Folate Metabolism (Homo sapiens)

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(Updated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.)
(Modified description)
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<?xml version="1.0" encoding="UTF-8"?>
<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Folate Metabolism" Organism="Homo sapiens">
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Folate Metabolism" Organism="Homo sapiens">
-
   <Comment Source="WikiPathways-description">The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.</Comment>
+
   <Comment Source="WikiPathways-description">The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
-
   <Graphics BoardWidth="4089.9999999999995" BoardHeight="2665.5" />
+
 
 +
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal].</Comment>
 +
   <Graphics BoardWidth="4089.9999999999995" BoardHeight="2665.5"/>
   <DataNode TextLabel="NFkB1" GraphId="a48fd" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="NFkB1" GraphId="a48fd" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
-
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     <Xref Database="Entrez Gene" ID="4790" />
+
     <Xref Database="Entrez Gene" ID="4790"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR1" GraphId="a7532" Type="GeneProduct">
   <DataNode TextLabel="FOLR1" GraphId="a7532" Type="GeneProduct">
     <Comment>folate receptor 1 (adult)</Comment>
     <Comment>folate receptor 1 (adult)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
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     <Xref Database="Entrez Gene" ID="2348" />
+
     <Xref Database="Entrez Gene" ID="2348"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="b3ff0" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="b3ff0" Type="Metabolite">
Line 18: Line 20:
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
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-
     <Xref Database="HMDB" ID="HMDB01442" />
+
     <Xref Database="HMDB" ID="HMDB01442"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="b4b3a" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="b4b3a" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="Wikidata" ID="Q33659470" />
+
     <Xref Database="Wikidata" ID="Q33659470"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RELA" GraphId="b84bc" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="RELA" GraphId="b84bc" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
-
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     <Xref Database="Entrez Gene" ID="5970" />
+
     <Xref Database="Entrez Gene" ID="5970"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="bdfc9" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="bdfc9" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="Wikidata" ID="Q33659470"/>
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   </DataNode>
   <DataNode TextLabel="MCP1" GraphId="c3fd6" Type="GeneProduct">
   <DataNode TextLabel="MCP1" GraphId="c3fd6" Type="GeneProduct">
Line 40: Line 42:
     <Comment>CCL2</Comment>
     <Comment>CCL2</Comment>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6347" />
+
     <Xref Database="Entrez Gene" ID="6347"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c5524" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c5524" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB05083"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MCP1" GraphId="c9530" Type="GeneProduct">
   <DataNode TextLabel="MCP1" GraphId="c9530" Type="GeneProduct">
Line 52: Line 54:
     <Comment>CCL2</Comment>
     <Comment>CCL2</Comment>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6347" />
+
     <Xref Database="Entrez Gene" ID="6347"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="p53" GraphId="cf80f" Type="GeneProduct">
   <DataNode TextLabel="p53" GraphId="cf80f" Type="GeneProduct">
Line 63: Line 65:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>fa0</BiopaxRef>
     <BiopaxRef>fa0</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="7157" />
+
     <Xref Database="Entrez Gene" ID="7157"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR4" GraphId="d1353" Type="GeneProduct">
   <DataNode TextLabel="FOLR4" GraphId="d1353" Type="GeneProduct">
     <Comment>folate receptor 4 (delta) homolog (mouse)</Comment>
     <Comment>folate receptor 4 (delta) homolog (mouse)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="390243" />
+
     <Xref Database="Entrez Gene" ID="390243"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="dc15d" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="dc15d" Type="Metabolite">
     <Comment>Prostaglandin E1</Comment>
     <Comment>Prostaglandin E1</Comment>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
-
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     <Xref Database="HMDB" ID="HMDB01442"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR3" GraphId="dd56f" Type="GeneProduct">
   <DataNode TextLabel="FOLR3" GraphId="dd56f" Type="GeneProduct">
     <Comment>folate receptor 3 (gamma)</Comment>
     <Comment>folate receptor 3 (gamma)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2352" />
+
     <Xref Database="Entrez Gene" ID="2352"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SLC19A1" GraphId="ddcdc" Type="GeneProduct">
   <DataNode TextLabel="SLC19A1" GraphId="ddcdc" Type="GeneProduct">
     <Comment>solute carrier family 19 (folate transporter), member 1</Comment>
     <Comment>solute carrier family 19 (folate transporter), member 1</Comment>
     <BiopaxRef>ef8</BiopaxRef>
     <BiopaxRef>ef8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6573"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="e2a77" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="e2a77" Type="Metabolite">
Line 94: Line 96:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01220"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NFkB2" GraphId="e3a3b" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="NFkB2" GraphId="e3a3b" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
-
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     <Xref Database="Entrez Gene" ID="4791" />
+
     <Xref Database="Entrez Gene" ID="4791"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="e3b53" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="e3b53" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB03252"/>
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   </DataNode>
   <DataNode TextLabel="Thromboxane A2" GraphId="e5c10" Type="Metabolite">
   <DataNode TextLabel="Thromboxane A2" GraphId="e5c10" Type="Metabolite">
Line 111: Line 113:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01452"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGF2a" GraphId="e63e6" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="e63e6" Type="Metabolite">
Line 118: Line 120:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01139" />
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     <Xref Database="HMDB" ID="HMDB01139"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e70db" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e70db" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB05083" />
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     <Xref Database="HMDB" ID="HMDB05083"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR2" GraphId="f27f3" Type="GeneProduct">
   <DataNode TextLabel="FOLR2" GraphId="f27f3" Type="GeneProduct">
     <Comment>folate receptor 2 (fetal)</Comment>
     <Comment>folate receptor 2 (fetal)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2350" />
+
     <Xref Database="Entrez Gene" ID="2350"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGF2a" GraphId="f3420" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="f3420" Type="Metabolite">
Line 136: Line 138:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
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   </DataNode>
   <DataNode TextLabel="SLC46A1" GraphId="f4789" Type="GeneProduct">
   <DataNode TextLabel="SLC46A1" GraphId="f4789" Type="GeneProduct">
     <Comment>solute carrier family 46 (folate transporter), member 1</Comment>
     <Comment>solute carrier family 46 (folate transporter), member 1</Comment>
     <BiopaxRef>ef8</BiopaxRef>
     <BiopaxRef>ef8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="113235" />
+
     <Xref Database="Entrez Gene" ID="113235"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="f52fa" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="f52fa" Type="Metabolite">
Line 149: Line 151:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01220" />
+
     <Xref Database="HMDB" ID="HMDB01220"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="f80f8" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="f80f8" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB03252"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFD2" GraphId="aa511" Type="Protein">
   <DataNode TextLabel="MTHFD2" GraphId="aa511" Type="Protein">
Line 161: Line 163:
     <Comment>methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase</Comment>
     <Comment>methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2374.3333333333335" CenterY="285.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="10797" />
+
     <Xref Database="Entrez Gene" ID="10797"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MSR*" GraphId="abcce" Type="Protein">
   <DataNode TextLabel="MSR*" GraphId="abcce" Type="Protein">
Line 169: Line 171:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
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     <Graphics CenterX="1546.3333333333333" CenterY="540.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="1546.3333333333333" CenterY="540.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4552" />
+
     <Xref Database="Entrez Gene" ID="4552"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAT" GraphId="d16de" Type="Protein">
   <DataNode TextLabel="MAT" GraphId="d16de" Type="Protein">
Line 176: Line 178:
     <Comment>Methionine adenosyltransferase</Comment>
     <Comment>Methionine adenosyltransferase</Comment>
     <BiopaxRef>e4d</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
-
     <Graphics CenterX="2017.0" CenterY="424.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2017.0" CenterY="424.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4143" />
+
     <Xref Database="Entrez Gene" ID="4143"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFD1*" GraphId="e1c42" Type="Protein">
   <DataNode TextLabel="MTHFD1*" GraphId="e1c42" Type="Protein">
Line 184: Line 186:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>aa9</BiopaxRef>
     <BiopaxRef>aa9</BiopaxRef>
-
     <Graphics CenterX="2367.3333333333335" CenterY="580.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2367.3333333333335" CenterY="580.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4522" />
+
     <Xref Database="Entrez Gene" ID="4522"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTR*" GraphId="e44d5" Type="Protein">
   <DataNode TextLabel="MTR*" GraphId="e44d5" Type="Protein">
Line 195: Line 197:
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1766.3333333333333" CenterY="857.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="1766.3333333333333" CenterY="857.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4548" />
+
     <Xref Database="Entrez Gene" ID="4548"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AHCY" GraphId="f949e" Type="Protein">
   <DataNode TextLabel="AHCY" GraphId="f949e" Type="Protein">
Line 202: Line 204:
     <Comment>Adenosylhomocysteinase</Comment>
     <Comment>Adenosylhomocysteinase</Comment>
     <BiopaxRef>e10</BiopaxRef>
     <BiopaxRef>e10</BiopaxRef>
-
     <Graphics CenterX="1489.3333333333333" CenterY="500.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="1489.3333333333333" CenterY="500.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="191" />
