Semaphorin interactions (Homo sapiens)

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27, 31, 32, 41, 562, 8, 13, 14, 2319, 40, 44, 48357, 912, 34536-38, 554311, 17, 26522517, 21, 426383, 28, 51579, 3718, 4828, 514, 24, 4522, 4715, 49431, 16, 29, 33, 5320, 5017, 46, 5839, 5410, 3037, 38, 55cytosolcytosolcytosolcytosolcytosolp-Y-PLXNB1 ROCK1 ERBB2 p-Y-PLXNA1 MET SEMA6A:PLXNA2,PLXNA4RAC1:GTPRHOA:GDPATPMyrG-CDK5R1(2-307) HSP90AA1,HSP90AB1ARHGEF12 p-Y-PLXNA1 SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35GTP PLXNA2 SEMA6A RAC1:GTPSEMA4D Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKFESCRMP's tetramersPLXNB3 SEMA4D SEMA7ARHOA p-Y-DPYSL4 GSK3BFYN PAK2 p-Y-PLXNA4 Sema4D:pPlexin-B1:Met:RAC1-GTPPAK1 p-T509,T514,S518,S522-DPYSL3 GTPTREM2 p-T19,S20-MYL9 PLXND1GTP pLIMK dimer:HSP-90PLXNA3 PLXNA4 PLXNC1RHOB SEMA4DNRP1 p-Y-PLXNB1 SEMA7A:PLXNC1PLXNA2,PLXNA4SEMA6D SEMA4D:PTPRCSema3A:NP-1:Plexin-A:Fes:CRMPPIP5K1gamma:Talin-1R-Ras-GDPATPSEMA3A ADPMET PLXNA1 PiRHOC RHOA FYN RND1 p-S,T508-LIMK1 p-Y-PLXNA4 PLXNA4 SEMA6D:PLXNA1:TREM2:DAP12MYL9 SEMA4D:MET:p-Y-PLXNB1TLN1MyrG-CDK5R1(2-307) SEMA5A LIMK2 MYH14 SEMA7A SEMA5Ap-Y-PLXNB1 TYROBP SEMA5A:PLXNB3GDP PLXNA2 PLXNA4 SEMA4D GDP p-T508-LIMK1NRP1 SEMA4D ARHGAP35RHOC MYH9 PLXNA3 p-S522-CRMP1 SEMA3A Plexin-A1-4:FYNp-S522-DPYSL3 NRP1 PLXNA2 PLXNA2 p-Y-PLXNA1 SEMA3A PAK1 SEMA4D PIP5K1C p-T505-LIMK2 ADPPAK1,2,3PTPRC RHOA GTP PIP5K1C ATPp-Y-PLXNB1 MyrG-CDK5R1(2-307) HSP90AA1 RHOA:GTPNRP1 ATPp-Y-PLXNA2 p-Y-PLXNA2 ADPSema3A:NRP-1:pPlexin-A:Fyn:FesFYN ATPRAC1 p-Y-PLXNA3 FYN ROCK1 FYN PAK1 FES FES PLXNA3 p-Y-DPYSL5 TREM2 p-Y-PLXNA3 ATPADPNRP1 p-T509,T514,S518,S522-DPYSL2 p-Y-PLXNB1 DPYSL3 GDP FARP2 RND1 SEMA6DPAK2 SEMA3A RRAS R-Ras-GDPSEMA4D:ERBB2:p-Y-PLXNB1:RND1p-T508-LIMK1 SEMA3A:PLXND1PLXND1 RHOB GTP SEMA7A NRP1 Sema3A:Nrp-1:PlexinA:Fyn:pCdk5ADPp-S,T508-LIMK1 GTP p-Y-PLXNA1 PLXNA3 p-Y-PLXNA3 ERBB2 SEMA4D GTP p-T509,T514,S518,S522-CRMP1 GDPPAK3 PLXNA3 SEMA4A:PLXND1ADPADPPLXNA2 ITGA1 p-Y-PLXNA3 LIMK1SEMA3A GTPGDP Sema3A dimerFYN ERBB2 PAK3 p-S144,T423-PAK1 p-Y-PLXNB1 p-Y-PLXNB1 LIM KinasesSEMA4D FYN PTPRCp-Y-DPYSL2 GTP SEMA3A Integrin alpha1beta1MYH10 p-Y-PLXNA4 p-Y-PLXNA4 PLXNA2 SEMA3EMYH11 DPYSL2 DPYSL5 ATPRAC1 LIMK1 PLXNA3 ROCK2 RHOA RND1:GTPActive LIMK1MYL12B FES ADPPLXNA1 p-Y-PLXNA2 p-Y-PLXNA3 PLXNB3ARHGEF11 ROCK2 RRAS NRP1 GTP TYROBP RhoA,B,C:GDPRHOC p-S154,T436-PAK3 p-Y-PLXNA3 Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sATPHSP90AB1 CRMP1 p-S141,T402-PAK2 RND1 SEMA7A:Integrinalpha1beta1Plexin-B1:ErbB2Sema3A:Nrp-1:PlexinA:FynGTP RAC1:GDPSEMA4A p-T508-LIMK1 PLXNB1 p-T19,S20-MYL12B MYH10 R-Ras-GTPMYL6 RAC1 RHOA NRP1 NRP1:PlexinA1-4:FYNMET SEMA4D dimerSEMA4ASEMA3A RND1 CDK5 NRP1:PlexinA1-4:FARP2:FYNp-S534-DPYSL5 FYN Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sNRP1 FES GTP PLXNA1 PLXNC1 FYN NRP1SEMA4D:CD72ATPPLXNA4 PLXNA2 PLXNA1 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1PLXNA1:TREM2:DAP12SEMA4D GTP ARHGEF11 ITGA1 SEMA4D dimerHSP90AB1 p-S522-DPYSL2 p-Y15-CDK5 p-S544-DPYSL4 SEMA3A ARHGAP35 SEMA3A PAK2 RHOB RRAS TLN1 PLXNA4 ARHGEF12 RAC1 p-Y-DPYSL3 FARP2 GDPSEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12PLXNA1 PiPLXNB1 SEMA4D:ERBB2:p-Y-PLXNB1H2Op-Y15-CDK5 RND1 ERBB2 SEMA4D PLXNA2 p-T19,S20-MRLC-smooth muscle/non-muscle myosin IISEMA6APLXND1 ADPPLXNA4 Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAKARHGEF11,ARHGEF12p-Y-PLXNA4 ADPPlexin-B1:MetGTP ATPp-S544-DPYSL4 FYN PLXNA3 CD72FYN MYH14 PiADPpCofilin: ActiveLIMK-1PLXNA4 ActivatedROCK:RhoA/B/C:GTPROCK1,ROCK2PLXNA2 NRP1 FARP2:PIP5KIgammaPLXNA2 p-Y-PLXNA1 ATPFARP2CFL1FYN p-Y-PLXNA2 RND1 GTP MyrG-CDK5R1(2-307) PLXNA4 SEMA3E FYN PLXNA1 p-S3-CFL1 DPYSL4 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPHSP90AA1 p-S534-DPYSL5 PLXNA4 CDK5:p35Sema3A dimerp-Y-PLXNA1 SEMA4D:MET:p-Y-PLXNB1:RND1:GTPGTP p-Y-CRMP1 p-Y-PLXNA2 SEMA4D FYN CD72 PLXNA1 Smoothmuscle/non-musclemyosin IIPLXNA1 SEMA3A RAC1 SEMA3A RHOA/B/C:GTPRND1 RRAS GDP p-Y-PLXNA2 ITGB1 PAK1,2,3 dimerATPSEMA3A MYL6 p-Y-PLXNA4 NRP1 NRP1 GTP ATPMET PLXNA4 MET RAC1 MYH9 NRP1 MYH11 p-Y15-CDK5 ADPPAK3 p-LIMKRAC1 RAC1 PLXND1Sema3A:Nrp-1:PlexinA:FynSEMA4D ITGB1 FES FES PLXNA1 SEMA3A PLXNA3 PLXNA1 RND1:GTPGTP R-Ras-GTPADP


