Semaphorin interactions (Homo sapiens)

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3, 4, 10, 17, 23495, 8, 19, 4026167, 5233, 3927, 3128, 38, 46, 47, 535134, 37, 42, 51216, 5512, 15, 482, 2919, 222, 25, 2913, 30, 4850, 541, 24, 571837, 42, 512631, 42589, 3511, 2014, 32, 4836, 41, 43, 45, 5644cytosolcytosolcytosolcytosolcytosolp-Y-DPYSL5 SEMA3A p-Y-PLXNB1 SEMA5ARHOC MET RND1 MYH10 ADPp-S534-DPYSL5 PLXNA2 p-Y-PLXNA1 PLXNA2 DPYSL5 PAK3 RAC2 GTP RAC1 p-Y-DPYSL2 SEMA4D dimerPLXNA3 SEMA4D NRP1 p-Y-PLXNA3 RHOA TLN1NRP1:PlexinA1-4:FYNGTP Smoothmuscle/non-musclemyosin IIp-Y-PLXNB1 p-T509,T514,S518,S522-DPYSL2 ATPFES SEMA3A p-Y-PLXNB1 RND1 RHOG PLXNA2 SEMA4D p-T509,T514,S518,S522-DPYSL3 p-S534-DPYSL5 PLXNB1 p-S522-DPYSL2 LARG and PDZ-RhoGEFHSP90AA1,HSP90AB1NRP1 p-Y-PLXNA4 R-Ras-GTPSEMA7A PIP5K1gamma:Talin-1DPYSL3 Integrin alpha1beta1PLXNA4 SEMA4AMYH10 GTP PLXNA1 FYN GTP p-Y-PLXNA3 Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAKATPRhoA (Mgcofactor):GDPRRAS SEMA7A:Integrinalpha1beta1p-S522-CRMP1 ADPFYN RAC1:GDPPLXNA3 PAK3 SEMA4D SEMA3A p-Y-PLXNA2 GDP PLXNA2 GTP FESSEMA3A PTPRC NRP1ADPLIM Kinasesp-Y-PLXNA2 PIP5K1C ARHGAP35 RAC1 HSP90AB1 Sema4D:pPlexin-B1:ErbB2:Rac1:Rnd1PAK3 ROCK2 RAC1:GTPATPFYN NRP1 p-Y15-CDK5 RAC1 RND1 Cdk5:p35PLXNA3 ADPPIP5K1C SEMA6A FYN PLXNA2 GTP PAK2 Sema4D:Plexin-B1:p190RhoGAP:Rac:Rnd1GTP MYH14 PLXND1 p-T505-LIMK2 Sema3A dimerp-S,T508-LIMK1 ATPSEMA3A FYN CDC42 CDC42 PLXNA2 Plexin-B1:ErbB2PLXNA1 RAC1 p-S141,T402-PAK2 GTP FARP2MYL6 PAK1 RHOC p-Y15-CDK5 Mg2+ SEMA4D dimerMyrG-CDK5R1(2-307) GDP Sema4D:pPlexin-B1:MetRAC1 PiNRP1 SEMA7A:PLXNC1PLXNA2 SEMA4D Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sROCK1,ROCK2FES GTP LIMK1 FYN ARHGEF12 GTP PLXND1 RND1 p-Y-PLXNB1 PLXNB1 PLXNA1 SEMA3A TREM2 ARHGEF12 NRP1 PAK1 Sema3A:NRP-1:pPlexin-A:Fyn:FesMYH11 GTP p-Y-PLXNA4 ITGB1 ADPRHOA PLXND1p-Y-PLXNA2 p-Y-PLXNA3 SEMA4A NRP1:PlexinA1-4:FARP2:FYNGTPPAK2 RAC1 PLXNA1:TREM2:DAP12ERBB2 SEMA5A MyrG-CDK5R1(2-307) ADPFES PLXNA4 PLXNA1 FARP2:PIP5KIgammaPLXNA3 ATPSEMA4D p-T508-LIMK1ATPGTP MYH11 PLXNA2,PLXNA4PLXNA4 CD72 RAC1 ITGA1 GTP FYN SEMA6ANRP1 MET CDK5 PLXNB3 Sema4D:Plexin-B1:Rac-Rnd1:LARG/PDZ-RhoGEFPAK1,2,3RAC1 RHOA p-Y-PLXNB1 RND1 RHOA Sema4D:pPlexin-B1:Met:Rnd1PAK1,2,3 dimerPLXNC1PLXNA1 pCofilin: ActiveLIMK-1Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sHSP90AA1 TYROBP p-Y-PLXNA1 ERBB2 MYL12B PLXNA4 Sema4D:pPlexin-B1:Met:RAC1-GTPNRP1 PLXNC1 SEMA3E