+
     <Xref Database="Entrez Gene" ID="191"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT" GraphId="fa33e" Type="Protein">
   <DataNode TextLabel="SHMT" GraphId="fa33e" Type="Protein">
Line 210: Line 212:
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2375.3333333333335" CenterY="730.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="6472" />
+
     <Xref Database="Entrez Gene" ID="6472"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DHFR" GraphId="fb4fe" Type="Protein">
   <DataNode TextLabel="DHFR" GraphId="fb4fe" Type="Protein">
Line 219: Line 221:
     <BiopaxRef>ad8</BiopaxRef>
     <BiopaxRef>ad8</BiopaxRef>
     <BiopaxRef>ef2</BiopaxRef>
     <BiopaxRef>ef2</BiopaxRef>
-
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     <Graphics CenterX="2365.3333333333335" CenterY="874.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="1719" />
+
     <Xref Database="Entrez Gene" ID="1719"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CBS" GraphId="e0635" Type="Protein">
   <DataNode TextLabel="CBS" GraphId="e0635" Type="Protein">
Line 227: Line 229:
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="1538.3333333333333" CenterY="755.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1538.3333333333333" CenterY="755.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="875" />
+
     <Xref Database="Entrez Gene" ID="875"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="c2767" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="c2767" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2284.4999999999995" CenterY="555.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2284.4999999999995" CenterY="555.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="cbdd9" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="cbdd9" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2284.4999999999995" CenterY="259.81666666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2284.4999999999995" CenterY="259.81666666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="d895a" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="d895a" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2291.4999999999995" CenterY="848.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2291.4999999999995" CenterY="848.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="ddda2" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="ddda2" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2163.1666666666665" CenterY="2219.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2163.1666666666665" CenterY="2219.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="f85b1" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="f85b1" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="919.1666666666666" CenterY="653.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="919.1666666666666" CenterY="653.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="fb622" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="fb622" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2163.1666666666665" CenterY="705.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2163.1666666666665" CenterY="705.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="ffaaa" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="ffaaa" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1756.5000000000002" CenterY="632.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="1756.5000000000002" CenterY="632.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00217" />
+
     <Xref Database="HMDB" ID="HMDB00217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="a2b1b" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="a2b1b" Type="Protein">
Line 272: Line 274:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
-
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     <Graphics CenterX="1293.6666666666667" CenterY="2365.483333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4353" />
+
     <Xref Database="Entrez Gene" ID="4353"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NOS" GraphId="aec15" Type="Protein">
   <DataNode TextLabel="NOS" GraphId="aec15" Type="Protein">
     <Comment>Nitric oxide synthase</Comment>
     <Comment>Nitric oxide synthase</Comment>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="876.3333333333334" CenterY="583.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="876.3333333333334" CenterY="583.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Uniprot-TrEMBL" ID="C9J5P6" />
+
     <Xref Database="Uniprot-TrEMBL" ID="C9J5P6"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Catalase" GraphId="b2d6c" Type="Protein">
   <DataNode TextLabel="Catalase" GraphId="b2d6c" Type="Protein">
Line 285: Line 287:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
-
     <Graphics CenterX="1213.3333333333333" CenterY="707.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1213.3333333333333" CenterY="707.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="847" />
+
     <Xref Database="Entrez Gene" ID="847"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="e56d6" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="e56d6" Type="Protein">
Line 295: Line 297:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
-
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     <Graphics CenterX="1293.6666666666667" CenterY="635.4833333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4353" />
+
     <Xref Database="Entrez Gene" ID="4353"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="c0e86" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="c0e86" Type="Metabolite">
-
     <Graphics CenterX="1349.0" CenterY="815.8333333333334" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1349.0" CenterY="815.8333333333334" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00574" />
+
     <Xref Database="HMDB" ID="HMDB00574"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="f5359" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="f5359" Type="Metabolite">
-
     <Graphics CenterX="1349.0" CenterY="2321.8333333333335" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1349.0" CenterY="2321.8333333333335" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00574" />
+
     <Xref Database="HMDB" ID="HMDB00574"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="ae193" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="ae193" Type="Protein">
Line 310: Line 312:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2734.483333333333" CenterY="2235.741646321615" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2734.483333333333" CenterY="2235.741646321615" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5327" />
+
     <Xref Database="Entrez Gene" ID="5327"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="b5988" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="b5988" Type="Protein">
Line 318: Line 320:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
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     <Graphics CenterX="2568.8166666666666" CenterY="1175.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2155" />
+
     <Xref Database="Entrez Gene" ID="2155"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="c70ad" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="c70ad" Type="Protein">
Line 325: Line 327:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2569.8166666666666" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2569.8166666666666" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5340" />
+
     <Xref Database="Entrez Gene" ID="5340"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="ce47c" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="ce47c" Type="Protein">
Line 332: Line 334:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2732.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2732.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5327" />
+
     <Xref Database="Entrez Gene" ID="5327"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="d3b1c" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="d3b1c" Type="Protein">
Line 340: Line 342:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
     <Graphics CenterX="2568.15" CenterY="1259.7086994291394" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2568.15" CenterY="1259.7086994291394" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2147" />
+
     <Xref Database="Entrez Gene" ID="2147"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="d843d" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="d843d" Type="Protein">
Line 348: Line 350:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
     <Graphics CenterX="2568.8166666666666" CenterY="2246.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2568.8166666666666" CenterY="2246.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2147" />
+
     <Xref Database="Entrez Gene" ID="2147"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="db3d2" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="db3d2" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2887.483333333333" CenterY="2235.7416463216146" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="5054" />
+
     <Xref Database="Entrez Gene" ID="5054"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="db5db" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="db5db" Type="Protein">
Line 362: Line 364:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
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     <Graphics CenterX="2568.8166666666666" CenterY="2280.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2155" />
+
     <Xref Database="Entrez Gene" ID="2155"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="dda8d" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="dda8d" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2887.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="5054" />
+
     <Xref Database="Entrez Gene" ID="5054"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="ffac8" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="ffac8" Type="Protein">
Line 375: Line 377:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2568.8166666666666" CenterY="2215.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2568.8166666666666" CenterY="2215.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5340" />
+
     <Xref Database="Entrez Gene" ID="5340"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 4" GraphId="bcee4" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 4" GraphId="bcee4" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.12</Comment>
     <Comment>EC 1.11.1.12</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
-
     <Graphics CenterX="1262.5" CenterY="423.0833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000" />
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     <Graphics CenterX="1262.5" CenterY="423.0833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2879" />
+
     <Xref Database="Entrez Gene" ID="2879"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O2" GraphId="e312e" Type="Metabolite">
   <DataNode TextLabel="H2O2" GraphId="e312e" Type="Metabolite">
     <Comment>Hydrogen peroxide</Comment>
     <Comment>Hydrogen peroxide</Comment>
-
     <Graphics CenterX="1124.0" CenterY="597.4554707379133" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1124.0" CenterY="597.4554707379133" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB03125" />
+
     <Xref Database="HMDB" ID="HMDB03125"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="(11S)-hydroxymethylene-THF" GraphId="b4e68" Type="Metabolite">
   <DataNode TextLabel="(11S)-hydroxymethylene-THF" GraphId="b4e68" Type="Metabolite">
     <Comment>(11S)-hydroxymethylenetetrahydrofolate</Comment>
     <Comment>(11S)-hydroxymethylenetetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2403.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="2403.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="b5a53" Type="Metabolite">
