Circadian Clock (Homo sapiens)

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4, 8, 47, 509, 39, 41, 553753275, 4245, 541, 2, 6, 10, 15...34, 4635, 532, 5611, 18362322542915, 35, 38, 4319, 21, 31, 447, 1815, 35, 38, 4327, 40135, 533, 24, 253017, 28cytosolnucleoplasmUBC(533-608) CSNK1E NFIL3 ferriheme b CLOCK gene p-S-CLOCK NR1D1:heme:Corepressors:CLOCK geneEP300ALA p-S-PER2 PER1 gene CRY2p-CREB:CRTC1:PER1geneNCOR1 p-S-ARNTL UBB(77-152) UBB(1-76) PER1 geneCSNK1E PER1 p-S133-CREB1 DEXA ARNTL p-S-CRY2 p-S-PER1 CLOCK p-BMAL1:p-CLOCK,NPAS2:RORA genePER1 gene MEF2D Ub-p-S-PER1 CSNK1D NPAS2CARM1 NCOR1 p-S-NPAS2 PER2 BTRC PPARGC1A PPARGC1AUBA52(1-76) UBC(229-304) CSNK1E PER1 ARNTLCRY1 UBC(153-228) p-S133-CREB1Peroxisome Proliferator Receptor Element (PPRE) CHD9 PER2 gene CSNK1D TGS1 NR1D1:heme:Corepressors:NR1D1 geneCUL1 p-S-NPAS2 ferriheme b p-S-ARNTL p-S-CRY2 PPARA:RXRACoactivator complexUBB(77-152) PER1 gene MEF2C,D:PPARGC1ARPS27A(1-76) RORA:EP300:NPAS2genep-S-PER1 ARNTL ferriheme bp-S-PER1 PER1RORA activates geneexpressionp-S-ARNTL HDAC3Ub-p-S-CRY1 p-BMAL1:p-CLOCK,NPAS2:NR1D1 geneCRTC1 PPARA Ub-p-S-CRY2 NR1D1MEF2C RORA p-S-PER2 EP300 CREBBP ub-p-CRY1,ub-p-CRY2p-S-ARNTL CSNK1E,CSNK1DCSNK1E NPAS2 p-S-PER1 PER1,PER2LINA NCOR1 PPP1CC p-T69,T71-ATF2HELZ2 Ub-p-S-PER2 UBC(533-608) CSNK1D Beta-TrCP1:PERNR1D1 gene p-S-CRY1 BTRC:CUL1:SKP1p-S-CLOCK BMAL1:CLOCK,NPAS2:CRYp-S-CRY2 NR1D1 gene BMAL1:CLOCK,NPAS2activates circadiangene expressionPER2 geneNR1D1 gene TBL1X BHLHE41 CLOCK UBB(153-228) UBC(1-76) RORA UBA52(1-76) UBC(153-228) PPP1CB NRIP1 PER2 gene UBC(1-76) SKP1 p-S-CLOCK RORA gene CRY2 HDAC3 p-S-CRY1 NPAS2 Palm HDAC3 EP300 CRY2 p-CRY1,p-CRY2p-S-NPAS2 BMAL1:CLOCK,NPAS2:CRY:PERTBL1XR1 RPS27A(1-76) p-S-PER2 p-S-CRY1 NRIP1p-BMAL1:p-CLOCK,NPAS2:PER2 geneNR3C1:Dexamethasonep-S-CLOCK ARNTL gene CRY1,2FBXL3:CRYHDAC3 CLOCKRXRA NR1D1 CREM isoform 6 (ICER1) NPAS2 genep-S-CRY2 p-S-ARNTL p-S-NPAS2 UBB(153-228) p-CRY:p-PER:KinasePER2UBC(77-152) CSNK1D PER2 RBM4:PER1 mRNAp-BMAL1:p-CLOCK,NPAS2NR1D1 NCOA2 EPA p-PPARGC1ASIRT1CLOCK CRY1BTRC p-S-CRY2 CRY2 NPAS2 gene p-S-CLOCK p-PER1,p-PER2p-S-NPAS2 HDAC3 NPAS2 gene UBC(609-684) ferriheme b BTRCFBXL3 CRY1 gene SIK1p-S-ARNTL PP1 catalyticsubunitPER2 NR1D1 FBXL3MED1 UBC(381-456) PPARGC1A genep-S-ARNTL p-S-NPAS2 ARNTL gene ferriheme b NCOR1 NR1D1:heme:Corepressors:ARNTL geneNCOA6 NR1D1 RAI1NR1D1 geneUBC(305-380) p-BMAL1:p-CLOCK,NPAS2:CRY1 genep-CRY:p-PER:KinaseNR1D1 CRY1 CLOCK geneUBC(609-684) CREM:PER1 genePPARGC1A gene PPARGC1A NCOR1ub-p-PER1,ub-p-PER2CLOCK,NPAS2RORANR1D1:heme:Corepressors:NPAS2 geneRORA:Coactivator:NR1D1 geneNPAS2 p-T178,S539-PPARGC1A CRY1 genep-S-CLOCK CRY2 geneNRIP1 UBC(305-380) NCOA1 p-S-CRY1 PER1 UBC(457-532) ARNTL genep-S-CRY1 Ubp-S-CLOCK HIF1ANCOR1 UBC(457-532) PPP1CA RORA RORA geneRBM4 p-S-PER2 UBC(381-456) NR1D1:heme:Corepressors:PPARGC1A geneUBC(229-304) PER1 mRNA p-S-NPAS2 NR3C1 NFIL3:BHLHE41:PER2geneBMAL1:CLOCK,NPAS2PPARGC1A SMARCD3 CRY1 AA HDAC3 NR1D1 (REV-ERBA)represses geneexpressionUbCSNK1E UBC(77-152) CRY:PER:KinaseUBB(1-76) RORA:Coactivator:ARNTL genep-BMAL1:p-CLOCK,NPAS2:PER1 geneEP300 CSNK1D ferriheme b p-T263,S266,T299-PPARGC1A 5314, 20, 57133, 4812, 513, 483015, 35, 38, 4326, 413, 48323619, 21, 31, 523313, 48