Folate Metabolism (Homo sapiens)

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47, 73, 129, 177, 229...140, 2972, 100, 26333, 165, 245, 273, 31033206116, 153288228, 24814456221, 224, 242240, 27595MetabolitesFrom intracellular part to the plasmaProcess or metabolism involved in Se PathwayProtein tyrosine nitrationCofactor conversionGlycogenesisReactionLipid peroxidationProtein*EnzymesOther proteinsOverarching processStimulationSelenium statusCatalysisTranscription factorLEGENDNegative Effectis composed ofNecessary stimulationMicronutrientsBindingSelenoproteinsCofactorsProstaglandins metabolismProtein with polymorphismCleavageInhibitionBiomarker forLipoprotein melabolismConversionIntracellularApoptosisDNA oxidationMethylation reactionsNovo purine biosynthetic pathwayPlasmaFOLR1FOLR2MCP18-Isoprostaglandin F2aPGE2NFkB1MCP1PGE28-Isoprostaglandin F2aPGE1PGE1PGF2aThromboxane B2Thromboxane B2Thromboxane A2p53FOLR4F2-IsoprostaneSLC46A1F2-IsoprostaneSLC19A1FOLR3NFkB2RELAPGF2a1891635204, 32412, 146189, 319, 3241638456, 73, 75, 155, 224...163141848414660, 324204, 324560, 32416314184189SHMTMTHFD1*MTR*MSR*MTHFD2MATAHCYDHFR5661, 10225, 50, 5834, 275112, 27517968, 102, 147, 305275CBS66, 68NADP+NADP+NADP+NADP+NADP+NADP+NADP+MPOMPOCatalaseNOS194, 225, 273, 314194, 225, 273, 31426333, 209CysteineCysteineFactor VIItPAtPAPLGFactor VIIPAI-1ThrombinThrombinPAI-1PLG21, 32523823823823823823821, 18121, 32521, 181GPX 4H2O2(11S)-hydroxymethylene-THF5,10-Methenyl-THFDihydrofolateFGAR(11R)-hydroxymethylene-THF10-Formyl-THF5-Formyl-THF5,10-Methylene-THFGAR240, 27527527558275275275240, 27558, 2755-methyl-THFFolate5-methyl-THFFolate5, 43, 56, 58, 141...58, 30558SOD3SOD3RFK197H2OGPX 3GPX 3CTH68Heme33, 66, 209THF58NADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX 6ManganeseManganeseFolic acidFolic acid58, 147, 21058, 147, 210GPX 2GPX 1RNS33, 288MTHFR*GARTSHMTMTHFS27558, 147240, 275275HomocysteineHomocysteine3255, 131, 221, 263, 295...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate12, 133, 318133, 318GlycineGlycineL-ArginineSerine34, 27534, 27534, 275246, 263APOA1-NO2TyrHDL/APOA1VLDLTAGSAA1ACTVLDL-TAGAPOA1HDLSAA2APOBLDLHDL-CLDLRAPOA1LDLSAA4HDL-CSAA3FMNACTCholesterolVLDLAPOBVLDL/APOBVLDL-TAGCholesterolHDL/SAAoxLDLSRB1HDLTAGABCA1oxLDL153175153, 15717572168, 175168, 175132175175175116, 131, 225, 267153, 15772, 30315315372, 303175153, 261153153218153153, 157, 218153, 218116, 131, 225, 261, 267116, 131, 225, 267153, 261153, 157153116, 131, 225, 261, 267152175153, 157O22288-OHdGCob(II)alaminCob(I)alaminFADFAD8-OHdGCob(I)alamin9561, 71, 10261, 10215261, 71, 10210295ADPADPChlorineMagnesiumMagnesiumChlorineS-nitrosohomocysteineCystathionine263, 295SOD2Serine34, 275ATPZincZincO3NONO2HOClHNO2NO194, 224, 263, 295, 314194, 314FibrinIL2IFNgTNFaCRPD-dimerIL1BFibrinogenHbA1cHbA1cD-dimerIL4IL10IL4sICAM-1HBBIL6TNFaIL1BFibrinIL10IFNgINSRFibrinogenHBA1IL6INSCSF1IL2ALBALBCSF1INS75, 129181, 23875, 129177155, 172, 301, 31019816349, 88, 330163231, 238172, 29719822975172, 297198277, 310181, 238382772297538231, 23819812, 43, 49, 248, 267...155, 301144, 159, 168144, 159, 168, 26347159, 28949, 17747, 49, 159, 310Riboflavin9O2 S-Adenosylmethionine S-Adenosylmethionine S-AdenosylhomocysteineMethionineMethionine S-Adenosylhomocysteine48, 58, 30558, 102, 2824858, 14558, 14556, 58, 102, 282ADPNitrotyrosineTetrahydrobiopterinONOO/ONOOHNitrotyrosine288288246, 263ATPATPFructosamineFructosamineGlucoseGlucose38144, 198144, 19838IronIron211211FLAD1197, 283


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  1. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  2. Steinbrenner H, Sies H; ''Protection against reactive oxygen species by selenoproteins.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  3. Ahlberg J, Angelin B, Björkhem I, Einarsson K, Leijd B; ''Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.''; J Lipid Res, 1979 PubMed Europe PMC
  4. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN; ''Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.''; Am J Physiol, 1998 PubMed Europe PMC
  5. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM; ''Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide.''; Biochemistry, 2006 PubMed Europe PMC
  6. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.''; Biochim Biophys Acta, 2006 PubMed Europe PMC
  7. Goldstein JL, Brown MS; ''Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.''; Proc Natl Acad Sci U S A, 1973 PubMed Europe PMC
  8. Vásquez-Vivar J; ''Tetrahydrobiopterin, superoxide, and vascular dysfunction.''; Free Radic Biol Med, 2009 PubMed Europe PMC
  9. May JM, Mendiratta S, Hill KE, Burk RF; ''Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase.''; J Biol Chem, 1997 PubMed Europe PMC
  10. Whitaker MO, Wyche A, Fitzpatrick F, Sprecher H, Needleman P; ''Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  11. Brigelius-Flohé R; ''Glutathione peroxidases and redox-regulated transcription factors.''; Biol Chem, 2006 PubMed Europe PMC
  12. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC
  13. Wang LH, Kulmacz RJ; ''Thromboxane synthase: structure and function of protein and gene.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  14. Powis G, Montfort WR; ''Properties and biological activities of thioredoxins.''; Annu Rev Pharmacol Toxicol, 2001 PubMed Europe PMC
  15. Hesse-Bähr K, Dreher I, Köhrle J; ''The influence of the cytokines Il-1beta and INFgamma on the expression of selenoproteins in the human hepatocarcinoma cell line HepG2.''; Biofactors, 2000 PubMed Europe PMC
  16. Herbert V; ''Vitamin B-12: plant sources, requirements, and assay.''; Am J Clin Nutr, 1988 PubMed Europe PMC
  17. Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M; ''Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5.''; Proc Natl Acad Sci U S A, 1986 PubMed Europe PMC
  18. MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV; ''Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms.''; Appl Environ Microbiol, 1982 PubMed Europe PMC
  19. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.''; Diabetes Care, 2007 PubMed Europe PMC
  20. Cheng JB, Jacquemin E, Gerhardt M, Nazer H, Cresteil D, Heubi JE, Setchell KD, Russell DW; ''Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC
  21. Taki T, Kanfer JN; ''Phospholipase D from rat brain.''; Methods Enzymol, 1981 PubMed Europe PMC
  22. Santhanam U, Ray A, Sehgal PB; ''Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.''; Proc Natl Acad Sci U S A, 1991 PubMed Europe PMC
  23. Mancini JA, Abramovitz M, Cox ME, Wong E, Charleson S, Perrier H, Wang Z, Prasit P, Vickers PJ; ''5-lipoxygenase-activating protein is an arachidonate binding protein.''; FEBS Lett, 1993 PubMed Europe PMC
  24. Sala A, Voelkel N, Maclouf J, Murphy RC; ''Leukotriene E4 elimination and metabolism in normal human subjects.''; J Biol Chem, 1990 PubMed Europe PMC
  25. Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ; ''''; , PubMed Europe PMC
  26. Packer L, Witt EH, Tritschler HJ; ''alpha-Lipoic acid as a biological antioxidant.''; Free Radic Biol Med, 1995 PubMed Europe PMC
  27. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.''; J Trace Elem Med Biol, 2002 PubMed Europe PMC
  28. Baker CH, Matsuda SP, Liu DR, Corey EJ; ''Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.''; Biochem Biophys Res Commun, 1995 PubMed Europe PMC
  29. Feng Q, Keshtgarpour M, Pelleymounter LL, Moon I, Kalari KR, Eckloff BW, Wieben ED, Weinshilboum RM; ''Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.''; J Neurochem, 2009 PubMed Europe PMC
  30. Lu C, Qiu F, Zhou H, Peng Y, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett, 2006 PubMed Europe PMC
  31. Yamashita S, Hosaka K, Numa S; ''Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes.''; Eur J Biochem, 1973 PubMed Europe PMC
  32. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W; ''Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.''; J Nutr, 2008 PubMed Europe PMC
