Signaling by PDGF (Homo sapiens)

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6, 19, 303, 6, 1561, 6, 254, 619519, 277, 17176, 26, 3013, 24, 28, 306, 146, 10, 1466, 8, 216, 23, 3066, 12, 16, 306196, 236, 22, 3019, 276, 9, 20PI3K-catalyticsubunit [cytosol]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF A-chainprecursor dimer[Golgi membrane]Phospho-alphareceptor homodimer[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]PDGF A homodimer[extracellularregion]Active PDGF dimers(AA, AB, BB)[extracellularregion]Processed PDGF-B[extracellularregion]PDGF B homodimer[extracellularregion]Processed PDGF-B[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]PDGF A homodimer[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]p21 RAS:GDP [plasmamembrane]PDGF B homodimer[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF-D chainprecursor dimer[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Phospho- PDGFreceptor dimer[plasma membrane]STAT family members[cytosol]Active PDGF dimers(AA, AB, BB)[extracellularregion]cytosolPhospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]endoplasmic reticulum lumenNCK [cytosol]PDGF B homodimer[extracellularregion]PDGF-C chainprecursor dimer[Golgi membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]Phospho-betareceptor homodimer[plasma membrane]PDGF B homodimer[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]PDGF B homodimer[extracellularregion]PDGF A/B heterodimer[extracellularregion]Processed PDGF-B[extracellularregion]PDGF:Phospho-PDGFreceptordimer:Crk:p130Cas:C3G[plasma membrane]PDGF A homodimer[extracellularregion]GRB2:SOS1 [cytosol]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF:phospho-PDGFreceptor dimer:STAT[plasma membrane]Collagen alpha-1(VI)chains[extracellularregion]PDGF A/B heterodimer[extracellularregion]Processed PDGF-B[extracellularregion]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]Phospho- PDGFreceptor dimer[plasma membrane]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF AB or BBhomodimers[extracellularregion]PI3K-regulatorysubunit [cytosol]PDGF:Phospho-PDGFreceptor dimer:Crk[plasma membrane]PDGF A-chainprecursor dimer[Golgi membrane]Alpha-Beta receptorheterodimer [plasmamembrane]PDGF A/B heterodimer[extracellularregion]Heparan sulphate[extracellularregion]Processed PDGF-B[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]p21 RAS [plasmamembrane]Processed PDGF-B[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Processed PDGF-B[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]p21 RAS:GTP [plasmamembrane]Phospho PDGFalpha-betadimer:PDGF AB or BBdimers [plasmamembrane]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF A homodimer[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]PDGF B homodimer[extracellularregion]Processed PDGF-B[extracellularregion]Alpha-Beta receptorheterodimer [plasmamembrane]PDGF B homodimer[extracellularregion]PDGF A homodimer[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]Collagenalpha-3(IV):Collagenalpha-4(IV):Collagenalpha-5(IV) triplehelix [extracellularregion]Active PDGF dimers(AA, AB, BB)[extracellularregion]PDGF AB precursorheterodimer[endoplasmicreticulum lumen]Processed PDGF-B[extracellularregion]PDGF A homodimer[extracellularregion]PDGF B homodimer[extracellularregion]PDGF B homodimer[extracellularregion]PDGF-D chainprecursor dimer[endoplasmicreticulum lumen]PDGF alpha/beta:PDGFAB and BB dimers[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]Processed PDGF-B[extracellularregion]PDGF A homodimer[extracellularregion]PDGF B homodimer[extracellularregion]Golgi lumenPDGF:Phospho-PDGFreceptor dimer:Src[plasma membrane]Phospho-alphareceptor