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="b5a53" Type="Metabolite">
Line 399: Line 401:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2246.7202751368486" CenterY="655.3166666666659" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01533" />
+
     <Xref Database="HMDB" ID="HMDB01533"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methenyl-THF" GraphId="c8a9d" Type="Metabolite">
   <DataNode TextLabel="5,10-Methenyl-THF" GraphId="c8a9d" Type="Metabolite">
     <Comment>5,10-Methenyltetrahydrofolic acid</Comment>
     <Comment>5,10-Methenyltetrahydrofolic acid</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2247.991666666667" CenterY="468.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2247.991666666667" CenterY="468.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01354" />
+
     <Xref Database="HMDB" ID="HMDB01354"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-Formyl-THF" GraphId="cf0a2" Type="Metabolite">
   <DataNode TextLabel="5-Formyl-THF" GraphId="cf0a2" Type="Metabolite">
     <Comment>5-Formyltetrahydrofolate</Comment>
     <Comment>5-Formyltetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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+
     <Graphics CenterX="2647.991666666667" CenterY="502.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01562" />
+
     <Xref Database="HMDB" ID="HMDB01562"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="10-Formyl-THF" GraphId="d0bb5" Type="Metabolite">
   <DataNode TextLabel="10-Formyl-THF" GraphId="d0bb5" Type="Metabolite">
     <Comment>10-formyltetrahydrofolate</Comment>
     <Comment>10-formyltetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2247.991666666667" CenterY="223.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="2247.991666666667" CenterY="223.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00972" />
+
     <Xref Database="HMDB" ID="HMDB00972"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="(11R)-hydroxymethylene-THF" GraphId="d1eb6" Type="Metabolite">
   <DataNode TextLabel="(11R)-hydroxymethylene-THF" GraphId="d1eb6" Type="Metabolite">
     <Comment>(11R)-hydroxymethylenetetrahydrofolate</Comment>
     <Comment>(11R)-hydroxymethylenetetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2647.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GAR" GraphId="d61a5" Type="Metabolite">
   <DataNode TextLabel="GAR" GraphId="d61a5" Type="Metabolite">
Line 430: Line 432:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
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+
     <Graphics CenterX="2573.991666666667" CenterY="643.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB02022" />
+
     <Xref Database="HMDB" ID="HMDB02022"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FGAR" GraphId="ead14" Type="Metabolite">
   <DataNode TextLabel="FGAR" GraphId="ead14" Type="Metabolite">
Line 437: Line 439:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2755.991666666667" CenterY="643.65" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2755.991666666667" CenterY="643.65" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="18272" />
+
     <Xref Database="ChEBI" ID="18272"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dihydrofolate" GraphId="ff915" Type="Metabolite">
   <DataNode TextLabel="Dihydrofolate" GraphId="ff915" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
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     <Graphics CenterX="2243.991666666667" CenterY="935.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01056" />
+
     <Xref Database="HMDB" ID="HMDB01056"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="c48e4" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="c48e4" Type="Metabolite">
Line 450: Line 452:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
-
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     <Graphics CenterX="1911.5" CenterY="655.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB01396" />
+
     <Xref Database="HMDB" ID="HMDB01396"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folate" GraphId="c9215" Type="Metabolite">
   <DataNode TextLabel="Folate" GraphId="c9215" Type="Metabolite">
     <Comment>Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).</Comment>
     <Comment>Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).</Comment>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
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     <Graphics CenterX="2095.579166666667" CenterY="2347.3166666666666" Width="129.50833333333333" Height="73.36666666666666" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="ChEBI" ID="37445" />
+
     <Xref Database="ChEBI" ID="37445"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folate" GraphId="f5e5d" Type="Metabolite">
   <DataNode TextLabel="Folate" GraphId="f5e5d" Type="Metabolite">
Line 472: Line 474:
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
-
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     <Graphics CenterX="2112.2458333333343" CenterY="1150.761419581714" Width="129.50833333333333" Height="73.36666666666666" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="ChEBI" ID="37445" />
+
     <Xref Database="ChEBI" ID="37445"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="fb8f4" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="fb8f4" Type="Metabolite">
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>Predominant food folate</Comment>
     <Comment>Predominant food folate</Comment>
-
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     <Graphics CenterX="1911.5" CenterY="2369.3166666666666" Width="106.01666666666688" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB01396" />
+
     <Xref Database="HMDB" ID="HMDB01396"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="b2954" Type="Protein">
   <DataNode TextLabel="SOD3" GraphId="b2954" Type="Protein">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
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     <Graphics CenterX="1059.15" CenterY="2235.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6649" />
+
     <Xref Database="Entrez Gene" ID="6649"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="dbcff" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD3" GraphId="dbcff" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
     <Graphics CenterX="1059.15" CenterY="533.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998" />
+
     <Graphics CenterX="1059.15" CenterY="533.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6649" />
+
     <Xref Database="Entrez Gene" ID="6649"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RFK" GraphId="bce08" Type="Protein">
   <DataNode TextLabel="RFK" GraphId="bce08" Type="Protein">
Line 497: Line 499:
     <Comment>riboflavin kinase</Comment>
     <Comment>riboflavin kinase</Comment>
     <BiopaxRef>a22</BiopaxRef>
     <BiopaxRef>a22</BiopaxRef>
-
     <Graphics CenterX="1823.3333333333333" CenterY="276.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1823.3333333333333" CenterY="276.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="55312" />
+
     <Xref Database="Entrez Gene" ID="55312"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O" GraphId="e023f" Type="Metabolite">
   <DataNode TextLabel="H2O" GraphId="e023f" Type="Metabolite">
     <Comment>Glutathione disulfide</Comment>
     <Comment>Glutathione disulfide</Comment>
-
     <Graphics CenterX="1142.185825410544" CenterY="344.18582541054445" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1142.185825410544" CenterY="344.18582541054445" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB02111" />
+
     <Xref Database="HMDB" ID="HMDB02111"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="a99ae" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 3" GraphId="a99ae" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1262.5" CenterY="408.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="408.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2878" />
+
     <Xref Database="Entrez Gene" ID="2878"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="f2daa" Type="Protein">
   <DataNode TextLabel="GPX 3" GraphId="f2daa" Type="Protein">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1467.5" CenterY="2418.383333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1467.5" CenterY="2418.383333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2878" />
+
     <Xref Database="Entrez Gene" ID="2878"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CTH" GraphId="b3fc3" Type="Protein">
   <DataNode TextLabel="CTH" GraphId="b3fc3" Type="Protein">
Line 521: Line 523:
     <Comment>cystathionase</Comment>
     <Comment>cystathionase</Comment>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="1413.3333333333333" CenterY="756.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1413.3333333333333" CenterY="756.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="1491" />
+
     <Xref Database="Entrez Gene" ID="1491"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Heme" GraphId="a07e7" Type="Metabolite">
   <DataNode TextLabel="Heme" GraphId="a07e7" Type="Metabolite">
Line 528: Line 530:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
-
     <Graphics CenterX="1346.3166666666666" CenterY="706.3166666666667" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1346.3166666666666" CenterY="706.3166666666667" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB03178" />
+
     <Xref Database="HMDB" ID="HMDB03178"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="THF" GraphId="e5400" Type="Metabolite">
   <DataNode TextLabel="THF" GraphId="e5400" Type="Metabolite">
     <Comment>Tetrahydrofolic acid</Comment>
     <Comment>Tetrahydrofolic acid</Comment>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
     <Graphics CenterX="2243.325000000006" CenterY="812.8594497263035" Width="106.01666666666688" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2243.325000000006" CenterY="812.8594497263035" Width="106.01666666666688" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01846" />
+
     <Xref Database="HMDB" ID="HMDB01846"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="a1df1" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="a1df1" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1756.5" CenterY="700.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="1756.5" CenterY="700.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b6c81" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b6c81" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="846.5" CenterY="653.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="846.5" CenterY="653.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b848b" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b848b" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2066.5" CenterY="706.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2066.5" CenterY="706.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="c222f" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="c222f" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2291.5" CenterY="899.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2291.5" CenterY="899.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="d656e" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="d656e" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2066.5" CenterY="2217.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2066.5" CenterY="2217.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="e0aa2" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="e0aa2" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2283.5" CenterY="604.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2283.5" CenterY="604.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="e3d0e" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="e3d0e" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2284.5" CenterY="313.31666666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2284.5" CenterY="313.31666666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00221" />
