Signaling by PDGF (Homo sapiens)

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7, 12, 277, 20274, 5, 12, 157, 197, 12, 207, 17, 302713, 247, 217, 8, 2116, 2777, 9, 12, 261, 7, 147777, 12, 221316, 27233, 7, 107, 11, 297, 12, 18Tropocollagen type VI PDGF A/B heterodimer PDGF B homodimer Phospho PDGF beta receptor PDGF chain B homodimer PDGF A/B heterodimer Processed PDGF-B PDGF B homodimer Processed PDGF-B Phospho-beta receptor homodimer PDGF beta receptorPDGF chain B homodimer PDGF A homodimer PDGFPhospho-PDGF receptor dimerGrb2Sos1 Active PDGF dimers Phospho- PDGF receptor dimer Processed PDGF-B PDGF A homodimer PDGF alpha/betaPDGF AB and BB dimers Phospho- PDGF receptor dimer Phospho-beta receptor homodimer Collagen type IX endoplasmic reticulum lumenGolgi lumenProcessed PDGF-B p21 RASGTP cytosolActive PDGF dimers PDGF A/B heterodimer PDGF A homodimer Beta receptor homodimer Active PDGF dimers PDGF A homodimer Phospho-beta receptor homodimer PDGF A/B heterodimer Processed PDGF-B Alpha receptor homodimer Active PDGF dimers PDGF B homodimer PDGF B homodimer PDGFPhospho-PDGF receptor dimer Processed PDGF-B Phospho-alpha-Phospho-beta receptor heterodimer Phospho- PDGF receptor dimer Processed PDGF-B Phospho-alpha-Phospho-beta receptor heterodimer PDGF B homodimer Phospho-alpha receptor homodimer PDGF A/B heterodimer PDGF B homodimer Processed PDGF-B PDGFPhospho-PDGF receptor dimerSrc Collagen alpha-2Processed PDGF-B PDGFphospho-PDGF receptor dimerSTAT Active PDGF dimers PDGF B homodimer PDGF A homodimer Active platelet-derived growth factor A chain isoforms PDGF A homodimer Phospho- PDGF receptor dimer Phospho-alpha receptor homodimer Phospho PDGF alpha receptorPDGF dimers Phospho-beta receptor homodimer PI3K-regulatory subunit Phospho-alpha receptor homodimer Phospho-beta receptor homodimer Type IV collagen PDGF B homodimer Active platelet-derived growth factor A chain isoforms PDGF A homodimer Active platelet-derived growth factor A chain isoforms PDGFPhospho-PDGFR receptor dimerNck CRK, CRKL PDGF A/B heterodimer PDGF A homodimer PDGFPhospho-PDGF receptor dimerPI3K Active platelet-derived growth factor A chain isoforms Active platelet-derived growth factor A chain isoforms NCK Beta receptor homodimer Active platelet-derived growth factor A chain isoforms PDGF A and B chainsECM complex GRB2SOS1 PDGF A homodimer Phospho-beta receptor homodimer Phospho-alpha receptor homodimer PDGFPhospho-PDGF receptor dimerGrb7 PDGFPhospho-PDGF receptor dimerphospho-Src PDGF B homodimer Phospho PDGF alpha-beta dimerPDGF AB or BB dimers PDGF receptor dimer Collagen alpha-1Active platelet-derived growth factor A chain isoforms Phospho-alpha-Phospho-beta receptor heterodimer Phospho-alpha receptor homodimer Phospho- PDGF receptor dimer p21 RAS PDGF B homodimer Processed PDGF-B Processed PDGF-B PDGF B homodimer Active platelet-derived growth factor A chain isoforms PDGF B homodimer Active PDGF dimers PDGF B homodimer Phospho-alpha receptor homodimer Phospho-beta receptor homodimer p21 RASGDP Processed PDGF-B Phospho- PDGF receptor dimer PDGF A homodimer PI3K-catalytic subunit Phospho-alpha-Phospho-beta receptor heterodimer Phospho-alpha receptor homodimer Collagen alpha-1PDGF A homodimer Phospho-alpha receptor homodimer PDGF