Integrated Breast Cancer Pathway (Homo sapiens)

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1642425162023219414711132151884222426419310MBASC ComplexG2Cell CycleSG15, 17, 19EP300UBP21ARSMAD3AHRTetradecanoylphorbol AcetateCCND1ATRGRNTFPIFLIP1Cell SurvivalBAKBADSMAD7SMEK1PIAS1FADDCell proliferationNFKB1SMEK2XRCC3cyc-DMDM2NCOA2CTNB1BRCA1SELKCSNK1DCell survival and ProliferationSMAD4GDITSC1ERC9JNK1TSC1CHK2RHEBWEE1HIPK2TestosteroneRHOE2F1PHBWEE1GSK3ACDC42FulvestrantP53CASP8CorticosteroneBACH1CASP9IPKARALARASGRP3FOXO1IKKATRADDSMAD1MSH2GCRP13RAD50FADDRaloxifeneHDAC1AKT1P65JUNCBPERAL1MTORMAPKsP85ACTNB1 degradationRAP1ACASP3CERKSMEK1CDK2PMLGADD45AJKIP1BRAFP13KPPARJAK1BAXBARD1PLK3B5MEC1ATRPRFluoxymesteroneIKKAAnastrozoleCancer DevelopmentCREBPTENRAD51BMPR1APlicamycinTGFR1BARD1TAB1SMAD7RAC1PLK1CERK1AQP73Methyl MethanesulfonatePPRB/RBCDC25AKRASP38AngiogenesisProteasomeMPIP1UBE2FITPKCDNADAG1ApoptosisCDH1TranscriptionDexamethasoneGene ExpressionE2F1CIP1MDM2RRASMMP1RHOEstradiolIRS1MYCATMRASGEF1ASTAT1HDAC1/HDAC2MSH6RAD54LExemstaneGRERKBLMCDK7TAK1LNF1ANDRProliferative genesATRATF1ABC3GJUNMIR29B1CDK2BCL2Q8NBS1CHK1DHTP53FlutamideSIRT1DonepezilABL1LetrozoleProteinTSC2MIR21BRCA1TCF/LEFAURKARRASATMUBP16CYP19A1SMAD6MYT1PaclitaxelCDK4HydrocortisoneMAXBMPR2SMAD4NocodazoleMitomycinRAFMPIP2HydroxyureaZMIZ1NOXA1MIR21AKT1STK11VEGFAUBIMLithium ChlorideTamoxifenfra-1Penicillin GSP1CERK1BRCA2B3KP27RRASMIR21P85ApoptosisSMCA4LapatnibRALGAPA1MYCNCOA3C9JNK1RPP38PKCB1ESR1SMAD2AmpicillinUBP21CASP3Cell Cycle arrestBADConjugated EstrogensALKB1UBP15DihydrotestosteroneDCAKDBIDANXA1PAK1TGFR2NAB1EGFRMRE11IMPA1PLK3CAAnti-ApoptosisBleomycinHDAC1C9JNK1ODC1CycloheximideMIR29B212