Signaling by PDGF (Homo sapiens)

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1, 40, 434014, 4012, 4037, 40, 432, 17, 30, 4344015, 40, 4136, 4020, 28, 401, 42, 4314, 18, 405, 7, 40251, 42, 434027, 40, 431121, 38, 40, 43401, 42, 43321, 428, 259, 11, 4012, 40, 43plasma membraneplasma membranecytosolendoplasmic reticulum lumenGolgi lumenPDGFA-2 ADPRAF/MAP kinasecascadep-11Y-PDGFRA PDGFA-2 Thrombospondin p-PDGFRB homo andheterodimersdephosphorylated atY1021p21 RAS:GTPp-11Y-PDGFRA PDGFB (82-190) PDGF alpha receptor:PDGF dimersPDGFB(82-241) Novel PDGF precursordimers (CC, DD)PDGFA-2 PDGFC-1 PDGFB (82-190) GRB2-1:SOS1PDGFB(82-241) NCK2 p-11Y-PDGFRA PDGFRA PDGF receptormonomerPDGF:Phospho-PDGFreceptor dimer:Grb7p-12Y-PDGFRB PDGFB(82-241) PDGFB(82-241) PDGFC-1(235-345) PIK3CB PDGFB(82-241) GRB7 STAT3 ADPPLG(20-580) PDGF:Phospho-PDGFreceptor dimerNRAS CRK serine-typeendopeptidasesinvolved in novelPDGF processingN-ter PDGFA-2 fragment RASA1PDGFRB PTPN11 STAT5A HRAS FURINPDGFB (82-190) p-12Y-PDGFRB PDGFB(82-241) PDGFA-2 PDGFA-2 PDGFA-1(1-211) p-11Y-PDGFRA PDGFB(82-241) PDGFB (82-190) PDGF:Phospho-PDGFreceptordimer:phospho-SrcGTP PDGF:Phospho-PDGFreceptordimer:Crk:p130Cas:C3GCRKL PDGFB (82-190) PDGFA-2 PDGFB(82-241) PDGFD(1-370) PDGFB(82-241) PDGFA-2 PDGFB(82-241) p-12Y-PDGFRB PDGF:Phospho-PDGFRreceptor dimer:NckPDGFRB PDGFB(82-241) PDGFA-1 PDGFA-1 CRK, CRKLPDGFA-2 p-12Y-PDGFRB GDPp-12Y-PDGFRB PTPN12PDGFA-2 PDGFA-2 PDGF A and Bchains:ECM complexPDGFB (82-190) PDGFA-1 PIK3R1 PLG(581-810) GDP SRC-1PDGFB(82-241) GRB7PDGFB(82-241) PDGFRA PDGF:Phospho-PDGFreceptor dimer:SrcPDGFA-2 STAT family membersPDGFA-1(1-211) PDGF:Phospho-PDGFreceptor dimer:PI3KPDGFA-2 CRKL ADPp-12Y-PDGFRB PDGFA-2 PDGFB (82-190) PDGFA-2 p21 RAS:GDPPDGF precursordimers (AA, BB,A/B, CC, DD)PDGFA-2 p-PDGFRB homo andheterodimersPDGFB(82-241) NRAS PDGFA-2 PTPN11PDGFB (82-190) PDGFA-1 Cleaved novel PDGFfragmentsPI3KPDGFB(82-241) PDGFB(1-241) PDGFB (82-190) PDGF:Phospho-PDGFreceptor dimer:SHP2PDGF:p-PDGFRdimer:p-PLCgammaPDGFA-1 ATPPhospho PDGFalpha-betadimer:PDGF AB or BBdimersPIP3 activates AKTsignalingPDGFC-1(24-234) CRK p-12Y-PDGFRB PDGFB(1-241) CRK Phospho PDGF alphareceptor:PDGFdimersPDGFB (82-190) SOS1 Heparan sulphate p-12Y-PDGFRB