A/B heterodimer PDGFp-PDGFR dimerp-PLCgamma Phospho- PDGF receptor dimer CRK, CRKL Active platelet-derived growth factor A chain isoforms Processed PDGF-B PDGF A homodimer PDGF A/B heterodimer Phospho- PDGF receptor dimer Phospho-alpha-Phospho-beta receptor heterodimer Active PDGF dimers PDGFPhospho-PDGF receptor dimer Phospho-beta receptor homodimer Phospho-alpha-Phospho-beta receptor heterodimer Alpha receptor homodimer Active PDGF dimers Alpha-Beta receptor heterodimer Phospho-alpha-Phospho-beta receptor heterodimer Phospho-alpha receptor homodimer PDGF B homodimer Processed PDGF-B PDGFPhospho-PDGF receptor dimer PDGF AB or BB homodimers PDGFPhospho-PDGF receptor dimer Active platelet-derived growth factor A chain isoforms Phospho-alpha receptor homodimer Processed PDGF-B Active PDGF dimers Processed PDGF-B Active PDGF dimers PI3K PDGF A and B chains with retention motif PDGF B homodimer Active platelet-derived growth factor A chain isoforms PDGF B homodimer PDGF A/B heterodimer Phospho-beta receptor homodimer Phospho-beta receptor homodimer PDGF A/B heterodimer Active platelet-derived growth factor A chain isoforms PI3K PDGF A/B heterodimer Active PDGF dimers Phospho-beta receptor homodimer Active PDGF dimers Phospho PDGF beta receptor PDGF chain B homodimer Collagen alpha-3Phospho-alpha-Phospho-beta receptor heterodimer PDGF alpha receptor PDGF dimers Collagens Processed PDGF-B PDGFPhospho-PDGF receptor dimerCrk Phospho-alpha-Phospho-beta receptor heterodimer Processed PDGF-B PDGF A homodimer PDGFPhospho-PDGF receptor dimerCrkp130CasC3G Phospho-alpha receptor homodimer PDGFPhospho-PDGF receptor dimerSHP2 PDGF A homodimer Phospho-beta receptor homodimer PDGFPhospho-PDGF receptor dimer PDGF A/B heterodimer Phospho-alpha receptor homodimer Processed PDGF-B p21 RAS PI3K-regulatory subunit Phospho-beta receptor homodimer Active platelet-derived growth factor A chain isoforms Active PDGF dimers Heparan sulphate Phospho-alpha-Phospho-beta receptor heterodimer Thrombospondin PDGF B homodimer PDGFPhospho-PDGF receptor dimerCrk PDGFPhospho-PDGF receptor dimerPLC-gamma Phospho-alpha receptor homodimer Phospho-alpha-Phospho-beta receptor heterodimer Active PDGF dimers Active PDGF dimers PI3K-catalytic subunit Phospho- PDGF receptor dimer PDGF A homodimer Processed PDGF-B PDGF B homodimer PDGF AB or BB homodimers Phospho-alpha receptor homodimer PDGF B homodimer PDGFPDGF receptor dimer PDGFPhospho-PDGF receptor dimer Active platelet-derived growth factor A chain isoforms Phospho- PDGF receptor dimer PDGF A homodimer Active PDGF dimers STAT family members Active platelet-derived growth factor A chain isoforms Phospho- PDGF receptor dimer PDGFPhospho-PDGF receptor dimer PDGF A/B heterodimer Phospho- PDGF receptor dimer PDGF A/B heterodimer PDGF A/B heterodimer Extracellular matrix ligands Phospho-alpha-Phospho-beta receptor heterodimer Phospho-alpha-Phospho-beta receptor heterodimer Active platelet-derived growth factor A chain isoforms PDGF B homodimer PDGF B homodimer Phospho- PDGF receptor dimer Phospho-beta receptor homodimer PDGF A/B heterodimer GRB2SOS1 Alpha-Beta receptor heterodimer Phospho-alpha-Phospho-beta receptor heterodimer Processed PDGF-B PDGF A/B heterodimer PDGF A/B heterodimer Phospho-beta receptor