Folate Metabolism (Homo sapiens)

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(HMDB identifier normalization)
(Modified description)
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   <Comment Source="WikiPathways-description">The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
   <Comment Source="WikiPathways-description">The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
-
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal].</Comment>
+
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal]</Comment>
-
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   <DataNode TextLabel="NFkB1" GraphId="a48fd" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="NFkB1" GraphId="a48fd" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
     <Comment>nuclear factor NF-kappa-B p50 subunit</Comment>
-
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     <Xref Database="Entrez Gene" ID="4790" />
+
     <Xref Database="Entrez Gene" ID="4790"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR1" GraphId="a7532" Type="GeneProduct">
   <DataNode TextLabel="FOLR1" GraphId="a7532" Type="GeneProduct">
     <Comment>folate receptor 1 (adult)</Comment>
     <Comment>folate receptor 1 (adult)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2348" />
+
     <Xref Database="Entrez Gene" ID="2348"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="b3ff0" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="b3ff0" Type="Metabolite">
Line 20: Line 20:
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001442" />
+
     <Xref Database="HMDB" ID="HMDB0001442"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="b4b3a" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="b4b3a" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="Wikidata" ID="Q33659470" />
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     <Xref Database="Wikidata" ID="Q33659470"/>
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   </DataNode>
   <DataNode TextLabel="RELA" GraphId="b84bc" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="RELA" GraphId="b84bc" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65</Comment>
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     <Xref Database="Entrez Gene" ID="5970" />
+
     <Xref Database="Entrez Gene" ID="5970"/>
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   </DataNode>
   <DataNode TextLabel="F2-Isoprostane" GraphId="bdfc9" Type="Metabolite">
   <DataNode TextLabel="F2-Isoprostane" GraphId="bdfc9" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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   <DataNode TextLabel="MCP1" GraphId="c3fd6" Type="GeneProduct">
   <DataNode TextLabel="MCP1" GraphId="c3fd6" Type="GeneProduct">
Line 42: Line 42:
     <Comment>CCL2</Comment>
     <Comment>CCL2</Comment>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6347" />
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     <Xref Database="Entrez Gene" ID="6347"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c5524" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="c5524" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0005083" />
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     <Xref Database="HMDB" ID="HMDB0005083"/>
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   </DataNode>
   <DataNode TextLabel="MCP1" GraphId="c9530" Type="GeneProduct">
   <DataNode TextLabel="MCP1" GraphId="c9530" Type="GeneProduct">
Line 54: Line 54:
     <Comment>CCL2</Comment>
     <Comment>CCL2</Comment>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6347" />
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   <DataNode TextLabel="p53" GraphId="cf80f" Type="GeneProduct">
   <DataNode TextLabel="p53" GraphId="cf80f" Type="GeneProduct">
Line 65: Line 65:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>fa0</BiopaxRef>
     <BiopaxRef>fa0</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="7157"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR4" GraphId="d1353" Type="GeneProduct">
   <DataNode TextLabel="FOLR4" GraphId="d1353" Type="GeneProduct">
     <Comment>folate receptor 4 (delta) homolog (mouse)</Comment>
     <Comment>folate receptor 4 (delta) homolog (mouse)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="390243" />
+
     <Xref Database="Entrez Gene" ID="390243"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE1" GraphId="dc15d" Type="Metabolite">
   <DataNode TextLabel="PGE1" GraphId="dc15d" Type="Metabolite">
     <Comment>Prostaglandin E1</Comment>
     <Comment>Prostaglandin E1</Comment>
     <BiopaxRef>e06</BiopaxRef>
     <BiopaxRef>e06</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001442" />
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     <Xref Database="HMDB" ID="HMDB0001442"/>
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   </DataNode>
   <DataNode TextLabel="FOLR3" GraphId="dd56f" Type="GeneProduct">
   <DataNode TextLabel="FOLR3" GraphId="dd56f" Type="GeneProduct">
     <Comment>folate receptor 3 (gamma)</Comment>
     <Comment>folate receptor 3 (gamma)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2352" />
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     <Xref Database="Entrez Gene" ID="2352"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SLC19A1" GraphId="ddcdc" Type="GeneProduct">
   <DataNode TextLabel="SLC19A1" GraphId="ddcdc" Type="GeneProduct">
     <Comment>solute carrier family 19 (folate transporter), member 1</Comment>
     <Comment>solute carrier family 19 (folate transporter), member 1</Comment>
     <BiopaxRef>ef8</BiopaxRef>
     <BiopaxRef>ef8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="6573" />
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     <Xref Database="Entrez Gene" ID="6573"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="e2a77" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="e2a77" Type="Metabolite">
Line 96: Line 96:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001220"/>
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   </DataNode>
   <DataNode TextLabel="NFkB2" GraphId="e3a3b" Type="GeneProduct" GroupRef="ec079">
   <DataNode TextLabel="NFkB2" GraphId="e3a3b" Type="GeneProduct" GroupRef="ec079">
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
     <Comment>nuclear factor of kappa light polypeptide gene enhancer in B-cells 2</Comment>
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     <Xref Database="Entrez Gene" ID="4791" />
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     <Xref Database="Entrez Gene" ID="4791"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="e3b53" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="e3b53" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0003252" />
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     <Xref Database="HMDB" ID="HMDB0003252"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane A2" GraphId="e5c10" Type="Metabolite">
   <DataNode TextLabel="Thromboxane A2" GraphId="e5c10" Type="Metabolite">
Line 113: Line 113:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
     <BiopaxRef>d18</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001452" />
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     <Xref Database="HMDB" ID="HMDB0001452"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGF2a" GraphId="e63e6" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="e63e6" Type="Metabolite">
Line 120: Line 120:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001139" />
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     <Xref Database="HMDB" ID="HMDB0001139"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e70db" Type="Metabolite">
   <DataNode TextLabel="8-Isoprostaglandin F2a" GraphId="e70db" Type="Metabolite">
     <BiopaxRef>bc2</BiopaxRef>
     <BiopaxRef>bc2</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0005083" />
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     <Xref Database="HMDB" ID="HMDB0005083"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOLR2" GraphId="f27f3" Type="GeneProduct">
   <DataNode TextLabel="FOLR2" GraphId="f27f3" Type="GeneProduct">
     <Comment>folate receptor 2 (fetal)</Comment>
     <Comment>folate receptor 2 (fetal)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="2350" />
+
     <Xref Database="Entrez Gene" ID="2350"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGF2a" GraphId="f3420" Type="Metabolite">
   <DataNode TextLabel="PGF2a" GraphId="f3420" Type="Metabolite">
Line 138: Line 138:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
     <BiopaxRef>add</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0001139"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SLC46A1" GraphId="f4789" Type="GeneProduct">
   <DataNode TextLabel="SLC46A1" GraphId="f4789" Type="GeneProduct">
     <Comment>solute carrier family 46 (folate transporter), member 1</Comment>
     <Comment>solute carrier family 46 (folate transporter), member 1</Comment>
     <BiopaxRef>ef8</BiopaxRef>
     <BiopaxRef>ef8</BiopaxRef>
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     <Xref Database="Entrez Gene" ID="113235" />
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     <Xref Database="Entrez Gene" ID="113235"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PGE2" GraphId="f52fa" Type="Metabolite">
   <DataNode TextLabel="PGE2" GraphId="f52fa" Type="Metabolite">
Line 151: Line 151:
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>f03</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
     <BiopaxRef>eb6</BiopaxRef>
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+
     <Xref Database="HMDB" ID="HMDB0001220"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thromboxane B2" GraphId="f80f8" Type="Metabolite">
   <DataNode TextLabel="Thromboxane B2" GraphId="f80f8" Type="Metabolite">
     <BiopaxRef>f21</BiopaxRef>
     <BiopaxRef>f21</BiopaxRef>
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+
     <Xref Database="HMDB" ID="HMDB0003252"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFD2" GraphId="aa511" Type="Protein">
   <DataNode TextLabel="MTHFD2" GraphId="aa511" Type="Protein">
Line 163: Line 163:
     <Comment>methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase</Comment>
     <Comment>methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2374.3333333333335" CenterY="285.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2374.3333333333335" CenterY="285.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="10797" />
+
     <Xref Database="Entrez Gene" ID="10797"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MSR*" GraphId="abcce" Type="Protein">
   <DataNode TextLabel="MSR*" GraphId="abcce" Type="Protein">
Line 171: Line 171:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1546.3333333333333" CenterY="540.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="1546.3333333333333" CenterY="540.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4552" />
+
     <Xref Database="Entrez Gene" ID="4552"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAT" GraphId="d16de" Type="Protein">
   <DataNode TextLabel="MAT" GraphId="d16de" Type="Protein">
Line 178: Line 178:
     <Comment>Methionine adenosyltransferase</Comment>
     <Comment>Methionine adenosyltransferase</Comment>
     <BiopaxRef>e4d</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
-
     <Graphics CenterX="2017.0" CenterY="424.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2017.0" CenterY="424.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4143" />
+
     <Xref Database="Entrez Gene" ID="4143"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFD1*" GraphId="e1c42" Type="Protein">
   <DataNode TextLabel="MTHFD1*" GraphId="e1c42" Type="Protein">
Line 186: Line 186:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>aa9</BiopaxRef>
     <BiopaxRef>aa9</BiopaxRef>
-
     <Graphics CenterX="2367.3333333333335" CenterY="580.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2367.3333333333335" CenterY="580.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4522" />
