Semaphorin interactions (Homo sapiens)

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21, 30, 31, 41, 44537, 22, 5019, 561461, 315, 23, 264525, 4622, 5013, 42, 48453933, 5123, 29, 342, 5, 16, 43, 474, 23, 2817, 32, 35, 5817, 32, 5812, 2040, 5598, 18, 27, 4918, 3810, 11, 36, 54, 5724, 3732, 555852cytosolcytosolcytosolcytosolcytosolPLXNA4 CD72PLXNA1 MYL6 ITGB1 ERBB2 PLXNA2 RHOB ADPNRP1:PlexinA1-4:FYNSEMA4D:pPlexin-B1:ErbB2 complexSEMA6D RND1 PAK2 RAC1:GTPp-Y-PLXNA3 ROCK1 ADPRhoA (Mgcofactor):GDPRAC1 PLXNA3 CDC42 ATPMYH11 MyrG-CDK5R1(2-307) SEMA3A SEMA3A RAC1:GTPPLXNA4 NRP1 PIP5K1C ERBB2 SEMA4DGTP NRP1PLXNB1 PiSEMA5A:PLXNB3RhoA,B,C:GDPNRP1 ERBB2 p-Y-PLXNB1 Sema3A:Nrp-1:PlexinA:FynGTPp-S522-DPYSL3 GTP FYN NRP1 RND1 PLXNA1 MyrG-CDK5R1(2-307) SEMA6DSema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1ROCK2 RAC1 ARHGEF11 HSP90AB1 RAC1 SEMA4D p-Y-DPYSL5 ADPSEMA3A PAK3 p-Y-DPYSL2 CFL1PLXNB3SEMA4D:PTPRCGDPSEMA3A SEMA3ESEMA4D dimerROCK1,ROCK2p-S,T508-LIMK1 ARHGEF12 NRP1 GTP SEMA3A p-T509,T514,S518,S522-DPYSL2 p-T19,S20-MRLC-smooth muscle/non-muscle myosin IIPTPRCPAK3 p-T19,S20-MYL12B PLXNC1MET SEMA6A:PLXNA2,PLXNA4Sema4D:pPlexin-B1:Metp-S534-DPYSL5 RHOA PLXND1Mg2+ ADPPLXNA3 ARHGAP35 CRMP's tetramersFYN PAK1 RND1 GDP Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKPiSEMA4D NRP1 RND1 RHOB ARHGAP35FYN RHOG p-Y-PLXNA1 Sema3A dimerFYN GTPMET SEMA4A GDPNRP1 R-Ras-GDPMYH14 RAC1 PLXNA3 GTP Sema4D:Plexin-B1:Rac-Rnd1:LARG/PDZ-RhoGEFGTP p-Y15-CDK5 RAC1 FESPLXNA2 HSP90AA1 ADPPLXNA1 FYN SEMA7APLXNC1 SEMA4D SEMA3A SEMA5ARHOA p-Y-PLXNA4 PLXNA3 p-Y-PLXNB1 PipCofilin: ActiveLIMK-1GTP Integrin alpha1beta1TLN1 PLXNA4 MYH11 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPNRP1 HSP90AA1,HSP90AB1PLXNA1 CDK5 PLXNA2 FYN MYL9 p-Y-PLXNA1 p-T509,T514,S518,S522-CRMP1 SEMA3A:PLXND1FYN PLXNA2,PLXNA4PLXND1Active LIMK1RRAS SEMA4D dimerRnd1-GTPp-Y-PLXNA2 RHOA SEMA7A PLXNA4 TLN1FES p-T505-LIMK2 GTP p-Y-PLXNA2 p-Y-PLXNB1 PLXNA3 MYH14 PLXNA2 FES PLXNA1 MET LIM KinasesGTP p-Y15-CDK5 pLIMK dimer:HSP-90SEMA6A RAC1 PLXNA4 RHOA p-S544-DPYSL4 SEMA4D PLXND1 GDP ADPSema3A:NP-1:Plexin-A:Fes:CRMPSEMA4D p-Y-PLXNB1 RAC2 GTP Smoothmuscle/non-musclemyosin IISEMA6ALIMK1 HSP90AA1 Sema4D:pPlexin-B1:ErbB2:Rac1:Rnd1SEMA3A Sema4D:Plexin-B1:p190RhoGAP:Rac:Rnd1RHOA p-Y-PLXNA2 PLXNA1 RAC2 Cdk5:p35Sema3A dimerITGA1 ATPARHGEF12 PLXNA4 PLXNA4 p-LIMKGDP SEMA3A PLXNA1:TREM2:DAP12p-Y-PLXNA1 LIMK2 Plexin-B1:ErbB2FARP2 ADPp-T508-LIMK1LIMK1PIP5K1C p-T508-LIMK1 RHOC p-S,T508-LIMK1 