homodimerGAP Phospho-beta receptor homodimer 3x4Hyp-3Hyp-5Hyl-COL6A1 PDGFBPDGFPhospho-PDGF receptor dimerPI3KPDGF alpha/betaPDGF AB and BB dimersGRB2-1 PDGF precursor dimers PDGFPhospho-PDGFR receptor dimerNckCOL9A3 p-12Y-PDGFRB PDGFB PDGFPhospho-PDGF receptor dimerPLC-gammaPDGFA-2 PDGFB PDGFBPDGFA-2 SOS1 ADPNRAS RAF/MAP kinase cascadePDGFA-2 PDGFA-2 GDP p-11Y-PDGFRA SPP1PDGFA-1 PDGFA-1 ADPCOL6A2 CRKL Phospho PDGF beta receptor PDGF chain B homodimerPDGFBPDGFB 3x4Hyp-3Hyp-COL6A1 ATPp-12Y-PDGFRB PIK3CA NCK1 ATPPDGFA-2 PDGFA-1 Phospho-beta receptor homodimerGAPPDGFB CRK, CRKL3x4Hyp-3Hyp-GlcGalHyl-COL6A1 PICRKL PDGFBPDGFRB PDGFA-2 ADPPIK3R1 p21 RASGDPPIK3R2 RAPGEF1 ATPPDGFA-2 RAPGEF1PDGFBCOL4A5PDGFB PDGFA-2 STAT6 GRB2SOS1p-11Y-PDGFRA PDGFA-1 PDGFPhospho-PDGF receptor dimerGrb7PTPN115Hyl-COL6A2 GlcGalHyl-COL6A1 p-12Y-PDGFRB PDGFA-1 PDGFA-1 KRASPDGFBPDGFB 3x4Hyp-3Hyp-5Hyl-COL6A2 PDGFBp-11Y-PDGFRA PDGFB PDGFPhospho-PDGF receptor dimerTHBS3 PDGFA-1 3x4Hyp-3Hyp-COL6A2 KRASPIK3CB NCKActive PDGF dimers p-11Y-PDGFRA PDGFB 3x4Hyp-GalHyl-COL6A2 SOS1 Heparan sulfate alpha-D-glucosaminide PDGFPhospho-PDGF receptor dimerphospho-SrcNCK2 PDGFBPDGFBHRASSTAT5A PDGFPhospho-PDGF receptor dimerCrkp130CasC3Gp-11Y-PDGFRA STAT5B PLCG1PTPN11 PDGFPhospho-PDGF receptor dimerSHP2COL4A1PDGFBPDGFA-2 PDGFA-1 3x4Hyp-5Hyl-COL6A2 GalHyl-COL6A1 PDGFA-1 COL4A2BCAR1 Heparan sulfate N-acetyl-alpha-D-glucosaminide GTPPDGFPhospho-PDGF receptor dimerCrkGRB2-1 PDGFB p-Y419-SRC-1 PDGFphospho-PDGF receptor dimerSTATp-11Y-PDGFRA PDGFPhospho-PDGF receptor dimerSrcp-11Y-PDGFRA PDGFB BCAR1p-12Y-PDGFRB PDGFBNovel PDGF precursor dimers STAT family membersPDGFB PDGFB PIP3 activates AKT signalingPDGFA-2 PDGFPDGF receptor dimerPDGFB PDGFB PDGFB PDGFB 3x4Hyp-3Hyp-GalHyl-COL6A2 THBS1 3x4Hyp-GlcGalHyl-COL6A2 PDGFB3x4Hyp-GalHyl-COL6A1 PIK3CA FURINPIPDGFPhospho-PDGF receptor dimerGrb2Sos15Hyl-COL6A1 p-4Y-PLCG1 SRC-1 SRC-1p-11Y-PDGFRA CRKPDGFA-2 PDGFB PDGFA-2 RASA1 PDGFB PIK3R2 PDGFRB GlcGalHyl-COL6A2 GTP p-12Y-PDGFRB PDGFRA PDGFA-1 HRASp-11Y-PDGFRA RASA1PDGF precursor dimers PDGFA-1 Active PDGF dimers STAT3 PDGF A and B chains with retention motifPDGFA-1 p-12Y-PDGFRB 3x4Hyp-COL6A2 DAG and IP3 signalingp-12Y-PDGFRB p-12Y-PDGFRB serine-type endopeptidases involved in novel PDGF processingGDPp-11Y-PDGFRA PLCG1PDGFA-2 PDGF receptor monomerPDGFA-1 3x4Hyp-5Hyl-COL6A1 PDGFBPDGFA-2 p-11Y-PDGFRA p-11Y-PDGFRA ADPCOL9A1 p-12Y-PDGFRB PDGFA-1 p-11Y-PDGFRA PDGFA-2 PDGFBCOL9A2 PDGFBPDGFBPDGFBCRKp-12Y-PDGFRB PDGFA-2 Phospho PDGF alpha receptorPDGF dimersExtracellular matrix ligandsp-12Y-PDGFRB PDGFBTHBS4 PDGFB NRAS PDGFRA PDGFA-2 STAT1 GalHyl-COL6A2 3x4Hyp-GlcGalHyl-COL6A1 3x4Hyp-COL6A1 PDGFB p-12Y-PDGFRB Classical PDGF precursor dimers GRB7 PDGFB p-12Y-PDGFRB Novel PDGF precursor dimers Cleaved classical PDGF peptidesPDGFp-PDGFR dimerp-PLCgammaPDGFA-2 3x4Hyp-3Hyp-GalHyl-COL6A1 ATPPhospho PDGF alpha-beta dimerPDGF AB or BB dimersPDGFA-1 COL4A4PDGF beta receptorPDGF chain B homodimerTHBS2 p-12Y-PDGFRB PDGFBPDGFBp-11Y-PDGFRA PIK3R1 PDGFA-1 p21 RASGTPPDGF A and B chainsECM complexPDGF alpha receptor PDGF dimersPIK3CB ADPPI3KPDGFB3x4Hyp-3Hyp-GlcGalHyl-COL6A2 PDGFRA PDGFBCleaved novel PDGF fragmentsp-11Y-PDGFRA PDGFRB p-4Y-PLCG1p-12Y-PDGFRB COL4A3PDGFA-1 COL6A1 GRB7p-12Y-PDGFRB ATP2, 62825