+
     <Xref Database="Entrez Gene" ID="4522"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTR*" GraphId="e44d5" Type="Protein">
   <DataNode TextLabel="MTR*" GraphId="e44d5" Type="Protein">
Line 197: Line 197:
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1766.3333333333333" CenterY="857.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1766.3333333333333" CenterY="857.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4548" />
+
     <Xref Database="Entrez Gene" ID="4548"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AHCY" GraphId="f949e" Type="Protein">
   <DataNode TextLabel="AHCY" GraphId="f949e" Type="Protein">
Line 204: Line 204:
     <Comment>Adenosylhomocysteinase</Comment>
     <Comment>Adenosylhomocysteinase</Comment>
     <BiopaxRef>e10</BiopaxRef>
     <BiopaxRef>e10</BiopaxRef>
-
     <Graphics CenterX="1489.3333333333333" CenterY="500.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1489.3333333333333" CenterY="500.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="191" />
+
     <Xref Database="Entrez Gene" ID="191"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT" GraphId="fa33e" Type="Protein">
   <DataNode TextLabel="SHMT" GraphId="fa33e" Type="Protein">
Line 212: Line 212:
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2375.3333333333335" CenterY="730.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2375.3333333333335" CenterY="730.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="6472" />
+
     <Xref Database="Entrez Gene" ID="6472"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DHFR" GraphId="fb4fe" Type="Protein">
   <DataNode TextLabel="DHFR" GraphId="fb4fe" Type="Protein">
Line 221: Line 221:
     <BiopaxRef>ad8</BiopaxRef>
     <BiopaxRef>ad8</BiopaxRef>
     <BiopaxRef>ef2</BiopaxRef>
     <BiopaxRef>ef2</BiopaxRef>
-
     <Graphics CenterX="2365.3333333333335" CenterY="874.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2365.3333333333335" CenterY="874.1666666666666" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32772" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="1719" />
+
     <Xref Database="Entrez Gene" ID="1719"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CBS" GraphId="e0635" Type="Protein">
   <DataNode TextLabel="CBS" GraphId="e0635" Type="Protein">
Line 229: Line 229:
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="1538.3333333333333" CenterY="755.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1538.3333333333333" CenterY="755.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32776" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="875" />
+
     <Xref Database="Entrez Gene" ID="875"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="c2767" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="c2767" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2284.4999999999995" CenterY="555.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2284.4999999999995" CenterY="555.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="cbdd9" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="cbdd9" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2284.4999999999995" CenterY="259.81666666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2284.4999999999995" CenterY="259.81666666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="d895a" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="d895a" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2291.4999999999995" CenterY="848.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2291.4999999999995" CenterY="848.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="ddda2" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="ddda2" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2163.1666666666665" CenterY="2219.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2163.1666666666665" CenterY="2219.8166666666666" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="f85b1" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="f85b1" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="919.1666666666666" CenterY="653.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="919.1666666666666" CenterY="653.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="fb622" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="fb622" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="2163.1666666666665" CenterY="705.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="2163.1666666666665" CenterY="705.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADP+" GraphId="ffaaa" Type="Metabolite">
   <DataNode TextLabel="NADP+" GraphId="ffaaa" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Oxidized</Comment>
-
     <Graphics CenterX="1756.5000000000002" CenterY="632.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00" />
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     <Graphics CenterX="1756.5000000000002" CenterY="632.8166666666667" Width="50.333333333333336" Height="15.7" ZOrder="32784" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000217" />
+
     <Xref Database="HMDB" ID="HMDB0000217"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="a2b1b" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="a2b1b" Type="Protein">
Line 274: Line 274:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
-
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     <Graphics CenterX="1293.6666666666667" CenterY="2365.483333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4353" />
+
     <Xref Database="Entrez Gene" ID="4353"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NOS" GraphId="aec15" Type="Protein">
   <DataNode TextLabel="NOS" GraphId="aec15" Type="Protein">
     <Comment>Nitric oxide synthase</Comment>
     <Comment>Nitric oxide synthase</Comment>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="876.3333333333334" CenterY="583.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="876.3333333333334" CenterY="583.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Uniprot-TrEMBL" ID="C9J5P6" />
+
     <Xref Database="Uniprot-TrEMBL" ID="C9J5P6"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Catalase" GraphId="b2d6c" Type="Protein">
   <DataNode TextLabel="Catalase" GraphId="b2d6c" Type="Protein">
Line 287: Line 287:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
     <BiopaxRef>de0</BiopaxRef>
-
     <Graphics CenterX="1213.3333333333333" CenterY="707.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1213.3333333333333" CenterY="707.15" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="847" />
+
     <Xref Database="Entrez Gene" ID="847"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MPO" GraphId="e56d6" Type="Protein">
   <DataNode TextLabel="MPO" GraphId="e56d6" Type="Protein">
Line 297: Line 297:
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
-
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+
     <Graphics CenterX="1293.6666666666667" CenterY="635.4833333333333" Width="88.66666666666664" Height="14.700000000000008" ZOrder="32786" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4353" />
+
     <Xref Database="Entrez Gene" ID="4353"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="c0e86" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="c0e86" Type="Metabolite">
-
     <Graphics CenterX="1349.0" CenterY="815.8333333333334" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1349.0" CenterY="815.8333333333334" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000574" />
+
     <Xref Database="HMDB" ID="HMDB0000574"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cysteine" GraphId="f5359" Type="Metabolite">
   <DataNode TextLabel="Cysteine" GraphId="f5359" Type="Metabolite">
-
     <Graphics CenterX="1349.0" CenterY="2321.8333333333335" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1349.0" CenterY="2321.8333333333335" Width="72.0" Height="30.0" ZOrder="32790" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000574" />
+
     <Xref Database="HMDB" ID="HMDB0000574"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="ae193" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="ae193" Type="Protein">
Line 312: Line 312:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2734.483333333333" CenterY="2235.741646321615" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2734.483333333333" CenterY="2235.741646321615" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5327" />
+
     <Xref Database="Entrez Gene" ID="5327"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="b5988" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="b5988" Type="Protein">
Line 320: Line 320:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
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     <Graphics CenterX="2568.8166666666666" CenterY="1175.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2155" />
+
     <Xref Database="Entrez Gene" ID="2155"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="c70ad" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="c70ad" Type="Protein">
Line 327: Line 327:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2569.8166666666666" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999" />
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     <Graphics CenterX="2569.8166666666666" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5340" />
+
     <Xref Database="Entrez Gene" ID="5340"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="tPA" GraphId="ce47c" Type="Protein">
   <DataNode TextLabel="tPA" GraphId="ce47c" Type="Protein">
Line 334: Line 334:
     <Comment>plasminogen activator, tissue</Comment>
     <Comment>plasminogen activator, tissue</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2732.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5327" />
+
     <Xref Database="Entrez Gene" ID="5327"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="d3b1c" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="d3b1c" Type="Protein">
Line 342: Line 342:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
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     <Graphics CenterX="2568.15" CenterY="1259.7086994291394" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2147" />
+
     <Xref Database="Entrez Gene" ID="2147"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Thrombin" GraphId="d843d" Type="Protein">
   <DataNode TextLabel="Thrombin" GraphId="d843d" Type="Protein">
Line 350: Line 350:
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
-
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     <Graphics CenterX="2568.8166666666666" CenterY="2246.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2147" />
+
     <Xref Database="Entrez Gene" ID="2147"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="db3d2" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="db3d2" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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+
     <Graphics CenterX="2887.483333333333" CenterY="2235.7416463216146" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="5054" />
+
     <Xref Database="Entrez Gene" ID="5054"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Factor VII" GraphId="db5db" Type="Protein">
   <DataNode TextLabel="Factor VII" GraphId="db5db" Type="Protein">
Line 364: Line 364:
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>cc7</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
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     <Graphics CenterX="2568.8166666666666" CenterY="2280.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2155" />
+
     <Xref Database="Entrez Gene" ID="2155"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAI-1" GraphId="dda8d" Type="Protein">
   <DataNode TextLabel="PAI-1" GraphId="dda8d" Type="Protein">
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <Comment>Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2887.483333333333" CenterY="1321.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="5054" />
