Signaling by PDGF (Homo sapiens)

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1-31, 2, 2322, 10, 112, 20, 211, 2, 242, 12, 131623, 61, 7-92, 222, 25, 2632, 18, 1931, 2, 2222, 173, 622, 191, 2, 14, 15endoplasmic reticulum lumenextracellular regionGolgi lumencytosolADPCrk isoformsp130CasPhospholipase C gamma 1Novel PDGF precursor dimers (CC, DD)p21 RAS:GTPADPPhosphatidylinositol-4,5-bisphosphateNovel PDGF precursor dimers (CC, DD)Active PDGF dimers (AA, AB, BB)Phosphatidylinositol-3,4,5-trisphosphateATPSRCGrb7GRB2:SOS1Phospho-beta receptor homodimer:GAPPhosphatidylinositol-4,5-bisphosphatePDGF:PDGF receptor dimerPDGF beta receptor:PDGF chain B homodimerPDGF:phospho-PDGF receptor dimer:STATPDGF:Phospho-PDGF receptor dimerPDGF:Phospho-PDGF receptor dimer:CrkActive PDGF dimers (CC, DD)STAT family membersPDGF:Phospho-PDGF receptor dimer:PI3KPDGF:Phospho-PDGF receptor dimer:phospho-SrcATPPDGF alpha/beta:PDGF AB and BB dimersCleaved novel PDGF fragmentsCleaved classical PDGF peptidesdiacylglycerolsPDGF alpha receptor: PDGF dimersPDGF:Phospho-PDGF receptor dimer:SHP2ADPPDGF:Phospho-PDGF receptor dimer:Grb7ADPPDGF:Phospho-PDGF receptor dimer:Grb2:Sos1Phospho PDGF alpha receptor:PDGF dimersRas GTPase-activating protein 1PDGF A and B chains:ECM complexPDGF receptor monomerPDGF A and B chains with retention motifNCKClassical PDGF precursor dimers (AA, AB, BB)serine-type endopeptidases involved in novel PDGF processingfurinRAF activationATPC3G isoform 1ATPGDPPI3KPDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3GPDGF precursor dimers (AA, BB, A/B, CC, DD)ADPSHP2MAP kinase cascadeExtracellular matrix ligandsPDGF precursor dimers (AA, BB, A/B, CC, DD)PDGF:Phospho-PDGF receptor dimer:PLC-gammap21 RAS:GDPPhospho PDGF alpha-beta dimer:PDGF AB or BB dimersATPPDGF:Phospho-PDGF receptor dimer:SrcPDGF:Phospho-PDGFR receptor dimer:Nck1D-myo-Inositol 1,4,5-trisphosphatePhospho PDGF beta receptor: PDGF chain B homodimerH2OGTP45


Description

Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
101493view11:36, 1 November 2018ReactomeTeamreactome version 66
101030view21:16, 31 October 2018ReactomeTeamreactome version 65
100563view19:50, 31 October 2018ReactomeTeamreactome version 64
100111view16:35, 31 October 2018ReactomeTeamreactome version 63
99661view15:06, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99261view12:45, 31 October 2018ReactomeTeamreactome version 62
93838view13:40, 16 August 2017ReactomeTeamreactome version 61
93393view11:22, 9 August 2017ReactomeTeamreactome version 61
86479view09:19, 11 July 2016ReactomeTeamreactome version 56
83084view09:55, 18 November 2015ReactomeTeamVersion54
81405view12:56, 21 August 2015ReactomeTeamVersion53
76874view08:14, 17 July 2014ReactomeTeamFixed remaining interactions
76579view11:56, 16 July 2014ReactomeTeamFixed remaining interactions
75912view09:56, 11 June 2014ReactomeTeamRe-fixing comment source
75612view10:47, 10 June 2014ReactomeTeamReactome 48 Update
74967view13:48, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74611view08:39, 30 April 2014ReactomeTeamReactome46
45212view17:24, 7 October 2011KhanspersOntology Term : 'PDGF signaling pathway' added !
42132view21:59, 4 March 2011MaintBotAutomatic update
39942view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1D-myo-Inositol

1,4,5-trisphosphate

Metabolite16595 (ChEBI)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
Active PDGF dimers

(AA, AB, BB)

ComplexREACT_17845 (Reactome)
Active PDGF dimers

(CC, DD)

ComplexREACT_17802 (Reactome)
C3G isoform 1 ProteinQ13905-1 (UniProt)
Classical PDGF

precursor dimers (AA, AB, BB)