homodimer[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]PDGF A/B heterodimer[extracellularregion]PDGF A homodimer[extracellularregion]PDGF A/B heterodimer[extracellularregion]PDGF precursordimers (AA, BB,A/B, CC, DD)[endoplasmicreticulum lumen]PDGF:Phospho-PDGFreceptordimer:Grb2:Sos1[plasma membrane]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF-D chainprecursor dimer[Golgi membrane]PDGF A homodimer[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF A/B heterodimer[extracellularregion]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF A and Bchains:ECM complex[extracellularregion]Beta receptorhomodimer [plasmamembrane]PDGF-D chain dimer[extracellularregion]PDGF:p-PDGFRdimer:p-PLCgamma[plasma membrane]PDGF A/B-chainprecursor heterodimer [Golgimembrane]PDGF B homodimer[extracellularregion]PDGF B homodimer[extracellularregion]PDGF:Phospho-PDGFreceptor dimer:Crk[plasma membrane]Phospho- PDGFreceptor dimer[plasma membrane]CRK, CRKL [cytosol]PDGF A and B chainswith retention motif[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Thrombospondin[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]PDGF A homodimer[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Active PDGF dimers(CC, DD)[extracellularregion]PDGF A homodimer[extracellularregion]PDGF-C chainprecursor dimer[Golgi membrane]PDGF B homodimer[extracellularregion]PDGF B-chainprecursor dimer[Golgi membrane]Phospho- PDGFreceptor dimer[plasma membrane]PI3K [cytosol]CRK, CRKL [cytosol]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF A homodimer[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]PI3K-regulatorysubunit [cytosol]PDGF betareceptor:PDGF chainB homodimer [plasmamembrane]PI3K-catalyticsubunit [cytosol]PDGF receptor dimer[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF:PDGF receptordimer [plasmamembrane]Processed PDGF-B[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]PDGF B homodimer[extracellularregion]Processed PDGF-B[extracellularregion]Processed PDGF-B[extracellularregion]Phospho-betareceptorhomodimer:GAP[plasma membrane]PDGF A isoforms[endoplasmicreticulum lumen]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]PDGF:Phospho-PDGFreceptordimer:phospho-Src[plasma membrane]p21 RAS [plasmamembrane]Processed PDGF-B[extracellularregion]PDGF A homodimer[extracellularregion]PDGF A/B heterodimer[extracellularregion]PDGF:Phospho-PDGFRreceptor dimer:Nck[plasma membrane]Phospho PDGF alphareceptor:PDGF dimers[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Type IV collagen[extracellularregion]PDGF A/B heterodimer[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]Extracellular matrixligands[extracellularregion]PDGF B homodimer[extracellularregion]Processed PDGF-B[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF A/B heterodimer[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]PDGF B-chainprecursor dimer[Golgi membrane]PDGF A/B heterodimer[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]Alpha receptorhomodimer [plasmamembrane]PDGF A homodimer[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Phospho-alphareceptor homodimer[plasma membrane]PDGF precursordimers (AA, BB, A/B,CC, DD) [Golgimembrane]Phospho-alphareceptor homodimer[plasma membrane]Collagenalpha-1(IV):Collagenalpha-2(IV)[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]PDGF A homodimer[extracellularregion]Phospho PDGF betareceptor: PDGF chainB homodimer [plasmamembrane]Phospho- PDGFreceptor dimer[plasma membrane]PDGF A/B heterodimer[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]Phospho-betareceptor homodimer[plasma membrane]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]Processed