Integrated cancer pathway (Homo sapiens)

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This integrated cancer pathway describes the key mechanisms involved in the development of cancer containing the key prognostic markers and pathogenetic factors.

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Ontology Terms



  1. Wang C, Bian Z, Wei D, Zhang JG; ''miR-29b regulates migration of human breast cancer cells.''; Mol Cell Biochem, 2011 PubMed Europe PMC Scholia
  2. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, Krichevsky AM; ''MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.''; Mol Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T; ''MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.''; Gastroenterology, 2007 PubMed Europe PMC Scholia
  4. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC Scholia


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117762view13:24, 22 May 2021EweitzModified title
106620view20:47, 12 September 2019KhanspersModified description
105629view05:02, 10 August 2019KhanspersModified description
103003view15:02, 31 January 2019Marvin M2Updated miRNA Ensembl IDs
98351view05:22, 24 August 2018EgonwUpdated the MIR21 identifier.
96025view15:33, 15 February 2018MkutmonModified description
82939view08:51, 14 November 2015EgonwUpdated Ensembl identifiers.
82938view08:31, 14 November 2015EgonwFixed a small topy in a comment.
82936view22:43, 13 November 2015AlexanderPicoModified title
80447view06:15, 23 June 2015KhanspersAdded mir29 targeting to PTEN
80431view20:03, 22 June 2015KhanspersAdded mir21 targeting of CDC25A
80425view18:50, 22 June 2015KhanspersAdded mi21 targeting, cleaned up layout, connected lines and added some xrefs
71249view20:29, 16 October 2013MaintBotAutomated update of data sources
67398view10:56, 26 June 2013DdiglesOntology Term : 'cancer pathway' added !
63221view21:01, 8 May 2013MaintBotUpdating gpml version
59118view22:27, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44858view09:54, 6 October 2011MartijnVanIerselOntology Term : 'cancer' added !
44469view20:30, 14 September 2011MaintBotAdded category
42356view23:30, 19 March 2011SaibrahiSpecify description
42355view23:20, 19 March 2011SaibrahiPeriodical save, work in progress
42354view22:22, 19 March 2011SaibrahiSpecify description
42262view21:45, 11 March 2011AlexanderPicoConnected BRCA1 to database
42257view14:35, 11 March 2011SaibrahiSpecify description
42256view14:31, 11 March 2011SaibrahiPeriodical save, work in progress
41986view11:44, 4 March 2011SaibrahiSpecify description
41985view11:36, 4 March 2011SaibrahiPeriodical save, work in progress
41984view11:26, 4 March 2011SaibrahiPeriodical save, work in progress
41976view02:50, 4 March 2011SaibrahiPeriodical save, work in progress
41975view02:48, 4 March 2011SaibrahiSpecify description
41076view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
40454view17:45, 1 March 2011SaibrahiPeriodical save, work in progress
40442view20:41, 25 February 2011SaibrahiPeriodical save, work in progress
40439view15:07, 25 February 2011SaibrahiSpecify description
40438view14:57, 25 February 2011SaibrahiPeriodical save, work in progress
40437view14:55, 25 February 2011SaibrahiSpecify description
40436view14:47, 25 February 2011SaibrahiPeriodical save, work in progress
40435view14:37, 25 February 2011SaibrahiPeriodical save, work in progress
40432view14:26, 25 February 2011SaibrahiSpecify description
40430view11:26, 25 February 2011SaibrahiNew pathway

External references


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NameTypeDatabase referenceComment
AKT1_HUMANProteinP31749 (Uniprot-TrEMBL)
ASK1Protein4217 (Entrez Gene)
ATF1GeneProductENSG00000123268 (Ensembl)
ATM_HUMANProteinQ13315 (Uniprot-TrEMBL)
ATR_HUMANProteinQ13535 (Uniprot-TrEMBL)
BACH1GeneProductENSG00000156273 (Ensembl)
BAD_HUMANProteinQ92934 (Uniprot-TrEMBL)
BARD1_HUMANProteinQ99728 (Uniprot-TrEMBL)
BAX_HUMANProteinQ07812 (Uniprot-TrEMBL)
BCL2_HUMANProteinP10415 (Uniprot-TrEMBL)
BLM_HUMANProteinP54132 (Uniprot-TrEMBL)
BRCA1_HUMANProteinP38398 (Uniprot-TrEMBL) Phosphorylated
CASP3_HUMANProteinP42574 (Uniprot-TrEMBL)
CASP8_HUMANProteinQ14790 (Uniprot-TrEMBL)
CASP9_HUMANProteinP55211 (Uniprot-TrEMBL)
CDC25AGeneProductENSG00000164045 (Ensembl)
CDC25BGeneProductENSG00000101224 (Ensembl)
CDC2_HUMANProteinP06493 (Uniprot-TrEMBL) Oncogene
CDK2_HUMANProteinP24941 (Uniprot-TrEMBL)
CDK4_HUMANProteinP11802 (Uniprot-TrEMBL)
CHK1_HUMANProteinO14757 (Uniprot-TrEMBL)
CHK2_HUMANProteinO96017 (Uniprot-TrEMBL) Phosphorylated
E2F1_HUMANProteinQ01094 (Uniprot-TrEMBL)
JAK1_HUMANProteinP23458 (Uniprot-TrEMBL)
MDM2_HUMANProteinQ00987 (Uniprot-TrEMBL) Oncogene
MIR21RnaENSG00000284190 (Ensembl)
MIR29B1RnaENSG00000283797 (Ensembl)
MIR29B2RnaENSG00000284203 (Ensembl)
MIR29CRnaENSG00000284214 (Ensembl)
MMP1_HUMANProteinP03956 (Uniprot-TrEMBL)
MRE11_HUMANProteinP49959 (Uniprot-TrEMBL)
MSH2_HUMANProteinP43246 (Uniprot-TrEMBL)
MSH6_HUMANProteinP52701 (Uniprot-TrEMBL)
MYCGeneProductENSG00000136997 (Ensembl)
NOXA1_HUMANProteinQ86UR1 (Uniprot-TrEMBL)
OCT1Protein5451 (Entrez Gene)
P53_HUMANProteinP04637 (Uniprot-TrEMBL)
PLK1GeneProductENSG00000166851 (Ensembl)
PTEN_HUMANProteinP60484 (Uniprot-TrEMBL)
PUMAProtein27113 (Entrez Gene)
Q8NBS1_HUMANProteinQ8NBS1 (Uniprot-TrEMBL)
RAD50_HUMANProteinQ92878 (Uniprot-TrEMBL)
RB_HUMANProteinP06400 (Uniprot-TrEMBL)
SMAD2_HUMANProteinQ15796 (Uniprot-TrEMBL) Tumor supressor
SMAD3_HUMANProteinP84022 (Uniprot-TrEMBL)
STAT1_HUMANProteinP42224 (Uniprot-TrEMBL)
p15Protein1030 (Entrez Gene)
p21Protein1026 (Entrez Gene)
p27Protein1027 (Entrez Gene)

Annotated Interactions

No annotated interactions

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