ABC-family proteins mediated transport (Homo sapiens)

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14, 50, 5732, 68173, 19, 25, 76, 8062, 636, 497111, 567, 718, 21, 28, 41, 51...5, 18, 30, 352329, 6440, 78, 7948, 65, 665, 18, 30, 357326, 344, 2761, 74, 8116, 45, 531, 7712, 22, 33, 67152, 9, 36, 42, 8024, 38, 46, 47, 597724, 38, 46, 47, 59691, 7, 10, 13, 37...20, 31, 39, 43, 52...mitochondrial matrixlamellar bodycytosolendoplasmic reticulum lumenlysosomal lumenperoxisomal matrixtransport vesiclePSMF1 OS9 UBB(153-228) H2OUb-misfolded nascentCFTR:ERAD complexPC DERL3 H2OABCD3 DERL3 CHOL PC RPS27A(1-76) UBC(533-608) K+ATPPSMB11 ABCA cholesteroltransportersLCFAVCP UBC(381-456) ATPPG UBC(305-380) RPS27A(1-76) ABCB4EIF2S3 PSMD14 H2OH2Oa xenobioticUBB(1-76) ABCC2PSMA1 phytosterols PSMD3 hemePSME3 RNF185 ATPCHOL26S proteasomeABCD1 RNF5 H2OPSMB1 PSMD6 PSMB5 UBC(1-76) UBC(1-76) ADPCFTRABCC9 UBC(305-380) UBC(609-684) PSMA3 PSME4 PC UBA52(1-76) ATPATPUBB(77-152) UBC(77-152) KCNJ11 ABCA4PSME1 ABCA7-dependentphospholipidsADPPSMA7 UBC(1-76) PSMB10 CFTR G551DporphyrinPCABCA8/B1/B5PCUBC(533-608) ABCB7(23-752) ATPATPIvacaftorPSMD9 SPHM H2ORNF5 H2OATPPSMC1 K+PiUBB(153-228) PSMD7 PiPiADPVCP ABCF1:EIF2S1:EIF2S2:EIF2S3ERLIN2 CFTR G551D PiLCFAporphyrinEIF2S2 ABCD2 ABCA5PSMA6 UBC(77-152) ABCB9 dimerPiPiPiATPRNF185 RNF5 ABCB10 ABCD2 ERLIN1 SEL1L ADPUBB(1-76) UBC(457-532) SPHM PiBMG ABCB9 PiUBC(229-304) SEL1L ADPHeme transportersH2OABCC1 PiABCC11 UBC(229-304) ATPH2OPiPiADPPSMA2 PiADPPEX19 H2OH2OPSMB6 PSMB7 ABCB6 UBC(153-228) ABCB5 CHOLBDG 23mer peptideADPABCF1ABCG5 ABCA3PSMC5 UBC(457-532) PSMD8 UBA52(1-76) ERLIN1 phytosterols ABCA7 H2OUBA52(1-76) organic anionlipidsUBB(153-228) ATPABCD1-3 dimersPSMC2 ABCC6 UBC(305-380) UBB(77-152) ERLEC1 ABCG1 dimerABCCsABCC5 CFTR ADPCl-PSMD10 PiAPOA1(25-266) ABCA8 UBC(1-76) CHOL ABCA9 OS9 PSMD13 H2OATPCHOLPEX3H2OATPATPABCG5:ABCG8PSMC3 ABCF1 Ivacaftor ABCB1 ADPABCD1 ERLIN1 PSMB9 BMG,BDGPSMA5 PSMD5 PG ADPPSMD12 misfolded CFTR HCO3-H2OUBC(381-456) Cl-ABCC3 PSMD11 KCNJ11:ABCC9lipidsABCG8 DERL2 PC, PGERAD complexCl-sterolsPSMB2 UBC(153-228) UBB(77-152) sterolshemeABCA12UBC(457-532) UBC(381-456) UBC(457-532) UBC(153-228) ABCB8 UBA52(1-76) misfolded CFTR:ERADcomplexRPS27A(1-76) UbDERL1 UBB(153-228) DERL2 PiEIF2S2 ABCA2 PC UBC(533-608) BMG OS9 PC, PGDERL2 ABCC2 CHOLHCO3-ERLEC1 ABCC9 PiDERL1 ADPATPUBC(533-608) EIF2S3 PSMC6 UBC(609-684) UBC(229-304) UBC(77-152) CHOLADPRNF185 ATPADPUBC(381-456) UBB(77-152) SEL1L UBC(77-152) misfolded CFTR PSMC4 