Integrated Breast Cancer Pathway (Homo sapiens)

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128632019147918165210111546G1SBASC ComplexMG2Cell Cycle1, 17, 20ANXA1PaclitaxelCDC25AProteasomeP53MPIP2ODC1PTENBAKRRASPHBATF1HIPK2ANDRCDK4ATRRHOCDK2HDAC1SIRT1PPARUBP15Lithium ChlorideDAG1FOXO1DonepezilMSH6DihydrotestosteronePLK1HydrocortisoneRAD54LCDK7RALARASGEF1AIKKAATMCell Cycle arrestJUNRRASMYT1Proliferative genesRAC1P13IPKABRCA1TAB1AHRNOXA1RAD50SMAD4ABL1GCRMethyl MethanesulfonateNAB1BARD1Anti-ApoptosisPKCB1SMEK1Gene ExpressionBADAKT1CDC42TGFR1IRS1XRCC3BLMPAK1NocodazoleC9JNK1CorticosteroneGRESR1TestosteroneCancer DevelopmentCASP9DCAKDPLK3P53CDK2ALKB1E2F1NCOA3MSH2UBP21AngiogenesisC9JNK1LapatnibAQP73RALGAPA1EstradiolCHK2CHK1TGFR2P65MitomycinUBE2Fcyc-DBACH1TranscriptionUBIMMDM2TRADDMDM2PPRB/RBSP1EP300ERAL1TamoxifenRAFSMCA4RPP38CTNB1 degradationATMSMAD1FADDCIP1FulvestrantConjugated EstrogensCDH1BMPR1ATetradecanoylphorbol AcetateApoptosisCell proliferationApoptosisGSK3AHydroxyureaMAXDexamethasonePLK3CAARMYCSMAD4PMLWEE1HDAC1/HDAC2STAT1RRASSMAD2UBP16DNARAD51CycloheximideCERK1Cell survival and ProliferationFluoxymesteroneCYP19A1RHOJAK1EGFRRHEBB3KP27GDIKRASMRE11JUNCERKATRSMAD7RASGRP3LetrozoleRAP1ARaloxifeneP85AB5MEC1FLIP1P38Cell SurvivalBAXUBP21MAPKsMMP1CBPBleomycinTFPINF1TAK1LSELKSTK11PRERPlicamycinP85BIDMPIP1VEGFAATRPIAS1CREBSMEK2BMPR2fra-1TSC2AmpicillinBADBCL2JKIP1MTORTSC1DHTSMAD7NFKB1TCF/LEFCASP8GRNPenicillin GNCOA2CERK1GADD45AFlutamideCCND1TSC1HDAC1ZMIZ1CSNK1DBRCA2ERKMYCABC3GWEE1ITPKCP13KFADDBARD1SMAD3AKT1E2F1CASP3CASP3C9JNK1AnastrozoleQ8NBS1AURKAProteinBRCA1ExemstaneSMEK1IKKACTNB1SMAD6BRAFIMPA113