ABC-family proteins mediated transport (Homo sapiens)

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1, 218-249-1214, 25, 2627-2913-173-8cytosolmitochondrial matrixperoxisomal matrixH2OCFTRATPABCB7OrthophosphateABCD1/ABCD3 homodimercholesterolPEX19:ABCD1/ABCD3cholesterolhemeHCO3-long-chain fatty acidsPEX3ADPHCO3-long-chain fatty acidsABCA7-1:ApoA1 complexABCA6, 10, 12 transportersABCA7-dependent phospholipidsABCA7-dependent phospholipidsPEX19heme


Description

The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but also are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
101456view11:32, 1 November 2018ReactomeTeamreactome version 66
100994view21:11, 31 October 2018ReactomeTeamreactome version 65
100530view19:45, 31 October 2018ReactomeTeamreactome version 64
100077view16:29, 31 October 2018ReactomeTeamreactome version 63
99628view15:01, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99234view12:44, 31 October 2018ReactomeTeamreactome version 62
93773view13:35, 16 August 2017ReactomeTeamreactome version 61
93299view11:19, 9 August 2017ReactomeTeamreactome version 61
86383view09:16, 11 July 2016ReactomeTeamreactome version 56
83823view13:07, 13 December 2015EgonwTypo: LFCA -> LCFA
83165view10:15, 18 November 2015ReactomeTeamVersion54
82708view09:11, 23 October 2015EgonwTypo: LFCA -> LCFA
81529view13:04, 21 August 2015ReactomeTeamVersion53
76998view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76703view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76516view11:41, 16 July 2014ReactomeTeamFixed remaining interactions
76029view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75738view11:22, 10 June 2014ReactomeTeamReactome 48 Update
75088view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74735view08:49, 30 April 2014ReactomeTeamReactome46
44936view12:20, 6 October 2011MartijnVanIerselOntology Term : 'transport pathway' added !
42004view21:49, 4 March 2011MaintBotAutomatic update
39806view05:50, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCA6, 10, 12

transporters

UnknownREACT_17258 (Reactome)
ABCA7-1:ApoA1

complex

ComplexREACT_17496 (Reactome)
ABCA7-dependent

phospholipids

MetaboliteREACT_15647 (Reactome)
ABCA7-dependent

phospholipids

MetaboliteREACT_16108 (Reactome)
ABCB7 UnknownREACT_23221 (Reactome)
ABCD1/ABCD3

homodimer

UnknownREACT_15658 (Reactome)
ADP Metabolite16761 (ChEBI)
ATP Metabolite15422 (ChEBI)
CFTR ProteinP13569 (UniProt)
H2O Metabolite15377 (ChEBI)
HCO3- Metabolite17544 (ChEBI)
Orthophosphate Metabolite18367 (ChEBI)
PEX19 UnknownREACT_15871 (Reactome)
PEX19:

ABCD1/ABCD3

ComplexREACT_15838 (Reactome)
PEX3 ProteinP56589 (UniProt)
cholesterol Metabolite16113 (ChEBI)
heme Metabolite17627 (ChEBI)
long-chain fatty

acids

Metabolite15904 (ChEBI)

Annotated Interactions

No annotated interactions

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