H2OABCC10 ABCD3 ADPDERL3 ATPABCC8 ABCA6 ADPUbEIF2S1:EIF2S2:EIF2S3PEX19:ABCD1/2/3H2OEIF2S1 UBC(305-380) PSMB4 CHOLUBC(229-304) ATPDERL1 misfolded CFTR PiUBB(1-76) 23mer peptidePiPSMD1 ABCG4 ERLIN2 VCP ABCA7-dependentphospholipidsSHFM1 ABCG4 dimerEIF2S1 ADPPSMB3 PSMA4 ABCG1 atRALPiUBC(153-228) Ub-misfolded nascentCFTRorganic anionBDG ADPPSMB8 ABCA7-1:ApoA1complexABCA10 PSMA8 PSME2 PEX19UBC(609-684) UBB(1-76) ABCC4 a xenobioticRPS27A(1-76) atRALmisfolded CFTRCHOLERLEC1 Ivacaftor:CFTR G551DBMG,BDGMTABC3 dimerUBC(609-684) H2OPSMD4 ERLIN2 PSMD2 ADPCFTR44, 7272


Description

The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. These substrates include amino acids, lipids, inorganic ions, peptides, saccharides, peptides for antigen presentation, metals, drugs, and proteins. The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. Human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease (Dean et al. 2001, Borst and Elferink 2002, Rees et al. 2009). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 382556
Reactome-version 
Reactome version: 63
Reactome Author 
Reactome Author: Gopinathrao, G

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
101456view11:32, 1 November 2018ReactomeTeamreactome version 66
100994view21:11, 31 October 2018ReactomeTeamreactome version 65
100530view19:45, 31 October 2018ReactomeTeamreactome version 64
100077view16:29, 31 October 2018ReactomeTeamreactome version 63
99628view15:01, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99234view12:44, 31 October 2018ReactomeTeamreactome version 62
93773view13:35, 16 August 2017ReactomeTeamreactome version 61
93299view11:19, 9 August 2017ReactomeTeamreactome version 61
86383view09:16, 11 July 2016ReactomeTeamreactome version 56
83823view13:07, 13 December 2015EgonwTypo: LFCA -> LCFA
83165view10:15, 18 November 2015ReactomeTeamVersion54
82708view09:11, 23 October 2015EgonwTypo: LFCA -> LCFA
81529view13:04, 21 August 2015ReactomeTeamVersion53
76998view08:29, 17 July 2014ReactomeTeamFixed remaining interactions
76703view12:07, 16 July 2014ReactomeTeamFixed remaining interactions
76516view11:41, 16 July 2014ReactomeTeamFixed remaining interactions
76029view10:09, 11 June 2014ReactomeTeamRe-fixing comment source
75738view11:22, 10 June 2014ReactomeTeamReactome 48 Update
75088view14:04, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74735view08:49, 30 April 2014ReactomeTeamReactome46
44936view12:20, 6 October 2011MartijnVanIerselOntology Term : 'transport pathway' added !