Description

Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=186797

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Bibliography

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History

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CompareRevisionActionTimeUserComment
101493view11:36, 1 November 2018ReactomeTeamreactome version 66
101030view21:16, 31 October 2018ReactomeTeamreactome version 65
100563view19:50, 31 October 2018ReactomeTeamreactome version 64
100111view16:35, 31 October 2018ReactomeTeamreactome version 63
99661view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99261view12:45, 31 October 2018ReactomeTeamreactome version 62
93838view13:40, 16 August 2017ReactomeTeamreactome version 61
93393view11:22, 9 August 2017ReactomeTeamreactome version 61
86479view09:19, 11 July 2016ReactomeTeamreactome version 56
83084view09:55, 18 November 2015ReactomeTeamVersion54
81405view12:56, 21 August 2015ReactomeTeamVersion53
76874view08:14, 17 July 2014ReactomeTeamFixed remaining interactions
76579view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75912view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75612view10:47, 10 June 2014ReactomeTeamReactome 48 Update
74967view13:48, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74611view08:39, 30 April 2014ReactomeTeamReactome46
45212view17:24, 7 October 2011KhanspersOntology Term : 'PDGF signaling pathway' added !
42132view21:59, 4 March 2011MaintBotAutomatic update
39942view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3x4Hyp-3Hyp-5Hyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-5Hyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GlcGalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-5Hyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-5Hyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-GalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-GalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-GlcGalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-GlcGalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
5Hyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
5Hyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Active PDGF dimers ComplexREACT_17802 (Reactome)
Active PDGF dimers ComplexREACT_17845 (Reactome)
BCAR1 ProteinP56945 (Uniprot-TrEMBL)
BCAR1ProteinP56945 (Uniprot-TrEMBL)
COL4A1ProteinP02462 (Uniprot-TrEMBL)
COL4A2ProteinP08572 (Uniprot-TrEMBL)
COL4A3ProteinQ01955 (Uniprot-TrEMBL)
COL4A4ProteinP53420 (Uniprot-TrEMBL)
COL4A5ProteinP29400 (Uniprot-TrEMBL)
COL6A1 ProteinP12109 (Uniprot-TrEMBL)
COL6A2 ProteinP12110 (Uniprot-TrEMBL)
COL9A1 ProteinP20849 (Uniprot-TrEMBL)
COL9A2 ProteinQ14055 (Uniprot-TrEMBL)
COL9A3 ProteinQ14050 (Uniprot-TrEMBL)
CRK, CRKLProteinREACT_17492 (Reactome)
CRKL ProteinP46109 (Uniprot-TrEMBL)
CRKProteinP46108 (Uniprot-TrEMBL)
Classical PDGF precursor dimers ComplexREACT_17671 (Reactome)
Cleaved classical PDGF peptidesProteinREACT_17262 (Reactome)
Cleaved novel PDGF fragmentsProteinREACT_18041 (Reactome)
DAG and IP3 signalingPathwayREACT_111064 (Reactome) This pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.
Extracellular matrix ligandsProteinREACT_17129 (Reactome)
FURINProteinP09958 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2 SOS1ComplexREACT_4435 (Reactome)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GRB7 ProteinQ14451 (Uniprot-TrEMBL)
GRB7ProteinQ14451 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
GalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
GalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
GlcGalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
GlcGalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
Heparan sulfate N-acetyl-alpha-D-glucosaminide MetaboliteCHEBI:17421 (ChEBI)
Heparan sulfate alpha-D-glucosaminide MetaboliteCHEBI:18137 (ChEBI)
KRASProteinP01116 (Uniprot-TrEMBL)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCK2 ProteinO43639 (Uniprot-TrEMBL)
NCKProteinREACT_17190 (Reactome)
NRAS ProteinP01111 (Uniprot-TrEMBL)
Novel PDGF precursor dimers ComplexREACT_17079 (Reactome)
Novel PDGF precursor dimers ComplexREACT_17162 (Reactome)
PDGF PDGF receptor dimerComplexREACT_18025 (Reactome)
PDGF

