Heme Biosynthesis (Mus musculus)

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Fe2+rate limiting stepdelta-aminolevulinatedelta-aminolevulinatesuccinyl-CoA + glycineprotoporphyrinogen IXRed - side productsH+Black - reactantsHmbshydroxymethylbilaneCO2Alas2coproporphyrinogen IIIPorphobilinogenprotohemeH2Oprotoporphyrin IXUrodFechPpoxCpoxCO2H2O2H2OCoAH2OporphobilinogenUrosNH3O2O2Alas1AladCO2uroporphyrinogen III


No description


This pathway was inferred from Homo sapiens pathway WP561(r21860) with a 60% conversion rate.

Quality Tags

Ontology Terms



No bibliography


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107200view14:29, 17 September 2019MaintBotChEBI identifier normalization
106861view13:34, 17 September 2019MaintBotHMDB identifier normalization
93013view15:02, 24 July 2017DeSlChanged (vague) CAS to ChEBI ID (which looked to be more relevant).
89923view13:34, 6 October 2016MkutmonModified description
69996view22:32, 11 July 2013MaintBotupdated to 2013 schema
67334view10:38, 26 June 2013Christine ChichesterOntology Term : 'heme biosynthetic pathway' added !
41372view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
35285view22:48, 11 February 2010Mills42Modified description
34418view23:14, 9 December 2009MaintBotAutomatic update of empty xrefs
32667view16:05, 27 August 2009KhanspersAdded CAS metabolites
31989view13:13, 14 August 2009MaintBotFixed group labels
30811view23:55, 29 July 2009MaintBotConverted from Homo sapiens
20713view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:Heme Biosynthesis]] moved to [[Pathway:WP18]]: Moved to stable identifier
8134view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Heme Biosynthesis]] moved to [[Pathway:Mus musculus:Heme Biosynthesis]]: Renaming species
7688view16:09, 18 December 2007MaintBotfixed category names
7373view12:42, 4 November 2007MaintBotAdded categories to GPML
19493view22:19, 22 May 2007M.Braymergpml file for [[Mouse:Heme_Biosynthesis]]
6456view22:19, 22 May 2007Kdahlquistgpml file for [[Mouse:Heme_Biosynthesis]]

External references


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NameTypeDatabase referenceComment
AladGeneProduct17025 (Entrez Gene)
Alas1GeneProduct11655 (Entrez Gene)
Alas2GeneProduct11656 (Entrez Gene)
CO2MetaboliteHMDB01967 (HMDB)
CoAMetaboliteHMDB01423 (HMDB)
CpoxGeneProduct12892 (Entrez Gene)
FechGeneProduct14151 (Entrez Gene)
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HmbsGeneProduct15288 (Entrez Gene)
NH3MetaboliteHMDB00051 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
PorphobilinogenMetaboliteHMDB00245 (HMDB)
PpoxGeneProduct19044 (Entrez Gene)
UrodGeneProduct22275 (Entrez Gene)
UrosGeneProduct22276 (Entrez Gene)
coproporphyrinogen IIIGeneProduct
protoporphyrin IXGeneProduct
uroporphyrinogen IIIGeneProduct

Annotated Interactions

No annotated interactions
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