+
     <Xref Database="Entrez Gene" ID="5054"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLG" GraphId="ffac8" Type="Protein">
   <DataNode TextLabel="PLG" GraphId="ffac8" Type="Protein">
Line 377: Line 377:
     <Comment>Plasminogen</Comment>
     <Comment>Plasminogen</Comment>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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+
     <Graphics CenterX="2568.8166666666666" CenterY="2215.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32792" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="5340" />
+
     <Xref Database="Entrez Gene" ID="5340"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 4" GraphId="bcee4" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 4" GraphId="bcee4" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.12</Comment>
     <Comment>EC 1.11.1.12</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 4</Comment>
-
     <Graphics CenterX="1262.5" CenterY="423.0833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000" />
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     <Graphics CenterX="1262.5" CenterY="423.0833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32794" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2879" />
+
     <Xref Database="Entrez Gene" ID="2879"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O2" GraphId="e312e" Type="Metabolite">
   <DataNode TextLabel="H2O2" GraphId="e312e" Type="Metabolite">
     <Comment>Hydrogen peroxide</Comment>
     <Comment>Hydrogen peroxide</Comment>
-
     <Graphics CenterX="1124.0" CenterY="597.4554707379133" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1124.0" CenterY="597.4554707379133" Width="80.0" Height="30.0" ZOrder="32802" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0003125" />
+
     <Xref Database="HMDB" ID="HMDB0003125"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="(11S)-hydroxymethylene-THF" GraphId="b4e68" Type="Metabolite">
   <DataNode TextLabel="(11S)-hydroxymethylene-THF" GraphId="b4e68" Type="Metabolite">
     <Comment>(11S)-hydroxymethylenetetrahydrofolate</Comment>
     <Comment>(11S)-hydroxymethylenetetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2403.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="2403.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="b5a53" Type="Metabolite">
   <DataNode TextLabel="5,10-Methylene-THF" GraphId="b5a53" Type="Metabolite">
Line 401: Line 401:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2246.7202751368486" CenterY="655.3166666666659" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001533" />
+
     <Xref Database="HMDB" ID="HMDB0001533"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methenyl-THF" GraphId="c8a9d" Type="Metabolite">
   <DataNode TextLabel="5,10-Methenyl-THF" GraphId="c8a9d" Type="Metabolite">
     <Comment>5,10-Methenyltetrahydrofolic acid</Comment>
     <Comment>5,10-Methenyltetrahydrofolic acid</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2247.991666666667" CenterY="468.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="2247.991666666667" CenterY="468.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001354" />
+
     <Xref Database="HMDB" ID="HMDB0001354"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-Formyl-THF" GraphId="cf0a2" Type="Metabolite">
   <DataNode TextLabel="5-Formyl-THF" GraphId="cf0a2" Type="Metabolite">
     <Comment>5-Formyltetrahydrofolate</Comment>
     <Comment>5-Formyltetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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+
     <Graphics CenterX="2647.991666666667" CenterY="502.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001562" />
+
     <Xref Database="HMDB" ID="HMDB0001562"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="10-Formyl-THF" GraphId="d0bb5" Type="Metabolite">
   <DataNode TextLabel="10-Formyl-THF" GraphId="d0bb5" Type="Metabolite">
     <Comment>10-formyltetrahydrofolate</Comment>
     <Comment>10-formyltetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2247.991666666667" CenterY="223.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2247.991666666667" CenterY="223.31666666666666" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000972" />
+
     <Xref Database="HMDB" ID="HMDB0000972"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="(11R)-hydroxymethylene-THF" GraphId="d1eb6" Type="Metabolite">
   <DataNode TextLabel="(11R)-hydroxymethylene-THF" GraphId="d1eb6" Type="Metabolite">
     <Comment>(11R)-hydroxymethylenetetrahydrofolate</Comment>
     <Comment>(11R)-hydroxymethylenetetrahydrofolate</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
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     <Graphics CenterX="2647.991666666667" CenterY="400.31666666666666" Width="144.01666666666668" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GAR" GraphId="d61a5" Type="Metabolite">
   <DataNode TextLabel="GAR" GraphId="d61a5" Type="Metabolite">
Line 432: Line 432:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
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+
     <Graphics CenterX="2573.991666666667" CenterY="643.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0002022" />
+
     <Xref Database="HMDB" ID="HMDB0002022"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FGAR" GraphId="ead14" Type="Metabolite">
   <DataNode TextLabel="FGAR" GraphId="ead14" Type="Metabolite">
Line 439: Line 439:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2755.991666666667" CenterY="643.65" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2755.991666666667" CenterY="643.65" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="18272" />
+
     <Xref Database="ChEBI" ID="18272"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dihydrofolate" GraphId="ff915" Type="Metabolite">
   <DataNode TextLabel="Dihydrofolate" GraphId="ff915" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
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     <Graphics CenterX="2243.991666666667" CenterY="935.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32812" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001056" />
+
     <Xref Database="HMDB" ID="HMDB0001056"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="c48e4" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="c48e4" Type="Metabolite">
Line 452: Line 452:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
-
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     <Graphics CenterX="1911.5" CenterY="655.3166666666667" Width="106.01666666666667" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0001396" />
+
     <Xref Database="HMDB" ID="HMDB0001396"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folate" GraphId="c9215" Type="Metabolite">
   <DataNode TextLabel="Folate" GraphId="c9215" Type="Metabolite">
     <Comment>Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).</Comment>
     <Comment>Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).</Comment>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
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     <Graphics CenterX="2095.579166666667" CenterY="2347.3166666666666" Width="129.50833333333333" Height="73.36666666666666" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="ChEBI" ID="37445" />
+
     <Xref Database="ChEBI" ID="37445"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folate" GraphId="f5e5d" Type="Metabolite">
   <DataNode TextLabel="Folate" GraphId="f5e5d" Type="Metabolite">
Line 474: Line 474:
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
-
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     <Graphics CenterX="2112.2458333333343" CenterY="1150.761419581714" Width="129.50833333333333" Height="73.36666666666666" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="ChEBI" ID="37445" />
+
     <Xref Database="ChEBI" ID="37445"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methyl-THF" GraphId="fb8f4" Type="Metabolite">
   <DataNode TextLabel="5-methyl-THF" GraphId="fb8f4" Type="Metabolite">
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>5-methyltetrahydrofolate</Comment>
     <Comment>Predominant food folate</Comment>
     <Comment>Predominant food folate</Comment>
-
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     <Graphics CenterX="1911.5" CenterY="2369.3166666666666" Width="106.01666666666688" Height="21.366666666666674" ZOrder="32818" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0001396" />
+
     <Xref Database="HMDB" ID="HMDB0001396"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="b2954" Type="Protein">
   <DataNode TextLabel="SOD3" GraphId="b2954" Type="Protein">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
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     <Graphics CenterX="1059.15" CenterY="2235.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6649" />
+
     <Xref Database="Entrez Gene" ID="6649"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="dbcff" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD3" GraphId="dbcff" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
     <Comment>superoxide dismutase 3, extracellular</Comment>
-
     <Graphics CenterX="1059.15" CenterY="533.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998" />
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     <Graphics CenterX="1059.15" CenterY="533.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32820" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6649" />
+
     <Xref Database="Entrez Gene" ID="6649"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RFK" GraphId="bce08" Type="Protein">
   <DataNode TextLabel="RFK" GraphId="bce08" Type="Protein">
Line 499: Line 499:
     <Comment>riboflavin kinase</Comment>
     <Comment>riboflavin kinase</Comment>
     <BiopaxRef>a22</BiopaxRef>
     <BiopaxRef>a22</BiopaxRef>
-
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     <Graphics CenterX="1823.3333333333333" CenterY="276.1666666666667" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32824" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="55312" />
+
     <Xref Database="Entrez Gene" ID="55312"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="H2O" GraphId="e023f" Type="Metabolite">
   <DataNode TextLabel="H2O" GraphId="e023f" Type="Metabolite">
     <Comment>Glutathione disulfide</Comment>
     <Comment>Glutathione disulfide</Comment>
-
     <Graphics CenterX="1142.185825410544" CenterY="344.18582541054445" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1142.185825410544" CenterY="344.18582541054445" Width="80.0" Height="30.0" ZOrder="32826" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0002111" />
+
     <Xref Database="HMDB" ID="HMDB0002111"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="a99ae" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 3" GraphId="a99ae" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1262.5" CenterY="408.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
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     <Graphics CenterX="1262.5" CenterY="408.3833333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2878" />
+
     <Xref Database="Entrez Gene" ID="2878"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 3" GraphId="f2daa" Type="Protein">
   <DataNode TextLabel="GPX 3" GraphId="f2daa" Type="Protein">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 3</Comment>
-
     <Graphics CenterX="1467.5" CenterY="2418.383333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1467.5" CenterY="2418.383333333333" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32828" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2878" />
+
     <Xref Database="Entrez Gene" ID="2878"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CTH" GraphId="b3fc3" Type="Protein">
   <DataNode TextLabel="CTH" GraphId="b3fc3" Type="Protein">
Line 523: Line 523:
     <Comment>cystathionase</Comment>