  33. Stoffel W, LeKim D, Sticht G; ''Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one).''; Hoppe Seylers Z Physiol Chem, 1968 PubMed Europe PMC
  34. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC
  35. Brigelius-Flohé R; ''Tissue-specific functions of individual glutathione peroxidases.''; Free Radic Biol Med, 1999 PubMed Europe PMC
  36. Imai H, Narashima K, Arai M, Sakamoto H, Chiba N, Nakagawa Y; ''Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase.''; J Biol Chem, 1998 PubMed Europe PMC
  37. Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, Choe SN, Wahle KW; ''Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants.''; Atherosclerosis, 2003 PubMed Europe PMC
  38. Hosaka K, Tanaka S, Nikawa J, Yamashita S; ''Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.''; FEBS Lett, 1992 PubMed Europe PMC
  39. Chen D, Zhang XY, Shi Y; ''Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.''; Biochem J, 2006 PubMed Europe PMC
  40. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE; ''Cyclooxygenase in biology and disease.''; FASEB J, 1998 PubMed Europe PMC
  41. Huijghebaert SM, Hofmann AF; ''Influence of the amino acid moiety on deconjugation of bile acid amidates by cholylglycine hydrolase or human fecal cultures.''; J Lipid Res, 1986 PubMed Europe PMC
  42. Pesch J, Brehm U, Staib C, Grummt F; ''Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53.''; J Interferon Cytokine Res, 1996 PubMed Europe PMC
  43. Guimarães MJ, Peterson D, Vicari A, Cocks BG, Copeland NG, Gilbert DJ, Jenkins NA, Ferrick DA, Kastelein RA, Bazan JF, Zlotnik A; ''Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  44. Wilson A, Leclerc D, Rosenblatt DS, Gravel RA; ''Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.''; Hum Mol Genet, 1999 PubMed Europe PMC
  45. Huwyler J, Bürgin M, Zeugin T, Gut J; ''Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione.''; Mol Pharmacol, 1991 PubMed Europe PMC
  46. Abate A, Yang G, Dennery PA, Oberle S, Schröder H; ''Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin.''; Free Radic Biol Med, 2000 PubMed Europe PMC
  47. Glickman JF, Schmid A; ''Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay.''; Assay Drug Dev Technol, 2007 PubMed Europe PMC
  48. Salem N Jr, Pawlosky R, Wegher B, Hibbeln J; ''In vivo conversion of linoleic acid to arachidonic acid in human adults.''; Prostaglandins Leukot Essent Fatty Acids, 1999 PubMed Europe PMC
  49. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev V; ''Structure-function relationships, physiological roles and evolution of mammalian ER-resident selenoproteins.''; Antioxid Redox Signal, 2009 PubMed Europe PMC
  50. Lykidis A, Jackson PD, Rock CO, Jackowski S; ''The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content.''; J Biol Chem, 1997 PubMed Europe PMC
  51. WikiPathways; ''Selenoproteins'';,
  52. McCay PB; ''Vitamin E: interactions with free radicals and ascorbate.''; Annu Rev Nutr, 1985 PubMed Europe PMC
  53. Penning TM, Jin Y, Steckelbroeck S, Lanisnik Rizner T, Lewis M; ''Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC
  54. Whanger PD; ''Selenoprotein W: a review.''; Cell Mol Life Sci, 2000 PubMed Europe PMC
  55. Bütikofer P, Yee MC, Schott MA, Lubin BH, Kuypers FA; ''Generation of phosphatidic acid during calcium-loading of human erythrocytes. Evidence for a phosphatidylcholine-hydrolyzing phospholipase D.''; Eur J Biochem, 1993 PubMed Europe PMC
  56. Smith WL, Langenbach R; ''Why there are two cyclooxygenase isozymes.''; J Clin Invest, 2001 PubMed Europe PMC
  57. Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J; ''Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.''; Cell Immunol, 2007 PubMed Europe PMC
  58. Bjørke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, Refsum H; ''Determinants of cobalamin status in newborns.''; Pediatrics, 2001 PubMed Europe PMC
  59. Johnsen IB, Nguyen TT, Ringdal M, Tryggestad AM, Bakke O, Lien E, Espevik T, Anthonsen MW; ''Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.''; EMBO J, 2006 PubMed Europe PMC
  60. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  61. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y; ''A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation.''; J Biol Chem, 1997 PubMed Europe PMC
  62. Holleran WM, Williams ML, Gao WN, Elias PM; ''''; , PubMed Europe PMC
  63. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  64. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A; ''Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.''; Biochem J, 2002 PubMed Europe PMC
  65. Sandrine A, Ferreiro A; ''Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signalling and calcium homeostasis.''; Antioxid Redox Signal, 2009 PubMed Europe PMC
  66. Niwa Y, Sakane T, Ichikawa M, Kondo T, Taniguchi S; ''Phospholipid transmethylation and choline phosphotransferase in microsomal fraction of human diseased liver.''; J Hepatol, 1986 PubMed Europe PMC
  67.; ''Arachidonic Acid Metabolism''; Ingenuity sofware,
  68. Lavie CJ, Milani RV, Mehra MR, Ventura HO; ''Omega-3 polyunsaturated fatty acids and cardiovascular diseases.''; J Am Coll Cardiol, 2009 PubMed Europe PMC
  69. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr., 1999 PubMed Europe PMC
  70. Basu S; ''F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  71. Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA; ''A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.''; Nature, 2004 PubMed Europe PMC
  72. Bianco AC, Kim BW; ''Deiodinases: implications of the local control of thyroid hormone action.''; J Clin Invest, 2006 PubMed Europe PMC
  73. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T; ''Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.''; J Biol Chem, 2004 PubMed Europe PMC
  74. Shigenaga MK, Gimeno CJ, Ames BN; ''Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC
  75. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  76. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC; ''Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.''; J Biol Chem, 2005 PubMed Europe PMC
  77. Pedretti A, Bocci E, Maggi R, Vistoli G; ''Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations.''; Steroids, 2008 PubMed Europe PMC
  78. Laden BP, Tang Y, Porter TD; ''Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase.''; Arch Biochem Biophys, 2000 PubMed Europe PMC
  79. Videla LA, Rodrigo R, Araya J, Poniachik J; ''Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease.''; Trends Mol Med, 2006 PubMed Europe PMC
  80. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W; ''Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study.''; Eur J Clin Nutr, 2008 PubMed Europe PMC
  81. Antonenkov VD, Van Veldhoven PP, Waelkens E, Mannaerts GP; ''Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates.''; J Biol Chem, 1997 PubMed Europe PMC
  82. Janciauskiene S, Wright HT; ''Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.''; Bioessays, 1998 PubMed Europe PMC
  83. Smith WL; ''Cyclooxygenases, peroxide tone and the allure of fish oil.''; Curr Opin Cell Biol, 2005 PubMed Europe PMC
  84. Kim YI; ''Role of the MTHFR polymorphisms in cancer risk modification and treatment.''; Future Oncol, 2009 PubMed Europe PMC
  85. Waterham HR, Wijburg FA, Hennekam RC, Vreken P, Poll-The BT, Dorland L, Duran M, Jira PE, Smeitink JA, Wevers RA, Wanders RJ; ''Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene.''; Am J Hum Genet, 1998 PubMed Europe PMC
  86. Franken PA, Van den Berg L, Huang J, Gunyuzlu P, Lugtigheid RB, Verheij HM, De Haas GH; ''Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.''; Eur J Biochem, 1992 PubMed Europe PMC
  87. Gustafsson J; ''Bile acid synthesis during development. Mitochondrial 12 alpha-hydroxylation in human fetal liver.''; J Clin Invest, 1985 PubMed Europe PMC
  88. ''''; , PubMed Europe PMC