Description

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 373755
Reactome-version 
Reactome version: 65
Reactome Author 
Reactome Author: Garapati, Phani Vijay

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018ReactomeTeamreactome version 65
100540view19:46, 31 October 2018ReactomeTeamreactome version 64
100088view16:31, 31 October 2018ReactomeTeamreactome version 63
99638view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99241view12:44, 31 October 2018ReactomeTeamreactome version 62
94051view13:54, 16 August 2017ReactomeTeamreactome version 61
93678view11:30, 9 August 2017ReactomeTeamreactome version 61
86802view09:26, 11 July 2016ReactomeTeamreactome version 56
83271view10:36, 18 November 2015ReactomeTeamVersion54
81381view12:54, 21 August 2015ReactomeTeamVersion53
76850view08:07, 17 July 2014ReactomeTeamFixed remaining interactions
76554view11:54, 16 July 2014ReactomeTeamFixed remaining interactions
75887view09:54, 11 June 2014ReactomeTeamRe-fixing comment source
75587view10:42, 10 June 2014ReactomeTeamReactome 48 Update
74942view13:47, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74586view08:38, 30 April 2014ReactomeTeamReactome46
45022view18:42, 6 October 2011ThomasOntology Term : 'signaling pathway' added !
42123view21:58, 4 March 2011MaintBotAutomatic update
39933view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARHGAP35 ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGAP35ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGEF11 ProteinO15085 (Uniprot-TrEMBL)
ARHGEF11,ARHGEF12ComplexR-HSA-416544 (Reactome)
ARHGEF12 ProteinQ9NZN5 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Activated ROCK:RhoA/B/C:GTPComplexR-HSA-422483 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
CD72 ProteinP21854 (Uniprot-TrEMBL)
CD72ProteinP21854 (Uniprot-TrEMBL)
CDK5 ProteinQ00535 (Uniprot-TrEMBL)
CDK5:p35ComplexR-HSA-421107 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRMP's tetramersComplexR-HSA-399843 (Reactome)
CRMP1 ProteinQ14194 (Uniprot-TrEMBL)
DPYSL2 ProteinQ16555 (Uniprot-TrEMBL)
DPYSL3 ProteinQ14195 (Uniprot-TrEMBL)
DPYSL4 ProteinO14531 (Uniprot-TrEMBL)
DPYSL5 ProteinQ9BPU6 (Uniprot-TrEMBL)
ERBB2 ProteinP04626 (Uniprot-TrEMBL)
FARP2 ProteinO94887 (Uniprot-TrEMBL)