Semaphorin interactions (Homo sapiens)

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12, 14, 25, 38, 4620, 30, 429, 13, 194451, 5731, 502, 116, 5410, 17, 40, 4124, 3921, 28, 363, 13, 5844524713, 34, 5337, 4318115, 354, 27, 29, 32, 485, 263355178, 22, 45, 49, 5617, 40, 417, 16, 23, 3528, 3624, 40cytosolcytosolcytosolcytosolcytosolFYN FYN PLXNA2 ActivatedROCK:RhoA/B/C:GTPLIMK2 RRAS Sema3A dimerp-Y-PLXNB1 p-S534-DPYSL5 SEMA3A GTP SEMA5A MET PLXNA1 SEMA4D Integrin alpha1beta1ATPPLXNA4 p-Y-DPYSL3 R-Ras-GDPp-T19,S20-MYL12B GTP PTPRCp-S144,T423-PAK1 RND1 SEMA3A SEMA4A:PLXND1ARHGAP35FES SEMA4D ATPADPPLXNA1 RAC1 MYH10 SEMA4D PLXNA1 ATPSema3A:Nrp-1:PlexinA:FynSEMA7ANRP1 SEMA3A PLXNA1 Smoothmuscle/non-musclemyosin IISema4D:pPlexin-B1:Met:RAC1-GTPFYN NRP1Active LIMK1p-Y-PLXNA2 ATPFYN PLXNA2 ATPFYN p-S522-CRMP1 PLXNA1 SEMA5A:PLXNB3p-S544-DPYSL4 ADPRND1 RHOA PIP5K1C Sema3A:NRP-1:pPlexin-A:Fyn:FesGDP ARHGAP35 ATPp-T19,S20-MRLC-smooth muscle/non-muscle myosin IINRP1 ATPFYN p-S,T508-LIMK1 p-Y-PLXNA3 NRP1 SEMA7A p-Y-PLXNA4 RND1:GTPPLXND1 ITGA1 CRMP's tetramersPLXNA4 MET NRP1 HSP90AA1,HSP90AB1GSK3BERBB2 FYN GTPp-Y-DPYSL4 pCofilin: ActiveLIMK-1p-T509,T514,S518,S522-DPYSL3 DPYSL4 PiMET LIM KinasesPLXNA4 TLN1PLXNA3 SEMA4D:PTPRCPAK2 p-S522-DPYSL3 SEMA3E ATPSEMA4D:ERBB2:p-Y-PLXNB1DPYSL5 RAC1 p-Y-PLXNA1 FARP2:PIP5KIgammap-S154,T436-PAK3 PLXNC1PLXNA3 RND1 ROCK1,ROCK2PLXNB1 PAK1 NRP1 p-Y-PLXNB1 MYH9 ADPARHGEF11 p-Y-PLXNB1 PLXNA1 p-Y-PLXNB1 GTP PLXNA2 Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1FARP2PLXNB1 p-T508-LIMK1MYH11 TLN1 SEMA4D SEMA3A ADPHSP90AB1 p-T509,T514,S518,S522-CRMP1 p-Y-PLXNB1 GTP FYN SEMA4D:ERBB2:p-Y-PLXNB1:RND1MyrG-CDK5R1(2-307) p-Y15-CDK5 SEMA3A RAC1 MyrG-CDK5R1(2-307) p-Y-PLXNA2 GDP ERBB2 HSP90AA1 RHOA SEMA4D p-T509,T514,S518,S522-DPYSL2 SEMA4D ATPSEMA4D dimerPAK3 GTPSEMA4D p-Y15-CDK5 p-Y-PLXNB1 PLXNA4 FARP2 RhoA,B,C:GDPGDPSEMA3A:PLXND1SEMA6A PLXNB3FES p-Y-DPYSL5 PLXNA2,PLXNA4Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPMYL9 PLXNA2 PLXNA1 FESRHOA:GTPRHOC RAC1:GTPR-Ras-GTPITGA1 FES PLXNA4 RHOB PLXNA3 p-S534-DPYSL5 NRP1 CD72p-Y-PLXNA3 ATPPLXNA4 Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAKMYH10 PLXNA1 R-Ras-GTPFYN HSP90AA1 p-Y-PLXNB1 FES SEMA7A:PLXNC1FYN Sema3A:Nrp-1:PlexinA:Fyn:pCdk5CD72 FYN PLXNA4 PLXNA2 SEMA4D GDP p-Y-PLXNA2 p-Y-PLXNA2 PLXNA3 PAK1,2,3 dimerARHGEF12 PLXNA2 p-LIMKFARP2 LIMK1PAK2 SEMA3A SEMA6DSEMA4D SEMA4DPLXNC1 SEMA6D SEMA3A p-S544-DPYSL4 PAK1 p-Y-PLXNA3 SEMA4D:CD72p-Y-PLXNA1 RHOA RHOA GTP GTP SEMA4AATPMYL12B MYH9 Plexin-B1:ErbB2ADPH2OPLXNA3 RAC1 PLXNA3 SEMA6A:PLXNA2,PLXNA4SEMA3A RND1:GTPPLXNA2 p-T505-LIMK2 PLXNA4 pLIMK dimer:HSP-90GTP MYH14 RHOC ADPRAC1 GTP SEMA4D RHOA:GDPADPSEMA3A PTPRC RHOA ROCK2 DPYSL2 MyrG-CDK5R1(2-307) SEMA3ERAC1 p-Y-PLXNA4 p-Y-PLXNA4 RND1 PLXNA2 PLXND1PLXND1PAK2 p-Y-PLXNA1 SEMA5ARND1 SEMA3A ADPMET SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35PLXNA1 ROCK1 PLXND1 p-Y-PLXNA3 SEMA3A GTP ITGB1 NRP1 CDK5:p35GTP PLXNA3 NRP1 MYH11 p-Y15-CDK5 p-Y-PLXNA2 HSP90AB1 SEMA4D p-T508-LIMK1 RAC1 PLXNA3 RAC1:GTPSEMA4D dimerPLXNB3 GDP PiNRP1 p-Y-PLXNA1 RHOA/B/C:GTPERBB2 ARHGEF11 PAK3 TYROBP NRP1 Plexin-A1-4:FYNPAK1 p-Y-PLXNA4 GTP Plexin-B1:MetARHGEF11,ARHGEF12SEMA3A GTP MYH14 p-Y-PLXNA1 PLXNA2 Sema3A:NP-1:Plexin-A:Fes:CRMPRRAS FES p-Y-PLXNA2 TYROBP SEMA4D:MET:p-Y-PLXNB1PAK3 p-T508-LIMK1 NRP1 CFL1MYL6 CDK5 NRP1 p-Y-PLXNA1 GDPGTP LIMK1 PiRND1 RRAS ROCK1 PLXNA1:TREM2:DAP12SEMA6Ap-Y-CRMP1 RRAS p-Y-PLXNA3 FYN p-T19,S20-MYL9 ATPMyrG-CDK5R1(2-307) ADPADPGTP GTP PLXNA2 p-Y-DPYSL2 PAK1,2,3SEMA7A p-S3-CFL1 MET R-Ras-GDPRAC1:GDPSEMA4D:MET:p-Y-PLXNB1:RND1:GTPITGB1 TREM2 Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKRHOB Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sARHGEF12 PIP5K1C ROCK2 MYL6 GDP FYN RHOB PLXNA4 RAC1 Sema3A:Nrp-1:PlexinA:FynSEMA4A FYN FES p-S522-DPYSL2 ERBB2 NRP1:PlexinA1-4:FARP2:FYNp-S,T508-LIMK1 PLXNA4 GTP RHOC SEMA3A TREM2 Sema3A dimerDPYSL3 CRMP1 NRP1:PlexinA1-4:FYNADPADPp-Y-PLXNA3 ADPATPSEMA6D:PLXNA1:TREM2:DAP12RND1 p-Y-PLXNA4 p-Y-PLXNA4 Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sPLXNA1 PIP5K1gamma:Talin-1SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12SEMA7A:Integrinalpha1beta1NRP1 p-S141,T402-PAK2