  89. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML.; ''Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.''; Nat Struct Biol., 2002 PubMed Europe PMC
  90. Guan ZZ, Wang YN, Xiao KQ, Hu PS, Liu JL; ''Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.''; Neurochem Int, 1999 PubMed Europe PMC
  91. Morrow JD, Roberts LJ 2nd.; ''The isoprostanes. Current knowledge and directions for future research.''; Biochem Pharmacol., 1996 PubMed Europe PMC
  92. Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA; ''Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.''; J Am Diet Assoc, 2009 PubMed Europe PMC
  93. Minkes M, Stanford N, Chi MM, Roth GJ, Raz A, Needleman P, Majerus PW; ''Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.''; J Clin Invest, 1977 PubMed Europe PMC
  94. ''''; ,
  95. Schumm K, Rocha S, Caamano J, Perkins ND; ''Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.''; EMBO J, 2006 PubMed Europe PMC
  96. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J; ''NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.''; J Biol Chem, 2006 PubMed Europe PMC
  97. Watanabe K; ''Prostaglandin F synthase.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  98. Adams RL, Bird RJ; ''Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants.''; Nephrology (Carlton), 2009 PubMed Europe PMC
  99. Whanger PD; ''Selenoprotein expression and function-Selenoprotein W.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  100. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; J Biol Chem, 1992 PubMed Europe PMC
  101. Magni G, Amici A, Emanuelli M, Orsomando G, Raffaelli N, Ruggieri S; ''Enzymology of NAD+ homeostasis in man.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  102. Betsholtz IH, Wikvall K; ''Cytochrome P450 CYP27-catalyzed oxidation of C27-steroid into C27-acid.''; J Steroid Biochem Mol Biol, 1995 PubMed Europe PMC
  103. Verrax J, Calderon PB; ''The controversial place of vitamin C in cancer treatment.''; Biochem Pharmacol, 2008 PubMed Europe PMC
  104. Lijnen HR; ''Elements of the fibrinolytic system.''; Ann N Y Acad Sci, 2001 PubMed Europe PMC
  105. Maccarrone M, Meloni C, Manca-di-Villahermosa S, Cococcetta N, Casciani CU, Finazzi-Agrò A, Taccone-Gallucci M; ''Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route.''; Am J Kidney Dis, 2001 PubMed Europe PMC
  106. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC
  107. Wu C, Bates SM; ''Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism?''; Pol Arch Med Wewn, 2009 PubMed Europe PMC
  108. Jeong D, Kim TS, Chung YW, Lee BJ, Kim IY; ''Selenoprotein W is a glutathione-dependent antioxidant in vivo.''; FEBS Lett, 2002 PubMed Europe PMC
  109. Hammarström S; ''Leukotrienes.''; Annu Rev Biochem, 1983 PubMed Europe PMC
  110. Eberhardt C, Gray PW, Tjoelker LW; ''Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.''; J Biol Chem, 1997 PubMed Europe PMC
  111. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA.; ''Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.''; Hum Mol Genet., 1996 PubMed Europe PMC
  112. Traber MG; ''Vitamin E regulatory mechanisms.''; Annu Rev Nutr, 2007 PubMed Europe PMC
  113. Selhub J.; ''Homocysteine metabolism.''; Annu Rev Nutr, 1999 PubMed Europe PMC
  114. Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID; ''The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.''; Mol Pharmacol, 2008 PubMed Europe PMC
  115. Miyazaki M, Kanto T, Inoue M, Itose I, Miyatake H, Sakakibara M, Yakushijin T, Kakita N, Hiramatsu N, Takehara T, Kasahara A, Hayashi N; ''Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.''; J Med Virol, 2008 PubMed Europe PMC
  116. Ma Y, Hébert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL, Tinker L, Rosal MC, Ockene IS, Ockene JK, Griffith JA, Liu S; ''Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study.''; Nutrition, 2008 PubMed Europe PMC
  117. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B; ''Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2.''; J Am Coll Nutr, 1998 PubMed Europe PMC
  118. Peters KL, Smith HL, Stark GR, Sen GC; ''IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC
  119. Leung DW, Tompkins CK, White T; ''Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.''; DNA Cell Biol, 1998 PubMed Europe PMC
  120. Baumruker T, Bornancin F, Billich A; ''The role of sphingosine and ceramide kinases in inflammatory responses.''; Immunol Lett, 2005 PubMed Europe PMC
  121. Johnson MR, Barnes S, Diasio RB; ''Radioassay of bile acid coenzyme A:glycine/taurine: N-acyltransferase using an n-butanol solvent extraction procedure.''; Anal Biochem, 1989 PubMed Europe PMC
  122. Yasutomi M, Ohshima Y, Omata N, Yamada A, Iwasaki H, Urasaki Y, Mayumi M; ''Erythromycin differentially inhibits lipopolysaccharide- or poly(I:C)-induced but not peptidoglycan-induced activation of human monocyte-derived dendritic cells.''; J Immunol, 2005 PubMed Europe PMC
  123. Evans P, Halliwell B; ''Free radicals and hearing. Cause, consequence, and criteria.''; Ann N Y Acad Sci, 1999 PubMed Europe PMC
  124. Clifton PM, Mackinnon AM, Barter PJ; ''Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction.''; J Lipid Res, 1985 PubMed Europe PMC
  125. Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ; ''Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.''; Am J Hum Genet, 2001 PubMed Europe PMC
  126. Momoi T, Ben-Yoseph Y, Nadler HL; ''Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls.''; Biochem J, 1982 PubMed Europe PMC
  127. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC
  128. Galton DJ; ''Lipogenesis in human adipose tissue.''; J Lipid Res, 1968 PubMed Europe PMC
  129. Zamocky M, Furtmüller PG, Obinger C; ''Evolution of catalases from bacteria to humans.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  130. Goetzl EJ, Sun FF; ''Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.''; J Exp Med, 1979 PubMed Europe PMC
  131. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed Europe PMC
  132. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr; ''Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy.''; Biol Trace Elem Res, 2008 PubMed Europe PMC
  133. Hussein O, Rosenblat M, Refael G, Aviram M; ''Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients.''; Transplantation, 1997 PubMed Europe PMC
  134. Choi SW, Mason JB; ''Folate and carcinogenesis: an integrated scheme.''; J Nutr, 2000 PubMed Europe PMC
  135. Nitahara Y, Aoyama Y, Horiuchi T, Noshiro M, Yoshida Y; ''Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.''; J Biochem, 1999 PubMed Europe PMC
  136. Kamagate A, Dong HH; ''FoxO1 integrates insulin signaling to VLDL production.''; Cell Cycle, 2008 PubMed Europe PMC
  137. Jakobsson A, Westerberg R, Jacobsson A; ''Fatty acid elongases in mammals: their regulation and roles in metabolism.''; Prog Lipid Res, 2006 PubMed Europe PMC
  138. Hoey L, McNulty H, Strain JJ; ''Studies of biomarker responses to intervention with riboflavin: a systematic review.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  139. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R; ''A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis.''; Clin Rheumatol, 2003 PubMed Europe PMC
  140. Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E; ''Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.''; J Biol Chem, 2007 PubMed Europe PMC
  141. Cuebas DA, Phillips C, Schmitz W, Conzelmann E, Novikov DK; ''The role of alpha-methylacyl-CoA racemase in bile acid synthesis.''; Biochem J, 2002 PubMed Europe PMC
  142. Isseroff RR, Ziboh VA, Chapkin RS, Martinez DT; ''''; , PubMed Europe PMC
  143. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC
  144.; ''Vitamin B 6''; Linus Paulin institute,
  145. Singh S, Madzelan P, Banerjee R; ''Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase.''; Nat Prod Rep, 2007 PubMed Europe PMC