p-T19,S20-MYL9 PTPRC SEMA6D:PLXNA1:TREM2:DAP12p-Y-PLXNA1 PLXNA3 MyrG-CDK5R1(2-307) RHOA/B/C:GTPFES SEMA4D p-Y-PLXNA3 ATPERBB2 ATPROCK1 SEMA3E SEMA4D:CD72RND1 GDP HSP90AB1 Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sNRP1 ATPDPYSL5 PLXNA2 PAK2 MYH9 FYN RAC1 p-Y-PLXNA2 TYROBP SEMA3A p-S154,T436-PAK3 MYL12B ROCK2 FES DPYSL4 CD72 p-Y-PLXNA1 PLXNA3 PLXNA4 Sema4D:pPlexin-B1:Met:Rnd1SEMA4D ADPFYN PIP5K1gamma:Talin-1SEMA5A FYN p-S522-DPYSL2 FARP2 FYN ADPNRP1 GTP GTP SEMA4D TYROBP RND1 Plexin-B1:MetSEMA3A SEMA4ARAC1 PLXNA2 PLXNA4 SEMA4D PLXND1 PAK1,2,3p-Y-PLXNA3 Sema4D:pPlexin-B1:Met:RAC1-GTPSema3A:Nrp-1:PlexinA:Fynp-T509,T514,S518,S522-DPYSL3 p-Y-PLXNA4 p-S534-DPYSL5 ATPGTP CDC42 p-Y-PLXNA3 GTP p-Y-PLXNA4 SEMA4D FYN GSK3BITGB1 ATPARHGEF11 p-S544-DPYSL4 Plexin-A1-4:FYNPLXNA1 RHOG Mg2+ RAC1 p-S522-CRMP1 p-Y-DPYSL4 ATPPAK2 p-Y-PLXNA4 RHOB PAK3 SEMA7A:Integrinalpha1beta1RhoA (Mgcofactor):GTPMYH10 GTP DPYSL3 ADPp-Y-PLXNB1 p-S141,T402-PAK2 RAC1 MYL6 ATPPLXNA4 Sema3A:Nrp-1:PlexinA:Fyn:pCdk5R-Ras-GDPp-Y-PLXNA4 GTP FES RND1 p-S3-CFL1 PLXNA2 PLXNA1 FARP2Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAKp-S144,T423-PAK1 MET NRP1 Sema3A:NRP-1:pPlexin-A:Fyn:FesFARP2:PIP5KIgammaTREM2 MET MYH9 SEMA4D FYN ADPPLXNB3 p-Y-CRMP1 R-Ras-GTPITGA1 RHOC R-Ras-GTPATPSEMA7A:PLXNC1p-Y-PLXNB1 p-Y-PLXNA3 FYN RHOC GTP TREM2 MYH10 p-Y-DPYSL3 RHOA CRMP1 ATPPLXNA2 ATPSema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sPLXNA3 NRP1:PlexinA1-4:FARP2:FYNPLXNA2 p-Y-PLXNA2 RAC1:GDPNRP1 GTP SEMA3A Rnd1-GTPATPSEMA7A p-Y-PLXNB1 ADPPLXNA1 PLXNA1 p-Y-PLXNA2 p-Y-PLXNA4 PLXNB1 SEMA4A:PLXND1GTP RRAS RHOA GDP p-Y-PLXNA1 ADPPAK1 ActivatedROCK:RhoA/B/C:GTPp-Y15-CDK5 p-Y-PLXNA3 RRAS FES p-T508-LIMK1 NRP1 DPYSL2 PAK1 MyrG-CDK5R1(2-307) PLXNA2 NRP1 SEMA3A RRAS SEMA3A PAK1,2,3 dimerLARG and PDZ-RhoGEF


Description

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 373755
Reactome-version 
Reactome version: 62
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Ontology Terms

 

Bibliography

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History

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101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018ReactomeTeamreactome version 65
100540view19:46, 31 October 2018ReactomeTeamreactome version 64
100088view16:31, 31 October 2018ReactomeTeamreactome version 63
99638view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99241view12:44, 31 October 2018ReactomeTeamreactome version 62
94051view13:54, 16 August 2017