42004view21:49, 4 March 2011MaintBotAutomatic update
39806view05:50, 21 January 2011MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
23mer peptideR-ALL-5223341 (Reactome)
23mer peptideR-ALL-5223344 (Reactome)
26S proteasomeComplexR-HSA-68819 (Reactome)
ABCA cholesterol transportersComplexR-HSA-383207 (Reactome)
ABCA10 ProteinQ8WWZ4 (Uniprot-TrEMBL)
ABCA12ProteinQ86UK0 (Uniprot-TrEMBL)
ABCA2 ProteinQ9BZC7 (Uniprot-TrEMBL)
ABCA3ProteinQ99758 (Uniprot-TrEMBL)
ABCA4ProteinP78363 (Uniprot-TrEMBL)
ABCA5ProteinQ8WWZ7 (Uniprot-TrEMBL)
ABCA6 ProteinQ8N139 (Uniprot-TrEMBL)
ABCA7 ProteinQ8IZY2 (Uniprot-TrEMBL)
ABCA7-1:ApoA1 complexComplexR-HSA-382558 (Reactome)
ABCA7-dependent phospholipidsComplexR-ALL-382526 (Reactome)
ABCA7-dependent phospholipidsComplexR-ALL-382530 (Reactome)
ABCA8 ProteinO94911 (Uniprot-TrEMBL)
ABCA8/B1/B5ComplexR-HSA-1467470 (Reactome)
ABCA9 ProteinQ8IUA7 (Uniprot-TrEMBL)
ABCB1 ProteinP08183 (Uniprot-TrEMBL)
ABCB10 ProteinQ9NRK6 (Uniprot-TrEMBL)
ABCB4ProteinP21439 (Uniprot-TrEMBL)
ABCB5 ProteinQ2M3G0 (Uniprot-TrEMBL)
ABCB6 ProteinQ9NP58 (Uniprot-TrEMBL)
ABCB7(23-752) ProteinO75027 (Uniprot-TrEMBL)
ABCB8 ProteinQ9NUT2 (Uniprot-TrEMBL)
ABCB9 ProteinQ9NP78 (Uniprot-TrEMBL)
ABCB9 dimerComplexR-HSA-5223347 (Reactome)
ABCC1 ProteinP33527 (Uniprot-TrEMBL)
ABCC10 ProteinQ5T3U5 (Uniprot-TrEMBL)
ABCC11 ProteinQ96J66 (Uniprot-TrEMBL)
ABCC2 ProteinQ92887 (Uniprot-TrEMBL)
ABCC2ProteinQ92887 (Uniprot-TrEMBL)
ABCC3 ProteinO15438 (Uniprot-TrEMBL)
ABCC4 ProteinO15439 (Uniprot-TrEMBL)
ABCC5 ProteinO15440 (Uniprot-TrEMBL)
ABCC6 ProteinO95255 (Uniprot-TrEMBL)
ABCC8 ProteinQ09428 (Uniprot-TrEMBL)
ABCC9 ProteinO60706 (Uniprot-TrEMBL)
ABCCsComplexR-HSA-1454912 (Reactome)
ABCD1 ProteinP33897 (Uniprot-TrEMBL)
ABCD1-3 dimersComplexR-HSA-1456465 (Reactome)
ABCD2 ProteinQ9UBJ2 (Uniprot-TrEMBL)
ABCD3 ProteinP28288 (Uniprot-TrEMBL)
ABCF1 ProteinQ8NE71 (Uniprot-TrEMBL)
ABCF1:EIF2S1:EIF2S2:EIF2S3ComplexR-HSA-5226905 (Reactome)
ABCF1ProteinQ8NE71 (Uniprot-TrEMBL)
ABCG1 ProteinP45844 (Uniprot-TrEMBL)
ABCG1 dimerComplexR-HSA-194222 (Reactome)
ABCG4 ProteinQ9H172 (Uniprot-TrEMBL)
ABCG4 dimerComplexR-HSA-1454940 (Reactome)
ABCG5 ProteinQ9H222 (Uniprot-TrEMBL)
ABCG5:ABCG8ComplexR-HSA-265452 (Reactome)
ABCG8 ProteinQ9H221 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:16761 (ChEBI)
APOA1(25-266) ProteinP02647 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
BDG MetaboliteCHEBI:18392 (ChEBI)
BMG MetaboliteCHEBI:16427 (ChEBI)
BMG,BDGComplexR-ALL-5679034 (Reactome)
BMG,BDGComplexR-ALL-5679042 (Reactome)
CFTR G551D ProteinP13569 (Uniprot-TrEMBL)
CFTR G551DProteinP13569 (Uniprot-TrEMBL)
CFTR ProteinP13569 (Uniprot-TrEMBL)
CFTRProteinP13569 (Uniprot-TrEMBL)
CHOL MetaboliteCHEBI:16113 (ChEBI)
CHOLMetaboliteCHEBI:16113 (ChEBI)
Cl-MetaboliteCHEBI:17996 (ChEBI)