     <Comment>cystathionase</Comment>
     <BiopaxRef>fe7</BiopaxRef>
     <BiopaxRef>fe7</BiopaxRef>
-
     <Graphics CenterX="1413.3333333333333" CenterY="756.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="1413.3333333333333" CenterY="756.5" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32832" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="1491" />
+
     <Xref Database="Entrez Gene" ID="1491"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Heme" GraphId="a07e7" Type="Metabolite">
   <DataNode TextLabel="Heme" GraphId="a07e7" Type="Metabolite">
Line 530: Line 530:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
     <BiopaxRef>cb6</BiopaxRef>
-
     <Graphics CenterX="1346.3166666666666" CenterY="706.3166666666667" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1346.3166666666666" CenterY="706.3166666666667" Width="88.66666666666664" Height="21.366666666666674" ZOrder="32836" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0003178" />
+
     <Xref Database="HMDB" ID="HMDB0003178"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="THF" GraphId="e5400" Type="Metabolite">
   <DataNode TextLabel="THF" GraphId="e5400" Type="Metabolite">
     <Comment>Tetrahydrofolic acid</Comment>
     <Comment>Tetrahydrofolic acid</Comment>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
     <Graphics CenterX="2243.325000000006" CenterY="812.8594497263035" Width="106.01666666666688" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2243.325000000006" CenterY="812.8594497263035" Width="106.01666666666688" Height="21.366666666666788" ZOrder="32858" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001846" />
+
     <Xref Database="HMDB" ID="HMDB0001846"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="a1df1" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="a1df1" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="1756.5" CenterY="700.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="1756.5" CenterY="700.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b6c81" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b6c81" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="846.5" CenterY="653.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="846.5" CenterY="653.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="b848b" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="b848b" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2066.5" CenterY="706.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2066.5" CenterY="706.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="c222f" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="c222f" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2291.5" CenterY="899.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2291.5" CenterY="899.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="d656e" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="d656e" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2066.5" CenterY="2217.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2066.5" CenterY="2217.3166666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="e0aa2" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="e0aa2" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2283.5" CenterY="604.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2283.5" CenterY="604.3166666666667" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="e3d0e" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="e3d0e" Type="Metabolite">
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
     <Comment>Nicotinamide adenine dinucleotide phosphate-Reduced</Comment>
-
     <Graphics CenterX="2284.5" CenterY="313.31666666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2284.5" CenterY="313.31666666666666" Width="51.0" Height="14.7" ZOrder="32866" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000221" />
+
     <Xref Database="HMDB" ID="HMDB0000221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 6" GraphId="c9baf" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 6" GraphId="c9baf" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 6</Comment>
-
     <Graphics CenterX="1262.5" CenterY="437.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="437.7833333333332" Width="88.66666666666674" Height="17.700000000000045" ZOrder="32872" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="257202" />
+
     <Xref Database="Entrez Gene" ID="257202"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="c4516" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="c4516" Type="Metabolite">
-
     <Graphics CenterX="1177.0" CenterY="2320.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
+
     <Graphics CenterX="1177.0" CenterY="2320.5" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
-
     <Xref Database="HMDB" ID="HMDB0001333" />
+
     <Xref Database="HMDB" ID="HMDB0001333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Manganese" GraphId="f238e" Type="Metabolite">
   <DataNode TextLabel="Manganese" GraphId="f238e" Type="Metabolite">
-
     <Graphics CenterX="1177.0" CenterY="509.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833" />
+
     <Graphics CenterX="1177.0" CenterY="509.4999999999999" Width="56.666666666666664" Height="21.33333333333337" ZOrder="32882" FontSize="10" Valign="Middle" Color="009833"/>
-
     <Xref Database="HMDB" ID="HMDB0001333" />
+
     <Xref Database="HMDB" ID="HMDB0001333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="f5c49" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="f5c49" Type="Metabolite">
Line 593: Line 593:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
-
     <Graphics CenterX="2245.0" CenterY="2380.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2245.0" CenterY="2380.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000121" />
+
     <Xref Database="HMDB" ID="HMDB0000121"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="fdd61" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="fdd61" Type="Metabolite">
Line 601: Line 601:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
     <BiopaxRef>f5b</BiopaxRef>
-
     <Graphics CenterX="2243.0" CenterY="1000.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2243.0" CenterY="1000.65" Width="106.01666666666688" Height="20.033333333333303" ZOrder="32888" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000121" />
+
     <Xref Database="HMDB" ID="HMDB0000121"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 2" GraphId="ee09f" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 2" GraphId="ee09f" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 2</Comment>
-
     <Graphics CenterX="1262.5" CenterY="393.68333333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="393.68333333333334" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32902" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2877" />
+
     <Xref Database="Entrez Gene" ID="2877"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GPX 1" GraphId="cc013" Type="Protein" GroupRef="d8311">
   <DataNode TextLabel="GPX 1" GraphId="cc013" Type="Protein" GroupRef="d8311">
     <Comment>EC 1.11.1.9</Comment>
     <Comment>EC 1.11.1.9</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
     <Comment>Selenoprotein-glutathione peroxidase 1</Comment>
-
     <Graphics CenterX="1262.5" CenterY="378.98333333333335" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="1262.5" CenterY="378.98333333333335" Width="88.66666666666667" Height="14.700000000000008" ZOrder="32914" FontSize="10" Valign="Middle" Color="ff0000"/>
-
     <Xref Database="Entrez Gene" ID="2876" />
+
     <Xref Database="Entrez Gene" ID="2876"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RNS" GraphId="ac095" Type="Metabolite">
   <DataNode TextLabel="RNS" GraphId="ac095" Type="Metabolite">
Line 621: Line 621:
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>fec</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
     <BiopaxRef>f11</BiopaxRef>
-
     <Graphics CenterX="972.3166666666667" CenterY="884.3333333333334" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="972.3166666666667" CenterY="884.3333333333334" Width="70.70000000000005" Height="30.0" ZOrder="32920" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="CHEBI:62764" />
+
     <Xref Database="ChEBI" ID="CHEBI:62764"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFR*" GraphId="aa7fc" Type="Protein">
   <DataNode TextLabel="MTHFR*" GraphId="aa7fc" Type="Protein">
Line 630: Line 630:
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>c2d</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
-
     <Graphics CenterX="2100.0" CenterY="736.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2100.0" CenterY="736.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="4524" />
+
     <Xref Database="Entrez Gene" ID="4524"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GART" GraphId="b1cf5" Type="Protein">
   <DataNode TextLabel="GART" GraphId="b1cf5" Type="Protein">
Line 638: Line 638:
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
     <BiopaxRef>e70</BiopaxRef>
-
     <Graphics CenterX="2729.0" CenterY="570.4999999999998" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2729.0" CenterY="570.4999999999998" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="2618" />
+
     <Xref Database="Entrez Gene" ID="2618"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTHFS" GraphId="b9e0d" Type="Protein">
   <DataNode TextLabel="MTHFS" GraphId="b9e0d" Type="Protein">
Line 645: Line 645:
     <Comment>5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)</Comment>
     <Comment>5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2487.0" CenterY="560.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2487.0" CenterY="560.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="10588" />
+
     <Xref Database="Entrez Gene" ID="10588"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT" GraphId="effec" Type="Protein">
   <DataNode TextLabel="SHMT" GraphId="effec" Type="Protein">
Line 652: Line 652:
     <Comment>Serine hydroxymethyltransferase 1 (soluble)</Comment>
     <Comment>Serine hydroxymethyltransferase 1 (soluble)</Comment>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
-
     <Graphics CenterX="2767.0" CenterY="451.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999" />
+
     <Graphics CenterX="2767.0" CenterY="451.1666666666664" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32926" FontSize="10" Valign="Middle" Color="999999"/>
-
     <Xref Database="Entrez Gene" ID="6470" />
+
     <Xref Database="Entrez Gene" ID="6470"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="e963d" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="e963d" Type="Metabolite">
     <BiopaxRef>c0b</BiopaxRef>
     <BiopaxRef>c0b</BiopaxRef>
-
     <Graphics CenterX="1603.0" CenterY="2329.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1603.0" CenterY="2329.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000742" />
+
     <Xref Database="HMDB" ID="HMDB0000742"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="f7b96" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="f7b96" Type="Metabolite">
Line 670: Line 670:
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
     <BiopaxRef>efb</BiopaxRef>
-
     <Graphics CenterX="1603.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1603.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32928" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000742" />
+
     <Xref Database="HMDB" ID="HMDB0000742"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD1" GraphId="c0bee" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD1" GraphId="c0bee" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
     <Comment>superoxide dismutase 1, soluble</Comment>
-
     <Graphics CenterX="1059.15" CenterY="505.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998" />
+
     <Graphics CenterX="1059.15" CenterY="505.81666666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32932" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6647" />