Description

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 373755
Reactome-version 
Reactome version: 64
Reactome Author 
Reactome Author: Garapati, Phani Vijay

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018ReactomeTeamreactome version 65
100540view19:46, 31 October 2018ReactomeTeamreactome version 64
100088view16:31, 31 October 2018ReactomeTeamreactome version 63
99638view15:02, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99241view12:44, 31 October 2018ReactomeTeamreactome version 62
94051view13:54, 16 August 2017ReactomeTeamreactome version 61
93678view11:30, 9 August 2017ReactomeTeamreactome version 61
86802view09:26, 11 July 2016ReactomeTeamreactome version 56
83271view10:36, 18 November 2015ReactomeTeamVersion54
81381view12:54, 21 August 2015ReactomeTeamVersion53
76850view08:07, 17 July 2014ReactomeTeamFixed remaining interactions
76554view11:54, 16 July 2014ReactomeTeamFixed remaining interactions
75887view09:54, 11 June 2014ReactomeTeamRe-fixing comment source
75587view10:42, 10 June 2014ReactomeTeamReactome 48 Update
74942view13:47, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74586view08:38, 30 April 2014ReactomeTeamReactome46
45022view18:42, 6 October 2011ThomasOntology Term : 'signaling pathway' added !
42123view21:58, 4 March 2011MaintBotAutomatic update
39933view05:57, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARHGAP35 ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGAP35ProteinQ9NRY4 (Uniprot-TrEMBL)
ARHGEF11 ProteinO15085 (Uniprot-TrEMBL)
ARHGEF11,ARHGEF12ComplexR-HSA-416544 (Reactome)
ARHGEF12 ProteinQ9NZN5 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
Activated ROCK:RhoA/B/C:GTPComplexR-HSA-422483 (Reactome)
Active LIMK1ComplexR-HSA-419630 (Reactome)
CD72 ProteinP21854 (Uniprot-TrEMBL)
CD72ProteinP21854 (Uniprot-TrEMBL)
CDK5 ProteinQ00535 (Uniprot-TrEMBL)
CDK5:p35ComplexR-HSA-421107 (Reactome)
CFL1ProteinP23528 (Uniprot-TrEMBL)
CRMP's tetramersComplexR-HSA-399843 (Reactome)
CRMP1 ProteinQ14194 (Uniprot-TrEMBL)
DPYSL2 ProteinQ16555 (Uniprot-TrEMBL)
DPYSL3 ProteinQ14195 (Uniprot-TrEMBL)
DPYSL4 ProteinO14531 (Uniprot-TrEMBL)
DPYSL5 ProteinQ9BPU6 (Uniprot-TrEMBL)
ERBB2 ProteinP04626 (Uniprot-TrEMBL)
FARP2 ProteinO94887 (Uniprot-TrEMBL)