Semaphorin interactions (Homo sapiens)

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1, 16, 21, 36, 5628, 455432, 5324, 6, 50, 547, 9, 1711, 42, 473920, 5010, 181412, 2441, 575812, 15, 52, 5522, 32, 5338, 436, 50, 54517, 34, 4913, 23, 26, 37, 40148, 25, 30, 46, 513520, 3329, 483, 17, 311927, 44cytosolcytosolcytosolcytosolcytosolFYN MYH11 NRP1 GTP PLXNA2 SEMA4D SEMA3A PLXNA4 RAC1 LIMK2 PLXNA2 ATPSEMA4D ERBB2 PIP5K1C p-T505-LIMK2 PLXNB1 p-Y-PLXNA2 GTP SEMA3A p-T19,S20-MYL12B PLXNA1 PLXND1Sema4D:Plexin-B1:p190RhoGAP:Rac:Rnd1SEMA4D:PTPRCSema3A:NRP-1:pPlexin-A:Fyn:FesMET PLXNA2 SEMA4AARHGEF11 FYN GDPSEMA7Ap-Y-PLXNA4 Sema3A dimerRhoA (Mgcofactor):GTPp-Y-DPYSL5 Rnd1-GTPSEMA6A NRP1 SEMA3A FARP2 PLXNA2 FYN RAC1 TYROBP PLXNA3 p-Y-DPYSL2 CD72p-Y-PLXNA2 SEMA4D p-Y-PLXNA1 p-Y-PLXNA4 SEMA7A PLXNA2 LIMK1 PLXNA1 RAC1 ROCK1,ROCK2PLXNA1 PLXNA4 ATPATPPLXNB3 HSP90AB1 RHOA NRP1 SEMA3A p-Y-PLXNA2 Sema3A:NP-1:Plexin-A:Fes:CRMPARHGAP35Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sADPGTP RRAS NRP1:PlexinA1-4:FYNSEMA4D PTPRC ATPFES GTP PiGTPTLN1RRAS SEMA5A SEMA4Dp-Y-PLXNA1 p-S144,T423-PAK1 Plexin-B1:Metp-Y-PLXNB1 ADPPLXND1GDPSEMA4D MYL12B SEMA3A CRMP's tetramersGTP CD72 PLXNA4 SEMA6D:PLXNA1:TREM2:DAP12CRMP1 RND1 MYH9 ATPCdk5:p35FYN p-T508-LIMK1RHOG ARHGEF12 FES p-Y-PLXNB1 PLXNA3 SEMA6DSEMA7A RHOG FARP2 CDC42 NRP1 ADPSema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPSEMA3A p-LIMKSEMA4D dimerPLXNA2 RND1 MYH14 ADPSEMA3EPAK1 PLXNA4 p-Y-PLXNA4 p-T19,S20-MRLC-smooth muscle/non-muscle myosin IIMYH9 RHOB NRP1PLXNA1:TREM2:DAP12GDP p-S522-DPYSL3 p-Y-PLXNA3 p-S534-DPYSL5 SEMA4D ActivatedROCK:RhoA/B/C:GTPROCK1 FARP2SEMA4D RHOC p-Y-PLXNA4 CDC42 FYN GTP R-Ras-GDPRAC2 SEMA3A MET ADPFYN p-Y15-CDK5 HSP90AA1 NRP1 Sema3A:Nrp-1:PlexinA:Fyn:pCdk5NRP1 GDP ARHGEF12 NRP1 DPYSL5 Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAKp-Y-PLXNA1 HSP90AB1 NRP1 p-Y-DPYSL4 FARP2:PIP5KIgammaSEMA5A:PLXNB3PLXNA1 DPYSL3 MYL6 FESRRAS RND1 TREM2 NRP1:PlexinA1-4:FARP2:FYNPLXNA2,PLXNA4GTP GTP p-Y-PLXNB1 Plexin-A1-4:FYNMET Integrin alpha1beta1R-Ras-GTPp-S,T508-LIMK1 R-Ras-GTPp-T509,T514,S518,S522-DPYSL2 p-Y-PLXNA3 NRP1 PAK1,2,3RHOA Active LIMK1PAK1 SEMA4D p-S3-CFL1 RAC1 Sema4D:pPlexin-B1:ErbB2:Rac1:Rnd1FYN GTPRAC1 ITGA1 PLXNA4 HSP90AA1,HSP90AB1p-S544-DPYSL4 GTP GTP SEMA4D:pPlexin-B1:ErbB2 complexSema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sRHOA PLXNA3 MyrG-CDK5R1(2-307) ARHGAP35 GTP MYL6 ATPGDP p-Y-PLXNA1 PAK2 ROCK2 PLXNA3 RHOB ERBB2 FYN HSP90AA1 GDP MYH10 