Integrated Breast Cancer Pathway (Homo sapiens)
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Zari
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BASC Complex
G2
M
S
Cell Cycle
G1
1, 17, 20
RHO
NAB1
TCF/LEF
BAD
GR
CTNB1 degradation
ATR
WEE1
SMAD1
EP300
PLK3CA
P53
PTEN
STAT1
AURKA
E2F1
CDK2
CDK4
Fluoxymesterone
FADD
ANXA1
RASGRP3
CASP8
CASP9
MPIP2
MRE11
Transcription
Cycloheximide
SMCA4
Ampicillin
CDC42
RAP1A
TSC1
CHK2
Estradiol
cyc-D
CERK1
BAX
SMEK1
RALA
P38
MPIP1
AR
CIP1
CDK7
PAK1
DAG1
TGFR2
CBP
NCOA2
Plicamycin
ATM
SP1
Donepezil
KRAS
AKT1
Anti-Apoptosis
BCL2
IKKA
TSC1
SMAD7
CASP3
HDAC1/HDAC2
MSH6
UBIM
Hydroxyurea
IKKA
AHR
Cell proliferation
ERAL1
Apoptosis
PML
CREB
DCAKD
HIPK2
UBP16
RHEB
ATM
Protein
Q8NBS1
UBP21
Proliferative genes
RALGAPA1
Testosterone
WEE1
RHO
P13K
ATF1
HDAC1
TAK1L
CYP19A1
Flutamide
MYC
Conjugated Estrogens
PKCB1
ESR1
BAK
NOXA1
BID
ATR
CDC25A
P13
CTNB1
E2F1
Cell Cycle arrest
AQP73
MAPKs
JKIP1
MYC
SMAD4
SMAD6
FLIP1
CDK2
Paclitaxel
Fulvestrant
PHB
SMAD7
Apoptosis
FADD
RAD54L
Bleomycin
MDM2
ANDR
BMPR1A
ITPKC
BLM
DHT
ZMIZ1
SMAD2
HDAC1
PLK1
GCR
CHK1
BAD
MAX
TRADD
Angiogenesis
UBE2F
Dexamethasone
NF1
IMPA1
Lapatnib
Letrozole
ALKB1
VEGFA
DNA
GSK3A
SMEK1
CASP3
ABC3G
BACH1
BRCA2
RRAS
BRCA1
TAB1
RASGEF1A
ODC1
BRAF
Exemstane
PLK3
EGFR
UBP21
Mitomycin
XRCC3
GRN
JAK1
ERK
PPRB/RB
TFPI
Corticosterone
P85A
RAC1
RPP38
C9JNK1
CDH1
NCOA3
Cell survival and Proliferation
BARD1
Cell Survival
B5MEC1
SMEK2
C9JNK1
RAD51
SIRT1
IRS1
SELK
RRAS
PPAR
MTOR
CSNK1D
P65
B3KP27
GDI
MMP1
UBP15
Gene Expression
STK11
Dihydrotestosterone
CERK1
TSC2
JUN
P85
Tetradecanoylphorbol Acetate
Raloxifene
FOXO1
SMAD3
MYT1
Hydrocortisone
P53
AKT1
MSH2
BMPR2
C9JNK1
ATR
BARD1
Nocodazole
fra-1
IPKA
MDM2
Tamoxifen
ER
Cancer Development
NFKB1
SMAD4
CCND1
BRCA1
Methyl Methanesulfonate
ABL1
CERK
Proteasome
RAD50
Penicillin G
JUN
PIAS1
Anastrozole
GADD45A
RAF
Lithium Chloride
TGFR1
RRAS
PR
13