DERL1 ProteinQ9BUN8 (Uniprot-TrEMBL)
DERL2 ProteinQ9GZP9 (Uniprot-TrEMBL)
DERL3 ProteinQ96Q80 (Uniprot-TrEMBL)
EIF2S1 ProteinP05198 (Uniprot-TrEMBL)
EIF2S1:EIF2S2:EIF2S3ComplexR-HSA-72515 (Reactome)
EIF2S2 ProteinP20042 (Uniprot-TrEMBL)
EIF2S3 ProteinP41091 (Uniprot-TrEMBL)
ERAD complexComplexR-HSA-8866531 (Reactome)
ERLEC1 ProteinQ96DZ1 (Uniprot-TrEMBL)
ERLIN1 ProteinO75477 (Uniprot-TrEMBL)
ERLIN2 ProteinO94905 (Uniprot-TrEMBL)
H2OMetaboliteCHEBI:15377 (ChEBI)
HCO3-MetaboliteCHEBI:17544 (ChEBI)
Heme transportersComplexR-HSA-1369030 (Reactome)
Ivacaftor MetaboliteCHEBI:66901 (ChEBI)
Ivacaftor:CFTR G551DComplexR-HSA-5678990 (Reactome)
IvacaftorMetaboliteCHEBI:66901 (ChEBI)
K+MetaboliteCHEBI:29103 (ChEBI)
KCNJ11 ProteinQ14654 (Uniprot-TrEMBL)
KCNJ11:ABCC9ComplexR-HSA-5678267 (Reactome)
LCFAMetaboliteCHEBI:15904 (ChEBI)
MTABC3 dimerComplexR-HSA-1368982 (Reactome)
OS9 ProteinQ13438 (Uniprot-TrEMBL)
PC MetaboliteCHEBI:16110 (ChEBI)
PC, PGComplexR-ALL-5684863 (Reactome)
PC, PGComplexR-ALL-5684869 (Reactome)
PCMetaboliteCHEBI:16110 (ChEBI)
PEX19 ProteinP40855 (Uniprot-TrEMBL)
PEX19:ABCD1/2/3ComplexR-HSA-382586 (Reactome)
PEX19ProteinP40855 (Uniprot-TrEMBL)
PEX3ProteinP56589 (Uniprot-TrEMBL)
PG MetaboliteCHEBI:17517 (ChEBI)
PSMA1 ProteinP25786 (Uniprot-TrEMBL)
PSMA2 ProteinP25787 (Uniprot-TrEMBL)
PSMA3 ProteinP25788 (Uniprot-TrEMBL)
PSMA4 ProteinP25789 (Uniprot-TrEMBL)
PSMA5 ProteinP28066 (Uniprot-TrEMBL)
PSMA6 ProteinP60900 (Uniprot-TrEMBL)
PSMA7 ProteinO14818 (Uniprot-TrEMBL)
PSMA8 ProteinQ8TAA3 (Uniprot-TrEMBL)
PSMB1 ProteinP20618 (Uniprot-TrEMBL)
PSMB10 ProteinP40306 (Uniprot-TrEMBL)
PSMB11 ProteinA5LHX3 (Uniprot-TrEMBL)
PSMB2 ProteinP49721 (Uniprot-TrEMBL)
PSMB3 ProteinP49720 (Uniprot-TrEMBL)
PSMB4 ProteinP28070 (Uniprot-TrEMBL)
PSMB5 ProteinP28074 (Uniprot-TrEMBL)
PSMB6 ProteinP28072 (Uniprot-TrEMBL)
PSMB7 ProteinQ99436 (Uniprot-TrEMBL)
PSMB8 ProteinP28062 (Uniprot-TrEMBL)
PSMB9 ProteinP28065 (Uniprot-TrEMBL)
PSMC1 ProteinP62191 (Uniprot-TrEMBL)
PSMC2 ProteinP35998 (Uniprot-TrEMBL)
PSMC3 ProteinP17980 (Uniprot-TrEMBL)
PSMC4 ProteinP43686 (Uniprot-TrEMBL)
PSMC5 ProteinP62195 (Uniprot-TrEMBL)
PSMC6 ProteinP62333 (Uniprot-TrEMBL)
PSMD1 ProteinQ99460 (Uniprot-TrEMBL)
PSMD10 ProteinO75832 (Uniprot-TrEMBL)
PSMD11 ProteinO00231 (Uniprot-TrEMBL)
PSMD12 ProteinO00232 (Uniprot-TrEMBL)
PSMD13 ProteinQ9UNM6 (Uniprot-TrEMBL)
PSMD14 ProteinO00487 (Uniprot-TrEMBL)
PSMD2 ProteinQ13200 (Uniprot-TrEMBL)
PSMD3 ProteinO43242 (Uniprot-TrEMBL)
PSMD4 ProteinP55036 (Uniprot-TrEMBL)
PSMD5 ProteinQ16401 (Uniprot-TrEMBL)
PSMD6 ProteinQ15008 (Uniprot-TrEMBL)
PSMD7 ProteinP51665 (Uniprot-TrEMBL)
PSMD8 ProteinP48556 (Uniprot-TrEMBL)
PSMD9 ProteinO00233 (Uniprot-TrEMBL)
PSME1 ProteinQ06323 (Uniprot-TrEMBL)
PSME2 ProteinQ9UL46 (Uniprot-TrEMBL)
PSME3 ProteinP61289 (Uniprot-TrEMBL)
PSME4 ProteinQ14997 (Uniprot-TrEMBL)
