Integrated Breast Cancer Pathway (Homo sapiens)

From WikiPathways

Revision as of 05:02, 10 August 2019 by Khanspers (Talk | contribs)
Jump to: navigation, search
192022251120491115175132311824111861116114712221BASC ComplexSG2G1Cell CycleM3, 17, 26XRCC3SMEK1PLK3RASGEF1ANCOA2TFPIANDRUBP16UBE2FNocodazoleMIR29B1STAT1ESR1CDC42AHRDAG1fra-1CDK4CHK2FulvestrantPHBATF1PPRB/RBIRS1MRE11MSH2TGFR2Cell proliferationE2F1KRASPMLTetradecanoylphorbol AcetateRAD51HDAC1/HDAC2CTNB1BAKCASP3HIPK2HDAC1NFKB1GRNDonepezilSMEK2JAK1ATRRAD50Cell survival and ProliferationTSC2BMPR1ASMAD6STK11SIRT1DihydrotestosteroneP85APIAS1Cell Cycle arrestRRASRHOUBP15AURKAAnastrozoleALKB1Cancer DevelopmentMIR21Methyl MethanesulfonatePKCB1AKT1IKKAProteinQ8NBS1DNAMDM2CHK1DHTBAXHydroxyureaP38SMAD7CIP1PAK1BADLapatnibP13KP53Proliferative genesPLK3CAWEE1AQP73BARD1CycloheximideRAD54LMIR21FlutamideP53SMAD1AngiogenesisAKT1PTENPenicillin GGene ExpressionMitomycinGRHydrocortisoneRASGRP3NAB1RPP38CDC25APLK1CERKCERK1SMAD4C9JNK1TamoxifenPPARMDM2RHOCBPMAXERMMP1GDISMAD2B5MEC1TAB1PRExemstaneTestosteroneMAPKsEstradiolMYT1BRAFTGFR1ERAL1ARUBP21MIR21C9JNK1CREBRALASMAD4ANXA1UBP21ATMCYP19A1FLIP1JUNFluoxymesteroneCASP8cyc-DSMAD7RRASAnti-ApoptosisBADSP1BRCA1GADD45ABACH1CDK2RAC1P65PlicamycinRAP1AFADDWEE1ATRMYCEGFRFOXO1RRASC9JNK1CASP3TSC1RaloxifeneHDAC1VEGFAFADDZMIZ1CERK1ABC3GIKKACell SurvivalCCND1MPIP1RALGAPA1DexamethasoneE2F1SMAD3GCRBIDMYCEP300TSC1TRADDTAK1LSELKTCF/LEFPaclitaxelBRCA1ApoptosisABL1NF1TranscriptionRHEBRAFLetrozoleCTNB1 degradationSMCA4IMPA1NCOA3ATMCDH1ODC1IPKABARD1GSK3ADCAKDNOXA1BCL2JKIP1AmpicillinITPKCBleomycinProteasomeMTORP85BMPR2CSNK1DBRCA2MSH6CDK2ApoptosisP13CDK7UBIMMPIP2B3KP27CASP9BLMJUNSMEK1ERKCorticosteroneLithium ChlorideATRConjugated Estrogens10MIR29B2


Description

This pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Breast Cancer. These proteins were then used to determine the most important pathways involved in Breast Cancer by using the Human Pathway Database (HPD). The pathways retrieved from the Human Pathway Database were from several sources such as Protein Lounge, BioCarta, KEGG, and NCI-Nature. The pathways were then annotated. Protein-protein relations for the most important proteins for Breast Cancer were determined by annotating the pathways and by literature review. The protein-protein interactions are mapped onto this pathway.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Persianinov LS; ''The use of electro-analgesia in obstetrics and gynecology. A survey by invitation.''; Acta Obstet Gynecol Scand, 1975 PubMed Europe PMC
  2. Zhang M, Lee CH, Luo DD, Krupa A, Fraser D, Phillips A; ''Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin.''; J Biol Chem, 2007 PubMed Europe PMC
  3. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC
  4. Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY; ''miR-21-mediated tumor growth.''; Oncogene, 2007 PubMed Europe PMC
  5. Wang W, Seki M, Narita Y, Sonoda E, Takeda S, Yamada K, Masuko T, Katada T, Enomoto T; ''Possible association of BLM in decreasing DNA double strand breaks during DNA replication.''; EMBO J, 2000 PubMed Europe PMC
  6. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S; ''Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells.''; J Biol Chem, 2002 PubMed Europe PMC
  7. Fritz G, Kaina B; ''Activation of c-Jun N-terminal kinase 1 by UV irradiation is inhibited by wortmannin without affecting c-iun expression.''; Mol Cell Biol, 1999 PubMed Europe PMC
  8. Taplin ME, Bubley GJ, Ko YJ, Small EJ, Upton M, Rajeshkumar B, Balk SP; ''Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.''; Cancer Res, 1999 PubMed Europe PMC
  9. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH; ''Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells.''; J Biol Chem, 2008 PubMed Europe PMC
  10. Li YJ, Azuma A, Usuki J, Abe S, Matsuda K, Sunazuka T, Shimizu T, Hirata Y, Inagaki H, Kawada T, Takahashi S, Kudoh S, Omura S; ''EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts.''; Respir Res, 2006 PubMed Europe PMC
  11. Ray R, Thomas S, Miller DM; ''Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.''; Am J Med Sci, 1990 PubMed Europe PMC
  12. Yu Y, Wang Y, Ren X, Tsuyada A, Li A, Liu LJ, Wang SE; ''Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells.''; Mol Cancer Res, 2010 PubMed Europe PMC
