Neurotransmitter clearance (Homo sapiens)

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1245, 63mitochondrial matrixcytosolCatechol O-methyltransferase5-hydroxyindole acetaldehydeCholineS-adenosylhomocysteineH2OSodium dependent Serotonin transporterHomocysteinesodium ionAcetylcholinesterase5-hydroxytryptamine N-methyl conjugateNoradrenalinealdehyde dehydrogenase, mitochondrial, tetramerNADHsodium ionsodium ionMAOA-FAD complexH2OOxygenH2O2Sodium dpendent Dopamine transporterNH3S-adenosylmethionineNoradrenalineNH3Acetate5-HydroxytryptamineDopamineS-adenosylmethionineH+NAD+Noradrenaline uptake transporterSerotonin5-hydroxytryptamine N-methyl conjugateDopamine5-Hydroxyindole acetic acidsodium ionOxygenO-acetylcholine1-chloro-2,4-dinitrobenzene


Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.
This topic will be annotated in a future release.

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87768view10:01, 25 July 2016RyanmillerOntology Term : 'signaling pathway' added !
87767view10:00, 25 July 2016RyanmillerOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
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External references


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NameTypeDatabase referenceComment


MetaboliteREACT_7022 (Reactome)

acetic acid

MetaboliteREACT_17511 (Reactome)
5-Hydroxytryptamine Metabolite28790 (ChEBI)


MetaboliteREACT_17970 (Reactome)

N-methyl conjugate

MetaboliteREACT_15971 (Reactome)
Acetate Metabolite15366 (ChEBI)
Acetylcholinesterase ProteinP22303 (UniProt)
Catechol O-


ProteinP21964 (UniProt)
Choline Metabolite15354 (ChEBI)
Dopamine Metabolite18243 (ChEBI)
H+ Metabolite15378 (ChEBI)
H2O Metabolite15377 (ChEBI)
H2O2 Metabolite16240 (ChEBI)
Homocysteine Metabolite17230 (ChEBI)
MAOA-FAD complex ComplexREACT_5113 (Reactome)
NAD+ Metabolite15846 (ChEBI)
NADH Metabolite16908 (ChEBI)
NH3 Metabolite16134 (ChEBI)
Noradrenaline Metabolite18357 (ChEBI)

uptake transporter

ProteinO15244 (UniProt)
O-acetylcholine Metabolite15355 (ChEBI)
Oxygen Metabolite15379 (ChEBI)


Metabolite16680 (ChEBI)
S-adenosylmethionine Metabolite15414 (ChEBI)
Serotonin Metabolite28790 (ChEBI)
Sodium dependent

Serotonin transporter

UnknownREACT_15766 (Reactome)
Sodium dpendent

Dopamine transporter

ProteinQ01959 (UniProt)

dehydrogenase, mitochondrial, tetramer

ComplexREACT_2466 (Reactome)
sodium ion Metabolite29101 (ChEBI)

Annotated Interactions

No annotated interactions

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