PSMF1 ProteinQ92530 (Uniprot-TrEMBL)
PiMetaboliteCHEBI:18367 (ChEBI)
RNF185 ProteinQ96GF1 (Uniprot-TrEMBL)
RNF5 ProteinQ99942 (Uniprot-TrEMBL)
RPS27A(1-76) ProteinP62979 (Uniprot-TrEMBL)
SEL1L ProteinQ9UBV2 (Uniprot-TrEMBL)
SHFM1 ProteinP60896 (Uniprot-TrEMBL)
SPHM MetaboliteCHEBI:17636 (ChEBI)
UBA52(1-76) ProteinP62987 (Uniprot-TrEMBL)
UBB(1-76) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(153-228) ProteinP0CG47 (Uniprot-TrEMBL)
UBB(77-152) ProteinP0CG47 (Uniprot-TrEMBL)
UBC(1-76) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(153-228) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(229-304) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(305-380) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(381-456) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(457-532) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(533-608) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(609-684) ProteinP0CG48 (Uniprot-TrEMBL)
UBC(77-152) ProteinP0CG48 (Uniprot-TrEMBL)
Ub-misfolded nascent CFTR:ERAD complexComplexR-HSA-8866535 (Reactome)
Ub-misfolded nascent CFTRComplexR-HSA-8866534 (Reactome)
UbComplexR-HSA-6793517 (Reactome)
VCP ProteinP55072 (Uniprot-TrEMBL)
a xenobioticMetaboliteCHEBI:35703 (ChEBI)
atRALMetaboliteCHEBI:17898 (ChEBI)
hemeMetaboliteCHEBI:17627 (ChEBI)
lipidsMetaboliteCHEBI:18059 (ChEBI)
misfolded CFTR ProteinP13569 (Uniprot-TrEMBL)
misfolded CFTR:ERAD complexComplexR-HSA-8866538 (Reactome)
misfolded CFTRProteinP13569 (Uniprot-TrEMBL)
organic anionMetaboliteCHEBI:25696 (ChEBI)
phytosterols MetaboliteCHEBI:26125 (ChEBI)
porphyrinMetaboliteCHEBI:8337 (ChEBI)
sterolsComplexR-ALL-265781 (Reactome)
sterolsComplexR-ALL-265784 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
23mer peptideArrowR-HSA-5223317 (Reactome)
23mer peptideR-HSA-5223317 (Reactome)
26S proteasomemim-catalysisR-HSA-8866553 (Reactome)
ABCA cholesterol transportersmim-catalysisR-HSA-1369028 (Reactome)
ABCA cholesterol transportersmim-catalysisR-HSA-1369052 (Reactome)
ABCA12mim-catalysisR-HSA-5682285 (Reactome)
ABCA3mim-catalysisR-HSA-5683714 (Reactome)
ABCA4mim-catalysisR-HSA-1467466 (Reactome)
ABCA5mim-catalysisR-HSA-8848053 (Reactome)
ABCA7-1:ApoA1 complexmim-catalysisR-HSA-382553 (Reactome)
ABCA7-dependent phospholipidsArrowR-HSA-382553 (Reactome)
ABCA7-dependent phospholipidsR-HSA-382553 (Reactome)
ABCA8/B1/B5mim-catalysisR-HSA-1467457 (Reactome)
ABCB4mim-catalysisR-HSA-5678706 (Reactome)
ABCB9 dimermim-catalysisR-HSA-5223317 (Reactome)
ABCC2mim-catalysisR-HSA-5679041 (Reactome)
ABCCsmim-catalysisR-HSA-1454916 (Reactome)
ABCD1-3 dimersArrowR-HSA-382613 (Reactome)
ABCD1-3 dimersmim-catalysisR-HSA-382575 (Reactome)
ABCF1:EIF2S1:EIF2S2:EIF2S3ArrowR-HSA-5227009 (Reactome)
ABCF1R-HSA-5227009 (Reactome)
ABCG1 dimermim-catalysisR-HSA-266082 (Reactome)