  13. Terasaki M, Reese TS; ''Interactions among endoplasmic reticulum, microtubules, and retrograde movements of the cell surface.''; Cell Motil Cytoskeleton, 1994 PubMed Europe PMC
  14. Su M, Bansal AK, Mantovani R, Sodek J; ''Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells.''; J Biol Chem, 2005 PubMed Europe PMC
  15. Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y, Nakshatri H; ''Estradiol-regulated microRNAs control estradiol response in breast cancer cells.''; Nucleic Acids Res, 2009 PubMed Europe PMC
  16. Paul R, Dalibart R, Lemoine S, Lestienne P; ''Expression of E. coli RecA targeted to mitochondria of human cells.''; Mutat Res, 2001 PubMed Europe PMC
  17. Sweezey NB, Ghibu F, Gagnon S, Schotman E, Hamid Q; ''Glucocorticoid receptor mRNA and protein in fetal rat lung in vivo: modulation by glucocorticoid and androgen.''; Am J Physiol, 1998 PubMed Europe PMC
  18. Paci C, Gobbato R, Carboni T, Sanguigni S, Santone A, Curatola L; ''P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia.''; Neurol Sci, 2006 PubMed Europe PMC
  19. Franklin RA, Tordai A, Patel H, Gardner AM, Johnson GL, Gelfand EW; ''Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes.''; J Clin Invest, 1994 PubMed Europe PMC
  20. Muأ±oz E, Courtois G, Veschambre P, Jalinot P, Israأ«l A; ''Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.''; J Virol, 1994 PubMed Europe PMC
  21. Ellis D, Sothi TD, Avner ED; ''Glucocorticoids modulate renal glucocorticoid receptors and Na-K ATPase activity.''; Kidney Int, 1987 PubMed Europe PMC
  22. Gu RG, Zhou CW, Ma QZ; ''[Effect of dihydrotestosterone on the transcriptions and expressions of Smad3 and Smad4 in LNCaP cell line].''; Zhonghua Nan Ke Xue, 2006 PubMed Europe PMC
  23. Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH; ''Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.''; J Biol Chem, 2005 PubMed Europe PMC
  24. Wang ZX, Lu BB, Wang H, Cheng ZX, Yin YM; ''MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN.''; Arch Med Res, 2011 PubMed Europe PMC
  25. Hall LL, Th'ng JP, Guo XW, Teplitz RL, Bradbury EM; ''A brief staurosporine treatment of mitotic cells triggers premature exit from mitosis and polyploid cell formation.''; Cancer Res, 1996 PubMed Europe PMC
  26. ''''; , PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
108101view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106619view20:46, 12 September 2019KhanspersModified description
106143view12:04, 16 August 2019MaintBotHMDB identifier normalization
105685view07:15, 13 August 2019EgonwReplaced a deprecated UniProt identifiers with the current one.
105682view07:01, 13 August 2019EgonwRemoved a deleted UniProt info, but do not have enough knowledge to replace it, given that the label has the same string.
105628view05:02, 10 August 2019KhanspersModified description
105392view21:37, 6 August 2019EgonwUgh... sorry, I missed that I was adding a secondary ChEBI identifier. Now fixed.
105376view05:01, 6 August 2019EgonwReplaced the PubChem CID with incomplete stereochem with the ChEBI one with full stereochem.
103002view15:01, 31 January 2019Marvin M2Reversed error in miRNA id
102999view14:52, 31 January 2019Marvin M2Updated miRNA ensembl ids
98352view05:24, 24 August 2018EgonwUpdated the MIR21 identifier.
95143view02:51, 17 November 2017AlexanderPicoconnected interactions
93247view12:15, 8 August 2017DeSlConnected unconnected interaction lines with appropriate nodes.
93246view12:06, 8 August 2017DeSlAdded two Pathway nodes, with links to an example PW from WPs.
92369view15:27, 30 May 2017DdiglesReverted to version '09:51, 14 November 2015' by Ddigles
92358view01:59, 30 May 2017Tdavid88Modified description
82941view09:51, 14 November 2015EgonwUpdated Ensembl identifiers.
80445view06:02, 23 June 2015KhanspersAdded mir29b targeting of PTEN
80429view19:56, 22 June 2015KhanspersAdded additional mir21 targeting
80428view19:33, 22 June 2015KhanspersAdded mir21 targeting of BMPR2
80427view19:03, 22 June 2015KhanspersAdded mir21 targeting of PTEN
79991view19:59, 29 April 2015Zariannotated ODC1 , MYC, JUN , fra-1 , cyc-D and PPAR
72732view00:57, 4 December 2013Jakechendeleted unconnected genes.