  146. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC; ''Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression.''; Science, 1989 PubMed Europe PMC
  147.; ''Folic acid''; Linus Pauling Institute,
  148. Amaral JD, Castro RE, Steer CJ, Rodrigues CM; ''p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis.''; Trends Mol Med, 2009 PubMed Europe PMC
  149. Erickson SK, Bösterling B; ''Cholesterol 7 alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles.''; J Lipid Res, 1981 PubMed Europe PMC
  150. Agaugué S, Perrin-Cocon L, Coutant F, André P, Lotteau V; ''1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity.''; J Immunol, 2006 PubMed Europe PMC
  151. Itabe H; ''Oxidative modification of LDL: its pathological role in atherosclerosis.''; Clin Rev Allergy Immunol, 2009 PubMed Europe PMC
  152. Puig-Kröger A, Sierra-Filardi E, Domínguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, Ratnam M, Sánchez-Mateos P, Corbí AL.; ''Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages.''; Cancer Res, 2009 PubMed Europe PMC
  153. Ellis E, Goodwin B, Abrahamsson A, Liddle C, Mode A, Rudling M, Bjorkhem I, Einarsson C; ''Bile acid synthesis in primary cultures of rat and human hepatocytes.''; Hepatology, 1998 PubMed Europe PMC
  154. Ben Jilani KE, Panee J, He Q, Berry MJ, Li PA; ''Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation.''; Int J Biol Sci, 2007 PubMed Europe PMC
  155. McKinley MC, McNulty H, McPartlin J, Strain JJ, Scott JM; ''Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status.''; Eur J Clin Nutr, 2002 PubMed Europe PMC
  156. Kimura T, Nakanishi K, Nakagawa T, Shibukawa A, Matsuzaki K; ''Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection.''; J Pharm Biomed Anal, 2005 PubMed Europe PMC
  157. Izzo AA, Piscitelli F, Capasso R, Marini P, Cristino L, Petrosino S, Di Marzo V; ''Basal and Fasting/Refeeding-regulated Tissue Levels of Endogenous PPAR-alpha Ligands in Zucker Rats.''; Obesity (Silver Spring), 2009 PubMed Europe PMC
  158. Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S; ''Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.''; J Biol Chem, 2001 PubMed Europe PMC
  159. Yun J, Kim JY, Kim OY, Jang Y, Chae JS, Kwak JH, Lim HH, Park HY, Lee SH, Lee JH; ''Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men.''; Nutr Metab Cardiovasc Dis, 2009 PubMed Europe PMC
  160. Needleman P, Raz A, Minkes MS, Ferrendelli JA, Sprecher H; ''Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  161. Helgerud P, Saarem K, Norum KR; ''Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.''; J Lipid Res, 1981 PubMed Europe PMC
  162. Jakubowski H; ''Molecular basis of homocysteine toxicity in humans.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  163. Chatterjee S, Castiglione E; ''UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.''; Biochim Biophys Acta, 1987 PubMed Europe PMC
  164. Klebanoff SJ; ''Myeloperoxidase: friend and foe.''; J Leukoc Biol, 2005 PubMed Europe PMC
  165. Ho TC, Chen SL, Yang YC, Chen CY, Feng FP, Hsieh JW, Cheng HC, Tsao YP; ''15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.''; J Biol Chem, 2008 PubMed Europe PMC
  166. Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U; ''Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.''; Mol Cell Endocrinol, 2008 PubMed Europe PMC
  167. Shimojo T, Akino T, Miura Y, Schroepfer GJ Jr; ''Sphingolipid base metabolism. Stereospecific uptake of proton in the enzymatic conversion of sphinganine 1-phosphate to ethanolamine 1-phosphate.''; J Biol Chem, 1976 PubMed Europe PMC
  168. Jiang LL, Kurosawa T, Sato M, Suzuki Y, Hashimoto T; ''Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.''; J Biochem, 1997 PubMed Europe PMC
  169. Stoffel W, LeKim D, Sticht G; ''''; , PubMed Europe PMC
  170. Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN; ''Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element.''; Mol Cell Biol, 2002 PubMed Europe PMC
  171. Olivier LM, Chambliss KL, Gibson KM, Krisans SK; ''Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.''; J Lipid Res, 1999 PubMed Europe PMC
  172. Ho AW, Wong CK, Lam CW; ''Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways.''; Immunobiology, 2008 PubMed Europe PMC
  173. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, Radermacher P, Calzia E; ''Glucose metabolism and catecholamines.''; Crit Care Med, 2007 PubMed Europe PMC
  174. Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A; ''Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment.''; Ann Neurol, 2009 PubMed Europe PMC
  175. Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, Kwan I, Pepin N, Lacoste J, Nguyen H, Bensi G; ''Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.''; Mol Cell Biol, 1993 PubMed Europe PMC
  176. Singh U, Devaraj S, Jialal I.; ''Vitamin E, oxidative stress, and inflammation.''; Annu Rev Nutr., 2005 PubMed Europe PMC
  177. Edmondson DE, Newton-Vinson P; ''The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction.''; Antioxid Redox Signal, 2001 PubMed Europe PMC
  178. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.''; J Biol Chem, 2007 PubMed Europe PMC
  179. Lu B, Xu FY, Jiang YJ, Choy PC, Hatch GM, Grunfeld C, Feingold KR; ''Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1).''; J Lipid Res, 2006 PubMed Europe PMC
  180. ''Food and Nutrition Board, Institute of Medicine. Vitamin B6. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Vitamin B12, Pantothenic Acid, Biotin, and Choline.''; Washington D.C.: National Academies Press, 1998
  181. Simmons DL, Botting RM, Hla T; ''Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.''; Pharmacol Rev, 2004 PubMed Europe PMC
  182. Bierbach H; ''Studies on long chain fatty acid:CoA ligase from human small intestine.''; Gut, 1980 PubMed Europe PMC
  183. Yang P, Chan D, Felix E, Cartwright C, Menter DG, Madden T, Klein RD, Fischer SM, Newman RA; ''Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.''; J Lipid Res, 2004 PubMed Europe PMC
  184. Huerta C, Borek D, Machius M, Grishin NV, Zhang H; ''Structure and mechanism of a eukaryotic FMN adenylyltransferase.''; J Mol Biol, 2009 PubMed Europe PMC
  185. Ben van Ommen, Susan Fairweather-Tait, Andreas Freidig, Alwine Kardinaal, Augustin Scalbert, Suzan Wopereis; ''A network biology model of micronutrient related health''; Br J Nutr, 2008
  186. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F; ''Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.''; Eur J Immunol, 2005 PubMed Europe PMC
  187. Goriely S, Molle C, Nguyen M, Albarani V, Haddou NO, Lin R, De Wit D, Flamand V, Willems F, Goldman M; ''Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation.''; Blood, 2006 PubMed Europe PMC
  188. Bertran N, Camps J, Fernandez-Ballart J, Arija V, Ferre N, Tous M, Simo D, Murphy MM, Vilella E, Joven J; ''Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study.''; J Lab Clin Med, 2005 PubMed Europe PMC
  189. Becker BF; ''Towards the physiological function of uric acid.''; Free Radic Biol Med, 1993 PubMed Europe PMC
  190. Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, Heng HH, Rommens JM, Scherer SW, Rosenblatt DS, Gravel RA; ''Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC
  191. Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS; ''Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1.''; Clin Immunol, 2009 PubMed Europe PMC
  192. Lund EG, Kerr TA, Sakai J, Li WP, Russell DW; ''cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.''; J Biol Chem, 1998 PubMed Europe PMC
  193. Remoli ME, Ragimbeau J, Giacomini E, Gafa V, Severa M, Lande R, Pellegrini S, Coccia EM; ''NF-{kappa}B is required for STAT-4 expression during dendritic cell maturation.''; J Leukoc Biol, 2007 PubMed Europe PMC
  194. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN; ''Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.''; Biochem Soc Trans, 2007 PubMed Europe PMC
