Integrated Breast Cancer Pathway (Homo sapiens)
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Zari
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12
8
6
3
20
19
14
7
9
18
16
5
2
10
11
15
4
6
G1
S
BASC Complex
M
G2
Cell Cycle
1, 17, 20
ANXA1
Paclitaxel
CDC25A
Proteasome
P53
MPIP2
ODC1
PTEN
BAK
RRAS
PHB
ATF1
HIPK2
ANDR
CDK4
ATR
RHO
CDK2
HDAC1
SIRT1
PPAR
UBP15
Lithium Chloride
DAG1
FOXO1
Donepezil
MSH6
Dihydrotestosterone
PLK1
Hydrocortisone
RAD54L
CDK7
RALA
RASGEF1A
IKKA
ATM
Cell Cycle arrest
JUN
RRAS
MYT1
Proliferative genes
RAC1
P13
IPKA
BRCA1
TAB1
AHR
NOXA1
RAD50
SMAD4
ABL1
GCR
Methyl Methanesulfonate
NAB1
BARD1
Anti-Apoptosis
PKCB1
SMEK1
Gene Expression
BAD
AKT1
CDC42
TGFR1
IRS1
XRCC3
BLM
PAK1
Nocodazole
C9JNK1
Corticosterone
GR
ESR1
Testosterone
Cancer Development
CASP9
DCAKD
PLK3
P53
CDK2
ALKB1
E2F1
NCOA3
MSH2
UBP21
Angiogenesis
C9JNK1
Lapatnib
AQP73
RALGAPA1
Estradiol
CHK2
CHK1
TGFR2
P65
Mitomycin
UBE2F
cyc-D
BACH1
Transcription
UBIM
MDM2
TRADD
MDM2
PPRB/RB
SP1
EP300
ERAL1
Tamoxifen
RAF
SMCA4
RPP38
CTNB1 degradation
ATM
SMAD1
FADD
CIP1
Fulvestrant
Conjugated Estrogens
CDH1
BMPR1A
Tetradecanoylphorbol Acetate
Apoptosis
Cell proliferation
Apoptosis
GSK3A
Hydroxyurea
MAX
Dexamethasone
PLK3CA
AR
MYC
SMAD4
PML
WEE1
HDAC1/HDAC2
STAT1
RRAS
SMAD2
UBP16
DNA
RAD51
Cycloheximide
CERK1
Cell survival and Proliferation
Fluoxymesterone
CYP19A1
RHO
JAK1
EGFR
RHEB
B3KP27
GDI
KRAS
MRE11
JUN
CERK
ATR
SMAD7
RASGRP3
Letrozole
RAP1A
Raloxifene
P85A
B5MEC1
FLIP1
P38
Cell Survival
BAX
UBP21
MAPKs
MMP1
CBP
Bleomycin
TFPI
NF1
TAK1L
SELK
STK11
PR
ER
Plicamycin
P85
BID
MPIP1
VEGFA
ATR
PIAS1
CREB
SMEK2
BMPR2
fra-1
TSC2
Ampicillin
BAD
BCL2
JKIP1
MTOR
TSC1
DHT
SMAD7
NFKB1
TCF/LEF
CASP8
GRN
Penicillin G
NCOA2
CERK1
GADD45A
Flutamide
CCND1
TSC1
HDAC1
ZMIZ1
CSNK1D
BRCA2
ERK
MYC
ABC3G
WEE1
ITPKC
P13K
FADD
BARD1
SMAD3
AKT1
E2F1
CASP3
CASP3
C9JNK1
Anastrozole
Q8NBS1
AURKA
Protein
BRCA1
Exemstane
SMEK1
IKKA
CTNB1
SMAD6
BRAF
IMPA1
13