Signaling by PDGF (Homo sapiens)

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13, 16, 2929281, 19, 2910, 29162957, 8, 296, 13, 2926, 29, 302, 5292916, 254, 11, 2912, 13, 2924, 2919, 293, 9, 13, 181610, 13, 2913, 21, 27, 2916, 2514, 17, 29Collagen alpha-1PDGFPhospho-PDGF receptor dimerPLC-gamma Processed PDGF-B Phospho-beta receptor homodimer GRB2SOS1 PDGF A/B heterodimer Processed PDGF-B PDGF A/B heterodimer Active PDGF dimers Beta receptor homodimer Active platelet-derived growth factor A chain isoforms Phospho- PDGF receptor dimer PDGF A homodimer Phospho-alpha receptor homodimer PDGF A/B heterodimer Active platelet-derived growth factor A chain isoforms Alpha-Beta receptor heterodimer Phospho-alpha receptor homodimer PDGF B homodimer Tropocollagen type VI Golgi lumencytosolPDGF A/B heterodimer p21 RAS PDGF A homodimer PDGFPhospho-PDGF receptor dimerSrc Active platelet-derived growth factor A chain isoforms PDGF B homodimer PDGF A homodimer Active platelet-derived growth factor A chain isoforms Active PDGF dimers PDGFPhospho-PDGF receptor dimerphospho-Src PDGF A/B heterodimer Alpha-Beta receptor heterodimer PDGF A homodimer Processed PDGF-B Processed PDGF-B Phospho- PDGF receptor dimer PDGF A/B heterodimer Phospho-beta receptor homodimer Phospho-alpha receptor homodimer PDGF A/B heterodimer Phospho-beta receptor homodimer Processed PDGF-B Phospho-alpha-Phospho-beta receptor heterodimer Phospho-alpha receptor homodimer Processed PDGF-B PDGFp-PDGFR dimerp-PLCgamma Phospho- PDGF receptor dimer Heparan sulphate PDGF A/B heterodimer PDGFPhospho-PDGF receptor dimer PDGF A homodimer Processed PDGF-B Active platelet-derived growth factor A chain isoforms PDGF B homodimer Active platelet-derived growth factor A chain isoforms Phospho-alpha receptor homodimer Phospho-alpha-Phospho-beta receptor heterodimer Active PDGF dimers Active PDGF dimers PI3K-catalytic subunit Phospho-alpha-Phospho-beta receptor heterodimer Active PDGF dimers Collagen alpha-1Processed PDGF-B PDGF B homodimer Active platelet-derived growth factor A chain isoforms PDGF B homodimer NCK PDGFPhospho-PDGF receptor dimerCrkp130CasC3G Alpha receptor homodimer Active platelet-derived growth factor A chain isoforms Phospho- PDGF receptor dimer PDGF B homodimer PDGF B homodimer PDGFPhospho-PDGF receptor dimer Active PDGF dimers PDGF B homodimer PDGF A and B chains with retention motif Active PDGF dimers Active platelet-derived growth factor A chain isoforms PDGF B homodimer Phospho-alpha-Phospho-beta receptor heterodimer PDGFPhospho-PDGF receptor dimer Phospho- PDGF receptor dimer Processed PDGF-B PDGF AB or BB homodimers Alpha receptor homodimer Collagen alpha-2PDGF B homodimer Phospho-beta receptor homodimer PDGF alpha/betaPDGF AB and BB dimers Phospho-alpha receptor homodimer p21 RASGTP Processed PDGF-B PDGF A/B heterodimer Phospho PDGF beta receptor PDGF chain B homodimer Processed PDGF-B PDGF B homodimer Processed PDGF-B PDGF A homodimer Processed PDGF-B Phospho-alpha-Phospho-beta receptor heterodimer Active PDGF dimers p21 RAS PDGF alpha receptor PDGF dimers Phospho-alpha receptor homodimer Active platelet-derived growth factor A chain isoforms PDGFPhospho-PDGF receptor dimerPI3K Phospho-beta receptor homodimer Phospho-alpha-Phospho-beta receptor heterodimer