Semaphorin interactions (Homo sapiens)

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3, 4, 10, 17, 2350, 547, 5234, 37, 42, 5119, 22214936, 41, 43, 45, 562, 25, 291, 24, 5737, 42, 5127, 31269, 35266, 5514, 32, 481613, 30, 481833, 3912, 15, 4851585, 8, 19, 404411, 2028, 38, 46, 47, 5331, 422, 29cytosolcytosolcytosolcytosolcytosolpCofilin: ActiveLIMK-1PLXNC1 PLXNA2 R-Ras-GDPPLXNA2 SEMA6A GTP PAK2 ADPPLXNA1 p-T509,T514,S518,S522-DPYSL3 MYH10 R-Ras-GTPp-Y-PLXNA2 GTP HSP90AB1 MYL9 PLXND1 GTP SEMA3A FARP2:PIP5KIgammaDPYSL2 PAK3 SEMA6D p-Y-PLXNA2 ATPATPMYH9 p-S,T508-LIMK1 ROCK2 SEMA3A:PLXND1GTP SEMA4D NRP1 ROCK1 SEMA4AMyrG-CDK5R1(2-307) p-Y-PLXNA3 PLXNA2 CFL1ATPDPYSL5 Sema4D:pPlexin-B1:ErbB2:Rac1:Rnd1GTP p-Y-PLXNA4 CDC42 Active LIMK1MYH9 SEMA7A:Integrinalpha1beta1p-Y-PLXNA3 RAC1 SEMA5A FARP2 TYROBP RND1 ATPp-Y-PLXNB1 SEMA4D ADPATPMYH14 PLXNB1 ERBB2 p-Y-PLXNA1 SEMA4D p-S544-DPYSL4 NRP1 MET RAC1:GDPSEMA3A p-Y-PLXNB1 GTP SEMA4A p-Y-CRMP1 p-T505-LIMK2 RAC1 PLXNA3 p-S3-CFL1 SEMA4D p-T19,S20-MYL12B GTPPLXNA1 RAC1 PLXND1SEMA7A PiPAK1,2,3SEMA3A p-S144,T423-PAK1 CRMP's tetramersRRAS GTP ADPPLXNA1 p-T508-LIMK1 FYN LIM KinasesFESHSP90AA1 MET PLXNA2 FES ERBB2 p-Y-PLXNB1 p-Y-DPYSL2 PLXNA4 FARP2SEMA5ASEMA7A FYN RhoA,B,C:GDPPAK3 NRP1 MYH10 p-Y-PLXNB1 RRAS RHOA ADPADPGTP PLXNA3 p-Y-PLXNA2 NRP1 p-Y-PLXNB1 ActivatedROCK:RhoA/B/C:GTPRHOA p-Y-PLXNA1 SEMA4D dimerROCK1 RHOB PLXNA1 GTP DPYSL3 PLXNA2 Smoothmuscle/non-musclemyosin IIRHOA p-Y-PLXNA4 MYH14 GTP Sema3A dimerp-S522-DPYSL3 FYN MET PLXNA1 FYN Sema4D:pPlexin-B1:Met:RAC1-GTPp-Y-PLXNA3 MYH11 MYL12B Plexin-A1-4:FYNp-S534-DPYSL5 LARG and PDZ-RhoGEFSEMA4D:CD72PLXNA3 FYN p-Y-PLXNA3 p-S522-DPYSL2 SEMA3E GTP PIP5K1gamma:Talin-1PLXNA2 PLXNA4 GTP FYN CDK5 SEMA4A:PLXND1p-T19,S20-MYL9 FYN GTP RND1 PLXNA3 FYN GDP ITGB1 p-S544-DPYSL4 SEMA7ARRAS R-Ras-GTPATPRAC1 p-Y-PLXNA4 FES p-Y-PLXNA3 SEMA3A PiSema3A:Nrp-1:PlexinA:Rac1-GTP:PAKPLXNA4 PLXNA3 PLXNA2 ARHGAP35RHOA ARHGEF11 PLXNA4 FYN RHOG NRP1 GDPSEMA3A Sema4D:Plexin-B1:Rac-Rnd1:LARG/PDZ-RhoGEFATPRND1 RHOA pLIMK dimer:HSP-90SEMA4D PLXNC1RhoA (Mgcofactor):GTPGTP Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPRND1 RAC1 GTP PIP5K1C p-Y-PLXNB1 ARHGEF12 