+
     <Xref Database="Entrez Gene" ID="6647"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="a379c" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="a379c" Type="Metabolite">
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>bf9</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
-
     <Graphics CenterX="1630.3333333333333" CenterY="2392.1666666666665" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1630.3333333333333" CenterY="2392.1666666666665" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0001491" />
+
     <Xref Database="HMDB" ID="HMDB0001491"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="f536b" Type="Metabolite">
   <DataNode TextLabel="Pyridoxal 5'-phosphate" GraphId="f536b" Type="Metabolite">
Line 690: Line 690:
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>cda</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="1602.3333333333333" CenterY="900.1666666666666" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933" />
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     <Graphics CenterX="1602.3333333333333" CenterY="900.1666666666666" Width="114.0" Height="30.0" ZOrder="32934" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0001491" />
+
     <Xref Database="HMDB" ID="HMDB0001491"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="a2828" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="a2828" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1312.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1312.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000123" />
+
     <Xref Database="HMDB" ID="HMDB0000123"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="cc841" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="cc841" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1330.0" CenterY="2226.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1330.0" CenterY="2226.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000123" />
+
     <Xref Database="HMDB" ID="HMDB0000123"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Arginine" GraphId="cd5bc" Type="Metabolite">
   <DataNode TextLabel="L-Arginine" GraphId="cd5bc" Type="Metabolite">
     <BiopaxRef>ac7</BiopaxRef>
     <BiopaxRef>ac7</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="768.0" CenterY="747.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="768.0" CenterY="747.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000517" />
+
     <Xref Database="HMDB" ID="HMDB0000517"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="d12af" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="d12af" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1475.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1475.0" CenterY="902.5" Width="72.0" Height="21.33333333333337" ZOrder="32936" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000187" />
+
     <Xref Database="HMDB" ID="HMDB0000187"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="a6262" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="a6262" Type="Metabolite">
Line 724: Line 724:
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
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+
     <Graphics CenterX="792.0" CenterY="1004.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39026" />
+
     <Xref Database="ChEBI" ID="39026"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="a6906" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="a6906" Type="Protein">
Line 732: Line 732:
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
-
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     <Graphics CenterX="791.0" CenterY="2318.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="12" />
+
     <Xref Database="Entrez Gene" ID="12"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="a8ce8" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="a8ce8" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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     <Graphics CenterX="809.3333333333334" CenterY="1376.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="338" />
+
     <Xref Database="Entrez Gene" ID="338"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/APOA1" GraphId="a971b" Type="Metabolite">
   <DataNode TextLabel="HDL/APOA1" GraphId="a971b" Type="Metabolite">
Line 745: Line 745:
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <Comment>ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="1286.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="ae262" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="ae262" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="1203.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="335" />
+
     <Xref Database="Entrez Gene" ID="335"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1" GraphId="aec06" Type="Protein">
   <DataNode TextLabel="APOA1" GraphId="aec06" Type="Protein">
     <Comment>apolipoprotein A-I</Comment>
     <Comment>apolipoprotein A-I</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="2371.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="335" />
+
     <Xref Database="Entrez Gene" ID="335"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDL" GraphId="b163e" Type="Metabolite">
   <DataNode TextLabel="LDL" GraphId="b163e" Type="Metabolite">
Line 767: Line 767:
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="2283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="791.0" CenterY="2283.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39026" />
+
     <Xref Database="ChEBI" ID="39026"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="b35b8" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="b35b8" Type="Metabolite">
Line 774: Line 774:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2279.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="687.3333333333334" CenterY="2279.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="17855" />
+
     <Xref Database="ChEBI" ID="17855"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOB" GraphId="b4497" Type="Protein">
   <DataNode TextLabel="APOB" GraphId="b4497" Type="Protein">
     <Comment>apolipoprotein B</Comment>
     <Comment>apolipoprotein B</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
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+
     <Graphics CenterX="687.3333333333334" CenterY="2346.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="338" />
+
     <Xref Database="Entrez Gene" ID="338"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="bf019" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="bf019" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="977.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="977.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000067" />
+
     <Xref Database="HMDB" ID="HMDB0000067"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL/SAA" GraphId="bfd83" Type="Metabolite">
   <DataNode TextLabel="HDL/SAA" GraphId="bfd83" Type="Metabolite">
Line 794: Line 794:
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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     <Graphics CenterX="589.3333333333334" CenterY="1291.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="c013c" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="c013c" Type="Metabolite">
Line 801: Line 801:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
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     <Graphics CenterX="898.3333333333334" CenterY="2485.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA1" GraphId="c1059" Type="Protein">
   <DataNode TextLabel="SAA1" GraphId="c1059" Type="Protein">
Line 808: Line 808:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="487.3333333333333" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="6288" />
+
     <Xref Database="Entrez Gene" ID="6288"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="c2ce6" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="c2ce6" Type="Metabolite">
Line 817: Line 817:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="2245.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="791.0" CenterY="2245.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="CHEBI:60151" />
+
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TAG" GraphId="c3879" Type="Metabolite">
   <DataNode TextLabel="TAG" GraphId="c3879" Type="Metabolite">
Line 824: Line 824:
     <Comment>Triacylglycerol</Comment>
     <Comment>Triacylglycerol</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="734.3333333333334" CenterY="1464.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="734.3333333333334" CenterY="1464.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="17855" />
+
     <Xref Database="ChEBI" ID="17855"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ABCA1" GraphId="c4c25" Type="Protein">
   <DataNode TextLabel="ABCA1" GraphId="c4c25" Type="Protein">
Line 831: Line 831:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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     <Graphics CenterX="812.3333333333334" CenterY="1316.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="19" />
+
     <Xref Database="Entrez Gene" ID="19"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA4" GraphId="c4c97" Type="Protein">
   <DataNode TextLabel="SAA4" GraphId="c4c97" Type="Protein">
Line 838: Line 838:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="711.3333333333334" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="6291" />
+
     <Xref Database="Entrez Gene" ID="6291"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA2" GraphId="c5808" Type="Protein">
   <DataNode TextLabel="SAA2" GraphId="c5808" Type="Protein">
Line 845: Line 845:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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     <Graphics CenterX="563.3333333333334" CenterY="1219.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="6289" />
+
     <Xref Database="Entrez Gene" ID="6289"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SRB1" GraphId="d2c4e" Type="Protein">
   <DataNode TextLabel="SRB1" GraphId="d2c4e" Type="Protein">
     <Comment>scavenger receptor class B, member 1</Comment>
     <Comment>scavenger receptor class B, member 1</Comment>
     <BiopaxRef>c7d</BiopaxRef>
     <BiopaxRef>c7d</BiopaxRef>
-
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     <Graphics CenterX="505.3333333333333" CenterY="1315.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="949" />
+
     <Xref Database="Entrez Gene" ID="949"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SAA3" GraphId="de80e" Type="Protein">
   <DataNode TextLabel="SAA3" GraphId="de80e" Type="Protein">
Line 858: Line 858:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
     <BiopaxRef>ea2</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="6290" />
+
     <Xref Database="Entrez Gene" ID="6290"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="df758" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="df758" Type="Metabolite">
Line 865: Line 865:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2314.983333333333" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="687.3333333333334" CenterY="2314.983333333333" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39027" />
+
     <Xref Database="ChEBI" ID="39027"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FMN" GraphId="e42a5" Type="Metabolite">
   <DataNode TextLabel="FMN" GraphId="e42a5" Type="Metabolite">
     <Comment>Flavin Mononucleotide</Comment>
     <Comment>Flavin Mononucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="1928.3333333333333" CenterY="337.31666666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1928.3333333333333" CenterY="337.31666666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001520" />
+
     <Xref Database="HMDB" ID="HMDB0001520"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="e4372" Type="Protein">
   <DataNode TextLabel="APOA1-NO2Tyr" GraphId="e4372" Type="Protein">