Collagen alpha-3Active platelet-derived growth factor A chain isoforms Phospho-alpha-Phospho-beta receptor heterodimer STAT family members PDGFPhospho-PDGF receptor dimer Phospho-alpha receptor homodimer PDGFPhospho-PDGFR receptor dimerNck PDGF B homodimer PDGF A/B heterodimer Active platelet-derived growth factor A chain isoforms PDGF beta receptorPDGF chain B homodimer Phospho-alpha receptor homodimer Phospho-beta receptor homodimer PDGF A homodimer Phospho- PDGF receptor dimer Active PDGF dimers Phospho-beta receptor homodimer Phospho PDGF alpha receptorPDGF dimers PDGF A homodimer PDGF AB or BB homodimers Phospho-beta receptor homodimer Phospho-alpha-Phospho-beta receptor heterodimer Processed PDGF-B PDGF A/B heterodimer Phospho- PDGF receptor dimer PDGF B homodimer Phospho- PDGF receptor dimer PDGF B homodimer Phospho-alpha-Phospho-beta receptor heterodimer PDGF A/B heterodimer PDGF A homodimer PDGF A/B heterodimer PDGF A homodimer PI3K-regulatory subunit Extracellular matrix ligands Processed PDGF-B PDGF B homodimer Processed PDGF-B p21 RASGDP Active PDGF dimers Active PDGF dimers endoplasmic reticulum lumenPDGF B homodimer PI3K-regulatory subunit CRK, CRKL PDGF A homodimer Active PDGF dimers PDGF A homodimer Phospho-beta receptor homodimer Collagen type IX PDGFPhospho-PDGF receptor dimer Active PDGF dimers Type IV collagen PDGF A/B heterodimer PDGFPhospho-PDGF receptor dimer Phospho-beta receptor homodimer PDGF A/B heterodimer Active platelet-derived growth factor A chain isoforms PDGFPhospho-PDGF receptor dimerCrk Phospho-alpha-Phospho-beta receptor heterodimer Phospho- PDGF receptor dimer Active platelet-derived growth factor A chain isoforms Active PDGF dimers Phospho- PDGF receptor dimer Phospho-beta receptor homodimerGAP Phospho-alpha-Phospho-beta receptor heterodimer PDGF A/B heterodimer PDGFphospho-PDGF receptor dimerSTAT PI3K-catalytic subunit PI3K PDGF B homodimer PDGF A homodimer Thrombospondin Phospho-beta receptor homodimer PDGFPDGF receptor dimer Processed PDGF-B PDGFPhospho-PDGF receptor dimer Phospho- PDGF receptor dimer Phospho-alpha-Phospho-beta receptor heterodimer Phospho-beta receptor homodimer PDGF A homodimer PDGF A homodimer Active PDGF dimers Phospho-alpha receptor homodimer Active platelet-derived growth factor A chain isoforms PDGF A/B heterodimer Processed PDGF-B PDGF B homodimer Phospho-alpha-Phospho-beta receptor heterodimer Processed PDGF-B PDGF receptor dimer Phospho- PDGF receptor dimer PDGF B homodimer Phospho-alpha receptor homodimer Active platelet-derived growth factor A chain isoforms PDGF A homodimer PDGFPhospho-PDGF receptor dimerCrk PDGF B homodimer Phospho-alpha receptor homodimer PDGF A and B chainsECM complex Phospho- PDGF receptor dimer PDGFPhospho-PDGF receptor dimerGrb7 Phospho-alpha receptor homodimer Phospho PDGF alpha-beta dimerPDGF AB or BB dimers CRK, CRKL Collagens Phospho-beta receptor homodimer Phospho-beta receptor homodimer PDGF B homodimer Processed PDGF-B Processed PDGF-B Phospho-alpha receptor homodimer Active PDGF dimers PDGFPhospho-PDGF receptor dimerSHP2 PDGFPhospho-PDGF receptor dimerGrb2Sos1 Beta receptor homodimer Phospho-beta receptor homodimer PDGF A/B heterodimer Phospho-alpha-Phospho-beta receptor heterodimer PI3K Phospho PDGF beta receptor PDGF