RAC1:GTPADPFES p-T509,T514,S518,S522-CRMP1 MET CDC42 RND1 RHOB ADPp-Y-PLXNA4 Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAKMYL6 PLXNA4 Sema3A:NRP-1:pPlexin-A:Fyn:FesPTPRCSEMA4D MyrG-CDK5R1(2-307) FES PLXNA3 PLXNA2,PLXNA4PLXNA3 Sema4D:Plexin-B1:p190RhoGAP:Rac:Rnd1CD72 GDPSEMA4DSEMA4D ADPSema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1p-T509,T514,S518,S522-DPYSL2 Sema3A:Nrp-1:PlexinA:Fyn:pCdk5RHOG FYN MyrG-CDK5R1(2-307) MET PLXNA2 Integrin alpha1beta1SEMA4D PAK1 PLXNA1 Rnd1-GTPADPp-Y-PLXNA2 RAC1 LIMK2 SEMA4D ADPITGB1 SEMA3EMYL6 TREM2 Plexin-B1:ErbB2RAC1 PLXND1 SEMA3A ATPROCK2 NRP1p-Y-PLXNA4 PLXNA1 RND1 LIMK1 Sema3A:Nrp-1:PlexinA:Fynp-T508-LIMK1 PLXNA4 ATPMyrG-CDK5R1(2-307) FES SEMA3A RAC2 FARP2 GDP PAK1 GDP p-Y-PLXNA1 NRP1 p-Y15-CDK5 Sema3A:Nrp-1:PlexinA:FynRRAS RAC1 ATPPAK2 p-S141,T402-PAK2 RHOC ATPSEMA4D PLXNA2 Sema4D:pPlexin-B1:MetTREM2 HSP90AA1 p-Y-PLXNA2 GTP p-Y-PLXNB1 SEMA5A:PLXNB3p-S154,T436-PAK3 p-S522-CRMP1 PAK3 NRP1 p-Y15-CDK5 p-Y-DPYSL5 Plexin-B1:MetPLXNA4 PiADPRHOC Sema3A:NP-1:Plexin-A:Fes:CRMPTLN1SEMA4D:PTPRCSEMA4D:pPlexin-B1:ErbB2 complexp-Y-PLXNA3 PLXNB1 RHOA SEMA7A:PLXNC1GSK3BCdk5:p35HSP90AA1,HSP90AB1RHOC DPYSL4 ATPARHGEF12 PLXNA1 SEMA3A NRP1 PLXNA1 RAC1:GTPNRP1:PlexinA1-4:FARP2:FYNHSP90AB1 ADPPLXNA3 p-Y-PLXNA1 ERBB2 Mg2+ p-T508-LIMK1PLXNA4 PAK1 GTPPLXNA2 FYN p-Y-PLXNA1 ITGA1 p-Y-PLXNA2 p-Y15-CDK5 SEMA3A RhoA (Mgcofactor):GDPSEMA4D NRP1 RHOB SEMA6ASEMA6A:PLXNA2,PLXNA4TLN1 PLXNA4 PLXNA1 Sema3A dimerSema4D:pPlexin-B1:Met:Rnd1SEMA6D:PLXNA1:TREM2:DAP12PLXNA4 RAC1 PLXNB3p-T19,S20-MRLC-smooth muscle/non-muscle myosin IIGDP PLXND1ARHGAP35 RHOA/B/C:GTPRAC2 SEMA3A ROCK1,ROCK2CD72Rnd1-GTPR-Ras-GDPPTPRC FYN p-LIMKGTP RAC1 PIP5K1C FYN SEMA3A p-Y-DPYSL3 LIMK1PLXNA1:TREM2:DAP12Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sTYROBP PAK1,2,3 dimerMg2+ RND1 NRP1 SEMA6DGTP PAK2 NRP1 SEMA3A MYH11 ADPITGA1 NRP1:PlexinA1-4:FYNp-Y-DPYSL4 NRP1 RHOA NRP1 ARHGEF11 CRMP1 p-Y-PLXNA4 ERBB2 p-Y-PLXNA1 Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP'sFES SEMA4D dimerFYN p-S,T508-LIMK1 PLXNB3 GDP ATPp-S534-DPYSL5 SEMA3A


Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins. View original pathway at:Reactome.


