Integrated breast cancer pathway (Homo sapiens)

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20124251518211531013121115165156215232219267189BASC ComplexSG2G1Cell CycleM4, 10, 17XRCC3SMEK1PLK3RASGEF1ANCOA2TFPIANDRUBP16UBE2FNocodazoleMIR29B1STAT1ESR1CDC42AHRDAG1fra-1CDK4CHK2FulvestrantPHBATF1PPRB/RBIRS1MRE11MSH2TGFR2Cell proliferationE2F1KRASPMLTetradecanoylphorbol AcetateRAD51HDAC1/HDAC2CTNB1BAKCASP3HIPK2HDAC1NFKB1GRNDonepezilSMEK2JAK1ATRRAD50Cell survival and ProliferationTSC2BMPR1ASMAD6STK11SIRT1DihydrotestosteroneP85APIAS1Cell Cycle arrestRRASRHOUBP15AURKAAnastrozoleALKB1Cancer DevelopmentMIR21Methyl MethanesulfonatePKCB1AKT1IKKAProteinQ8NBS1DNAMDM2CHK1DHTBAXHydroxyureaP38SMAD7CIP1PAK1BADLapatnibP13KP53Proliferative genesPLK3CAWEE1AQP73BARD1CycloheximideRAD54LMIR21FlutamideP53SMAD1AngiogenesisAKT1PTENPenicillin GGene ExpressionMitomycinGRHydrocortisoneRASGRP3NAB1RPP38CDC25APLK1CERKCERK1SMAD4C9JNK1TamoxifenPPARMDM2RHOCBPMAXERMMP1GDISMAD2B5MEC1TAB1PRExemstaneTestosteroneMAPKsEstradiolMYT1BRAFTGFR1ERAL1ARUBP21MIR21C9JNK1CREBRALASMAD4ANXA1UBP21ATMCYP19A1FLIP1JUNFluoxymesteroneCASP8cyc-DSMAD7RRASAnti-ApoptosisBADSP1BRCA1GADD45ABACH1CDK2RAC1P65PlicamycinRAP1AFADDWEE1ATRMYCEGFRFOXO1RRASC9JNK1CASP3TSC1RaloxifeneHDAC1VEGFAFADDZMIZ1CERK1ABC3GIKKACell SurvivalCCND1MPIP1RALGAPA1DexamethasoneE2F1SMAD3GCRBIDMYCEP300TSC1TRADDTAK1LSELKTCF/LEFPaclitaxelBRCA1ApoptosisABL1NF1TranscriptionRHEBRAFLetrozoleCTNB1 degradationSMCA4IMPA1NCOA3ATMCDH1ODC1IPKABARD1GSK3ADCAKDNOXA1BCL2JKIP1AmpicillinITPKCBleomycinProteasomeMTORP85BMPR2CSNK1DBRCA2MSH6CDK2ApoptosisP13CDK7UBIMMPIP2B3KP27CASP9BLMJUNSMEK1ERKCorticosteroneLithium ChlorideATRConjugated Estrogens14MIR29B2