  195. Bailey JM, Bryant RW, Whiting J, Salata K; ''Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells.''; J Lipid Res, 1983 PubMed Europe PMC
  196. Serhan CN; ''Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?''; Prostaglandins, 1997 PubMed Europe PMC
  197. Schnurr K, Belkner J, Ursini F, Schewe T, Kühn H; ''The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.''; J Biol Chem, 1996 PubMed Europe PMC
  198. Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM; ''Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.''; J Biol Chem, 2003 PubMed Europe PMC
  199. Anderson ME, Allison RD, Meister A; ''Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.''; Proc Natl Acad Sci U S A, 1982 PubMed Europe PMC
  200. Draus E, Niefind J, Vietor K, Havsteen B; ''Isolation and characterization of the human liver ethanolamine kinase.''; Biochim Biophys Acta, 1990 PubMed Europe PMC
  201. Hoey L, Strain JJ, McNulty H; ''Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.''; Am J Clin Nutr, 2009 PubMed Europe PMC
  202. Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, Neufeld EJ, Notarangelo LD; ''Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter.''; Clin Immunol, 2009 PubMed Europe PMC
  203. Banning A, Florian S, Deubel S, Thalmann S, Müller-Schmehl K, Jacobasch G, Brigelius-Flohé R; ''GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells.''; Antioxid Redox Signal, 2008 PubMed Europe PMC
  204. Skacel N, Menon LG, Mishra PJ, Peters R, Banerjee D, Bertino JR, Abali EE; ''Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.''; J Biol Chem, 2005 PubMed Europe PMC
  205. Bates CJ, Thane CW, Prentice A, Delves HT; ''Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over.''; J Trace Elem Med Biol, 2002 PubMed Europe PMC
  206. Giera M, Renard D, Plössl F, Bracher F; ''Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors.''; Steroids, 2008 PubMed Europe PMC
  207. Hahn FM, Xuan JW, Chambers AF, Poulter CD; ''Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization.''; Arch Biochem Biophys, 1996 PubMed Europe PMC
  208. Bailey SW, Ayling JE; ''The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC
  209. Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, Tommasino M, Vlach J; ''Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  210. Burk RF, Hill KE, Motley AK; ''Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P.''; J Nutr, 2003 PubMed Europe PMC
  211. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC
  212. Moore SA, Hurt E, Yoder E, Sprecher H, Spector AA; ''Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.''; J Lipid Res, 1995 PubMed Europe PMC
  213. Köhrle J, Jakob F, Contempré B, Dumont JE; ''Selenium, the thyroid, and the endocrine system.''; Endocr Rev, 2005 PubMed Europe PMC
  214. Kimura M, Okuno E, Inada J, Ohyama H, Kido R; ''Purification and characterization of amino-acid N-choloyltransferase from human liver.''; Hoppe Seylers Z Physiol Chem, 1983 PubMed Europe PMC
  215. Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM; ''''; , PubMed Europe PMC
  216. Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M; ''Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.''; Clin Exp Allergy, 2006 PubMed Europe PMC
  217. Okuma M, Yamashita S, Numa S; ''Enzymic studies on phosphatidic acid synthesis in human platelets.''; Blood, 1973 PubMed Europe PMC
  218. Marnett LJ; ''Lipid peroxidation-DNA damage by malondialdehyde.''; Mutat Res, 1999 PubMed Europe PMC
  219. Labunskyy VM, Hatfield DL, Gladyshev VN; ''The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum.''; IUBMB Life, 2007 PubMed Europe PMC
  220. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC
  221. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN; ''Characterization of mammalian selenoproteomes.''; Science, 2003 PubMed Europe PMC
  222. Kainou T, Kawamura K, Tanaka K, Matsuda H, Kawamukai M; ''Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  223. Traupe H, Has C; ''The Conradi-Hünermann-Happle syndrome is caused by mutations in the gene that encodes a 8- 7 sterol isomerase and is biochemically related to the CHILD syndrome.''; Eur J Dermatol, 2000 PubMed Europe PMC
  224. Sica A, Tan TH, Rice N, Kretzschmar M, Ghosh P, Young HA; ''The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.''; Proc Natl Acad Sci U S A, 1992 PubMed Europe PMC
  225. Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL; ''Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.''; J Biol Chem, 2008 PubMed Europe PMC
  226. Arnér ES, Nordberg J, Holmgren A; ''Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase.''; Biochem Biophys Res Commun, 1996 PubMed Europe PMC
  227. Karthikeyan S, Zhou Q, Osterman AL, Zhang H; ''Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism.''; Biochemistry, 2003 PubMed Europe PMC
  228. Ghosh J, Myers CE; ''Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC
  229. Doo YC, Han SJ, Park WJ, Kim SM, Choi SH, Cho GY, Hong KS, Han KR, Lee NH, Oh DJ, Ryu KH, Rhim CY, Lee KH, Lee Y; ''Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication.''; Clin Cardiol, 2005 PubMed Europe PMC
  230. Fang JY, Xiao SD, Zhu SS, Yuan JM, Qiu DK, Jiang SJ; ''Relationship of plasma folic acid and status of DNA methylation in human gastric cancer.''; J Gastroenterol, 1997 PubMed Europe PMC
  231. Pikuleva IA, Puchkaev A, Björkhem I; ''Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1.''; Biochemistry, 2001 PubMed Europe PMC
  232. Kovacs E; ''The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy.''; Biomed Pharmacother, 2005 PubMed Europe PMC
  233. Molnár I, Balázs C, Szegedi G, Sipka S; ''Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue.''; Immunol Lett, 2002 PubMed Europe PMC
  234. Setty BN, Stuart MJ, Walenga RW; ''Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.''; Biochim Biophys Acta, 1985 PubMed Europe PMC
  235. Kalpakcioglu B, Senel K; ''The interrelation of glutathione reductase, catalase, glutathione peroxidase, superoxide dismutase, and glucose-6-phosphate in the pathogenesis of rheumatoid arthritis.''; Clin Rheumatol, 2008 PubMed Europe PMC
  236. Schöneich C; ''Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease.''; Biochim Biophys Acta, 2005 PubMed Europe PMC
  237. Eklund CM; ''Proinflammatory cytokines in CRP baseline regulation.''; Adv Clin Chem, 2009 PubMed Europe PMC
  238. Vladimir Kery, Loelle Poneleit, Jeffrey D. Meyer, Mark C. Manning, Jan P. Kraus; ''Binding of Pyridoxal 5'-Phosphate to the Heme Protein Human Cystathionine -Synthase''; Biochemistry., 1998
  239. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, Cooperman BS, Douglas SD, Rubin H; ''Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin.''; J Immunol, 1991 PubMed Europe PMC
  240. Lu J, Holmgren A; ''Selenoproteins.''; J Biol Chem, 2009 PubMed Europe PMC
  241. Ogawa H, Gomi T, Fujioka M; ''Serine hydroxymethyltransferase and threonine aldolase: are they identical?''; Int J Biochem Cell Biol, 2000 PubMed Europe PMC
  242. Shen W, Stone K, Jales A, Leitenberg D, Ladisch S; ''Inhibition of TLR activation and up-regulation of IL-1R-associated kinase-M expression by exogenous gangliosides.''; J Immunol, 2008 PubMed Europe PMC
  243. White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB; ''Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708.''; J Lipid Res, 1981 PubMed Europe PMC
  244. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T; ''Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.''; Arterioscler Thromb Vasc Biol, 2002 PubMed Europe PMC
  245. Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A; ''Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.''; J Biol Chem, 2007 PubMed Europe PMC
  246. Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M; ''Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c -->t methylenetetrahydrofolate reductase and 2756a -->g methionine synthase genotypes.''; Mol Genet Metab, 2000 PubMed Europe PMC
