Integrated Breast Cancer Pathway (Homo sapiens)

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1864221692131219158132051771219SBASC ComplexG2G1Cell CycleM11, 12, 14Gene ExpressionMYCNOXA1AmpicillinRHOMitomycinSTK11AURKADCAKDCCND1SMAD4BARD1SIRT1HydrocortisoneSP1TestosteroneHydroxyureaP53PMLAnti-ApoptosisCSNK1DHIPK2AnastrozoleTGFR1MTORPLK3CACBPTSC1ATRP13KBADMAPKsPREP300MPIP1MSH6IRS1BRCA1BAXCYP19A1PKCB1AKT1UBP21IPKAESR1RAD50TamoxifenCERK1PHBCDC42ATF1ZMIZ1CASP3GCRLapatnibPAK1DihydrotestosteroneIKKAHDAC1UBP21CorticosteroneALKB1JAK1SMEK2BMPR1AXRCC3PTENTSC1BRCA2CREBCDH1Cell survival and ProliferationJUNCycloheximideTFPIP85SMAD4CERK1MIR21ATRE2F1ATMCIP1FLIP1RAP1ATCF/LEFCERKBRAFGRNPIAS1CDK2BMPR2Lithium ChlorideRAD54LPPRB/RBcyc-DLetrozoleCHK1ERAKT1RALATAK1LBADMDM2TranscriptionNFKB1DexamethasoneMYT1C9JNK1NCOA3FlutamideSMAD1Penicillin GUBIMSMAD2SMAD7SMAD3CTNB1 degradationODC1PlicamycinATRAQP73WEE1IMPA1P85ARAC1BARD1MDM2SMEK1CDK4Cell Cycle arrestCDC25ABAKRRASGDIHDAC1EGFRWEE1ANDRTGFR2FADDMMP1B3KP27KRASFADDProteasomeANXA1Conjugated EstrogensRRASUBP16NocodazoleUBP15NF1AngiogenesisMSH2STAT1ARB5MEC1SMAD7BLMRHOMRE11GRCASP8JKIP1TAB1Cell proliferationIKKAFluoxymesteroneCDK2ProteinGSK3APLK3C9JNK1ABC3GRRASRASGEF1AMethyl MethanesulfonateERAL1ApoptosisNCOA2RPP38DAG1TRADDBCL2ERKCell SurvivalRASGRP3ATMExemstaneApoptosisMIR21CTNB1DNARHEBSMAD6BleomycinCASP3EstradiolRAD51CASP9P65RAFMPIP2ABL1PPARUBE2FSMEK1SMCA4fra-1RALGAPA1SELKE2F1NAB1DHTJUNRaloxifeneQ8NBS1P53GADD45AP13Tetradecanoylphorbol AcetatePLK1FOXO1P38MYCC9JNK1ITPKCHDAC1/HDAC2BIDCDK7CHK2FulvestrantDonepezilBRCA1AHRPaclitaxelProliferative genesVEGFATSC2MAXBACH1Cancer Development10


Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress
50408view17:03, 15 August 2012SaibrahiPeriodical save, work in progress
46412view16:54, 26 January 2012SaibrahiPeriodical save, work in progress
44857view09:53, 6 October 2011MartijnVanIerselOntology Term : 'breast cancer' added !
44468view20:27, 14 September 2011MaintBotModified categories
43855view13:21, 8 August 2011SaibrahiPeriodical save, work in progress
43849view19:54, 5 August 2011SaibrahiPeriodical save, work in progress
43848view19:43, 5 August 2011SaibrahiPeriodical save, work in progress
43847view19:33, 5 August 2011SaibrahiPeriodical save, work in progress
43846view19:22, 5 August 2011SaibrahiPeriodical save, work in progress
43845view18:59, 5 August 2011SaibrahiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
ATF1ProteinP18846 (Uniprot-TrEMBL)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl)
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
Angiogenesis
Anti-Apoptosis
Apoptosis
B3KP27ProteinB3KP27 (Uniprot-TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot-TrEMBL)
BACH1ProteinO14867 (Uniprot-TrEMBL)
BADProteinQ92934 (Uniprot-TrEMBL)
BAKProteinQ16611 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
BleomycinMetabolite456190 (PubChem-compound)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBPGeneProductENSG00000005810 (Ensembl)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
CDK4ProteinP11802 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL) Phosphorylated
CIP1ProteinQ9NPC3 (Uniprot-TrEMBL)
CREBGeneProductENSG00000118260 (Ensembl)
CSNK1DGeneProductENSG00000141551 (Ensembl)
CTNB1 degradation
CTNB1ProteinP35222 (Uniprot-TrEMBL)
CYP19A1GeneProductENSG00000137869 (Ensembl)
Cancer Development
Cell Cycle arrest
Cell Survival
Cell proliferation
Cell survival and Proliferation
Conjugated Estrogens
CorticosteroneMetabolite5753 (PubChem-compound)
CycloheximideMetabolite6197 (PubChem-compound)
DAG1GeneProductENSG00000173402 (Ensembl)
DCAKDProteinQ8WVC6 (Uniprot-TrEMBL)
DHTGeneProductENSG00000181192 (Ensembl)
DNA
DexamethasoneMetabolite5743 (PubChem-compound)
DihydrotestosteroneMetaboliteHMDB02961 (HMDB)
DonepezilMetabolite3152 (PubChem-compound)
E2F1GeneProduct1869 (Entrez Gene)
E2F1ProteinQ01094 (Uniprot-TrEMBL)
EGFRProteinP00533 (Uniprot-TrEMBL)
EP300GeneProductENSG00000100393 (Ensembl)
ERAL1GeneProductENSG00000132591 (Ensembl)
ERKGeneProduct64781 (Entrez Gene)
ERProteinP16591 (Uniprot-TrEMBL)
ESR1GeneProductENSG00000091831 (Ensembl)
EstradiolMetabolite5757 (PubChem-compound)
Exemstane
FADDGeneProductENSG00000168040 (Ensembl)
FADDProteinQ13158 (Uniprot-TrEMBL)
FLIP1ProteinQ7Z7B0 (Uniprot-TrEMBL)
FOXO1GeneProductENSG00000150907 (Ensembl)
FluoxymesteroneMetabolite6205 (Chemspider)
FlutamideMetabolite3397 (PubChem-compound)
FulvestrantMetabolite104741 (PubChem-compound)
GADD45AGeneProductENSG00000116717 (Ensembl)
GCRGeneProductENSG00000113161 (Ensembl)
GDIGeneProduct2664 (Entrez Gene)
GR ProteinP01833 (Uniprot-TrEMBL)
GRNGeneProductENSG00000030582 (Ensembl)
GSK3AProteinP49840 (Uniprot-TrEMBL)
Gene Expression
HDAC1Protein
HDAC1/HDAC2GeneProductENSG00000116478 (Ensembl)
HDAC1ProteinQ13547 (Uniprot-TrEMBL)
HIPK2ProteinQ9H2X6 (Uniprot-TrEMBL)
HydrocortisoneMetabolite5754 (PubChem-compound)
HydroxyureaMetabolite3657 (PubChem-compound)
IKKAProteinO15111 (Uniprot-TrEMBL)
IMPA1GeneProductENSG00000133731 (Ensembl)
IPKAProtein