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <Comment>Nitrotyrosinated apolipoprotein A-I</Comment>
     <BiopaxRef>c65</BiopaxRef>
     <BiopaxRef>c65</BiopaxRef>
-
     <Graphics CenterX="897.9916666666667" CenterY="973.3166666666667" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="897.9916666666667" CenterY="973.3166666666667" Width="86.01666666666667" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="335" />
+
     <Xref Database="Entrez Gene" ID="335"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL" GraphId="e69a0" Type="Metabolite">
   <DataNode TextLabel="HDL" GraphId="e69a0" Type="Metabolite">
Line 884: Line 884:
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
     <BiopaxRef>c76</BiopaxRef>
-
     <Graphics CenterX="979.3333333333334" CenterY="1237.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="979.3333333333334" CenterY="1237.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39025" />
+
     <Xref Database="ChEBI" ID="39025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="ede1f" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="ede1f" Type="Metabolite">
Line 891: Line 891:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="1355.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="898.3333333333334" CenterY="1355.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47775" />
+
     <Xref Database="ChEBI" ID="47775"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HDL-C" GraphId="f3b52" Type="Metabolite">
   <DataNode TextLabel="HDL-C" GraphId="f3b52" Type="Metabolite">
Line 898: Line 898:
     <Comment>Cholesterol transport</Comment>
     <Comment>Cholesterol transport</Comment>
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2407.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="898.3333333333334" CenterY="2407.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47775" />
+
     <Xref Database="ChEBI" ID="47775"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACT" GraphId="f58a9" Type="Protein">
   <DataNode TextLabel="ACT" GraphId="f58a9" Type="Protein">
Line 906: Line 906:
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
     <BiopaxRef>ce6</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="860.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="791.0" CenterY="860.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="12" />
+
     <Xref Database="Entrez Gene" ID="12"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL" GraphId="f5e1f" Type="Metabolite">
   <DataNode TextLabel="VLDL" GraphId="f5e1f" Type="Metabolite">
Line 913: Line 913:
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
     <Graphics CenterX="732.3333333333334" CenterY="1403.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="732.3333333333334" CenterY="1403.65" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39027" />
+
     <Xref Database="ChEBI" ID="39027"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="f97c7" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="f97c7" Type="Metabolite">
Line 920: Line 920:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="687.3333333333334" CenterY="2243.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="687.3333333333334" CenterY="2243.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47776" />
+
     <Xref Database="ChEBI" ID="47776"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="oxLDL" GraphId="fa1dc" Type="Metabolite">
   <DataNode TextLabel="oxLDL" GraphId="fa1dc" Type="Metabolite">
Line 929: Line 929:
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>caf</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
     <BiopaxRef>ae8</BiopaxRef>
-
     <Graphics CenterX="791.0" CenterY="1095.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="791.0" CenterY="1095.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="CHEBI:60151" />
+
     <Xref Database="ChEBI" ID="CHEBI:60151"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cholesterol" GraphId="fa941" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="fa941" Type="Metabolite">
     <BiopaxRef>e99</BiopaxRef>
     <BiopaxRef>e99</BiopaxRef>
-
     <Graphics CenterX="898.3333333333334" CenterY="2442.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="898.3333333333334" CenterY="2442.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000067" />
+
     <Xref Database="HMDB" ID="HMDB0000067"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL/APOB" GraphId="fbb71" Type="Metabolite">
   <DataNode TextLabel="VLDL/APOB" GraphId="fbb71" Type="Metabolite">
Line 941: Line 941:
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <Comment>The VLDL is produced in the liver, contains one molecule of apoB100</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="809.3333333333334" CenterY="1437.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="809.3333333333334" CenterY="1437.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="39027" />
+
     <Xref Database="ChEBI" ID="39027"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LDLR" GraphId="fca6e" Type="Protein">
   <DataNode TextLabel="LDLR" GraphId="fca6e" Type="Protein">
     <Comment>low density lipoprotein receptor</Comment>
     <Comment>low density lipoprotein receptor</Comment>
     <BiopaxRef>e9b</BiopaxRef>
     <BiopaxRef>e9b</BiopaxRef>
-
     <Graphics CenterX="792.0" CenterY="913.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="792.0" CenterY="913.3166666666667" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3949" />
+
     <Xref Database="Entrez Gene" ID="3949"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VLDL-TAG" GraphId="fcc5d" Type="Metabolite">
   <DataNode TextLabel="VLDL-TAG" GraphId="fcc5d" Type="Metabolite">
Line 954: Line 954:
     <Comment>Triglyceride transport</Comment>
     <Comment>Triglyceride transport</Comment>
     <BiopaxRef>de8</BiopaxRef>
     <BiopaxRef>de8</BiopaxRef>
-
     <Graphics CenterX="809.3333333333334" CenterY="1499.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="809.3333333333334" CenterY="1499.3166666666666" Width="70.70000000000002" Height="21.333333333333314" ZOrder="32946" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="47776" />
+
     <Xref Database="ChEBI" ID="47776"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="bc4c4" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="bc4c4" Type="Metabolite">
     <BiopaxRef>d63</BiopaxRef>
     <BiopaxRef>d63</BiopaxRef>
-
     <Graphics CenterX="1291.0" CenterY="599.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1291.0" CenterY="599.0" Width="80.0" Height="30.0" ZOrder="32948" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001377" />
+
     <Xref Database="HMDB" ID="HMDB0001377"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(I)alamin" GraphId="aebe4" Type="Metabolite">
   <DataNode TextLabel="Cob(I)alamin" GraphId="aebe4" Type="Metabolite">
Line 967: Line 967:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
-
     <Graphics CenterX="1700.3333333333333" CenterY="573.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1700.3333333333333" CenterY="573.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0002174" />
+
     <Xref Database="HMDB" ID="HMDB0002174"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="b57a6" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="b57a6" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>af3</BiopaxRef>
     <BiopaxRef>af3</BiopaxRef>
-
     <Graphics CenterX="2066.3333333333335" CenterY="612.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="2066.3333333333335" CenterY="612.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001248" />
+
     <Xref Database="HMDB" ID="HMDB0001248"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(I)alamin" GraphId="de2a9" Type="Metabolite">
   <DataNode TextLabel="Cob(I)alamin" GraphId="de2a9" Type="Metabolite">
Line 981: Line 981:
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
     <BiopaxRef>cfb</BiopaxRef>
-
     <Graphics CenterX="1702.3333333333333" CenterY="2271.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1702.3333333333333" CenterY="2271.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0002174" />
+
     <Xref Database="HMDB" ID="HMDB0002174"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="eeb89" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="eeb89" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="680.3333333333334" CenterY="560.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="680.3333333333334" CenterY="560.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0003333" />
+
     <Xref Database="HMDB" ID="HMDB0003333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FAD" GraphId="f468f" Type="Metabolite">
   <DataNode TextLabel="FAD" GraphId="f468f" Type="Metabolite">
     <Comment>Flavin adenine dinucleotide</Comment>
     <Comment>Flavin adenine dinucleotide</Comment>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
-
     <Graphics CenterX="1828.3333333333333" CenterY="698.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1828.3333333333333" CenterY="698.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001248" />
+
     <Xref Database="HMDB" ID="HMDB0001248"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cob(II)alamin" GraphId="f4b4d" Type="Metabolite">
   <DataNode TextLabel="Cob(II)alamin" GraphId="f4b4d" Type="Metabolite">
Line 1,000: Line 1,000:
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
     <BiopaxRef>c3a</BiopaxRef>
-
     <Graphics CenterX="1700.3333333333333" CenterY="762.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1700.3333333333333" CenterY="762.3166666666667" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0002174" />
+
     <Xref Database="HMDB" ID="HMDB0002174"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="8-OHdG" GraphId="f4ca6" Type="Metabolite">
   <DataNode TextLabel="8-OHdG" GraphId="f4ca6" Type="Metabolite">
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <Comment>8-Hydroxy-deoxyguanosine</Comment>
     <BiopaxRef>be4</BiopaxRef>
     <BiopaxRef>be4</BiopaxRef>
-
     <Graphics CenterX="537.6666666666666" CenterY="2220.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="537.6666666666666" CenterY="2220.3166666666666" Width="70.7000000000001" Height="21.333333333333314" ZOrder="32952" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0003333" />
+
     <Xref Database="HMDB" ID="HMDB0003333"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="b52e8" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="b52e8" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="2039.0" CenterY="367.98333333333335" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2039.0" CenterY="367.98333333333335" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0001341" />
+
     <Xref Database="HMDB" ID="HMDB0001341"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADP" GraphId="cd72a" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="cd72a" Type="Metabolite">
     <Comment>Adenosine diphosphate</Comment>
     <Comment>Adenosine diphosphate</Comment>
-
     <Graphics CenterX="2531.0" CenterY="522.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="2531.0" CenterY="522.9833333333333" Width="51.0" Height="14.7" ZOrder="32956" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0001341" />
+
     <Xref Database="HMDB" ID="HMDB0001341"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Magnesium" GraphId="ab890" Type="Metabolite">
   <DataNode TextLabel="Magnesium" GraphId="ab890" Type="Metabolite">
-
     <Graphics CenterX="2182.0" CenterY="2272.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2182.0" CenterY="2272.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000547" />
+
     <Xref Database="HMDB" ID="HMDB0000547"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="b7263" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="b7263" Type="Metabolite">
-
     <Graphics CenterX="1115.0" CenterY="2262.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1115.0" CenterY="2262.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000492" />