chain B homodimer GRB2SOS1 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 CRKL p-11Y-PDGFRA PDGFRA SOS1 NCK1 COL9A1 PDGFA-1 PDGFBp-11Y-PDGFRA PDGFB PDGFBGRB7PDGFB PDGFA-1 PDGFPhospho-PDGF receptor dimerGTP PIP3 activates AKT signalingPDGFB PDGFB GTPp-12Y-PDGFRB Heparan sulfate N-acetyl-alpha-D-glucosaminide PDGFA-2 COL4A2PTPN11GlcGalHyl-COL6A2 CRKp-12Y-PDGFRB p-Y419-SRC-1 PDGFB3x4Hyp-GalHyl-COL6A1 Phospho PDGF alpha-beta dimerPDGF AB or BB dimersSRC-1 PIK3CB NCK2 PIPDGFB PDGFA-2 RASA1 PDGFBPDGFPhospho-PDGF receptor dimerCrk3x4Hyp-3Hyp-COL6A1 ADPCRKPDGFPhospho-PDGF receptor dimerPLC-gammaPDGFB PDGFB SRC-1PIK3R2 HRASPIK3CA NCKPhospho PDGF alpha receptorPDGF dimersPDGFB PLCG1PDGFRA COL9A3 PDGFBPDGFB CRK, CRKLGRB2-1 p-12Y-PDGFRB PDGFA-2 GRB7 PDGFPhospho-PDGF receptor dimerSHP2COL6A2 3x4Hyp-3Hyp-GalHyl-COL6A2 PDGFA-1 PDGFA-2 PDGFA-2 NRAS p-11Y-PDGFRA PDGFB3x4Hyp-3Hyp-GlcGalHyl-COL6A2 PDGFA-2 p-12Y-PDGFRB PDGFBp-11Y-PDGFRA THBS4 PDGFA-2 3x4Hyp-GalHyl-COL6A2 NRAS PDGFA-1 PDGFPhospho-PDGFR receptor dimerNckserine-type endopeptidases involved in novel PDGF processingp-12Y-PDGFRB PDGFB3x4Hyp-5Hyl-COL6A2 PDGFPhospho-PDGF receptor dimerGrb2Sos1THBS1 p-11Y-PDGFRA p-11Y-PDGFRA RASA1RAF/MAP kinase cascadeKRASSTAT5B p-11Y-PDGFRA p-12Y-PDGFRB STAT1 PDGFA-1 p-11Y-PDGFRA COL4A3p-4Y-PLCG1PDGFB PDGFA-2 3x4Hyp-GlcGalHyl-COL6A2 5Hyl-COL6A1 PDGFA-2 COL4A1RAPGEF1 Heparan sulfate alpha-D-glucosaminide p21 RASGTPp-11Y-PDGFRA SOS1 PDGFBADPp-11Y-PDGFRA p-12Y-PDGFRB p-11Y-PDGFRA p-12Y-PDGFRB PDGFBPDGFPhospho-PDGF receptor dimerCrkp130CasC3GPIK3R1 PDGFA-1 Novel PDGF precursor dimers PDGFphospho-PDGF receptor dimerSTATPDGFBPDGFBDAG and IP3 signalingp-11Y-PDGFRA PDGFRA PDGFBPDGFBPDGFBPDGFB3x4Hyp-3Hyp-5Hyl-COL6A2 THBS2 3x4Hyp-COL6A2 ATP3x4Hyp-5Hyl-COL6A1 PIK3CB Novel PDGF precursor dimers ATPp-11Y-PDGFRA COL6A1 p-11Y-PDGFRA PDGFA-1 PDGFPhospho-PDGF receptor dimerSrcADPBCAR1PDGFB PDGFBPDGFB p-12Y-PDGFRB PDGFBPIK3CA PDGFA-1 SPP1GDPADPPDGFRB PDGFA-2 KRASp-12Y-PDGFRB Phospho-beta receptor homodimerGAPClassical PDGF precursor dimers PDGFA-2 Cleaved classical PDGF peptidesSTAT5A PDGF A and B chainsECM complexPDGFA-2 PDGFA-1 GalHyl-COL6A2 PDGFp-PDGFR dimerp-PLCgammaPTPN11 PDGFB Extracellular matrix ligandsSTAT family membersp-12Y-PDGFRB PIPDGFB PDGFPDGF receptor dimerPDGFA-2 3x4Hyp-GlcGalHyl-COL6A1 PLCG1PDGFB p-12Y-PDGFRB p-12Y-PDGFRB Phospho PDGF beta receptor PDGF chain B homodimerCOL9A2 GRB2-1 PDGFA-2 p-12Y-PDGFRB PDGFB PI3K3x4Hyp-3Hyp-GalHyl-COL6A1 PDGFA-2 p21 RASGDPADPBCAR1 PDGFA-1 ATPPDGFA-1 PDGF A and B chains with retention motifPDGFA-1 PDGF alpha receptor PDGF dimersPDGF receptor monomerPDGFBGDP PDGFRB PDGFB STAT6 5Hyl-COL6A2 3x4Hyp-COL6A1 GalHyl-COL6A1 PDGFBPDGFB Active PDGF dimers p-11Y-PDGFRA PDGFBPDGFA-1 Cleaved novel PDGF fragmentsFURINp-4Y-PLCG1 PDGFB 3x4Hyp-3Hyp-5Hyl-COL6A1 PDGF precursor dimers PDGFPhospho-PDGF receptor dimerphospho-SrcPDGFB PDGFA-2 COL4A5PDGFRB THBS3 PDGFA-1 ATPGRB2SOS1p-12Y-PDGFRB PIK3R2 PDGFA-2 HRASPDGFBPDGFA-1 PDGFPhospho-PDGF receptor dimerPI3KPDGF alpha/betaPDGF AB and BB dimersPIK3R1 STAT3 PDGF precursor dimers 3x4Hyp-3Hyp-COL6A2 ATPCRKL Active PDGF dimers p-12Y-PDGFRB PDGFB RAPGEF1PDGFA-1 COL4A4PDGFA-2 GlcGalHyl-COL6A1 PDGFPhospho-PDGF receptor dimerGrb7PDGFA-1 PDGF beta receptorPDGF chain B homodimer202315, 22


