Integrated Breast Cancer Pathway (Homo sapiens)

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128632019147918165210111546BASC ComplexG2MSCell CycleG11, 17, 20RHONAB1TCF/LEFBADGRCTNB1 degradationATRWEE1SMAD1EP300PLK3CAP53PTENSTAT1AURKAE2F1CDK2CDK4FluoxymesteroneFADDANXA1RASGRP3CASP8CASP9MPIP2MRE11TranscriptionCycloheximideSMCA4AmpicillinCDC42RAP1ATSC1CHK2Estradiolcyc-DCERK1BAXSMEK1RALAP38MPIP1ARCIP1CDK7PAK1DAG1TGFR2CBPNCOA2PlicamycinATMSP1DonepezilKRASAKT1Anti-ApoptosisBCL2IKKATSC1SMAD7CASP3HDAC1/HDAC2MSH6UBIMHydroxyureaIKKAAHRCell proliferationERAL1ApoptosisPMLCREBDCAKDHIPK2UBP16RHEBATMProteinQ8NBS1UBP21Proliferative genesRALGAPA1TestosteroneWEE1RHOP13KATF1HDAC1TAK1LCYP19A1FlutamideMYCConjugated EstrogensPKCB1ESR1BAKNOXA1BIDATRCDC25AP13CTNB1E2F1Cell Cycle arrestAQP73MAPKsJKIP1MYCSMAD4SMAD6FLIP1CDK2PaclitaxelFulvestrantPHBSMAD7ApoptosisFADDRAD54LBleomycinMDM2ANDRBMPR1AITPKCBLMDHTZMIZ1SMAD2HDAC1PLK1GCRCHK1BADMAXTRADDAngiogenesisUBE2FDexamethasoneNF1IMPA1LapatnibLetrozoleALKB1VEGFADNAGSK3ASMEK1CASP3ABC3GBACH1BRCA2RRASBRCA1TAB1RASGEF1AODC1BRAFExemstanePLK3EGFRUBP21MitomycinXRCC3GRNJAK1ERKPPRB/RBTFPICorticosteroneP85ARAC1RPP38C9JNK1CDH1NCOA3Cell survival and ProliferationBARD1Cell SurvivalB5MEC1SMEK2C9JNK1RAD51SIRT1IRS1SELKRRASPPARMTORCSNK1DP65B3KP27GDIMMP1UBP15Gene ExpressionSTK11DihydrotestosteroneCERK1TSC2JUNP85Tetradecanoylphorbol AcetateRaloxifeneFOXO1SMAD3MYT1HydrocortisoneP53AKT1MSH2BMPR2C9JNK1ATRBARD1Nocodazolefra-1IPKAMDM2TamoxifenERCancer DevelopmentNFKB1SMAD4CCND1BRCA1Methyl MethanesulfonateABL1CERKProteasomeRAD50Penicillin GJUNPIAS1AnastrozoleGADD45ARAFLithium ChlorideTGFR1RRASPR13