Integrated Breast Cancer Pathway (Homo sapiens)

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2127164214114319222484201341018416239152526BASC ComplexSG2G1Cell CycleM5, 17, 19Cell proliferationAQP73IKKADCAKDXRCC3NF1MYCPLK3BMPR2PPRB/RBMPIP1PHBERKEP300CCND1SMAD4CERK1MIR21HDAC1JUNBRCA2FulvestrantUBIMTranscriptionP85AngiogenesisRHEBGCRPTENDAG1fra-1MIR21MAPKsAnastrozoleBleomycinConjugated EstrogensTAK1LP13PLK3CABADUBP15DexamethasoneALKB1Q8NBS1ARMYCSMAD7CorticosteroneVEGFATSC1AKT1BMPR1ACASP8CERK1BRAFC9JNK1MAXCDK2MTORNCOA3ABL1AHRBARD1CTNB1 degradationAmpicillinSMEK2ATF1PLK1EGFRMIR21JUNGADD45ARRASATMRAD51P85ACSNK1DHIPK2Cell survival and ProliferationEstradiolMPIP2B5MEC1ATRMIR29B1LapatnibBACH1MMP1FADDSMAD4cyc-DSMAD1ZMIZ1MDM2RPP38AURKAFlutamideGSK3ATFPIRaloxifenePKCB1IMPA1PaclitaxelCTNB1ProteinTetradecanoylphorbol AcetateWEE1GRNFADDCHK2CDK7Methyl MethanesulfonateBAXTSC2UBE2FPenicillin GKRASRAD50HDAC1MSH2E2F1RHOTSC1UBP16PPARTAB1RAP1AIKKABLMCDH1PMLP65MSH6MYT1RALGAPA1MDM2UBP21BRCA1CIP1SMEK1CDK2JAK1DHTHydrocortisoneABC3GTRADDHydroxyureaTGFR2CDK4DihydrotestosteroneBAKRASGRP3RASGEF1ASP1ODC1P53LetrozoleATMRAC1ERRRASGDIB3KP27P13KERAL1PlicamycinNOXA1MitomycinTestosteroneProteasomeDonepezilCERKSTK11CycloheximideSMAD2E2F1CHK1ATRRALAPAK1HDAC1/HDAC2PRNFKB1RAFNCOA2AKT1SMCA4C9JNK1TamoxifenCell SurvivalSMEK1BRCA1Gene ExpressionCell Cycle arrestTGFR1NocodazoleSELKWEE1DNACDC25ACASP3SMAD3BCL2ANXA1Anti-ApoptosisRHOApoptosisLithium ChlorideMRE11JKIP1UBP21ApoptosisRAD54LCYP19A1GRP53BARD1ATRITPKCFLIP1CASP3P38IPKATCF/LEFProliferative genesESR1RRASCREBFOXO1SMAD6NAB1STAT1BADC9JNK1CBPANDRBIDExemstaneCASP9SIRT1CDC42PIAS1Cancer DevelopmentSMAD7FluoxymesteroneIRS112MIR29B2