneProduct50909 (Entrez Gene)
C1sGeneProduct50908 (Entrez Gene)
C2GeneProduct12263 (Entrez Gene)
C3GeneProduct12266 (Entrez Gene)
C4aGeneProduct625018 (Entrez Gene)
C4bGeneProduct12268 (Entrez Gene)
C6GeneProduct12274 (Entrez Gene)
C7GeneProduct109828 (Entrez Gene)
C8aGeneProduct230558 (Entrez Gene)
C8bGeneProduct110382 (Entrez Gene)
C9GeneProduct12279 (Entrez Gene)
Daf1GeneProduct13136 (Entrez Gene)
H2OMetaboliteHMDB02111 (HMDB)
HcGeneProduct15139 (Entrez Gene)
Masp1GeneProduct17174 (Entrez Gene)

Annotated Interactions

No annotated interactions
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