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Wikipathways-description 
Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell.

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=186797

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Bibliography

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History

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CompareRevisionActionTimeUserComment
101493view11:36, 1 November 2018ReactomeTeamreactome version 66
101030view21:16, 31 October 2018ReactomeTeamreactome version 65
100563view19:50, 31 October 2018ReactomeTeamreactome version 64
100111view16:35, 31 October 2018ReactomeTeamreactome version 63
99661view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99261view12:45, 31 October 2018ReactomeTeamreactome version 62
93838view13:40, 16 August 2017ReactomeTeamreactome version 61
93393view11:22, 9 August 2017ReactomeTeamreactome version 61
86479view09:19, 11 July 2016ReactomeTeamreactome version 56
83084view09:55, 18 November 2015ReactomeTeamVersion54
81405view12:56, 21 August 2015ReactomeTeamVersion53
76874view08:14, 17 July 2014ReactomeTeamFixed remaining interactions
76579view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75912view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75612view10:47, 10 June 2014ReactomeTeamReactome 48 Update
74967view13:48, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74611view08:39, 30 April 2014ReactomeTeamReactome46
45212view17:24, 7 October 2011KhanspersOntology Term : 'PDGF signaling pathway' added !
42132view21:59, 4 March 2011MaintBotAutomatic update
39942view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3x4Hyp-3Hyp-5Hyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-5Hyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GlcGalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-3Hyp-GlcGalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-5Hyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-5Hyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-GalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-GalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
3x4Hyp-GlcGalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
3x4Hyp-GlcGalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
5Hyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
5Hyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
Active PDGF dimers ComplexREACT_17802 (Reactome)
Active PDGF dimers ComplexREACT_17845 (Reactome)
BCAR1 ProteinP56945 (Uniprot-TrEMBL)
BCAR1ProteinP56945 (Uniprot-TrEMBL)
COL4A1ProteinP02462 (Uniprot-TrEMBL)
COL4A2ProteinP08572 (Uniprot-TrEMBL)
COL4A3ProteinQ01955 (Uniprot-TrEMBL)
COL4A4ProteinP53420 (Uniprot-TrEMBL)
COL4A5ProteinP29400 (Uniprot-TrEMBL)
COL6A1 ProteinP12109 (Uniprot-TrEMBL)
COL6A2 ProteinP12110 (Uniprot-TrEMBL)
COL9A1 ProteinP20849 (Uniprot-TrEMBL)
COL9A2 ProteinQ14055 (Uniprot-TrEMBL)
COL9A3 ProteinQ14050 (Uniprot-TrEMBL)
CRK, CRKLProteinREACT_17492 (Reactome)
CRKL ProteinP46109 (Uniprot-TrEMBL)
CRKProteinP46108 (Uniprot-TrEMBL)
Classical PDGF precursor dimers ComplexREACT_17671 (Reactome)
Cleaved classical PDGF peptidesProteinREACT_17262 (Reactome)
Cleaved novel PDGF fragmentsProteinREACT_18041 (Reactome)
DAG and IP3 signalingPathwayREACT_111064 (Reactome) This pathway describes the generation of DAG and IP3 by the PLCgamma-mediated hydrolysis of PIP2 and the subsequent downstream signaling events.
Extracellular matrix ligandsProteinREACT_17129 (Reactome)
FURINProteinP09958 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2 SOS1ComplexREACT_4435 (Reactome)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GRB7 ProteinQ14451 (Uniprot-TrEMBL)
GRB7ProteinQ14451 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
GalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
GalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
GlcGalHyl-COL6A1 ProteinP12109 (Uniprot-TrEMBL)
GlcGalHyl-COL6A2 ProteinP12110 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
Heparan sulfate N-acetyl-alpha-D-glucosaminide MetaboliteCHEBI:17421 (ChEBI)
Heparan sulfate alpha-D-glucosaminide MetaboliteCHEBI:18137 (ChEBI)
KRASProteinP01116 (Uniprot-TrEMBL)
NCK1 ProteinP16333 (Uniprot-TrEMBL)
NCK2 ProteinO43639 (Uniprot-TrEMBL)
NCKProteinREACT_17190 (Reactome)
NRAS ProteinP01111 (Uniprot-TrEMBL)
Novel PDGF precursor dimers ComplexREACT_17079 (Reactome)
Novel PDGF precursor dimers ComplexREACT_17162 (Reactome)
PDGF PDGF receptor dimerComplexREACT_18025 (Reactome)
PDGF