Extracellular matrixligandsSRC-1 p-11Y-PDGFRA PDGFD(1-370) PDGFB (82-190) PDGFB (82-190) PDGFB(82-241) PDGF precursordimers (AA, BB,A/B, CC, DD)p-11Y-PDGFRA PDGFB(82-241) PDGF alpha/beta:PDGFAB and BB dimersp-11Y-PDGFRB p-12Y-PDGFRB ATPPDGFB (82-190) H2OPDGFA-2 PDGFB(82-241) PDGFB(82-241) PDGFA-2 PLAT(36-562) PDGFB (82-190) PIK3R1 PDGFB(1-81) BCAR1PDGFA-2 Collagens PDGFB (82-190) ATPPDGFA-1 Phospho-betareceptorhomodimer:GAPp-12Y-PDGFRB RAPGEF1PDGFB (82-190) PLCG1 p-11Y-PDGFRA PDGFB(1-241) KRAS CRKL PDGFA-1 PDGFA-1 Collagens STAT6 PI(3,4,5)P3Novel PDGF precursordimers (CC, DD)Cleaved PDGF-BpeptidesDAG and IP3signalingGRB2-1 PDGFA-2 PDGFA-2 ATPp-11Y-PDGFRA p-12Y-PDGFRB PDGFD(258-370) ADPPDGFB(82-241) p-12Y-PDGFRB PDGFA-1 PDGFA-1(1-211) STAT5B STAT5A PDGFRB PDGFB(82-241) PDGF:Phospho-PDGFreceptordimer:PLC-gammaPIK3CA PDGFRA proPDGF-AA dimerNCK2 PDGFA-1 p-4Y-PLCG1 PDGFB (82-190) N-ter PDGFA-1 fragment PDGFB (82-190) PDGFA-2 PIK3CB PI(4,5)P2NCK1,NCK2p-11Y-PDGFRA NCK1 PDGFA-1 KRAS SPP1 PLCG1PDGFA-1 PDGF:Phospho-PDGFreceptor dimer:CrkSOS1 p-11Y-PDGFRA Phospho PDGF betareceptor: PDGFchain B homodimerPIK3CA PDGFB(82-241) PDGFA-2 Active PDGF dimers(AA, AB, BB)Thrombospondin PDGFC-1 p-12Y-PDGFRB p-4Y-PLCG1PDGFA-1 PDGFRB SPP1 PDGFB (82-190) PDGFB(191-241) Heparan sulphate STAT1 PDGFB (82-190) GRB2-1 PDGFC-1 PDGF A and B chainswith retentionmotifPDGFRA RAPGEF1 p-11Y-PDGFRA PDGF A/B heterodimerADPSTAT5B PDGFB(82-241) PiPDGFA-1 PDGFA-2 GTPp-Y419-SRC-1 PDGFD(1-370) PDGFB (82-190) PDGFB(82-241) active PDGF-AA dimerproPDGF-BB dimerPDGFB(1-241) PDGFA-1 STAT1 PDGF:PDGF receptordimerBCAR1 PIK3R2 NCK1 proPDGF-AB dimerp-12Y-PDGFRB p-11Y-PDGFRA PIK3R2 HRAS PDGFA-2 STAT3 ATPp-11Y-PDGFRA PDGF:phospho-PDGFreceptor dimer:STATN-ter PDGFA-2fragmentPDGFA-1 PDGFA-2 PDGFD(19-370) active PDGF-BB dimerActive PDGF dimers(CC, DD)p-12Y-PDGFRB PDGFB(82-241) PDGFA-1 PDGFB (82-190) PDGFC-1(23-345) p-11Y-PDGFRA PDGFB (82-190) PDGFA-1 RASA1 PDGF betareceptor:PDGF chainB homodimerPDGFB (82-190) PDGFB (82-190) PDGFB(82-241) p-12Y-PDGFRB N-ter PDGF-AfragmentPDGFA-1 PDGFB (82-190) PDGF:Phospho-PDGFreceptordimer:Grb2:Sos1p-11Y-PDGFRA PDGFA-1 p-11Y-PDGFRA p-11Y-PDGFRA PDGFB(82-241) p-12Y-PDGFRB PDGFD(20-257) PDGFA-2 STAT6 3, 6, 13, 16, 19...2610