Pathway is converted from Reactome ID: 373755
Reactome version: 61
Reactome Author 
Reactome Author: Garapati, Phani Vijay

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  1. Edwards DC, Sanders LC, Bokoch GM, Gill GN.; ''Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.''; PubMed Europe PMC Scholia
  2. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL.; ''The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.''; PubMed Europe PMC Scholia
  3. Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M.; ''Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse.''; PubMed Europe PMC Scholia
  4. Raper JA.; ''Semaphorins and their receptors in vertebrates and invertebrates.''; PubMed Europe PMC Scholia
  5. Ueda K, Murata-Hori M, Tatsuka M, Hosoya H.; ''Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells.''; PubMed Europe PMC Scholia
  6. Vikis HG, Li W, Guan KL.; ''The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.''; PubMed Europe PMC Scholia
  7. Sebbagh M, Hamelin J, Bertoglio J, Solary E, Bréard J.; ''Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.''; PubMed Europe PMC Scholia
  8. Sturdivant JM, Royalty SM, Lin CW, Moore LA, Yingling JD, Laethem CL, Sherman B, Heintzelman GR, Kopczynski CC, deLong MA.; ''Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma.''; PubMed Europe PMC Scholia
  9. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K.; ''Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.''; PubMed Europe PMC Scholia
  10. Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L.; ''Plexin-B3 is a functional receptor for semaphorin 5A.''; PubMed Europe PMC Scholia
  11. Leung T, Chen XQ, Manser E, Lim L.; ''The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.''; PubMed Europe PMC Scholia
  12. Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, Hori M.; ''Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.''; PubMed Europe PMC Scholia
  13. Billard C, Delaire S, Raffoux E, Bensussan A, Boumsell L.; ''Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage.''; PubMed Europe PMC Scholia
  14. Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S.; ''Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.''; PubMed Europe PMC Scholia
  15. Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, Tamagnone L, Comoglio PM.; ''The semaphorin 4D receptor controls invasive growth by coupling with Met.''; PubMed Europe PMC Scholia
  16. Gatti A, Huang Z, Tuazon PT, Traugh JA.; ''Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.''; PubMed Europe PMC Scholia
  17. Tanna AP, Johnson M.; ''Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension.''; PubMed Europe PMC Scholia
  18. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H.; ''Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.''; PubMed Europe PMC Scholia
  19. Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM.; ''Structural bases for CRMP function in plexin-dependent semaphorin3A signaling.''; PubMed Europe PMC Scholia
  20. Ahmed A, Eickholt BJ.; ''Intracellular kinases in semaphorin signaling.''; PubMed Europe PMC Scholia
  21. Dickson BJ.; ''Molecular mechanisms of axon guidance.''; PubMed Europe PMC Scholia
  22. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD.; ''Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.''; PubMed Europe PMC Scholia
  23. Halloran MC, Wolman MA.; ''Repulsion or adhesion: receptors make the call.''; PubMed Europe PMC Scholia
  24. Swiercz JM, Kuner R, Offermanns S.; ''Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2.''; PubMed Europe PMC Scholia
  25. Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L.; ''p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.''; PubMed Europe PMC Scholia
  26. Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H.; ''Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.''; PubMed Europe PMC Scholia
  27. Oinuma I, Katoh H, Negishi M.; ''Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity.''; PubMed Europe PMC Scholia
  28. Pasterkamp RJ, Verhaagen J.; ''Semaphorins in axon regeneration: developmental guidance molecules gone wrong?''; PubMed Europe PMC Scholia
  29. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y.; ''Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.''; PubMed Europe PMC Scholia
  30. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K.; ''Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase).''; PubMed Europe PMC Scholia
  31. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S.; ''Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.''; PubMed Europe PMC Scholia
