Folate Metabolism (Homo sapiens)

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52, 244118, 16656, 66, 103, 114, 122...166, 22410, 24, 26, 56, 238238116128, 16314210093, 254140225, 270, 278133152, 229Selenium statusLipoprotein melabolismReactionCleavageCofactor conversionConversionGlycogenesisTranscription factorBindingEnzymesProtein*Lipid peroxidationOther proteinsInhibitionBiomarker forProtein with polymorphismProstaglandins metabolismNegative EffectCofactorsCatalysisOverarching processFrom intracellular part to the plasmaStimulationNecessary stimulationMetabolitesSelenoproteinsLEGENDProcess or metabolism involved in Se Pathwayis composed ofMicronutrientsProtein tyrosine nitrationIntracellularDNA oxidationApoptosisMethylation reactionsNovo purine biosynthetic pathwayPlasmap538-Isoprostaglandin F2aNFkB1F2-IsoprostanePGE2FOLR4Thromboxane A2PGE1MCP1SLC19A1F2-IsoprostaneFOLR1RELANFkB2PGE1PGE2Thromboxane B2MCP1SLC46A1Thromboxane B2PGF2aFOLR28-Isoprostaglandin F2aPGF2aFOLR378, 15110, 114, 133, 147, 265...28778, 1512561564242151, 25915625612915626626669, 28712915612922, 42, 151129151, 259DHFRMATAHCYMTHFD1*MSR*MTR*MTHFD2SHMT158, 179, 185, 187119, 215, 284125, 18715232, 152133328152, 320CBS9, 158NADP+NADP+NADP+NADP+NADP+NADP+NADP+NOSMPOCatalaseMPO6, 23824, 107, 172, 23524, 107, 172, 23569CysteineCysteinePLGFactor VIIPLGPAI-1PAI-1tPAFactor VIIThrombinThrombintPA85, 2393385, 2163333333385, 2393385, 216GPX 4H2O25,10-Methenyl-THF5-Formyl-THF5,10-Methylene-THF(11R)-hydroxymethylene-THF(11S)-hydroxymethylene-THFFGARDihydrofolateGAR10-Formyl-THF215152152152, 215152152, 229152, 2291521525-methyl-THFFolate5-methyl-THFFolate45, 75, 133, 156, 166...215185, 215SOD3SOD3RFK171H2OGPX 3GPX 3CTH158Heme6, 9, 238THF215NADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX 6ManganeseManganeseFolic acidFolic acid179, 215, 280179, 215, 280GPX 2GPX 1RNS100, 238SHMTGARTMTHFSMTHFR*179, 215152152, 229152HomocysteineHomocysteine2392, 56, 103, 176, 185...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate69, 249, 315249, 315GlycineSerineGlycineL-Arginine32, 15232, 1527532, 152VLDL-TAGLDLVLDLCholesterolTAGLDLRHDLACTSAA1SRB1oxLDLVLDL/APOBHDL/SAAFMNSAA3SAA4VLDLHDL-CACTVLDL-TAGAPOA1APOBABCA1APOBAPOA1-NO2TyrLDLAPOA1HDL-CSAA2HDLTAGoxLDLHDL/APOA1Cholesterol1285, 124, 12820445, 135, 163, 172, 176135, 163, 172, 176227135, 163, 172, 1765, 12845, 135, 163, 172, 17620445, 12822820445, 128128124, 128204126, 204227, 330204128227, 3301241282045, 128128204126, 2041285, 12841285, 128O22548-OHdGFAD8-OHdGCob(I)alaminCob(II)alaminCob(I)alaminFAD140140125, 18722821, 125, 18721, 125, 187187ADPADPMagnesiumChlorineChlorineMagnesiumCystathionineS-nitrosohomocysteine2SOD2Serine32, 152ATPZincZincNOHOClO3NO2NOHNO22, 107, 235, 270107, 235TNFaIL1BALBHBBIL10FibrinIFNgIL2INSFibrinogensICAM-1ALBINSHbA1cIL6D-dimerINSRFibrinogenCSF1IL1BIL10TNFaFibrinIFNgHbA1cCRPD-dimerIL4IL2HBA1IL6CSF1IL4253207121122103, 139, 31812156, 122, 139, 21869, 93, 112, 135, 139...33, 31056, 147, 224, 30220756, 21226533, 31012133, 216139, 25315696, 21815633, 216265116, 126, 21821266, 26566, 265300116, 126, 218300147, 302166, 224121Riboflavin250O2Methionine S-Adenosylmethionine S-Adenosylhomocysteine S-Adenosylmethionine S-AdenosylhomocysteineMethionine132, 215187, 215, 272133, 187, 215, 272132, 215185, 213, 215213ADPTetrahydrobiopterinNitrotyrosineONOO/ONOOHNitrotyrosine75100100ATPATPGlucoseFructosamineFructosamineGlucose207116, 121207116, 121IronIron327327FLAD1171, 173FGAFGBFGG