ComplexREACT_17671 (Reactome)
Cleaved classical

PDGF peptides

ProteinREACT_17262 (Reactome)
Cleaved novel PDGF

fragments

ProteinREACT_18041 (Reactome)
Crk isoforms ProteinREACT_17492 (Reactome)
Extracellular matrix

ligands

ProteinREACT_17129 (Reactome)
GDP Metabolite17552 (ChEBI)
GRB2:

SOS1

ComplexREACT_4435 (Reactome)
GTP Metabolite15996 (ChEBI)
Grb7 ProteinQ14451 (UniProt)
H2O Metabolite15377 (ChEBI)
MAP kinase

cascade

PathwayREACT_634 (Reactome) The MAP kinase cascade describes a sequence of phosphorylation events involving serine/threonine-specific protein kinases. Used by various signal transduction pathways, this cascade constitutes a common 'module' in the transmission of an extracellular signal into the nucleus.
NCK ProteinREACT_17190 (Reactome)
Novel PDGF

precursor dimers (CC, DD)

ComplexREACT_17079 (Reactome)
Novel PDGF

precursor dimers (CC, DD)

ComplexREACT_17162 (Reactome)
PDGF A and B chains

with retention motif

ProteinREACT_17714 (Reactome)
PDGF A and B chains:

ECM complex

ComplexREACT_17710 (Reactome)
PDGF alpha

receptor: PDGF dimers

ComplexREACT_17393 (Reactome)
PDGF alpha/beta:

PDGF AB and BB dimers

ComplexREACT_17544 (Reactome)
PDGF beta receptor:

PDGF chain B homodimer

ComplexREACT_17457 (Reactome)
PDGF precursor

dimers (AA, BB, A/B, CC, DD)

ComplexREACT_17541 (Reactome)
PDGF precursor

dimers (AA, BB, A/B, CC, DD)

ComplexREACT_17912 (Reactome)
PDGF receptor

monomer

ProteinREACT_18211 (Reactome)
PDGF:PDGF receptor

dimer

ComplexREACT_18025 (Reactome)
PDGF:Phospho-

PDGFR receptor dimer:Nck

ComplexREACT_17490 (Reactome)
PDGF:Phospho-PDGF

receptor dimer

ComplexREACT_17756 (Reactome)
PDGF:Phospho-PDGF

receptor dimer: phospho-Src

ComplexREACT_17206 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:Crk

ComplexREACT_17941 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:Crk: p130Cas:C3G

ComplexREACT_17351 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:Grb2: Sos1

ComplexREACT_18248 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:Grb7

ComplexREACT_17607 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:PI3K

ComplexREACT_17825 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:PLC- gamma

ComplexREACT_17327 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:SHP2

ComplexREACT_17654 (Reactome)
PDGF:Phospho-PDGF

receptor dimer:Src

ComplexREACT_18132 (Reactome)
PDGF:phospho-

PDGF receptor dimer:STAT

ComplexREACT_17883 (Reactome)
PI3K ComplexREACT_4240 (Reactome)
Phosphatidylinositol-

3,4,5-trisphosphate

Metabolite16618 (ChEBI)
Phosphatidylinositol-

4,5-bisphosphate

Metabolite18348 (ChEBI)
Phospho PDGF

alpha-beta dimer: PDGF AB or BB dimers

ComplexREACT_17875 (Reactome)
Phospho PDGF alpha

receptor:PDGF dimers

ComplexREACT_17261 (Reactome)
Phospho PDGF beta

receptor: PDGF chain B homodimer

ComplexREACT_17403 (Reactome)
Phospho-beta

receptor homodimer:GAP

ComplexREACT_17783 (Reactome)
Phospholipase C

gamma 1

ProteinP19174 (UniProt)
RAF activation PathwayREACT_2077 (Reactome) Phosphorylated RAF is activated by Ras binding and stabilised in its active form by transient disassociation and reassociation of 14-3-3, as well as further phosphorylation.
Ras GTPase-

activating protein 1

ProteinP20936 (UniProt)
SHP2 ProteinQ06124 (UniProt)
SRC ProteinP12931-1 (UniProt)
STAT family

members

ProteinREACT_17706 (Reactome)
diacylglycerols Metabolite18035 (ChEBI)
furin ProteinP09958 (UniProt)
p130Cas ProteinP56945 (UniProt)
p21 RAS:GDP ComplexREACT_2657 (Reactome)
p21 RAS:GTP ComplexREACT_4782 (Reactome)
serine-type

endopeptidases involved in novel PDGF processing

UnknownREACT_17837 (Reactome)

Annotated Interactions

No annotated interactions

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