  247. Nilsson A, Duan RD; ''Absorption and lipoprotein transport of sphingomyelin.''; J Lipid Res, 2006 PubMed Europe PMC
  248. Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL; ''Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease.''; J Clin Invest, 2004 PubMed Europe PMC
  249. Gao Y, Feng HC, Walder K, Bolton K, Sunderland T, Bishara N, Quick M, Kantham L, Collier GR; ''Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein.''; FEBS Lett, 2004 PubMed Europe PMC
  250. Esmon CT; ''Does inflammation contribute to thrombotic events?''; Haemostasis, 2000 PubMed Europe PMC
  251. Schäfer M, Werner S; ''Oxidative stress in normal and impaired wound repair.''; Pharmacol Res, 2008 PubMed Europe PMC
  252. Horrobin DF; ''Fatty acid metabolism in health and disease: the role of delta-6-desaturase.''; Am J Clin Nutr, 1993 PubMed Europe PMC
  253. Malle E, Marsche G, Arnhold J, Davies MJ; ''Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid.''; Biochim Biophys Acta, 2006 PubMed Europe PMC
  254. Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M, Dai W; ''Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.''; J Biol Chem, 2001 PubMed Europe PMC
  255. Schwarz M, Wright AC, Davis DL, Nazer H, Björkhem I, Russell DW; ''The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.''; J Clin Invest, 2000 PubMed Europe PMC
  256. Mayer O Jr, Simon J, Rosolová H, Hromádka M, Subrt I, Vobrubová I; ''The effects of folate supplementation on some coagulation parameters and oxidative status surrogates.''; Eur J Clin Pharmacol, 2002 PubMed Europe PMC
  257. Joensen AM, Schmidt EB, Dethlefsen C, Johnsen SP, Tjønneland A, Rasmussen LH, Overvad K; ''Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome - a cohort study.''; Br J Nutr, 2009 PubMed Europe PMC
  258. Cao S, Zhang X, Edwards JP, Mosser DM; ''NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages.''; J Biol Chem, 2006 PubMed Europe PMC
  259. Paradisi G, Cucinelli F, Mele MC, Barini A, Lanzone A, Caruso A; ''Endothelial function in post-menopausal women: effect of folic acid supplementation.''; Hum Reprod, 2004 PubMed Europe PMC
  260. Pyne S, Pyne NJ; ''Sphingosine 1-phosphate signalling in mammalian cells.''; Biochem J, 2000 PubMed Europe PMC
  261. Struys EA, Jansen EE, de Meer K, Jakobs C; ''Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry.''; Clin Chem, 2000 PubMed Europe PMC
  262. Fernandes-Costa F: Metz J.; ''Vitamin B12 binders (transcobalamins) in serum.''; Crit Rev Clin Lab Sci., 1982 PubMed Europe PMC
  263. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL; ''A new human selenium-containing protein. Purification, characterization, and cDNA sequence.''; J Biol Chem, 1998 PubMed Europe PMC
  264. Gao Y, Hannan NR, Wanyonyi S, Konstantopolous N, Pagnon J, Feng HC, Jowett JB, Kim KH, Walder K, Collier GR; ''Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells.''; Cytokine, 2006 PubMed Europe PMC
  265. ''''; ,
  266. Grumolato L, Ghzili H, Montero-Hadjadje M, Gasman S, Lesage J, Tanguy Y, Galas L, Ait-Ali D, Leprince J, Guérineau NC, Elkahloun AG, Fournier A, Vieau D, Vaudry H, Anouar Y; ''Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion.''; FASEB J, 2008 PubMed Europe PMC
  267. Basu S.; ''Isoprostanes: novel bioactive products of lipid peroxidation.''; Free Radic Res., 2004 PubMed Europe PMC
  268. Lewis GF, Rader DJ; ''New insights into the regulation of HDL metabolism and reverse cholesterol transport.''; Circ Res, 2005 PubMed Europe PMC
  269. Araya Z, Wikvall K; ''6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  270. Ferré P; ''The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity.''; Diabetes, 2004 PubMed Europe PMC
  271. Liu YY, Han TY, Giuliano AE, Cabot MC; ''Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.''; J Biol Chem, 1999 PubMed Europe PMC
  272. Abello N, Kerstjens HA, Postma DS, Bischoff R; ''Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.''; J Proteome Res, 2009 PubMed Europe PMC
  273. Neumann D, Kollewe C, Resch K, Martin MU.; ''The death domain of IRAK-1: an oligomerization domain mediating interactions with MyD88, Tollip, IRAK-1, and IRAK-4.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC
  274. Bose R, Kolesnick R; ''Measurement of ceramide synthase activity.''; Methods Enzymol, 2000 PubMed Europe PMC
  275. Kwak SE, Kim JE, Kim DW, Kwon OS, Choi SY, Kang TC; ''Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.''; Hippocampus, 2009 PubMed Europe PMC
  276. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie JS, Harrison RW, Zeichner J, Mudrick D, Marbán E, Kass DA, Hare JM; ''Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart.''; Circ Res, 2002 PubMed Europe PMC
  277. Heirman I, Ginneberge D, Brigelius-Flohé R, Hendrickx N, Agostinis P, Brouckaert P, Rottiers P, Grooten J; ''Blocking tumor cell eicosanoid synthesis by GP x 4 impedes tumor growth and malignancy.''; Free Radic Biol Med, 2006 PubMed Europe PMC
  278. Bills TK, Smith JB, Silver MJ; ''Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.''; J Clin Invest, 1977 PubMed Europe PMC
  279. Voelker DR; ''Phosphatidylserine decarboxylase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  280. Nakamura MT, Nara TY; ''Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases.''; Annu Rev Nutr, 2004 PubMed Europe PMC
  281. Son YH, Jeong YT, Lee KA, Choi KH, Kim SM, Rhim BY, Kim K; ''Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.''; J Cardiovasc Pharmacol, 2008 PubMed Europe PMC
  282. Murakami M, Nakatani Y, Tanioka T, Kudo I; ''Prostaglandin E synthase.''; Prostaglandins Other Lipid Mediat, 2002 PubMed Europe PMC
  283. Rampersaud GC, Kauwell GP, Bailey LB; ''Folate: a key to optimizing health and reducing disease risk in the elderly.''; J Am Coll Nutr, 2003 PubMed Europe PMC
  284. Bai YP, Liu YH, Chen J, Song T, You Y, Tang ZY, Li YJ, Zhang GG; ''Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC
  285. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC
  286. Panee J, Stoytcheva ZR, Liu W, Berry MJ; ''''; , PubMed Europe PMC
  287. Bakovic M, Fullerton MD, Michel V; ''Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2).''; Biochem Cell Biol, 2007 PubMed Europe PMC
  288. Chen Y, Dennis EA; ''Expression and characterization of human group V phospholipase A2.''; Biochim Biophys Acta, 1998 PubMed Europe PMC
  289. Das UN; ''Folic acid says NO to vascular diseases.''; Nutrition, 2003 PubMed Europe PMC
  290. Sakurai T, Yamamoto Y, Baba N, Nakano M; ''Phospholipase A(2) activity in non-glycated and glycated low density lipoproteins.''; Biochim Biophys Acta, 1996 PubMed Europe PMC
  291. Finkelstein JD; ''The metabolism of homocysteine: pathways and regulation.''; Eur J Pediatr, 1998 PubMed Europe PMC
  292. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC
  293. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.''; Nat Struct Biol, 2003 PubMed Europe PMC
  294. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC
  295. Lu C, Qiu F, Zhou H, Peng Yp, Hao W, Xu J, Yuan J, Wang S, Qiang B, Xu C, Peng X.; ''Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.''; FEBS Lett., 2006 PubMed Europe PMC
  296. Fowler B.; ''Homocysteine: overview of biochemistry, molecular biology, and role in disease processes.''; Semin Vasc Med, 2005 PubMed Europe PMC
  297. Collart MA, Baeuerle P, Vassalli P; ''Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.''; Mol Cell Biol, 1990 PubMed Europe PMC
  298. Shields DJ, Lehner R, Agellon LB, Vance DE; ''Membrane topography of human phosphatidylethanolamine N-methyltransferase.''; J Biol Chem, 2003 PubMed Europe PMC
  299. Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ; ''Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.''; J Biol Chem, 1997 PubMed Europe PMC