+
     <Xref Database="HMDB" ID="HMDB00221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 6" GraphId="c9baf" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 6" GraphId="c9baf" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
-
     <Graphics CenterX="1262.5" CenterY="437.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="437.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="257202" />
+
     <Xref Database="Entrez Gene" ID="257202"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="c4516" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="c4516" Type="Metabolite">
-
     <Graphics CenterX="1177.0" CenterY="2320.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
+
     <Graphics CenterX="1177.0" CenterY="2320.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
-
     <Xref Database="HMDB" ID="HMDB01333" />
+
     <Xref Database="HMDB" ID="HMDB01333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="f238e" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="f238e" Type="Metabolite">
-
     <Graphics CenterX="1177.0" CenterY="509.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
+
     <Graphics CenterX="1177.0" CenterY="509.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
-
     <Xref Database="HMDB" ID="HMDB01333" />
+
     <Xref Database="HMDB" ID="HMDB01333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="f5c49" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="f5c49" Type="Metabolite">
Line 591: Line 593:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
-
     <Graphics CenterX="2245.0" CenterY="2380.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2245.0" CenterY="2380.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00121" />
+
     <Xref Database="HMDB" ID="HMDB00121"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="fdd61" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="fdd61" Type="Metabolite">
Line 599: Line 601:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
-
     <Graphics CenterX="2243.0" CenterY="1000.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2243.0" CenterY="1000.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00121" />
+
     <Xref Database="HMDB" ID="HMDB00121"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 2" GraphId="ee09f" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 2" GraphId="ee09f" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
-
     <Graphics CenterX="1262.5" CenterY="393.68333333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="393.68333333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2877" />
+
     <Xref Database="Entrez Gene" ID="2877"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 1" GraphId="cc013" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 1" GraphId="cc013" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
-
     <Graphics CenterX="1262.5" CenterY="378.98333333333335" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="378.98333333333335" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2876" />
+
     <Xref Database="Entrez Gene" ID="2876"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RNS" GraphId="ac095" Type="Metabolite">
   <DataNode TextLabel="RNS" GraphId="ac095" Type="Metabolite">
Line 619: Line 621:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
-
     <Graphics CenterX="972.3166666666667" CenterY="884.3333333333334" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="972.3166666666667" CenterY="884.3333333333334" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="CHEBI:62764" />
+
     <Xref Database="ChEBI" ID="CHEBI:62764"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFR*" GraphId="aa7fc" Type="Protein">
   <DataNode TextLabel="MTHFR*" GraphId="aa7fc" Type="Protein">
Line 628: Line 630:
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
     <Graphics CenterX="2100.0" CenterY="736.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2100.0" CenterY="736.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4524" />
+
     <Xref Database="Entrez Gene" ID="4524"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GART" GraphId="b1cf5" Type="Protein">
   <DataNode TextLabel="GART" GraphId="b1cf5" Type="Protein">
Line 636: Line 638:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2729.0" CenterY="570.4999999999998" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2729.0" CenterY="570.4999999999998" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2618" />
+
     <Xref Database="Entrez Gene" ID="2618"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFS" GraphId="b9e0d" Type="Protein">
   <DataNode TextLabel="MTHFS" GraphId="b9e0d" Type="Protein">
Line 643: Line 645:
     <Comment>5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)</Comment>
     <Comment>5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2487.0" CenterY="560.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2487.0" CenterY="560.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="10588" />
+
     <Xref Database="Entrez Gene" ID="10588"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT" GraphId="effec" Type="Protein">
   <DataNode TextLabel="SHMT" GraphId="effec" Type="Protein">
Line 650: Line 652:
     <Comment>Serine hydroxymethyltransferase 1 (soluble)</Comment>
     <Comment>Serine hydroxymethyltransferase 1 (soluble)</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2767.0" CenterY="451.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2767.0" CenterY="451.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="6470" />
+
     <Xref Database="Entrez Gene" ID="6470"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="e963d" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="e963d" Type="Metabolite">
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
     <Graphics CenterX="1603.0" CenterY="2329.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1603.0" CenterY="2329.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00742" />
+
     <Xref Database="HMDB" ID="HMDB00742"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="f7b96" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="f7b96" Type="Metabolite">
Line 668: Line 670:
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
-
     <Graphics CenterX="1603.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1603.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00742" />
+
     <Xref Database="HMDB" ID="HMDB00742"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD1" GraphId="c0bee" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD1" GraphId="c0bee" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
-
     <Graphics CenterX="1059.15" CenterY="505.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998" />
+
     <Graphics CenterX="1059.15" CenterY="505.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6647" />
+
     <Xref Database="Entrez Gene" ID="6647"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="a379c" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="a379c" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
-
     <Graphics CenterX="1630.3333333333333" CenterY="2392.1666666666665" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1630.3333333333333" CenterY="2392.1666666666665" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB01491" />
+
     <Xref Database="HMDB" ID="HMDB01491"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="f536b" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="f536b" Type="Metabolite">
Line 688: Line 690:
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="1602.3333333333333" CenterY="900.1666666666666" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933" />
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     <Graphics CenterX="1602.3333333333333" CenterY="900.1666666666666" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB01491" />
+
     <Xref Database="HMDB" ID="HMDB01491"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="a2828" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="a2828" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1312.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1312.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00123" />
+
     <Xref Database="HMDB" ID="HMDB00123"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="cc841" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="cc841" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1330.0" CenterY="2226.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1330.0" CenterY="2226.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00123" />
+
     <Xref Database="HMDB" ID="HMDB00123"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Arginine" GraphId="cd5bc" Type="Metabolite">
   <DataNode TextLabel="L-Arginine" GraphId="cd5bc" Type="Metabolite">
     <BiopaxRef>ac7</BiopaxRef>
     <BiopaxRef>ac7</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="768.0" CenterY="747.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="768.0" CenterY="747.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00517" />
+
     <Xref Database="HMDB" ID="HMDB00517"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="d12af" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="d12af" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1475.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1475.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00187" />
+
     <Xref Database="HMDB" ID="HMDB00187"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="a6262" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="a6262" Type="Metabolite">
Line 722: Line 724:
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
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+
     <Graphics CenterX="792.0" CenterY="1004.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39026" />
+
     <Xref Database="ChEBI" ID="39026"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="a6906" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="a6906" Type="Protein">
Line 730: Line 732:
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
-
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     <Graphics CenterX="791.0" CenterY="2318.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="12" />
+
     <Xref Database="Entrez Gene" ID="12"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="a8ce8" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="a8ce8" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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     <Graphics CenterX="809.3333333333334" CenterY="1376.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="338" />
+
     <Xref Database="Entrez Gene" ID="338"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/APOA1" GraphId="a971b" Type="Metabolite">
   <DataNode TextLabel="HDL/APOA1" GraphId="a971b" Type="Metabolite">
Line 743: Line 745:
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="1286.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="ae262" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="ae262" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="1203.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="335" />
+
     <Xref Database="Entrez Gene" ID="335"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="aec06" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="aec06" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="2371.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="335" />
+
     <Xref Database="Entrez Gene" ID="335"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="b163e" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="b163e" Type="Metabolite">
Line 765: Line 767:
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="2283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="791.0" CenterY="2283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39026" />
+
     <Xref Database="ChEBI" ID="39026"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="b35b8" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="b35b8" Type="Metabolite">
Line 772: Line 774:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2279.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="687.3333333333334" CenterY="2279.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="17855" />
+
     <Xref Database="ChEBI" ID="17855"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="b4497" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="b4497" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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     <Graphics CenterX="687.3333333333334" CenterY="2346.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="338" />
+
     <Xref Database="Entrez Gene" ID="338"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="bf019" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="bf019" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="977.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="977.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00067" />
+
     <Xref Database="HMDB" ID="HMDB00067"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/SAA" GraphId="bfd83" Type="Metabolite">
   <DataNode TextLabel="HDL/SAA" GraphId="bfd83" Type="Metabolite">
Line 792: Line 794:
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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     <Graphics CenterX="589.3333333333334" CenterY="1291.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="c013c" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="c013c" Type="Metabolite">
Line 799: Line 801:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
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-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA1" GraphId="c1059" Type="Protein">
   <DataNode TextLabel="SAA1" GraphId="c1059" Type="Protein">
Line 806: Line 808:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="6288" />
+
     <Xref Database="Entrez Gene" ID="6288"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="c2ce6" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="c2ce6" Type="Metabolite">
Line 815: Line 817:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="2245.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="791.0" CenterY="2245.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="CHEBI:60151" />
+
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="c3879" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="c3879" Type="Metabolite">
Line 822: Line 824:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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     <Graphics CenterX="734.3333333333334" CenterY="1464.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="17855" />
+
     <Xref Database="ChEBI" ID="17855"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ABCA1" GraphId="c4c25" Type="Protein">
   <DataNode TextLabel="ABCA1" GraphId="c4c25" Type="Protein">
Line 829: Line 831:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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     <Graphics CenterX="812.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="19" />
+
     <Xref Database="Entrez Gene" ID="19"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA4" GraphId="c4c97" Type="Protein">
   <DataNode TextLabel="SAA4" GraphId="c4c97" Type="Protein">
Line 836: Line 838:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="711.3333333333334" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="6291" />
+
     <Xref Database="Entrez Gene" ID="6291"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA2" GraphId="c5808" Type="Protein">
   <DataNode TextLabel="SAA2" GraphId="c5808" Type="Protein">
Line 843: Line 845:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="563.3333333333334" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="6289" />
+
     <Xref Database="Entrez Gene" ID="6289"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SRB1" GraphId="d2c4e" Type="Protein">
   <DataNode TextLabel="SRB1" GraphId="d2c4e" Type="Protein">
     <Comment>scavenger receptor class B, member 1</Comment>
     <Comment>scavenger receptor class B, member 1</Comment>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="949" />
+
     <Xref Database="Entrez Gene" ID="949"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA3" GraphId="de80e" Type="Protein">
   <DataNode TextLabel="SAA3" GraphId="de80e" Type="Protein">
Line 856: Line 858:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="6290" />
+
     <Xref Database="Entrez Gene" ID="6290"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="df758" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="df758" Type="Metabolite">
Line 863: Line 865:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2314.983333333333" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="687.3333333333334" CenterY="2314.983333333333" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39027" />
+
     <Xref Database="ChEBI" ID="39027"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FMN" GraphId="e42a5" Type="Metabolite">
   <DataNode TextLabel="FMN" GraphId="e42a5" Type="Metabolite">
     <Comment>Flavin Mononucleotide</Comment>
     <Comment>Flavin Mononucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="1928.3333333333333" CenterY="337.31666666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1928.3333333333333" CenterY="337.31666666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01520" />
+
     <Xref Database="HMDB" ID="HMDB01520"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="e4372" Type="Protein">
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="e4372" Type="Protein">
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <BiopaxRef>c65</BiopaxRef>
     <BiopaxRef>c65</BiopaxRef>
-
     <Graphics CenterX="897.9916666666667" CenterY="973.3166666666667" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="897.9916666666667" CenterY="973.3166666666667" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="335" />
+
     <Xref Database="Entrez Gene" ID="335"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="e69a0" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="e69a0" Type="Metabolite">
Line 882: Line 884:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
     <Graphics CenterX="979.3333333333334" CenterY="1237.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="979.3333333333334" CenterY="1237.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="ede1f" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="ede1f" Type="Metabolite">
Line 889: Line 891:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="1355.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="898.3333333333334" CenterY="1355.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47775" />
+
     <Xref Database="ChEBI" ID="47775"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="f3b52" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="f3b52" Type="Metabolite">
Line 896: Line 898:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2407.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="898.3333333333334" CenterY="2407.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47775" />
+
     <Xref Database="ChEBI" ID="47775"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="f58a9" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="f58a9" Type="Protein">
Line 904: Line 906:
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="860.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="791.0" CenterY="860.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="12" />
+
     <Xref Database="Entrez Gene" ID="12"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="f5e1f" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="f5e1f" Type="Metabolite">
Line 911: Line 913:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="732.3333333333334" CenterY="1403.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="732.3333333333334" CenterY="1403.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39027" />
+
     <Xref Database="ChEBI" ID="39027"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="f97c7" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="f97c7" Type="Metabolite">
Line 918: Line 920:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2243.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="687.3333333333334" CenterY="2243.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47776" />
+
     <Xref Database="ChEBI" ID="47776"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="fa1dc" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="fa1dc" Type="Metabolite">
Line 927: Line 929:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="1095.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="791.0" CenterY="1095.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="CHEBI:60151" />
+
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="fa941" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="fa941" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2442.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="898.3333333333334" CenterY="2442.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00067" />
+
     <Xref Database="HMDB" ID="HMDB00067"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL/APOB" GraphId="fbb71" Type="Metabolite">
   <DataNode TextLabel="VLDL/APOB" GraphId="fbb71" Type="Metabolite">
Line 939: Line 941:
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="809.3333333333334" CenterY="1437.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="809.3333333333334" CenterY="1437.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39027" />
+
     <Xref Database="ChEBI" ID="39027"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDLR" GraphId="fca6e" Type="Protein">
   <DataNode TextLabel="LDLR" GraphId="fca6e" Type="Protein">
     <Comment>low density lipoprotein receptor</Comment>
     <Comment>low density lipoprotein receptor</Comment>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
-
     <Graphics CenterX="792.0" CenterY="913.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="792.0" CenterY="913.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3949" />
+
     <Xref Database="Entrez Gene" ID="3949"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="fcc5d" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="fcc5d" Type="Metabolite">
Line 952: Line 954:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="809.3333333333334" CenterY="1499.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="809.3333333333334" CenterY="1499.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47776" />
+
     <Xref Database="ChEBI" ID="47776"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="bc4c4" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="bc4c4" Type="Metabolite">
     <BiopaxRef>d63</BiopaxRef>
     <BiopaxRef>d63</BiopaxRef>
-
     <Graphics CenterX="1291.0" CenterY="599.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1291.0" CenterY="599.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01377" />
+
     <Xref Database="HMDB" ID="HMDB01377"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(I)alamin" GraphId="aebe4" Type="Metabolite">
   <DataNode TextLabel="Cob(I)alamin" GraphId="aebe4" Type="Metabolite">
Line 965: Line 967:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
-
     <Graphics CenterX="1700.3333333333333" CenterY="573.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1700.3333333333333" CenterY="573.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB02174" />
+