+
     <Xref Database="HMDB" ID="HMDB0000492"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Chlorine" GraphId="c0f46" Type="Metabolite">
   <DataNode TextLabel="Chlorine" GraphId="c0f46" Type="Metabolite">
-
     <Graphics CenterX="1053.0" CenterY="708.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1053.0" CenterY="708.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000492" />
+
     <Xref Database="HMDB" ID="HMDB0000492"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Magnesium" GraphId="f4fec" Type="Metabolite">
   <DataNode TextLabel="Magnesium" GraphId="f4fec" Type="Metabolite">
-
     <Graphics CenterX="2182.0" CenterY="285.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="2182.0" CenterY="285.5" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32960" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000547" />
+
     <Xref Database="HMDB" ID="HMDB0000547"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="S-nitrosohomocysteine" GraphId="c8bf3" Type="Metabolite">
   <DataNode TextLabel="S-nitrosohomocysteine" GraphId="c8bf3" Type="Metabolite">
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="1306.5" CenterY="527.5" Width="123.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1306.5" CenterY="527.5" Width="123.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
-
     <Xref Database="PubChem-compound" ID="3035701" />
+
     <Xref Database="PubChem-compound" ID="3035701"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cystathionine" GraphId="cb485" Type="Metabolite">
   <DataNode TextLabel="Cystathionine" GraphId="cb485" Type="Metabolite">
-
     <Graphics CenterX="1468.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1468.0" CenterY="815.5" Width="72.0" Height="30.0" ZOrder="32962" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000099" />
+
     <Xref Database="HMDB" ID="HMDB0000099"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD2" GraphId="ed5ed" Type="Protein" GroupRef="c56ac">
   <DataNode TextLabel="SOD2" GraphId="ed5ed" Type="Protein" GroupRef="c56ac">
     <Comment>EC 1.15.1.1</Comment>
     <Comment>EC 1.15.1.1</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
     <Comment>superoxide dismutase 2, mitochondrial</Comment>
-
     <Graphics CenterX="1059.15" CenterY="519.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998" />
+
     <Graphics CenterX="1059.15" CenterY="519.8166666666667" Width="88.66666666666674" Height="14.700000000000008" ZOrder="32966" FontSize="10" Valign="Middle" Color="999998"/>
-
     <Xref Database="Entrez Gene" ID="6648" />
+
     <Xref Database="Entrez Gene" ID="6648"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Serine" GraphId="f3084" Type="Metabolite">
   <DataNode TextLabel="Serine" GraphId="f3084" Type="Metabolite">
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>af8</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
     <BiopaxRef>c29</BiopaxRef>
-
     <Graphics CenterX="1475.0" CenterY="2227.816619873047" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1475.0" CenterY="2227.816619873047" Width="72.0" Height="21.33333333333337" ZOrder="32970" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000187" />
+
     <Xref Database="HMDB" ID="HMDB0000187"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ATP" GraphId="e2d51" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="e2d51" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
-
     <Graphics CenterX="1789.4916666666666" CenterY="368.98333333333335" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00" />
+
     <Graphics CenterX="1789.4916666666666" CenterY="368.98333333333335" Width="51.0" Height="14.7" ZOrder="32974" FontSize="10" Valign="Middle" Color="ffff00"/>
-
     <Xref Database="HMDB" ID="HMDB0000538" />
+
     <Xref Database="HMDB" ID="HMDB0000538"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="e1371" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="e1371" Type="Metabolite">
-
     <Graphics CenterX="1828.0" CenterY="574.8333333333334" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1828.0" CenterY="574.8333333333334" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0001303" />
+
     <Xref Database="HMDB" ID="HMDB0001303"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Zinc" GraphId="fc87c" Type="Metabolite">
   <DataNode TextLabel="Zinc" GraphId="fc87c" Type="Metabolite">
-
     <Graphics CenterX="1828.0" CenterY="2264.8333333333335" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933" />
+
     <Graphics CenterX="1828.0" CenterY="2264.8333333333335" Width="56.666666666666664" Height="21.333333333333314" ZOrder="32986" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0001303" />
+
     <Xref Database="HMDB" ID="HMDB0001303"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="a2c0e" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="a2c0e" Type="Metabolite">
Line 1,077: Line 1,077:
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fc5</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
     <Graphics CenterX="1017.3333333333334" CenterY="754.6666666666666" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1017.3333333333334" CenterY="754.6666666666666" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0003378" />
+
     <Xref Database="HMDB" ID="HMDB0003378"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HOCl" GraphId="aeb17" Type="Metabolite">
   <DataNode TextLabel="HOCl" GraphId="aeb17" Type="Metabolite">
     <Comment>Hypochlorite</Comment>
     <Comment>Hypochlorite</Comment>
-
     <Graphics CenterX="1126.3333333333333" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1126.3333333333333" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001050" />
+
     <Xref Database="HMDB" ID="HMDB0001050"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO" GraphId="b9847" Type="Metabolite">
   <DataNode TextLabel="NO" GraphId="b9847" Type="Metabolite">
Line 1,089: Line 1,089:
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>ceb</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
     <BiopaxRef>c51</BiopaxRef>
-
     <Graphics CenterX="1017.3333333333334" CenterY="2208.6666666666665" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1017.3333333333334" CenterY="2208.6666666666665" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0003378" />
+
     <Xref Database="HMDB" ID="HMDB0003378"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O3" GraphId="c177c" Type="Metabolite">
   <DataNode TextLabel="O3" GraphId="c177c" Type="Metabolite">
     <Comment>ozone</Comment>
     <Comment>ozone</Comment>
-
     <Graphics CenterX="1020.3333333333334" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1020.3333333333334" CenterY="668.0" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="25812" />
+
     <Xref Database="ChEBI" ID="25812"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NO2" GraphId="d599e" Type="Metabolite">
   <DataNode TextLabel="NO2" GraphId="d599e" Type="Metabolite">
     <Comment>Nitrogen dioxide</Comment>
     <Comment>Nitrogen dioxide</Comment>
-
     <Graphics CenterX="1100.3333333333333" CenterY="756.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1100.3333333333333" CenterY="756.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="33101" />
+
     <Xref Database="ChEBI" ID="33101"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HNO2" GraphId="e4fb0" Type="Metabolite">
   <DataNode TextLabel="HNO2" GraphId="e4fb0" Type="Metabolite">
     <Comment>Nitrous acid</Comment>
     <Comment>Nitrous acid</Comment>
-
     <Graphics CenterX="1103.3333333333333" CenterY="800.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1103.3333333333333" CenterY="800.3333333333334" Width="48.0" Height="18.0" ZOrder="32996" FontSize="10" Valign="Middle"/>
-
     <Xref Database="ChEBI" ID="25567" />
+
     <Xref Database="ChEBI" ID="25567"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="a0188" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="a0188" Type="Protein">
     <Comment>interleukin 1, beta</Comment>
     <Comment>interleukin 1, beta</Comment>
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>b78</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2499.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1145.8166666666666" CenterY="2499.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3553" />
+
     <Xref Database="Entrez Gene" ID="3553"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL2" GraphId="a36b0" Type="Protein">
   <DataNode TextLabel="IL2" GraphId="a36b0" Type="Protein">
Line 1,117: Line 1,117:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2566.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1145.8166666666666" CenterY="2566.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3558" />
+
     <Xref Database="Entrez Gene" ID="3558"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="a741c" Type="Protein" GroupRef="d5ce7">
   <DataNode TextLabel="Fibrinogen" GraphId="a741c" Type="Protein" GroupRef="d5ce7">
-
     <Graphics CenterX="2394.961729643253" CenterY="1210.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2394.961729643253" CenterY="1210.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q381899" />
+
     <Xref Database="Wikidata" ID="Q381899"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL1B" GraphId="a8c2d" Type="Protein">
   <DataNode TextLabel="IL1B" GraphId="a8c2d" Type="Protein">
Line 1,128: Line 1,128:
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>b78</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
-
     <Graphics CenterX="1245.8166666666666" CenterY="1324.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1245.8166666666666" CenterY="1324.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3553" />
+
     <Xref Database="Entrez Gene" ID="3553"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CRP" GraphId="aa691" Type="Protein">
   <DataNode TextLabel="CRP" GraphId="aa691" Type="Protein">
Line 1,139: Line 1,139:
     <BiopaxRef>be5</BiopaxRef>
     <BiopaxRef>be5</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
     <BiopaxRef>afd</BiopaxRef>
-
     <Graphics CenterX="1501.8166666666666" CenterY="1115.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1501.8166666666666" CenterY="1115.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="1401" />
+
     <Xref Database="Entrez Gene" ID="1401"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBB" GraphId="acb2b" Type="Protein">
   <DataNode TextLabel="HBB" GraphId="acb2b" Type="Protein">
     <Comment>hemoglobin, beta</Comment>
     <Comment>hemoglobin, beta</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2032.8166666666666" CenterY="1710.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2032.8166666666666" CenterY="1710.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3043" />
+
     <Xref Database="Entrez Gene" ID="3043"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INSR" GraphId="b05cc" Type="Protein">
   <DataNode TextLabel="INSR" GraphId="b05cc" Type="Protein">
Line 1,152: Line 1,152:
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
     <BiopaxRef>e66</BiopaxRef>
-
     <Graphics CenterX="1738.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1738.8166666666666" CenterY="1788.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3643" />
+
     <Xref Database="Entrez Gene" ID="3643"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HBA1" GraphId="b31e0" Type="Protein">
   <DataNode TextLabel="HBA1" GraphId="b31e0" Type="Protein">
     <Comment>hemoglobin, alpha 1</Comment>
     <Comment>hemoglobin, alpha 1</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2032.8166666666666" CenterY="1654.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2032.8166666666666" CenterY="1654.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3039" />
+
     <Xref Database="Entrez Gene" ID="3039"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="b5d1d" Type="Protein">