  300. Gautier G, Humbert M, Deauvieau F, Scuiller M, Hiscott J, Bates EE, Trinchieri G, Caux C, Garrone P; ''A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.''; J Exp Med, 2005 PubMed Europe PMC
  301. Peters-Golden M, Brock TG; ''5-lipoxygenase and FLAP.''; Prostaglandins Leukot Essent Fatty Acids, 2003 PubMed Europe PMC
  302. Bender DA; ''Biochemistry of tryptophan in health and disease.''; Mol Aspects Med, 1983 PubMed Europe PMC
  303. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN.; ''Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.''; Proc Natl Acad Sci U S A., 2002 PubMed Europe PMC
  304. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC
  305. Petersen Shay K, Moreau RF, Smith EJ, Hagen TM.; ''Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.''; IUBMB Life., 2008 PubMed Europe PMC
  306. Correa-Cerro LS, Porter FD; ''3beta-hydroxysterol Delta7-reductase and the Smith-Lemli-Opitz syndrome.''; Mol Genet Metab, 2005 PubMed Europe PMC
  307. Bosschaerts T, Guilliams M, Noel W, Hérin M, Burk RF, Hill KE, Brys L, Raes G, Ghassabeh GH, De Baetselier P, Beschin A; ''Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.''; J Immunol, 2008 PubMed Europe PMC
  308. Cipollone F, Cicolini G, Bucci M; ''Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.''; Pharmacol Ther, 2008 PubMed Europe PMC
  309. Cali JJ, Russell DW; ''Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.''; J Biol Chem, 1991 PubMed Europe PMC
  310. Lööf L, Wengle B; ''Enzymatic sulphation of bile salts in human liver.''; Biochim Biophys Acta, 1978 PubMed Europe PMC
  311. Guzik TJ, Korbut R, Adamek-Guzik T; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol, 2003 PubMed Europe PMC
  312. Lucock M; ''Folic acid: nutritional biochemistry, molecular biology, and role in disease processes.''; Mol Genet Metab, 2000 PubMed Europe PMC
  313. Bowser PA, Gray GM; ''Sphingomyelinase in pig and human epidermis.''; J Invest Dermatol, 1978 PubMed Europe PMC
  314. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC
  315. Paul P, Kamisaka Y, Marks DL, Pagano RE; ''Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes.''; J Biol Chem, 1996 PubMed Europe PMC
  316. Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O; ''Purification and characterization of human phosphatidylserine synthase 1 and 2.''; Biochem J, 2008 PubMed Europe PMC
  317. Reilly IA, FitzGerald GA; ''Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.''; Blood, 1987 PubMed Europe PMC
  318. Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S; ''Functional characterization of human sphingosine kinase-1.''; FEBS Lett, 2000 PubMed Europe PMC
  319. Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R; ''A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.''; Molecular genetics and metabolism, 1999 PubMed Europe PMC
  320. Semnani RT, Venugopal PG, Leifer CA, Mostbˆck S, Sabzevari H, Nutman TB; ''Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites.''; Blood, 2008 PubMed Europe PMC
  321. Youssef D, El Abbassi A, Jordan RM, Peiris AN; ''Fructosamine--an underutilized tool in diabetes management: case report and literature review.''; Tenn Med, 2008 PubMed Europe PMC
  322. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone''; Prostaglandins., 1982 PubMed Europe PMC
  323. Weisel JW; ''Fibrinogen and fibrin.''; Adv Protein Chem, 2005 PubMed Europe PMC
  324. Manieri W, Moore ME, Soellner MB, Tsang P, Caperelli CA; ''Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.''; Biochemistry, 2007 PubMed Europe PMC
  325. Faust JR, Goldstein JL, Brown MS; ''Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.''; Proc Natl Acad Sci U S A, 1979 PubMed Europe PMC
  326. Engels F, Nijkamp FP; ''Pharmacological inhibition of leukotriene actions.''; Pharm World Sci, 1998 PubMed Europe PMC
  327.; ''Prostaglandin and Leukotriene Metabolism''; Ingenuity software,
  328. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, Lane DA; ''Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes.''; Circulation, 2000 PubMed Europe PMC
  329. Schaap D, de Widt J, van der Wal J, Vandekerckhove J, van Damme J, Gussow D, Ploegh HL, van Blitterswijk WJ, van der Bend RL; ''Purification, cDNA-cloning and expression of human diacylglycerol kinase.''; FEBS Lett, 1990 PubMed Europe PMC
  330. Abu-Soud HM, Hazen SL; ''Nitric oxide is a physiological substrate for mammalian peroxidases.''; J Biol Chem, 2000 PubMed Europe PMC


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107123view14:20, 17 September 2019MaintBotChEBI identifier normalization
106422view22:01, 28 August 2019KhanspersModified description
106179view12:07, 16 August 2019MaintBotHMDB identifier normalization
105599view04:49, 10 August 2019KhanspersModified description
105139view15:21, 10 July 2019DeSlUpdated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.
104839view14:22, 20 June 2019Fehrhartfixed an interaction NADPH - anchor
104837view14:16, 20 June 2019Fehrhart
101939view06:14, 19 November 2018EgonwReplaced Wikipedia with Wikidata identifiers.
98245view14:17, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
97550view14:45, 24 May 2018Youssefwalid
97549view14:44, 24 May 2018YoussefwalidNOS ID mapping to Uniprot
96337view15:34, 8 March 2018Mkutmonremove old WP category
96279view08:20, 5 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
95971view09:23, 11 February 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
95130view16:06, 16 November 2017Fehrhartconnecting unconnected connections
95129view16:03, 16 November 2017Fehrhartconnecting unconnected lines
93690view15:08, 9 August 2017DeSlModified description
85063view11:25, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82704view08:49, 23 October 2015EgonwoxLDL has a separate identifier.
79883view12:32, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 12831960)
79877view11:39, 23 April 2015Mkutmonuse labels and graphical lines in the legend
74202view07:11, 5 April 2014EgonwReplaced "Other" data sources with nothing and with Wikipedia.
74096view13:37, 29 March 2014EgonwFibrin from PubChem is a metabolite.
72364view09:11, 13 November 2013EgonwWhere WP identifiers were given as comment and Wikipedia already listed as DataSource, I fixed the identifier.
71710view20:02, 17 October 2013MaintBotremoved data source from nodes without identifier
70465view11:12, 5 August 2013EgonwLinked to the WP page.
70111view19:07, 12 July 2013MaintBotupdated to 2013 schema
68034view10:41, 29 June 2013EgonwMore char encoding fixes in references.
68033view10:26, 29 June 2013EgonwFixed char encoding issues in references.
68032view10:04, 29 June 2013EgonwFixed EC number data source.
68030view09:57, 29 June 2013EgonwFixed an char encoding issue in a reference.
60226view20:06, 14 March 2013EgonwRemoved more escape codes in PubChem-substance identifier, and replaced one with a PubChem-compound ID.
60225view20:03, 14 March 2013EgonwRemoved escape code.
57622view20:18, 30 January 2013EgonwFibrin PubChem references are PubChem-compound.
56291view16:08, 5 January 2013EgonwFixed fibrin node data type from protein to metabolite.
54695view12:27, 7 December 2012Andra
54694view12:17, 7 December 2012AndraSpecify description
49543view10:10, 20 July 2012AndraWp tidy
49538view09:38, 20 July 2012AndraCorrected error in identifier
48247view06:19, 17 May 2012MaintBotUpdating PubChem xrefs
45271view18:50, 7 October 2011AlexanderPicoOntology Term : 'pathway of folate cycle/metabolism' added !
41127view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39753view06:58, 17 January 2011AlexanderPicomore specific title
36515view12:55, 29 March 2010Damarizohdg
36214view15:35, 9 March 2010Damariz5metTHF nec stimul
36205view13:39, 8 March 2010Damarizf2 isopros
36204view13:37, 8 March 2010Damarizb12 can
36203view13:36, 8 March 2010Damarizb12
35903view19:06, 19 February 2010Damarizcanc5
35902view19:04, 19 February 2010Damarizfolate

External references


View all...