Phospho-PDGF receptor dimer Crk p130Cas

C3G
ComplexREACT_17351 (Reactome)
PDGF

Phospho-PDGF receptor dimer

Crk
ComplexREACT_17941 (Reactome)
PDGF

Phospho-PDGF receptor dimer Grb2

Sos1
ComplexREACT_18248 (Reactome)
PDGF

Phospho-PDGF receptor dimer

Grb7
ComplexREACT_17607 (Reactome)
PDGF

Phospho-PDGF receptor dimer

PI3K
ComplexREACT_17825 (Reactome)
PDGF

Phospho-PDGF receptor dimer

PLC-gamma
ComplexREACT_17327 (Reactome)
PDGF

Phospho-PDGF receptor dimer

SHP2
ComplexREACT_17654 (Reactome)
PDGF

Phospho-PDGF receptor dimer

Src
ComplexREACT_18132 (Reactome)
PDGF

Phospho-PDGF receptor dimer

phospho-Src
ComplexREACT_17206 (Reactome)
PDGF Phospho-PDGF receptor dimerComplexREACT_17756 (Reactome)
PDGF

Phospho-PDGFR receptor dimer

Nck
ComplexREACT_17490 (Reactome)
PDGF

p-PDGFR dimer

p-PLCgamma
ComplexREACT_111673 (Reactome)
PDGF

phospho-PDGF receptor dimer

STAT
ComplexREACT_17883 (Reactome)
PDGF A and B chains ECM complexComplexREACT_17710 (Reactome)
PDGF A and B chains with retention motifProteinREACT_17714 (Reactome)
PDGF alpha receptor PDGF dimersComplexREACT_17393 (Reactome)
PDGF alpha/beta PDGF AB and BB dimersComplexREACT_17544 (Reactome)
PDGF beta receptor PDGF chain B homodimerComplexREACT_17457 (Reactome)
PDGF precursor dimers ComplexREACT_17541 (Reactome)
PDGF precursor dimers ComplexREACT_17912 (Reactome)
PDGF receptor monomerProteinREACT_18211 (Reactome)
PDGFA-1 ProteinP04085-1 (Uniprot-TrEMBL)
PDGFA-2 ProteinP04085-2 (Uniprot-TrEMBL)
PDGFB ProteinP01127 (Uniprot-TrEMBL)
PDGFBProteinP01127 (Uniprot-TrEMBL)
PDGFRA ProteinP16234 (Uniprot-TrEMBL)
PDGFRB ProteinP09619 (Uniprot-TrEMBL)
PI3KComplexREACT_4240 (Reactome)
PIMetaboliteCHEBI:16618 (ChEBI)
PIMetaboliteCHEBI:18348 (ChEBI)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIP3 activates AKT signalingPathwayREACT_75829 (Reactome) Signaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimulated cells, PI3K class IA enzymes reside in the cytosol as inactive heterodimers composed of p85 regulatory subunit and p110 catalytic subunit. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Upon binding of extracellular ligands to RTKs, receptors dimerize and undergo autophosphorylation. The regulatory subunit of PI3K, p85, is recruited to phosphorylated cytosolic RTK domains either directly or indirectly, through adaptor proteins, leading to a conformational change in the PI3K IA heterodimer that relieves inhibition of the p110 catalytic subunit. Activated PI3K IA phosphorylates PIP2, converting it to PIP3; this reaction is negatively regulated by PTEN phosphatase. PIP3 recruits AKT to the plasma membrane, allowing TORC2 to phosphorylate a conserved serine residue of AKT. Phosphorylation of this serine induces a conformation change in AKT, exposing a conserved threonine residue that is then phosphorylated by PDPK1 (PDK1). Phosphorylation of both the threonine and the serine residue is required to fully activate AKT. The active AKT then dissociates from PIP3 and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007.