MYH11 Sema3A:Nrp-1:PlexinA:FynRHOA/B/C:GTPp-Y-PLXNA4 ARHGEF11 Mg2+ p-S154,T436-PAK3 R-Ras-GDPMg2+ PLXNA3 PLXNA1 MyrG-CDK5R1(2-307) RAC1:GTPSEMA3A:PLXND1RAC1 p-Y-PLXNB1 FES SEMA6AMYH14 RAC1 ADPPAK2 PLXNA2 GTP p-T19,S20-MYL9 p-T508-LIMK1 p-Y-PLXNA2 GTP RAC1:GDPTREM2 PLXNC1RHOA PiRHOB PLXNA3 ADPPLXND1 p-Y-PLXNA4 ADPSEMA3E Sema4D:pPlexin-B1:MetpLIMK dimer:HSP-90PLXNA4 p-Y-PLXNA3 PiRAC1 RND1 SEMA3A NRP1 NRP1 ATPPAK1,2,3 dimerSmoothmuscle/non-musclemyosin IIp-Y-PLXNB1 ERBB2 PLXNA4 TYROBP SEMA7A:PLXNC1RND1 FYN SEMA6D SEMA4D ITGB1 ADPPLXND1 SEMA4D dimerSema4D:Plexin-B1:Rac-Rnd1:LARG/PDZ-RhoGEFPLXNA2 PIP5K1gamma:Talin-1p-Y-PLXNA1 PLXNA2 RND1 TLN1 RHOA LIMK1p-S522-CRMP1 FYN NRP1 RHOA PLXNA3 RRAS RAC1:GTPPLXNA4 SEMA4D:CD72MET RHOC p-Y-PLXNB1 SEMA3A FYN PLXNB3ERBB2 Plexin-B1:ErbB2GSK3BSEMA3A FYN PLXNA1 PLXNB1 GTP PAK3 SEMA4A NRP1 FES PLXNA1 GDP Sema4D:pPlexin-B1:Met:Rnd1PAK3 RHOA ATPSema3A dimerMET ADPp-S534-DPYSL5 PTPRCPLXNA1 MYL9 p-S522-DPYSL2 PAK3 ROCK1 pCofilin: ActiveLIMK-1p-Y-PLXNB1 MyrG-CDK5R1(2-307) FES RAC2 p-S,T508-LIMK1 LIM KinasesATPMYH10 p-Y-CRMP1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1p-Y-PLXNA3 ADPATPRND1 SEMA3A ITGA1 p-T509,T514,S518,S522-CRMP1 DPYSL4 LARG and PDZ-RhoGEFSEMA3A SEMA4A:PLXND1Rnd1-GTPPLXNA4 SEMA7A:Integrinalpha1beta1SEMA6A:PLXNA2,PLXNA4ATPp-Y-DPYSL3 PLXNA4 p-Y-PLXNA3 FYN FES ADPp-T509,T514,S518,S522-DPYSL3 SEMA3A PLXNC1 RAC1 ROCK2 p-Y15-CDK5 CDK5 ATPGTP p-Y-PLXNA3 RhoA (Mgcofactor):GDPSEMA4D Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKSema4D:pPlexin-B1:Met:RAC1-GTPp-Y-PLXNA2 RAC1 p-S544-DPYSL4 ADPPAK1 PLXNA1 PLXNA2 GTP MyrG-CDK5R1(2-307) RhoA,B,C:GDPp-T508-LIMK1 p-S141,T402-PAK2 CFL1RHOC SEMA5APLXNA1 Sema3A:Nrp-1:PlexinA:FynPLXNA3 p-Y-PLXNA1 SEMA4D ATPPIP5K1C PAK2 p-Y-PLXNA2 GTP ITGB1 FYN DPYSL2 p-Y15-CDK5 GTP


Description

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 373755
Reactome-version 
Reactome version: 62
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Ontology Terms

 

Bibliography

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History

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101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018ReactomeTeamreactome version 65
100540view19:46, 31 October 2018ReactomeTeamreactome version 64
100088view16:31, 31 October 2018ReactomeTeamreactome version 63
99638view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99241view12:44, 31 October 2018ReactomeTeamreactome version 62
94051view13:54, 16 August 2017