PDGF-B[extracellularregion]Phospho PDGF betareceptor: PDGF chainB homodimer [plasmamembrane]Tropocollagen typeVI [extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]Collagen type IX[extracellularregion]PDGF A-chainprecursor dimer[endoplasmicreticulum lumen]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]Alpha receptorhomodimer [plasmamembrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]Processed PDGF-B[extracellularregion]PDGF-C chainprecursor dimer[extracellularregion]Processed PDGF-B[extracellularregion]PDGF B homodimer[extracellularregion]Beta receptorhomodimer [plasmamembrane]Novel PDGF precursordimers (CC, DD)[Golgi membrane]Classical PDGFprecursor dimers(AA, AB, BB) [Golgimembrane]Phospho-alphareceptor homodimer[plasma membrane]Phospho- PDGFreceptor dimer[plasma membrane]PDGF A homodimer[extracellularregion]Collagens[extracellularregion]Novel PDGF precursordimers (CC, DD)[extracellularregion]PDGF A/B-chainprecursor heterodimer [Golgimembrane]PDGF AB or BBhomodimers[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]Processed PDGF-B[extracellularregion]PDGF A/B heterodimer[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]Processed PDGF-B[extracellularregion]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]PDGF A isoforms[Golgi membrane]PDGF:Phospho-PDGFreceptor dimer:Grb7[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF A/B heterodimer[extracellularregion]PDGF A/B heterodimer[extracellularregion]Processed PDGF-B[extracellularregion]PDGF A/B heterodimer[extracellularregion]Phospho-betareceptor homodimer[plasma membrane]PDGF A/B heterodimer[extracellularregion]PDGF-C chainprecursor dimer[endoplasmicreticulum lumen]PDGF-D chainprecursor dimer[Golgi membrane]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]PDGF B homodimer[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]Activeplatelet-derivedgrowth factor Achain isoforms[extracellularregion]PDGF:Phospho-PDGFreceptor dimer:PI3K[plasma membrane]PDGF A isoforms[Golgi membrane]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]PDGF B homodimer[extracellularregion]PDGF A/B heterodimer[extracellularregion]Active PDGF dimers(AA, AB, BB)[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]Phospho-alphareceptor homodimer[plasma membrane]PDGF A homodimer[extracellularregion]Active PDGF dimers(AA, AB, BB)[extracellularregion]PDGF-C chain dimer[extracellularregion]PDGF B homodimer[extracellularregion]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]Processed PDGF-B[extracellularregion]PDGF B homodimer[extracellularregion]PDGF:Phospho-PDGFreceptor dimer[plasma membrane]Collagen alpha-2(VI)chains[extracellularregion]PDGF A/B heterodimer[extracellularregion]PI3K [cytosol]PDGF:Phospho-PDGFreceptor dimer:SHP2[plasma membrane]Phospho-alpha-Phospho-betareceptor heterodimer[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]PDGF B homodimer[extracellularregion]Phospho- PDGFreceptor dimer[plasma membrane]PDGF:Phospho-PDGFreceptordimer:PLC-gamma[plasma membrane]Active PDGF dimers(AA, AB, BB)[extracellularregion]PDGF alpha receptor:PDGF dimers [plasmamembrane]PDGF B homodimer[extracellularregion]Phospho-alphareceptor homodimer[plasma membrane]GRB2:SOS1 [cytosol]PDGF A/B heterodimer[extracellularregion]PDGF B-chainprecursor dimer[endoplasmicreticulum lumen]CRK, CRKLPDGFA-2[extracellularregion]COL9A2[extracellularregion]PDGFB(82-241)[extracellularregion]Phospho PDGF alphareceptor:PDGF dimersCRK(2-304) [cytosol]RAF/MAP kinasecascadePI(3,4,5)P3PDGF:Phospho-PDGFreceptor dimerTHBS3 [extracellularregion]COL6A1[extracellularregion]PDGFA-1[extracellularregion]p-12Y-PDGFRB [plasmamembrane]PDGFA-1[extracellularregion]Active PDGF