     <Xref Database="HMDB" ID="HMDB02174"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="b57a6" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="b57a6" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="2066.3333333333335" CenterY="612.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2066.3333333333335" CenterY="612.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01248" />
+
     <Xref Database="HMDB" ID="HMDB01248"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(I)alamin" GraphId="de2a9" Type="Metabolite">
   <DataNode TextLabel="Cob(I)alamin" GraphId="de2a9" Type="Metabolite">
Line 979: Line 981:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
-
     <Graphics CenterX="1702.3333333333333" CenterY="2271.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1702.3333333333333" CenterY="2271.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB02174" />
+
     <Xref Database="HMDB" ID="HMDB02174"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="eeb89" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="eeb89" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="680.3333333333334" CenterY="560.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="680.3333333333334" CenterY="560.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB03333" />
+
     <Xref Database="HMDB" ID="HMDB03333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="f468f" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="f468f" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1828.3333333333333" CenterY="698.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1828.3333333333333" CenterY="698.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01248" />
+
     <Xref Database="HMDB" ID="HMDB01248"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(II)alamin" GraphId="f4b4d" Type="Metabolite">
   <DataNode TextLabel="Cob(II)alamin" GraphId="f4b4d" Type="Metabolite">
Line 998: Line 1,000:
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
-
     <Graphics CenterX="1700.3333333333333" CenterY="762.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1700.3333333333333" CenterY="762.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB02174" />
+
     <Xref Database="HMDB" ID="HMDB02174"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="f4ca6" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="f4ca6" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="537.6666666666666" CenterY="2220.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="537.6666666666666" CenterY="2220.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB03333" />
+
     <Xref Database="HMDB" ID="HMDB03333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="b52e8" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="b52e8" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="2039.0" CenterY="367.98333333333335" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2039.0" CenterY="367.98333333333335" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB01341" />
+
     <Xref Database="HMDB" ID="HMDB01341"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="cd72a" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="cd72a" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="2531.0" CenterY="522.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2531.0" CenterY="522.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB01341" />
+
     <Xref Database="HMDB" ID="HMDB01341"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Magnesium" GraphId="ab890" Type="Metabolite">
   <DataNode TextLabel="Magnesium" GraphId="ab890" Type="Metabolite">
-
     <Graphics CenterX="2182.0" CenterY="2272.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2182.0" CenterY="2272.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00547" />
+
     <Xref Database="HMDB" ID="HMDB00547"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="b7263" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="b7263" Type="Metabolite">
-
     <Graphics CenterX="1115.0" CenterY="2262.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1115.0" CenterY="2262.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00492" />
+
     <Xref Database="HMDB" ID="HMDB00492"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="c0f46" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="c0f46" Type="Metabolite">
-
     <Graphics CenterX="1053.0" CenterY="708.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1053.0" CenterY="708.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00492" />
+
     <Xref Database="HMDB" ID="HMDB00492"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Magnesium" GraphId="f4fec" Type="Metabolite">
   <DataNode TextLabel="Magnesium" GraphId="f4fec" Type="Metabolite">
-
     <Graphics CenterX="2182.0" CenterY="285.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2182.0" CenterY="285.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00547" />
+
     <Xref Database="HMDB" ID="HMDB00547"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="S-nitrosohomocysteine" GraphId="c8bf3" Type="Metabolite">
   <DataNode TextLabel="S-nitrosohomocysteine" GraphId="c8bf3" Type="Metabolite">
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="1306.5" CenterY="527.5" Width="123.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1306.5" CenterY="527.5" Width="123.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
-
     <Xref Database="PubChem-compound" ID="3035701" />
+
     <Xref Database="PubChem-compound" ID="3035701"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cystathionine" GraphId="cb485" Type="Metabolite">
   <DataNode TextLabel="Cystathionine" GraphId="cb485" Type="Metabolite">
-
     <Graphics CenterX="1468.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1468.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00099" />
+
     <Xref Database="HMDB" ID="HMDB00099"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD2" GraphId="ed5ed" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD2" GraphId="ed5ed" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
-
     <Graphics CenterX="1059.15" CenterY="519.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998" />
+
     <Graphics CenterX="1059.15" CenterY="519.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6648" />
+
     <Xref Database="Entrez Gene" ID="6648"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="f3084" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="f3084" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1475.0" CenterY="2227.816619873047" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1475.0" CenterY="2227.816619873047" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00187" />
+
     <Xref Database="HMDB" ID="HMDB00187"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ATP" GraphId="e2d51" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="e2d51" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
-
     <Graphics CenterX="1789.4916666666666" CenterY="368.98333333333335" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="1789.4916666666666" CenterY="368.98333333333335" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB00538" />
+
     <Xref Database="HMDB" ID="HMDB00538"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="e1371" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="e1371" Type="Metabolite">
-
     <Graphics CenterX="1828.0" CenterY="574.8333333333334" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1828.0" CenterY="574.8333333333334" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB01303" />
+
     <Xref Database="HMDB" ID="HMDB01303"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="fc87c" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="fc87c" Type="Metabolite">
-
     <Graphics CenterX="1828.0" CenterY="2264.8333333333335" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1828.0" CenterY="2264.8333333333335" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB01303" />
+
     <Xref Database="HMDB" ID="HMDB01303"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="a2c0e" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="a2c0e" Type="Metabolite">
Line 1,075: Line 1,077:
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="1017.3333333333334" CenterY="754.6666666666666" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1017.3333333333334" CenterY="754.6666666666666" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB03378" />
+
     <Xref Database="HMDB" ID="HMDB03378"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HOCl" GraphId="aeb17" Type="Metabolite">
   <DataNode TextLabel="HOCl" GraphId="aeb17" Type="Metabolite">
     <Comment>Hypochlorite</Comment>
     <Comment>Hypochlorite</Comment>
-
     <Graphics CenterX="1126.3333333333333" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1126.3333333333333" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01050" />
+
     <Xref Database="HMDB" ID="HMDB01050"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="b9847" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="b9847" Type="Metabolite">
Line 1,087: Line 1,089:
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
-
     <Graphics CenterX="1017.3333333333334" CenterY="2208.6666666666665" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1017.3333333333334" CenterY="2208.6666666666665" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB03378" />
+
     <Xref Database="HMDB" ID="HMDB03378"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O3" GraphId="c177c" Type="Metabolite">
   <DataNode TextLabel="O3" GraphId="c177c" Type="Metabolite">
     <Comment>ozone</Comment>
     <Comment>ozone</Comment>
-
     <Graphics CenterX="1020.3333333333334" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1020.3333333333334" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="25812" />
+
     <Xref Database="ChEBI" ID="25812"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO2" GraphId="d599e" Type="Metabolite">
   <DataNode TextLabel="NO2" GraphId="d599e" Type="Metabolite">
     <Comment>Nitrogen dioxide</Comment>
     <Comment>Nitrogen dioxide</Comment>
-
     <Graphics CenterX="1100.3333333333333" CenterY="756.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1100.3333333333333" CenterY="756.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="33101" />
+
     <Xref Database="ChEBI" ID="33101"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HNO2" GraphId="e4fb0" Type="Metabolite">
   <DataNode TextLabel="HNO2" GraphId="e4fb0" Type="Metabolite">
     <Comment>Nitrous acid</Comment>
     <Comment>Nitrous acid</Comment>
-
     <Graphics CenterX="1103.3333333333333" CenterY="800.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1103.3333333333333" CenterY="800.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="25567" />
+
     <Xref Database="ChEBI" ID="25567"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="a0188" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="a0188" Type="Protein">
     <Comment>interleukin 1, beta</Comment>
     <Comment>interleukin 1, beta</Comment>
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>b78</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2499.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1145.8166666666666" CenterY="2499.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3553" />
+
     <Xref Database="Entrez Gene" ID="3553"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL2" GraphId="a36b0" Type="Protein">
   <DataNode TextLabel="IL2" GraphId="a36b0" Type="Protein">
Line 1,115: Line 1,117:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2566.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1145.8166666666666" CenterY="2566.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3558" />
+
     <Xref Database="Entrez Gene" ID="3558"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="a741c" Type="Protein" GroupRef="d5ce7">
   <DataNode TextLabel="Fibrinogen" GraphId="a741c" Type="Protein" GroupRef="d5ce7">
-
     <Graphics CenterX="2394.961729643253" CenterY="1210.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2394.961729643253" CenterY="1210.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q381899" />