72731view00:56, 4 December 2013Jakechenupdated DAG1
71652view19:34, 17 October 2013MaintBotUpdated data sources
70228view18:59, 15 July 2013KhanspersReverted to version '11:48, 29 June 2013' by Khanspers
70227view18:57, 15 July 2013Khanspersminor layout
68045view11:48, 29 June 2013EgonwAdded more identifiers for metabolites which were previously marked as 'unknown'.
68044view11:32, 29 June 2013EgonwAdding identifiers for metabolites which were previously marked as 'unknown'.
67397view10:55, 26 June 2013DdiglesOntology Term : 'breast cancer pathway' added !
63220view21:01, 8 May 2013MaintBotUpdating gpml version
59204view19:37, 22 February 2013MaintBotUpdated Ensembl data source
51834view19:03, 23 September 2012SaibrahiPeriodical save, work in progress
51161view21:15, 30 August 2012SaibrahiPeriodical save, work in progress
51083view19:46, 28 August 2012Pragat11Periodical save, work in progress
51082view19:36, 28 August 2012Pragat11Periodical save, work in progress
51081view19:25, 28 August 2012Pragat11Periodical save, work in progress
51020view19:18, 26 August 2012SaibrahiSpecify description
51019view19:12, 26 August 2012SaibrahiPeriodical save, work in progress
51018view19:01, 26 August 2012SaibrahiPeriodical save, work in progress
50408view17:03, 15 August 2012SaibrahiPeriodical save, work in progress
46412view16:54, 26 January 2012SaibrahiPeriodical save, work in progress
44857view09:53, 6 October 2011MartijnVanIerselOntology Term : 'breast cancer' added !
44468view20:27, 14 September 2011MaintBotModified categories
43855view13:21, 8 August 2011SaibrahiPeriodical save, work in progress
43849view19:54, 5 August 2011SaibrahiPeriodical save, work in progress
43848view19:43, 5 August 2011SaibrahiPeriodical save, work in progress
43847view19:33, 5 August 2011SaibrahiPeriodical save, work in progress
43846view19:22, 5 August 2011SaibrahiPeriodical save, work in progress
43845view18:59, 5 August 2011SaibrahiPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC3GProteinQ9HC16 (Uniprot-TrEMBL)
ABL1GeneProductENSG00000097007 (Ensembl)
AHRGeneProductENSG00000106546 (Ensembl)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALKB1ProteinQ13686 (Uniprot-TrEMBL)
ANDRProteinP10275 (Uniprot-TrEMBL)
ANXA1GeneProductENSG00000135046 (Ensembl)
AQP73ProteinA6NL99 (Uniprot-TrEMBL)
ARProteinQ9UNE0 (Uniprot-TrEMBL)
ATF1ProteinP18846 (Uniprot-TrEMBL)
ATMProteinQ13315 (Uniprot-TrEMBL)
ATRProteinQ13535 (Uniprot-TrEMBL)
AURKAGeneProductENSG00000087586 (Ensembl)
AmpicillinMetabolite6249 (PubChem-compound)
AnastrozoleMetabolite2102 (Chemspider)
AngiogenesisPathwayWP1993 (WikiPathways) Example of Angiogenesis PW (homo sapiens)
Anti-Apoptosis
Apoptosis
ApoptosisPathwayWP254 (WikiPathways) Example Pw for apoptosis (homo sapiens)
B3KP27ProteinB3KP27 (Uniprot-TrEMBL)
B5MEC1ProteinB5MEC1 (Uniprot-TrEMBL)
BACH1ProteinO14867 (Uniprot-TrEMBL)
BADProteinQ92934 (Uniprot-TrEMBL)
BAKProteinQ16611 (Uniprot-TrEMBL)
BARD1GeneProduct580 (Entrez Gene)
BARD1GeneProductENSG00000138376 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BIDProteinP55957 (Uniprot-TrEMBL)
BLMProteinP54132 (Uniprot-TrEMBL)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR2ProteinQ13873 (Uniprot-TrEMBL)
BRAFProteinP15056 (Uniprot-TrEMBL)
BRCA1ProteinP38398 (Uniprot-TrEMBL)
BRCA2GeneProductENSG00000139618 (Ensembl)
BleomycinMetabolite456190 (PubChem-compound)
C9JNK1ProteinC9JNK1 (Uniprot-TrEMBL)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBPGeneProductENSG00000005810 (Ensembl)
CCND1ProteinP24385 (Uniprot-TrEMBL)
CDC25AGeneProduct993 (Entrez Gene)
CDC42GeneProductENSG00000070831 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK2ProteinP24941 (Uniprot-TrEMBL)
CDK4ProteinP11802 (Uniprot-TrEMBL)
CDK7GeneProduct1022 (Entrez Gene)
CERK1ProteinQ8TCT0 (Uniprot-TrEMBL)
CERKGeneProduct64781 (Entrez Gene)
CHK1ProteinO14757 (Uniprot-TrEMBL)
CHK2ProteinO96017 (Uniprot-TrEMBL)