RRAS GTP FYN ARHGEF11 p-Y-DPYSL3 FES PLXNA2 MET NRP1 p-Y-PLXNA3 PiATPSEMA3A MyrG-CDK5R1(2-307) FES SEMA7ATYROBP Rnd1-GTPCRMP's tetramersPLXNA2 p-Y-PLXNA4 SEMA3A ITGB1 NRP1 ROCK2 p-Y-PLXNA1 Plexin-A1-4:FYNSEMA6A:PLXNA2,PLXNA4RAC1 SEMA3A ATPp-Y-PLXNA1 MyrG-CDK5R1(2-307) R-Ras-GDPMYH9 ERBB2 RAC1:GTPRhoA,B,C:GDPp-LIMKMYH14 ADPPLXNA1 FYN SEMA4DSEMA3A GDP p-Y-PLXNA1 RRAS SEMA4D PLXNA3 NRP1 Sema3A:NP-1:Plexin-A:Fes:CRMPARHGEF11 p-Y-PLXNB1 p-Y-PLXNA1 SEMA4A:PLXND1SEMA4D:CD72PTPRCSEMA4D ATPp-Y-CRMP1 PLXNA4 RHOB CD72SEMA5A:PLXNB3R-Ras-GTPp-S544-DPYSL4 p-S154,T436-PAK3 PLXNB3p-Y-PLXNA4 GDPActivatedROCK:RhoA/B/C:GTPPLXNA1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPATPDPYSL2 PLXNA1 RHOB GTP RHOA/B/C:GTPGDP FYN ROCK1 ARHGAP35SEMA6D RHOA Sema3A:Nrp-1:PlexinA:FynPLXNA4 GTP SEMA3Ep-Y-PLXNA2 p-Y15-CDK5 PLXNA3 SEMA4D:pPlexin-B1:ErbB2 complexFYN PAK2 Sema3A:Nrp-1:PlexinA:Fyn:pCdk5LIMK2 p-Y-PLXNB1 RHOC CRMP1 ATPRHOB p-S544-DPYSL4 SEMA6DADPADPHSP90AA1 p-Y-PLXNA2 MYL9 SEMA3A MYH9 SEMA3A PLXNA4 RhoA (Mgcofactor):GTPFES RHOA Sema3A:Nrp-1:PlexinA:Fynp-S,T508-LIMK1 Rnd1-GTPHSP90AB1 PLXNA3 PLXND1Active LIMK1RND1 ADPFARP2 p-Y-PLXNA3 SEMA4D ATPSEMA6D:PLXNA1:TREM2:DAP12PLXNA1 FYN GSK3BLIMK1FYN SEMA4D NRP1 ITGA1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1CFL1Mg2+ GDPADPPLXNA4 GTPSEMA4D p-T508-LIMK1 FYN RRAS p-S144,T423-PAK1 MYL6 p-S3-CFL1 Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKPLXNA1 R-Ras-GDPSEMA7A p-Y-PLXNA4 pLIMK dimer:HSP-90GTP ROCK1 ADPRND1 RHOG TLN1 RAC2 MET p-Y-PLXNA4 p-T19,S20-MYL12B NRP1 PLXNA3 Pip-T508-LIMK1 PLXNA2 SEMA4D DPYSL4 p-T509,T514,S518,S522-CRMP1 SEMA3A NRP1 p-T19,S20-MRLC-smooth muscle/non-muscle myosin IIPlexin-B1:Metp-Y-DPYSL4 TREM2 PLXNA4 SEMA4D:PTPRCPAK1 p-Y-PLXNA2 RHOA SEMA3A:PLXND1FARP2 GDP MET ERBB2 p-T19,S20-MYL9 ATPRAC1 PLXNA4 Sema3A dimerp-Y-PLXNA3 ADPp-S522-DPYSL3 GTP


Description

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 373755
Reactome-version 
Reactome version: 61
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018ReactomeTeamreactome version 65
100540view19:46, 31 October 2018ReactomeTeamreactome version 64
100088view16:31, 31 October 2018ReactomeTeamreactome version 63
99638view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99241view12:44, 31 October 2018ReactomeTeamreactome version 62
94051view13:54, 16 August 2017ReactomeTeamreactome version 61
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