+
     <Xref Database="Wikidata" ID="Q381899"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="a8c2d" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="a8c2d" Type="Protein">
Line 1,126: Line 1,128:
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
-
     <Graphics CenterX="1245.8166666666666" CenterY="1324.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1245.8166666666666" CenterY="1324.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3553" />
+
     <Xref Database="Entrez Gene" ID="3553"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CRP" GraphId="aa691" Type="Protein">
   <DataNode TextLabel="CRP" GraphId="aa691" Type="Protein">
Line 1,137: Line 1,139:
     <BiopaxRef>be5</BiopaxRef>
     <BiopaxRef>be5</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="1501.8166666666666" CenterY="1115.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1501.8166666666666" CenterY="1115.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="1401" />
+
     <Xref Database="Entrez Gene" ID="1401"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBB" GraphId="acb2b" Type="Protein">
   <DataNode TextLabel="HBB" GraphId="acb2b" Type="Protein">
     <Comment>hemoglobin, beta</Comment>
     <Comment>hemoglobin, beta</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2032.8166666666666" CenterY="1710.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2032.8166666666666" CenterY="1710.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3043" />
+
     <Xref Database="Entrez Gene" ID="3043"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INSR" GraphId="b05cc" Type="Protein">
   <DataNode TextLabel="INSR" GraphId="b05cc" Type="Protein">
Line 1,150: Line 1,152:
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
-
     <Graphics CenterX="1738.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1738.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3643" />
+
     <Xref Database="Entrez Gene" ID="3643"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBA1" GraphId="b31e0" Type="Protein">
   <DataNode TextLabel="HBA1" GraphId="b31e0" Type="Protein">
     <Comment>hemoglobin, alpha 1</Comment>
     <Comment>hemoglobin, alpha 1</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2032.8166666666666" CenterY="1654.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2032.8166666666666" CenterY="1654.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3039" />
+
     <Xref Database="Entrez Gene" ID="3039"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="b5d1d" Type="Protein">
   <DataNode TextLabel="Fibrin" GraphId="b5d1d" Type="Protein">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2394.483333333333" CenterY="2253.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2394.483333333333" CenterY="2253.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q27205" />
+
     <Xref Database="Wikidata" ID="Q27205"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="b696d" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="b696d" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>bd7</BiopaxRef>
     <BiopaxRef>bd7</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1403.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1244.8166666666666" CenterY="1403.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="b7344" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="b7344" Type="Protein">
Line 1,175: Line 1,177:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2301.483333333333" CenterY="2572.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2301.483333333333" CenterY="2572.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q311213" />
+
     <Xref Database="Wikidata" ID="Q311213"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL2" GraphId="b8177" Type="Protein">
   <DataNode TextLabel="IL2" GraphId="b8177" Type="Protein">
Line 1,182: Line 1,184:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1246.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1244.8166666666666" CenterY="1246.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3558" />
+
     <Xref Database="Entrez Gene" ID="3558"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL4" GraphId="ba6d9" Type="Protein">
   <DataNode TextLabel="IL4" GraphId="ba6d9" Type="Protein">
     <Comment>interleukin 4</Comment>
     <Comment>interleukin 4</Comment>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1206.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1244.8166666666666" CenterY="1206.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3565" />
+
     <Xref Database="Entrez Gene" ID="3565"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSF1" GraphId="bd2f6" Type="Protein">
   <DataNode TextLabel="CSF1" GraphId="bd2f6" Type="Protein">
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
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     <Graphics CenterX="1246.8166666666666" CenterY="1449.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="1435" />
+
     <Xref Database="Entrez Gene" ID="1435"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="be83d" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="be83d" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
     <Graphics CenterX="2034.8166666666666" CenterY="1750.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="2034.8166666666666" CenterY="1750.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="213" />
+
     <Xref Database="Entrez Gene" ID="213"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="bfe70" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="bfe70" Type="Protein">
Line 1,207: Line 1,209:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
-
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     <Graphics CenterX="2394.483333333333" CenterY="2219.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q2162109" />
+
     <Xref Database="Wikidata" ID="Q2162109"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="c2c56" Type="Protein">
   <DataNode TextLabel="INS" GraphId="c2c56" Type="Protein">
Line 1,216: Line 1,218:
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
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     <Graphics CenterX="1738.8166666666666" CenterY="1687.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3630" />
+
     <Xref Database="Entrez Gene" ID="3630"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="c7788" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="c7788" Type="Protein">
Line 1,223: Line 1,225:
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
-
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     <Graphics CenterX="1243.8166666666598" CenterY="1359.964174589454" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="c7ee6" Type="Protein">
   <DataNode TextLabel="Fibrinogen" GraphId="c7ee6" Type="Protein">
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
-
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     <Graphics CenterX="2395.15" CenterY="2289.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q381899" />
+
     <Xref Database="Wikidata" ID="Q381899"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="sICAM-1" GraphId="cbdfe" Type="Protein">
   <DataNode TextLabel="sICAM-1" GraphId="cbdfe" Type="Protein">
Line 1,237: Line 1,239:
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>c22</BiopaxRef>
     <BiopaxRef>c22</BiopaxRef>
-
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     <Graphics CenterX="1247.8166666666666" CenterY="1594.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3383" />
+
     <Xref Database="Entrez Gene" ID="3383"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="cbe08" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="cbe08" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>bd7</BiopaxRef>
     <BiopaxRef>bd7</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2442.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="1145.8166666666666" CenterY="2442.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL4" GraphId="cd348" Type="Protein">
   <DataNode TextLabel="IL4" GraphId="cd348" Type="Protein">
     <Comment>interleukin 4</Comment>
     <Comment>interleukin 4</Comment>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2596.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="1145.8166666666666" CenterY="2596.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3565" />
+
     <Xref Database="Entrez Gene" ID="3565"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="d2268" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="d2268" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>b42</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2471.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="1145.8166666666666" CenterY="2471.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="d2dd6" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="d2dd6" Type="Protein">
Line 1,264: Line 1,266:
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1286.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="1244.8166666666666" CenterY="1286.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="7124" />
+
     <Xref Database="Entrez Gene" ID="7124"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="dc833" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="dc833" Type="Protein">
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <BiopaxRef>dde</BiopaxRef>
     <BiopaxRef>dde</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2532.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="1145.8166666666666" CenterY="2532.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="7124" />
+
     <Xref Database="Entrez Gene" ID="7124"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="e43dd" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="e43dd" Type="Protein">
Line 1,277: Line 1,279:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
-
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     <Graphics CenterX="2394.961729643253" CenterY="1364.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q2162109" />
+
     <Xref Database="Wikidata" ID="Q2162109"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="e86dd" Type="Metabolite">
   <DataNode TextLabel="Fibrin" GraphId="e86dd" Type="Metabolite">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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+
     <Graphics CenterX="2394.961729643253" CenterY="1291.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc33"/>
-
     <Xref Database="Wikidata" ID="Q27205" />
+
     <Xref Database="Wikidata" ID="Q27205"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSF1" GraphId="ee610" Type="Protein">
   <DataNode TextLabel="CSF1" GraphId="ee610" Type="Protein">
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
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     <Graphics CenterX="1145.8166666666666" CenterY="2415.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="1435" />
+
     <Xref Database="Entrez Gene" ID="1435"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="f72a3" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="f72a3" Type="Protein">
Line 1,296: Line 1,298:
     <BiopaxRef>fc9</BiopaxRef>
     <BiopaxRef>fc9</BiopaxRef>
     <BiopaxRef>d53</BiopaxRef>
     <BiopaxRef>d53</BiopaxRef>
-
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     <Graphics CenterX="1145.8166666666666" CenterY="2628.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3569" />
+
     <Xref Database="Entrez Gene" ID="3569"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="fae15" Type="Protein">
   <DataNode TextLabel="INS" GraphId="fae15" Type="Protein">
Line 1,304: Line 1,306:
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
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     <Graphics CenterX="1668.8166666666666" CenterY="2591.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3630" />