NameTypeDatabase referenceComment
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
10-Formyl-THFMetaboliteHMDB00972 (HMDB) 10-formyltetrahydrofolate
5,10-Methenyl-THFMetaboliteHMDB01354 (HMDB) 5,10-Methenyltetrahydrofolic acid
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
5-Formyl-THFMetaboliteHMDB01562 (HMDB) 5-Formyltetrahydrofolate
5-methyl-THFMetaboliteHMDB01396 (HMDB)
  • 5-methyltetrahydrofolate
  • Predominant food folate
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
8-OHdGMetaboliteHMDB03333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
ADPMetaboliteHMDB01341 (HMDB) Adenosine diphosphate
AHCYProtein191 (Entrez Gene)
  • EC
  • Adenosylhomocysteinase
ALBProtein213 (Entrez Gene) albumin
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
APOBProtein338 (Entrez Gene) apolipoprotein B
ATPMetaboliteHMDB00538 (HMDB) Adenosine triphosphate
CBSProtein875 (Entrez Gene)
  • EC
  • cystathionine-beta-synthase
CRPProtein1401 (Entrez Gene) C-reactive protein, pentraxin-related
CSF1Protein1435 (Entrez Gene) colony stimulating factor 1 (macrophage)
CTHProtein1491 (Entrez Gene)
  • EC
  • cystathionase
CatalaseProtein847 (Entrez Gene) EC
ChlorineMetaboliteHMDB00492 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
Cob(I)alaminMetaboliteHMDB02174 (HMDB) Reduced cobalamin
Cob(II)alaminMetaboliteHMDB02174 (HMDB) oxidized cobalamin
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
D-dimerProtein (Wikipedia)
DHFRProtein1719 (Entrez Gene)
  • EC
  • Dihydrofolate reductase
DihydrofolateMetaboliteHMDB01056 (HMDB)
F2-IsoprostaneMetabolite53788444 (PubChem-substance)
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
FGARMetabolite18272 (ChEBI) formylglycinamide ribonucleotide
FLAD1Protein80308 (Entrez Gene)
  • EC
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
FMNMetaboliteHMDB01520 (HMDB) Flavin Mononucleotide
FOLR1GeneProduct2348 (Entrez Gene) folate receptor 1 (adult)
FOLR2GeneProduct2350 (Entrez Gene) folate receptor 2 (fetal)
FOLR3GeneProduct2352 (Entrez Gene) folate receptor 3 (gamma)
FOLR4GeneProduct390243 (Entrez Gene) folate receptor 4 (delta) homolog (mouse)
Factor VIIProtein2155 (Entrez Gene)
  • EC
  • coagulation factor VII (serum prothrombin conversion accelerator)
FibrinProtein439199 (PubChem-compound)
FibrinogenProteinGO:0005577 (Other)
FolateMetabolite37445 (ChEBI) Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).
Folic acidMetaboliteHMDB00121 (HMDB) Synthetic folate
FructosamineMetaboliteHMDB02030 (HMDB)
GARMetaboliteHMDB02022 (HMDB) glycinamide ribonucleotide
GARTProtein2618 (Entrez Gene)
  • EC
  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GPX 1Protein2876 (Entrez Gene)
  • EC
  • Selenoprotein-glutathione peroxidase 1
GPX 2Protein2877 (Entrez Gene)
  • EC
  • Selenoprotein-glutathione peroxidase 2
GPX 3Protein2878 (Entrez Gene)
  • EC
  • Selenoprotein-glutathione peroxidase 3
GPX 4Protein2879 (Entrez Gene)
  • EC
  • Selenoprotein-glutathione peroxidase 4
GPX 6Protein257202 (Entrez Gene)
  • EC
  • Selenoprotein-glutathione peroxidase 6
GlucoseMetaboliteHMDB00122 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB02111 (HMDB) Glutathione disulfide
HBA1Protein3039 (Entrez Gene) hemoglobin, alpha 1
HBBProtein3043 (Entrez Gene) hemoglobin, beta
HDL-CMetabolite47775 (ChEBI)
  • high-density lipoprotein cholesterol
  • Cholesterol transport
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetabolite39025 (ChEBI) high-density lipoprotein
HNO2Metabolite25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
  • Glycated hemoglobin
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
IFNgProtein3458 (Entrez Gene) interferon, gamma
IL10Protein3458 (Entrez Gene) interferon, gamma
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
IL2Protein3558 (Entrez Gene) interleukin 2
IL4Protein3565 (Entrez Gene) interleukin 4
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
INSProtein3630 (Entrez Gene) Insulin
INSRProtein3643 (Entrez Gene) Insulin receptor
IronMetaboliteHMDB00692 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
LDLMetabolite39026 (ChEBI) low-density lipoprotein
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
MATProtein4143 (Entrez Gene)
  • EC
  • Methionine adenosyltransferase
MCP1GeneProduct6347 (Entrez Gene)
  • Monocyte Chemotactic Protein 1
  • CCL2
MPOProtein4353 (Entrez Gene)
  • EC
  • Myeloperoxidase
MSR*Protein4552 (Entrez Gene)
  • EC
  • 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTHFD1*Protein4522 (Entrez Gene)
  • EC
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1
MTHFD2Protein10797 (Entrez Gene)
  • EC
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTHFR*Protein4524 (Entrez Gene)
  • EC
  • 5,10-methylenetetrahydrofolate reductase
  • Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia
MTHFSProtein10588 (Entrez Gene)
  • EC
  • 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTR*Protein4548 (Entrez Gene)
  • EC
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
  • Also known as MS
MagnesiumMetaboliteHMDB00547 (HMDB)
ManganeseMetaboliteHMDB01333 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFkB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
NFkB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
NOSProtein1.14.13.39 (EC Number) Nitric oxide synthase
NitrotyrosineMetaboliteHMDB01904 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
O2MetaboliteHMDB02168 (HMDB) Superoxide
O3Metabolite25812 (ChEBI) ozone
ONOO/ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
PAI-1Protein5054 (Entrez Gene) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
PLGProtein5340 (Entrez Gene)
  • EC
  • Plasminogen
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
RFKProtein55312 (Entrez Gene)
  • EC
  • riboflavin kinase
  • reactive nitrogen species
RiboflavinMetaboliteHMDB00244 (HMDB)
S-nitrosohomocysteineMetabolite3035701 (PubChem-compound)
SAA1Protein6288 (Entrez Gene) serum amyloid A1
SAA2Protein6289 (Entrez Gene) serum amyloid A2
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
SHMTProtein6470 (Entrez Gene)
  • EC
  • Serine hydroxymethyltransferase 1 (soluble)
SHMTProtein6472 (Entrez Gene)
  • EC
  • Serine hydroxymethyltransferase
SLC19A1GeneProduct6573 (Entrez Gene) solute carrier family 19 (folate transporter), member 1
SLC46A1GeneProduct113235 (Entrez Gene) solute carrier family 46 (folate transporter), member 1
SOD1Protein6647 (Entrez Gene)
  • EC
  • superoxide dismutase 1, soluble
SOD2Protein6648 (Entrez Gene)
  • EC
  • superoxide dismutase 2, mitochondrial
SOD3Protein6649 (Entrez Gene)
  • EC
  • superoxide dismutase 3, extracellular
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
SerineMetaboliteHMDB00187 (HMDB)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
TetrahydrobiopterinMetaboliteHMDB00027 (HMDB) H4B
ThrombinProtein2147 (Entrez Gene)
  • EC
  • coagulation factor II (thrombin)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
ZincMetaboliteHMDB01303 (HMDB)
oxLDLMetabolite39026 (ChEBI) oxidized low-density lipoprotein
p53GeneProduct7157 (Entrez Gene) tumor protein p53
sICAM-1Protein3383 (Entrez Gene) soluble intercellular adhesion molecule 1
tPAProtein5327 (Entrez Gene)
  • EC
  • plasminogen activator, tissue

Annotated Interactions

No annotated interactions

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