  32. Garnock-Jones KP.; ''Ripasudil: first global approval.''; PubMed Europe PMC Scholia
  33. Araki S, Ito M, Kureishi Y, Feng J, Machida H, Isaka N, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T.; ''Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase.''; PubMed Europe PMC Scholia
  34. Chong C, Tan L, Lim L, Manser E.; ''The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.''; PubMed Europe PMC Scholia
  35. Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K.; ''GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.''; PubMed Europe PMC Scholia
  36. Nakamura F, Kalb RG, Strittmatter SM.; ''Molecular basis of semaphorin-mediated axon guidance.''; PubMed Europe PMC Scholia
  37. Koncina E, Roth L, Gonthier B, Bagnard D.; ''Role of semaphorins during axon growth and guidance.''; PubMed Europe PMC Scholia
  38. Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, Morton CJ, Parker MW, Yarden Y, Bernard O.; ''Hsp90 increases LIM kinase activity by promoting its homo-dimerization.''; PubMed Europe PMC Scholia
  39. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I.; ''Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.''; PubMed Europe PMC Scholia
  40. Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, Kikutani H.; ''FARP2 triggers signals for Sema3A-mediated axonal repulsion.''; PubMed Europe PMC Scholia
  41. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S.; ''The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.''; PubMed Europe PMC Scholia
  42. Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF.; ''Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.''; PubMed Europe PMC Scholia
  43. Pasterkamp RJ, Kolodkin AL.; ''Semaphorin junction: making tracks toward neural connectivity.''; PubMed Europe PMC Scholia
  44. Zhou Y, Gunput RA, Pasterkamp RJ.; ''Semaphorin signaling: progress made and promises ahead.''; PubMed Europe PMC Scholia
  45. Ikebe M, Hartshorne DJ.; ''Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase.''; PubMed Europe PMC Scholia
  46. Swiercz JM, Worzfeld T, Offermanns S.; ''ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.''; PubMed Europe PMC Scholia
  47. Ikebe M, Koretz J, Hartshorne DJ.; ''Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin.''; PubMed Europe PMC Scholia
  48. Pandey D, Pandey D, Goyal P, Bamburg JR, Siess W.; ''Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets.''; PubMed Europe PMC Scholia
  49. Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H.; ''Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.''; PubMed Europe PMC Scholia
  50. Vikis HG, Li W, He Z, Guan KL.; ''The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.''; PubMed Europe PMC Scholia
  51. Bernard O, Ganiatsas S, Kannourakis G, Dringen R.; ''Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons.''; PubMed Europe PMC Scholia
  52. Schmidt EF, Strittmatter SM.; ''The CRMP family of proteins and their role in Sema3A signaling.''; PubMed Europe PMC Scholia
  53. Watanabe T, Hosoya H, Yonemura S.; ''Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells.''; PubMed Europe PMC Scholia
  54. Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y.; ''Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.''; PubMed Europe PMC Scholia
  55. Herold C, Elhabazi A, Bismuth G, Bensussan A, Boumsell L.; ''CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion.''; PubMed Europe PMC Scholia
  56. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM.; ''Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.''; PubMed Europe PMC Scholia
  57. Oinuma I, Katoh H, Harada A, Negishi M.; ''Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells.''; PubMed Europe PMC Scholia
  58. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA.; ''Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.''; PubMed Europe PMC Scholia
  59. Sumi T, Matsumoto K, Nakamura T.; ''Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.''; PubMed Europe PMC Scholia
  60. Whitford KL, Ghosh A.; ''Plexin signaling via off-track and rho family GTPases.''; PubMed Europe PMC Scholia
  61. Bernard O.; ''Lim kinases, regulators of actin dynamics.''; PubMed Europe PMC Scholia


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113342view11:41, 2 November 2020ReactomeTeamReactome version 74
112552view15:52, 9 October 2020ReactomeTeamReactome version 73
101466view11:33, 1 November 2018ReactomeTeamreactome version 66
101004view21:12, 31 October 2018