+
     <Xref Database="Entrez Gene" ID="3630"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="fb407" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="fb407" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
     <Graphics CenterX="1974.8166666666666" CenterY="2585.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1974.8166666666666" CenterY="2585.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="213" />
+
     <Xref Database="Entrez Gene" ID="213"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="fd377" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="fd377" Type="Protein">
Line 1,317: Line 1,319:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
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     <Graphics CenterX="2150.8166666666666" CenterY="1683.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="ffd35" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="ffd35" Type="Protein">
Line 1,326: Line 1,328:
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
-
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     <Graphics CenterX="1244.8166666666666" CenterY="1164.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3569" />
+
     <Xref Database="Entrez Gene" ID="3569"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Riboflavin" GraphId="b78d1" Type="Metabolite">
   <DataNode TextLabel="Riboflavin" GraphId="b78d1" Type="Metabolite">
     <BiopaxRef>ca9</BiopaxRef>
     <BiopaxRef>ca9</BiopaxRef>
-
     <Graphics CenterX="1723.3166666666666" CenterY="337.31666666666666" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933" />
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     <Graphics CenterX="1723.3166666666666" CenterY="337.31666666666666" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB00244" />
+
     <Xref Database="HMDB" ID="HMDB00244"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="ff48f" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="ff48f" Type="Metabolite">
     <Comment>Superoxide</Comment>
     <Comment>Superoxide</Comment>
-
     <Graphics CenterX="1017.0" CenterY="600.0" Width="48.0" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1017.0" CenterY="600.0" Width="48.0" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB02168" />
+
     <Xref Database="HMDB" ID="HMDB02168"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="a0e9a" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="a0e9a" Type="Metabolite">
Line 1,344: Line 1,346:
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
-
     <Graphics CenterX="1757.0" CenterY="448.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1757.0" CenterY="448.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB01185" />
+
     <Xref Database="HMDB" ID="HMDB01185"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="a47a5" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="a47a5" Type="Metabolite">
Line 1,351: Line 1,353:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
-
     <Graphics CenterX="1935.0" CenterY="522.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1935.0" CenterY="522.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00696" />
+
     <Xref Database="HMDB" ID="HMDB00696"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="bbd30" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="bbd30" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
-
     <Graphics CenterX="1442.5" CenterY="2277.5" Width="125.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1442.5" CenterY="2277.5" Width="125.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00939" />
+
     <Xref Database="HMDB" ID="HMDB00939"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="d8487" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="d8487" Type="Metabolite">
     <BiopaxRef>aa7</BiopaxRef>
     <BiopaxRef>aa7</BiopaxRef>
-
     <Graphics CenterX="1922.0" CenterY="2288.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1922.0" CenterY="2288.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB00696" />
+
     <Xref Database="HMDB" ID="HMDB00696"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="de0ee" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="de0ee" Type="Metabolite">
Line 1,369: Line 1,371:
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
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     <Graphics CenterX="1757.0" CenterY="2326.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
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     <Xref Database="HMDB" ID="HMDB01185" />
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     <Xref Database="HMDB" ID="HMDB01185"/>
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   </DataNode>
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="f12e8" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="f12e8" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB00939"/>
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   <DataNode TextLabel="ADP" GraphId="d0d40" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="d0d40" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB01341"/>
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   <DataNode TextLabel="ONOO/ONOOH" GraphId="a23e3" Type="Metabolite">
   <DataNode TextLabel="ONOO/ONOOH" GraphId="a23e3" Type="Metabolite">
     <Comment>Peroxynitrite</Comment>
     <Comment>Peroxynitrite</Comment>
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     <Xref Database="HMDB" ID="HMDB02179"/>
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   <DataNode TextLabel="Nitrotyrosine" GraphId="b950b" Type="Metabolite">
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     <BiopaxRef>f11</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01904"/>
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   <DataNode TextLabel="Nitrotyrosine" GraphId="d35d3" Type="Metabolite">
   <DataNode TextLabel="Nitrotyrosine" GraphId="d35d3" Type="Metabolite">
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     <BiopaxRef>f11</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB01904"/>
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   <DataNode TextLabel="Tetrahydrobiopterin" GraphId="dd14d" Type="Metabolite">
   <DataNode TextLabel="Tetrahydrobiopterin" GraphId="dd14d" Type="Metabolite">
Line 1,402: Line 1,404:
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     <Xref Database="HMDB" ID="HMDB00027"/>
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   <DataNode TextLabel="ATP" GraphId="a1aad" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="a1aad" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB00538"/>
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   <DataNode TextLabel="ATP" GraphId="de676" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="de676" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB00538"/>
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   </DataNode>
   <DataNode TextLabel="Glucose" GraphId="bbc0b" Type="Metabolite">
   <DataNode TextLabel="Glucose" GraphId="bbc0b" Type="Metabolite">
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB00122"/>
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   <DataNode TextLabel="Glucose" GraphId="bc2dc" Type="Metabolite">
   <DataNode TextLabel="Glucose" GraphId="bc2dc" Type="Metabolite">
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB00122"/>
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   <DataNode TextLabel="Fructosamine" GraphId="cb21d" Type="Metabolite">
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     <BiopaxRef>c31</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB02030"/>
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   <DataNode TextLabel="Fructosamine" GraphId="cb8ee" Type="Metabolite">
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   <DataNode TextLabel="Iron" GraphId="a6473" Type="Metabolite">
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     <Xref Database="HMDB" ID="HMDB00692"/>
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   <DataNode TextLabel="Iron" GraphId="fef7a" Type="Metabolite">
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     <Xref Database="HMDB" ID="HMDB00692"/>
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   <DataNode TextLabel="FLAD1" GraphId="ae58b" Type="Protein">
Line 1,452: Line 1,454:
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     <Xref Database="Entrez Gene" ID="80308" />
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     <Xref Database="Entrez Gene" ID="80308"/>
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     <Xref Database="Ensembl" ID="ENSG00000171560"/>
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     <Xref Database="Ensembl" ID="ENSG00000171564"/>
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     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="a9e4a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="a9f6c">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="aabd6">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="aad44">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="abefe">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="ad82b">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="adba7">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="ae60e">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="af294">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="af7a6">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b2a6d">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b2ae1">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b318a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="bd2d2">
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     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="bf21a">
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     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c172a">
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     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c5e56">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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       <Point X="1782.0" Y="2591.15" GraphRef="bc2dc" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/>
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   <Interaction GraphId="c625f">
   <Interaction GraphId="c625f">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c8299">
   <Interaction GraphId="c8299">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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       <Point X="1971.0" Y="522.5" GraphRef="a47a5" RelX="1.0" RelY="0.0"/>
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       <Point X="1958.0" Y="2288.5" GraphRef="d8487" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/>
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     <Xref Database="" ID=""/>
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   <Interaction GraphId="cac4e">
   <Interaction GraphId="cac4e">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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       <Point X="1222.6499999999999" Y="1213.5" GraphRef="ba6d9" RelX="-0.5" RelY="1.0"/>
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       <Point X="1102.325" Y="1229.0" />
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       <Point X="1102.325" Y="1229.0"/>
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       <Point X="982.0" Y="1912.575" />
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       <Point X="982.0" Y="1912.575"/>
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       <Point X="1101.4833333333331" Y="2596.15" GraphRef="cd348" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/>
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   <Interaction GraphId="cd7b3">
   <Interaction GraphId="cd7b3">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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