PLCG1ProteinP19174 (Uniprot-TrEMBL)
PTPN11 ProteinQ06124 (Uniprot-TrEMBL)
PTPN11ProteinQ06124 (Uniprot-TrEMBL)
Phospho PDGF alpha receptor PDGF dimersComplexREACT_17261 (Reactome)
Phospho PDGF alpha-beta dimer PDGF AB or BB dimersComplexREACT_17875 (Reactome)
Phospho PDGF beta receptor PDGF chain B homodimerComplexREACT_17403 (Reactome)
Phospho-beta receptor homodimer GAPComplexREACT_17783 (Reactome)
RAF/MAP kinase cascadePathwayREACT_634 (Reactome) The MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a common 'module' in the transmission of an extracellular signal into the nucleus.
RAPGEF1 ProteinQ13905 (Uniprot-TrEMBL)
RAPGEF1ProteinQ13905 (Uniprot-TrEMBL)
RASA1 ProteinP20936 (Uniprot-TrEMBL)
RASA1ProteinP20936 (Uniprot-TrEMBL)
SOS1 ProteinQ07889 (Uniprot-TrEMBL)
SPP1ProteinP10451 (Uniprot-TrEMBL)
SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
SRC-1ProteinP12931-1 (Uniprot-TrEMBL)
STAT family membersProteinREACT_17706 (Reactome)
STAT1 ProteinP42224 (Uniprot-TrEMBL)
STAT3 ProteinP40763 (Uniprot-TrEMBL)
STAT5A ProteinP42229 (Uniprot-TrEMBL)
STAT5B ProteinP51692 (Uniprot-TrEMBL)
STAT6 ProteinP42226 (Uniprot-TrEMBL)
THBS1 ProteinP07996 (Uniprot-TrEMBL)
THBS2 ProteinP35442 (Uniprot-TrEMBL)
THBS3 ProteinP49746 (Uniprot-TrEMBL)
THBS4 ProteinP35443 (Uniprot-TrEMBL)
p-11Y-PDGFRA ProteinP16234 (Uniprot-TrEMBL)
p-12Y-PDGFRB ProteinP09619 (Uniprot-TrEMBL)
p-4Y-PLCG1 ProteinP19174 (Uniprot-TrEMBL)
p-4Y-PLCG1ProteinP19174 (Uniprot-TrEMBL)
p-Y419-SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
p21 RAS GDPComplexREACT_2657 (Reactome)
p21 RAS GTPComplexREACT_4782 (Reactome)
serine-type endopeptidases involved in novel PDGF processingREACT_17837 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ADPArrowREACT_16877 (Reactome)
ADPArrowREACT_16926 (Reactome)
ADPArrowREACT_16991 (Reactome)
ADPArrowREACT_16993 (Reactome)
ADPArrowREACT_17034 (Reactome)
ATPREACT_16877 (Reactome)
ATPREACT_16926 (Reactome)
ATPREACT_16991 (Reactome)
ATPREACT_16993 (Reactome)
ATPREACT_17034 (Reactome)
Active PDGF dimers ArrowREACT_16891 (Reactome)
Active PDGF dimers ArrowREACT_17059 (Reactome)
Active PDGF dimers REACT_16905 (Reactome)
BCAR1REACT_16951 (Reactome)
CRK, CRKLREACT_16940 (Reactome)
Cleaved classical PDGF peptidesArrowREACT_17059 (Reactome)