dimers(AA, AB, BB)PDGFA-2[extracellularregion]PIK3R1 [cytosol]PDGFA-1[extracellularregion]serine-typeendopeptidasesinvolved in novelPDGF processingPDGFB [extracellularregion]p-12Y-PDGFRB [plasmamembrane]PDGFA-2[extracellularregion]SRC-1 [plasmamembrane]PDGFB [extracellularregion]PDGFC-1(235-345)[extracellularregion]PDGFA-2 [Golgimembrane]PDGFB [extracellularregion]p21 RAS:GTPPDGF betareceptor:PDGF chainB homodimerPDGFB [extracellularregion]PDGFB [extracellularregion]p-11Y-PDGFRA [plasmamembrane]PDGFA-2 [endoplasmicreticulum lumen]PDGFB(82-241)[extracellularregion]PIK3R2 [cytosol]GDPPDGFB(82-241)[extracellularregion]Novel PDGF precursordimers (CC, DD)BCAR1Heparan sulfateN-acetyl-alpha-D-glucosaminide[extracellularregion]p-11Y-PDGFRA [plasmamembrane]COL9A3[extracellularregion]STAT5A [cytosol]ADP3x4Hyp-COL6A2[extracellularregion]3x4Hyp-COL6A1[extracellularregion]3x4Hyp-GlcGalHyl-COL6A1[extracellularregion]p-Y419-SRC-1 [plasmamembrane]PDGFB(82-241)[extracellularregion]PIK3CA [cytosol]PDGFB [extracellularregion]p-12Y-PDGFRB [plasmamembrane]PDGFB(82-241)[extracellularregion]RASA1 [cytosol]GalHyl-COL6A2[extracellularregion]PIK3CB [cytosol]5Hyl-COL6A1[extracellularregion]Phospho-betareceptorhomodimer:GAP5Hyl-COL6A2[extracellularregion]3x4Hyp-3Hyp-GlcGalHyl-COL6A1[extracellularregion]GTP [cytosol]PLCG1(2-1290)ADPCOL4A5(27-?)[extracellularregion]PI(4,5)P2PDGF:Phospho-PDGFreceptor dimer:Grb7Classical PDGFprecursor dimers(AA, AB, BB)PDGFA-1(1-211)[Golgi membrane]GRB2-1 [cytosol]PDGFD(1-370) [Golgimembrane]PDGFA-1[extracellularregion]PDGF:Phospho-PDGFreceptordimer:Grb2:Sos1PDGFA-1[extracellularregion]PIK3R2 [cytosol]PDGFA-1[extracellularregion]PDGFB(82-241)[extracellularregion]p-11Y-PDGFRA [plasmamembrane]PDGFB(82-241)[extracellularregion]PDGFRB [plasmamembrane]PDGFB(82-241)[extracellularregion]GRB2:SOS1p-11Y-PDGFRA [plasmamembrane]PDGFA-2[extracellularregion]GRB2-1 [cytosol]PDGFRA [plasmamembrane]PDGFA-2[extracellularregion]PDGFA-1[extracellularregion]PDGFA-1[extracellularregion]PDGFC-1 [Golgimembrane]GRB7 [cytosol]PDGFB(82-241)[extracellularregion]PDGFA-1[extracellularregion]Extracellular matrixligandsp-11Y-PDGFRA [plasmamembrane]Phospho PDGFalpha-betadimer:PDGF AB or BBdimers3x4Hyp-5Hyl-COL6A1[extracellularregion]ATPp-12Y-PDGFRB [plasmamembrane]GlcGalHyl-COL6A1[extracellularregion]PDGF:p-PDGFRdimer:p-PLCgammap-12Y-PDGFRB [plasmamembrane]p-11Y-PDGFRA [plasmamembrane]PDGFB(82-241)[extracellularregion]HRAS(1-186) [plasmamembrane]NRAS [plasmamembrane]PDGFB [extracellularregion]PDGF:PDGF receptordimerSRC-1PDGFB [extracellularregion]p-11Y-PDGFRA [plasmamembrane]KRAS(1-186) [plasmamembrane]PDGF alpha/beta:PDGFAB and BB dimersPDGFB(82-241)[extracellularregion]PDGFB [extracellularregion]PDGFRA [plasmamembrane]PDGFA-1[extracellularregion]p-12Y-PDGFRB [plasmamembrane]PI3KSOS1 [cytosol]PDGFB [extracellularregion]Phospho PDGF betareceptor: PDGF chainB homodimerPDGFB [extracellularregion]p-11Y-PDGFRA [plasmamembrane]STAT3 [cytosol]THBS2 [extracellularregion]p-11Y-PDGFRA [plasmamembrane]PDGFA-1[extracellularregion]PDGFB(82-241)[extracellularregion]NRAS [plasmamembrane]p-12Y-PDGFRB [plasmamembrane]PLCG1(2-1290)[plasma membrane]PDGFB(82-241)[extracellularregion]p-4Y-PLCG1 [plasmamembrane]PIK3CB [cytosol]PDGFA-2[extracellularregion]PDGF:Phospho-PDGFreceptor dimer:SHP2ATPp-12Y-PDGFRB [plasmamembrane]PDGF:Phospho-PDGFreceptor dimer:SrcGlcGalHyl-COL6A2[extracellularregion]PDGFB [extracellularregion]PDGF:phospho-PDGFreceptor dimer:STATPDGFB(82-241)[extracellularregion]PDGFA-2[extracellularregion]PDGFA-2[extracellularregion]3x4Hyp-3Hyp-5Hyl-COL6A1[extracellularregion]p-11Y-PDGFRA [plasmamembrane]Novel PDGF precursordimers (CC, DD)PDGFA-1[extracellularregion]PTPN11 [cytosol]Active PDGF dimers(CC, DD)COL4A2(184-?)