Phospho-PDGF receptor dimer Crk p130Cas

C3G
ComplexREACT_17351 (Reactome)
PDGF

Phospho-PDGF receptor dimer

Crk
ComplexREACT_17941 (Reactome)
PDGF

Phospho-PDGF receptor dimer Grb2

Sos1
ComplexREACT_18248 (Reactome)
PDGF

Phospho-PDGF receptor dimer

Grb7
ComplexREACT_17607 (Reactome)
PDGF

Phospho-PDGF receptor dimer

PI3K
ComplexREACT_17825 (Reactome)
PDGF

Phospho-PDGF receptor dimer

PLC-gamma
ComplexREACT_17327 (Reactome)
PDGF

Phospho-PDGF receptor dimer

SHP2
ComplexREACT_17654 (Reactome)
PDGF

Phospho-PDGF receptor dimer

Src
ComplexREACT_18132 (Reactome)
PDGF

Phospho-PDGF receptor dimer

phospho-Src
ComplexREACT_17206 (Reactome)
PDGF Phospho-PDGF receptor dimerComplexREACT_17756 (Reactome)
PDGF

Phospho-PDGFR receptor dimer

Nck
ComplexREACT_17490 (Reactome)
PDGF

p-PDGFR dimer

p-PLCgamma
ComplexREACT_111673 (Reactome)
PDGF

phospho-PDGF receptor dimer

STAT
ComplexREACT_17883 (Reactome)
PDGF A and B chains ECM complexComplexREACT_17710 (Reactome)
PDGF A and B chains with retention motifProteinREACT_17714 (Reactome)
PDGF alpha receptor PDGF dimersComplexREACT_17393 (Reactome)
PDGF alpha/beta PDGF AB and BB dimersComplexREACT_17544 (Reactome)
PDGF beta receptor PDGF chain B homodimerComplexREACT_17457 (Reactome)
PDGF precursor dimers ComplexREACT_17541 (Reactome)
PDGF precursor dimers ComplexREACT_17912 (Reactome)
PDGF receptor monomerProteinREACT_18211 (Reactome)
PDGFA-1 ProteinP04085-1 (Uniprot-TrEMBL)
PDGFA-2 ProteinP04085-2 (Uniprot-TrEMBL)
PDGFB ProteinP01127 (Uniprot-TrEMBL)
PDGFBProteinP01127 (Uniprot-TrEMBL)
PDGFRA ProteinP16234 (Uniprot-TrEMBL)
PDGFRB ProteinP09619 (Uniprot-TrEMBL)
PI3KComplexREACT_4240 (Reactome)
PIMetaboliteCHEBI:16618 (ChEBI)
PIMetaboliteCHEBI:18348 (ChEBI)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIP3 activates AKT signalingPathwayREACT_75829 (Reactome) Signaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimulated cells, PI3K class IA enzymes reside in the cytosol as inactive heterodimers composed of p85 regulatory subunit and p110 catalytic subunit. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Upon binding of extracellular ligands to RTKs, receptors dimerize and undergo autophosphorylation. The regulatory subunit of PI3K, p85, is recruited to phosphorylated cytosolic RTK domains either directly or indirectly, through adaptor proteins, leading to a conformational change in the PI3K IA heterodimer that relieves inhibition of the p110 catalytic subunit. Activated PI3K IA phosphorylates PIP2, converting it to PIP3; this reaction is negatively regulated by PTEN phosphatase. PIP3 recruits AKT to the plasma membrane, allowing TORC2 to phosphorylate a conserved serine residue of AKT. Phosphorylation of this serine induces a conformation change in AKT, exposing a conserved threonine residue that is then phosphorylated by PDPK1 (PDK1). Phosphorylation of both the threonine and the serine residue is required to fully activate AKT. The active AKT then dissociates from PIP3 and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007.
