Integrated Breast Cancer Pathway (Homo sapiens)

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71562151591381213120112612192416101523525182215G2Cell CycleBASC ComplexMG1S4, 10, 17CorticosteroneC9JNK1MPIP2JKIP1TSC2ANXA1BRAFHydrocortisoneCDH1CASP3NCOA2AnastrozoleFADDMPIP1CCND1FulvestrantRALADCAKDSMEK1RASGRP3AKT1B3KP27DonepezilSTK11SMAD2HydroxyureaP53MIR21Cancer DevelopmentFOXO1BCL2ZMIZ1RASGEF1ACASP9ERAL1RAD50CDK4PTENRRASTFPIEGFRSMCA4UBP15RHOCTNB1 degradationSMAD1cyc-DUBP16SELKNFKB1DHTGCRCell SurvivalHDAC1/HDAC2Anti-ApoptosisODC1CDC25AIKKAP13KMYCMAXPPRB/RBIRS1SMAD4RHOLetrozoleRRASHIPK2ApoptosisConjugated EstrogensPLK1BACH1JUNfra-1BLMPenicillin GBMPR2B5MEC1BleomycinCell proliferationTRADDBMPR1ACTNB1FluoxymesteroneMitomycinIKKABAXNF1BRCA1MTORProteinWEE1BARD1TamoxifenITPKCGDIDihydrotestosteronePHBCBPP85SMAD7SP1PLK3E2F1TAK1LBADCDC42BARD1Tetradecanoylphorbol AcetateTCF/LEFMYT1RAP1ATranscriptionCycloheximideATF1GSK3APRMRE11CSNK1DCell Cycle arrestARATRGene ExpressionMSH6IPKARPP38RAD54LFLIP1CERKRAC1FlutamideCERK1ExemstanePIAS1AmpicillinLapatnibSMAD3EP300Methyl MethanesulfonateMDM2C9JNK1MSH2FADDCHK1MAPKsCYP19A1RALGAPA1DNAMYCABC3GSMAD7Lithium ChlorideBADP13P53PaclitaxelMIR21CHK2AngiogenesisIMPA1ESR1ATMSIRT1P65TGFR2STAT1AKT1GRNE2F1CREBP38BRCA2PLK3CATGFR1Proliferative genesBAKATRNOXA1Q8NBS1CIP1NCOA3PAK1CDK2TAB1NAB1ProteasomeJAK1PMLHDAC1RRASGADD45AC9JNK1ABL1ALKB1JUNCASP3MMP1HDAC1CDK2RAD51AHRCell survival and ProliferationTestosteroneSMEK1PPARCASP8PlicamycinSMAD4EstradiolWEE1AURKACDK7UBIMGRUBP21ANDRMIR21ERKRASMDM2CERK1SMEK2ATRMIR29B1ApoptosisP85APKCB1DexamethasoneATMBRCA1AQP73XRCC3ERKTSC1RHEBUBP21TSC1SMAD6BIDDAG1RAFNocodazoleUBE2FVEGFARaloxifene14MIR29B2