Integrated Breast Cancer Pathway (Homo sapiens)

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252314169241119222116171511201711211320511418812SCell CycleMG1BASC ComplexG23, 17, 26HDAC1Methyl MethanesulfonateFlutamideNAB1ESR1FulvestrantRASGEF1ACIP1SMAD1SMCA4TSC2MSH2Q8NBS1HydrocortisoneCDK4Cell proliferationMYCC9JNK1Anti-ApoptosisTGFR1Cancer DevelopmentEGFRRHOCorticosteroneDNARAP1AJKIP1RAD50P13ABL1PKCB1UBP16SMAD3MRE11RRASGSK3APIAS1CREBRASGRP3AHRSIRT1RRASIKKAFOXO1B3KP27IKKAGRCCND1AKT1WEE1MAPKsNocodazolePaclitaxelTSC1CDK7LapatnibSMAD7AKT1RRASGADD45AP53ProteasomeXRCC3cyc-DATMP38BRCA2LetrozoleCHK2BIDCycloheximideRAC1ATRMSH6SMEK1IMPA1PTENBADDAG1UBP21BRCA1ZMIZ1P53ERRAD54LBMPR1AMYT1CTNB1 degradationfra-1UBIMCell Cycle arrestP65ATRCHK1NOXA1MYCPPRB/RBAmpicillinITPKCCASP9NFKB1AngiogenesisCERKNF1ARBMPR2MIR21TAK1LBAKBAXSMAD4STK11E2F1BCL2Penicillin GBARD1SMEK2NCOA3CDH1MDM2Conjugated EstrogensRALAMMP1WEE1RAD51CDK2DihydrotestosteroneRALGAPA1TAB1B5MEC1PLK1ABC3GPRCYP19A1TranscriptionIPKASMAD2PMLSMAD4MPIP2FADDP85AERAL1EstradiolNCOA2ATMMTORGene ExpressionCBPRAFSMAD6ERKC9JNK1CDK2ANXA1FluoxymesteroneVEGFADonepezilATRFADDAnastrozoleMIR21ApoptosisBACH1JUNCTNB1Cell SurvivalUBP15HDAC1TestosteroneHIPK2SELKIRS1CASP3ALKB1P13KMDM2BRAFC9JNK1DHTRPP38JUNSMEK1P85ATF1ApoptosisBARD1CASP3PHBCell survival and ProliferationRHEBBLMProliferative genesProteinTamoxifenGCRPLK3CATSC1UBE2FTCF/LEFDCAKDGDIBADCDC42DexamethasoneUBP21CDC25AExemstaneMIR29B1AQP73PPARTRADDPAK1TGFR2PlicamycinTetradecanoylphorbol AcetatePLK3RHOMPIP1CSNK1DKRASCERK1E2F1ODC1FLIP1Lithium ChlorideRaloxifeneMAXHDAC1/HDAC2ANDRJAK1EP300BleomycinMIR21SP1STAT1HydroxyureaCASP8MitomycinSMAD7CERK1TFPIGRNAURKABRCA110MIR29B2