PLCG1ProteinP19174 (Uniprot-TrEMBL)
PTPN11 ProteinQ06124 (Uniprot-TrEMBL)
PTPN11ProteinQ06124 (Uniprot-TrEMBL)
Phospho PDGF alpha receptor PDGF dimersComplexREACT_17261 (Reactome)
Phospho PDGF alpha-beta dimer PDGF AB or BB dimersComplexREACT_17875 (Reactome)
Phospho PDGF beta receptor PDGF chain B homodimerComplexREACT_17403 (Reactome)
Phospho-beta receptor homodimer GAPComplexREACT_17783 (Reactome)
RAF/MAP kinase cascadePathwayREACT_634 (Reactome) The MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a common 'module' in the transmission of an extracellular signal into the nucleus.
RAPGEF1 ProteinQ13905 (Uniprot-TrEMBL)
RAPGEF1ProteinQ13905 (Uniprot-TrEMBL)
RASA1 ProteinP20936 (Uniprot-TrEMBL)
RASA1ProteinP20936 (Uniprot-TrEMBL)
SOS1 ProteinQ07889 (Uniprot-TrEMBL)
SPP1ProteinP10451 (Uniprot-TrEMBL)
SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
SRC-1ProteinP12931-1 (Uniprot-TrEMBL)
STAT family membersProteinREACT_17706 (Reactome)
STAT1 ProteinP42224 (Uniprot-TrEMBL)
STAT3 ProteinP40763 (Uniprot-TrEMBL)
STAT5A ProteinP42229 (Uniprot-TrEMBL)
STAT5B ProteinP51692 (Uniprot-TrEMBL)
STAT6 ProteinP42226 (Uniprot-TrEMBL)
THBS1 ProteinP07996 (Uniprot-TrEMBL)
THBS2 ProteinP35442 (Uniprot-TrEMBL)
THBS3 ProteinP49746 (Uniprot-TrEMBL)
THBS4 ProteinP35443 (Uniprot-TrEMBL)
p-11Y-PDGFRA ProteinP16234 (Uniprot-TrEMBL)
p-12Y-PDGFRB ProteinP09619 (Uniprot-TrEMBL)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-Y419-SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
p21 RAS GDPComplexREACT_2657 (Reactome)
p21 RAS GTPComplexREACT_4782 (Reactome)
serine-type endopeptidases involved in novel PDGF processingREACT_17837 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ADPArrowREACT_16877 (Reactome)
ADPArrowREACT_16926 (Reactome)
ADPArrowREACT_16991 (Reactome)
ADPArrowREACT_16993 (Reactome)
ADPArrowREACT_17034 (Reactome)
ATPREACT_16877 (Reactome)
ATPREACT_16926 (Reactome)
ATPREACT_16991 (Reactome)
ATPREACT_16993 (Reactome)
ATPREACT_17034 (Reactome)
Active PDGF dimers ArrowREACT_16891 (Reactome)
Active PDGF dimers ArrowREACT_17059 (Reactome)
Active PDGF dimers REACT_16905 (Reactome)
BCAR1REACT_16951 (Reactome)
CRK, CRKLREACT_16940 (Reactome)
Cleaved classical PDGF peptidesArrowREACT_17059 (Reactome)
Cleaved novel PDGF fragmentsArrow