[extracellularregion]GalHyl-COL6A1[extracellularregion]PDGFB(1-241) [Golgimembrane]PDGF:Phospho-PDGFreceptordimer:Crk:p130Cas:C3Gp-12Y-PDGFRB [plasmamembrane]3x4Hyp-GalHyl-COL6A1[extracellularregion]3x4Hyp-GlcGalHyl-COL6A2[extracellularregion]PDGFB(82-241)[extracellularregion]GRB7PDGFB [extracellularregion]Heparan sulfatealpha-D-glucosaminide[extracellularregion]COL6A2[extracellularregion]PDGFA-2[extracellularregion]PDGFA-2[extracellularregion]PDGFA-1[extracellularregion]p-12Y-PDGFRB [plasmamembrane]PDGFA-2[extracellularregion]PDGFD(1-370)[endoplasmicreticulum lumen]p-12Y-PDGFRB [plasmamembrane]ADPPDGFB [extracellularregion]3x4Hyp-3Hyp-COL6A1[extracellularregion]PDGFB(82-241)[extracellularregion]PDGFD(258-370)[extracellularregion]PDGFA-2[extracellularregion]DAG and IP3signaling3x4Hyp-3Hyp-5Hyl-COL6A2[extracellularregion]CRKL [cytosol]PDGFA-2[extracellularregion]ATPADPPDGFB(82-241)[extracellularregion]p-12Y-PDGFRB [plasmamembrane]PDGFB [extracellularregion]RAPGEF1p-12Y-PDGFRB [plasmamembrane]PDGF:Phospho-PDGFreceptor dimer:Crkp-11Y-PDGFRA [plasmamembrane]PDGFA-1[extracellularregion]PDGFB(82-241)[extracellularregion]p-4Y-PLCG1NCK1 [cytosol]PDGFA-2[extracellularregion]ADPPTPN11p-12Y-PDGFRB [plasmamembrane]STAT1 [cytosol]NCKPDGFA-2[extracellularregion]PDGF:Phospho-PDGFreceptordimer:phospho-Src3x4Hyp-5Hyl-COL6A2[extracellularregion]PDGFB(1-241) [Golgimembrane]p-12Y-PDGFRB [plasmamembrane]3x4Hyp-GalHyl-COL6A2[extracellularregion]PDGFB [extracellularregion]PDGFB [extracellularregion]PDGFRA [plasmamembrane]SPP1(17-?)[extracellularregion]PDGFA-1(1-211)[endoplasmicreticulum lumen]ATPPDGFB(82-241)[extracellularregion]STAT5B [cytosol]THBS1 [extracellularregion]PDGF A and B chainswith retention motifPDGFB [extracellularregion]COL4A1(173-1669)[extracellularregion]Cleaved novel PDGFfragmentsp-11Y-PDGFRA [plasmamembrane]PDGFB [extracellularregion]PDGFB(82-241)[extracellularregion]p-11Y-PDGFRA [plasmamembrane]PDGFB [extracellularregion]GDP [cytosol]PDGFD(1-370) [Golgimembrane]PDGFA-2 [Golgimembrane]3x4Hyp-3Hyp-GalHyl-COL6A2[extracellularregion]PDGFC-1 [endoplasmicreticulum lumen]CRKL [cytosol]GTP3x4Hyp-3Hyp-COL6A2[extracellularregion]PDGFRB [plasmamembrane]p-11Y-PDGFRA [plasmamembrane]Cleaved classicalPDGF peptides3x4Hyp-3Hyp-GlcGalHyl-COL6A2[extracellularregion]PIK3R1 [cytosol]CRK(2-304) [cytosol]PDGFB(82-241)[extracellularregion]PDGFB(1-241)[endoplasmicreticulum lumen]PDGFA-2[extracellularregion]ATPPDGFD(19-370)[extracellularregion]p21 RAS:GDPPDGFA-1[extracellularregion]p-11Y-PDGFRA [plasmamembrane]PDGFA-1[extracellularregion]KRAS(1-186) [plasmamembrane]PDGFA-1[extracellularregion]PDGFA-2[extracellularregion]SOS1 [cytosol]RAPGEF1 [cytosol]STAT6 [cytosol]NCK2 [cytosol]PDGF receptormonomerPDGFC-1(23-345)[extracellularregion]PDGFA-1[extracellularregion]PDGF:Phospho-PDGFRreceptor dimer:NckPDGF precursordimers (AA, BB,A/B, CC, DD)PDGF:Phospho-PDGFreceptordimer:PLC-gammaHRAS(1-186) [plasmamembrane]THBS4 [extracellularregion]PDGFB(82-241)[extracellularregion]PDGF alpha receptor:PDGF dimers3x4Hyp-3Hyp-GalHyl-COL6A1[extracellularregion]COL4A4(39-?)[extracellularregion]PDGFA-1(1-211)[Golgi membrane]PDGFA-2[extracellularregion]PDGF precursordimers (AA, BB, A/B,CC, DD)COL9A1[extracellularregion]RASA1PDGFB [extracellularregion]COL4A3(29-1670)[extracellularregion]PDGFA-2[extracellularregion]PIP3 activates AKTsignalingSTAT family membersPDGFC-1 [Golgimembrane]PIK3CA [cytosol]PDGFB(82-241)[extracellularregion]PDGF:Phospho-PDGFreceptor dimer:PI3KFURINp-12Y-PDGFRB [plasmamembrane]PDGF A and Bchains:ECM complexPDGFB [extracellularregion]PDGFRB [plasmamembrane]BCAR1 [cytosol]218, 2911