   <DataNode TextLabel="Fibrin" GraphId="b5d1d" Type="Protein">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
     <Graphics CenterX="2394.483333333333" CenterY="2253.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2394.483333333333" CenterY="2253.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q27205" />
+
     <Xref Database="Wikidata" ID="Q27205"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="b696d" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="b696d" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>bd7</BiopaxRef>
     <BiopaxRef>bd7</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1403.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1244.8166666666666" CenterY="1403.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="b7344" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="b7344" Type="Protein">
Line 1,177: Line 1,177:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
     <Graphics CenterX="2301.483333333333" CenterY="2572.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="2301.483333333333" CenterY="2572.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q311213" />
+
     <Xref Database="Wikidata" ID="Q311213"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL2" GraphId="b8177" Type="Protein">
   <DataNode TextLabel="IL2" GraphId="b8177" Type="Protein">
Line 1,184: Line 1,184:
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
     <BiopaxRef>a54</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1246.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1244.8166666666666" CenterY="1246.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3558" />
+
     <Xref Database="Entrez Gene" ID="3558"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL4" GraphId="ba6d9" Type="Protein">
   <DataNode TextLabel="IL4" GraphId="ba6d9" Type="Protein">
     <Comment>interleukin 4</Comment>
     <Comment>interleukin 4</Comment>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
-
     <Graphics CenterX="1244.8166666666666" CenterY="1206.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1244.8166666666666" CenterY="1206.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3565" />
+
     <Xref Database="Entrez Gene" ID="3565"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSF1" GraphId="bd2f6" Type="Protein">
   <DataNode TextLabel="CSF1" GraphId="bd2f6" Type="Protein">
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
     <Graphics CenterX="1246.8166666666666" CenterY="1449.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
+
     <Graphics CenterX="1246.8166666666666" CenterY="1449.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="1435" />
+
     <Xref Database="Entrez Gene" ID="1435"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="be83d" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="be83d" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="213" />
+
     <Xref Database="Entrez Gene" ID="213"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="bfe70" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="bfe70" Type="Protein">
Line 1,209: Line 1,209:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
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-
     <Xref Database="Wikidata" ID="Q2162109" />
+
     <Xref Database="Wikidata" ID="Q2162109"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="c2c56" Type="Protein">
   <DataNode TextLabel="INS" GraphId="c2c56" Type="Protein">
Line 1,218: Line 1,218:
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
     <BiopaxRef>fa3</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="3630" />
+
     <Xref Database="Entrez Gene" ID="3630"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="c7788" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="c7788" Type="Protein">
Line 1,225: Line 1,225:
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
-
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     <Graphics CenterX="1243.8166666666598" CenterY="1359.964174589454" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrinogen" GraphId="c7ee6" Type="Protein">
   <DataNode TextLabel="Fibrinogen" GraphId="c7ee6" Type="Protein">
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
     <BiopaxRef>d08</BiopaxRef>
-
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     <Graphics CenterX="2395.15" CenterY="2289.483333333333" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q381899" />
+
     <Xref Database="Wikidata" ID="Q381899"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="sICAM-1" GraphId="cbdfe" Type="Protein">
   <DataNode TextLabel="sICAM-1" GraphId="cbdfe" Type="Protein">
Line 1,239: Line 1,239:
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>cd0</BiopaxRef>
     <BiopaxRef>c22</BiopaxRef>
     <BiopaxRef>c22</BiopaxRef>
-
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     <Graphics CenterX="1247.8166666666666" CenterY="1594.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3383" />
+
     <Xref Database="Entrez Gene" ID="3383"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL10" GraphId="cbe08" Type="Protein">
   <DataNode TextLabel="IL10" GraphId="cbe08" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>bd7</BiopaxRef>
     <BiopaxRef>bd7</BiopaxRef>
-
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     <Graphics CenterX="1145.8166666666666" CenterY="2442.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL4" GraphId="cd348" Type="Protein">
   <DataNode TextLabel="IL4" GraphId="cd348" Type="Protein">
     <Comment>interleukin 4</Comment>
     <Comment>interleukin 4</Comment>
     <BiopaxRef>f7c</BiopaxRef>
     <BiopaxRef>f7c</BiopaxRef>
-
     <Graphics CenterX="1145.8166666666666" CenterY="2596.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00" />
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     <Graphics CenterX="1145.8166666666666" CenterY="2596.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3565" />
+
     <Xref Database="Entrez Gene" ID="3565"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IFNg" GraphId="d2268" Type="Protein">
   <DataNode TextLabel="IFNg" GraphId="d2268" Type="Protein">
     <Comment>interferon, gamma</Comment>
     <Comment>interferon, gamma</Comment>
     <BiopaxRef>b42</BiopaxRef>
     <BiopaxRef>b42</BiopaxRef>
-
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     <Graphics CenterX="1145.8166666666666" CenterY="2471.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3458" />
+
     <Xref Database="Entrez Gene" ID="3458"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="d2dd6" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="d2dd6" Type="Protein">
Line 1,266: Line 1,266:
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>e34</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
     <BiopaxRef>b4a</BiopaxRef>
-
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     <Graphics CenterX="1244.8166666666666" CenterY="1286.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="7124" />
+
     <Xref Database="Entrez Gene" ID="7124"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TNFa" GraphId="dc833" Type="Protein">
   <DataNode TextLabel="TNFa" GraphId="dc833" Type="Protein">
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <Comment>tumor necrosis factor (TNF superfamily, member 2)</Comment>
     <BiopaxRef>dde</BiopaxRef>
     <BiopaxRef>dde</BiopaxRef>
-
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     <Graphics CenterX="1145.8166666666666" CenterY="2532.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="7124" />
+
     <Xref Database="Entrez Gene" ID="7124"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="D-dimer" GraphId="e43dd" Type="Protein">
   <DataNode TextLabel="D-dimer" GraphId="e43dd" Type="Protein">
Line 1,279: Line 1,279:
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
     <BiopaxRef>a00</BiopaxRef>
-
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     <Graphics CenterX="2394.961729643253" CenterY="1364.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Wikidata" ID="Q2162109" />
+
     <Xref Database="Wikidata" ID="Q2162109"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Fibrin" GraphId="e86dd" Type="Metabolite">
   <DataNode TextLabel="Fibrin" GraphId="e86dd" Type="Metabolite">
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f17</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
     <BiopaxRef>f7a</BiopaxRef>
-
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     <Graphics CenterX="2394.961729643253" CenterY="1291.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc33"/>
-
     <Xref Database="Wikidata" ID="Q27205" />
+
     <Xref Database="Wikidata" ID="Q27205"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSF1" GraphId="ee610" Type="Protein">
   <DataNode TextLabel="CSF1" GraphId="ee610" Type="Protein">
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <Comment>colony stimulating factor 1 (macrophage)</Comment>
     <BiopaxRef>e2f</BiopaxRef>
     <BiopaxRef>e2f</BiopaxRef>
-
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-
     <Xref Database="Entrez Gene" ID="1435" />
+
     <Xref Database="Entrez Gene" ID="1435"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="f72a3" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="f72a3" Type="Protein">
Line 1,298: Line 1,298:
     <BiopaxRef>fc9</BiopaxRef>
     <BiopaxRef>fc9</BiopaxRef>
     <BiopaxRef>d53</BiopaxRef>
     <BiopaxRef>d53</BiopaxRef>
-
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     <Graphics CenterX="1145.8166666666666" CenterY="2628.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3569" />
+
     <Xref Database="Entrez Gene" ID="3569"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="INS" GraphId="fae15" Type="Protein">
   <DataNode TextLabel="INS" GraphId="fae15" Type="Protein">
Line 1,306: Line 1,306:
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
     <BiopaxRef>ba4</BiopaxRef>
-
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     <Graphics CenterX="1668.8166666666666" CenterY="2591.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3630" />
+
     <Xref Database="Entrez Gene" ID="3630"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ALB" GraphId="fb407" Type="Protein">
   <DataNode TextLabel="ALB" GraphId="fb407" Type="Protein">
     <Comment>albumin</Comment>
     <Comment>albumin</Comment>
     <BiopaxRef>c31</BiopaxRef>
     <BiopaxRef>c31</BiopaxRef>
-
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     <Graphics CenterX="1974.8166666666666" CenterY="2585.8166666666666" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="213" />
+
     <Xref Database="Entrez Gene" ID="213"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HbA1c" GraphId="fd377" Type="Protein">
   <DataNode TextLabel="HbA1c" GraphId="fd377" Type="Protein">
Line 1,319: Line 1,319:
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <Comment>http://en.wikipedia.org/wiki/Glycated_hemoglobin</Comment>
     <BiopaxRef>cef</BiopaxRef>
     <BiopaxRef>cef</BiopaxRef>
-
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     <Graphics CenterX="2150.8166666666666" CenterY="1683.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IL6" GraphId="ffd35" Type="Protein">
   <DataNode TextLabel="IL6" GraphId="ffd35" Type="Protein">
Line 1,328: Line 1,328:
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>d77</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
     <BiopaxRef>af4</BiopaxRef>
-
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     <Graphics CenterX="1244.8166666666666" CenterY="1164.15" Width="88.66666666666674" Height="14.700000000000008" ZOrder="33002" FontSize="10" Valign="Middle" Color="ffcc00"/>
-
     <Xref Database="Entrez Gene" ID="3569" />
+
     <Xref Database="Entrez Gene" ID="3569"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Riboflavin" GraphId="b78d1" Type="Metabolite">
   <DataNode TextLabel="Riboflavin" GraphId="b78d1" Type="Metabolite">
     <BiopaxRef>ca9</BiopaxRef>
     <BiopaxRef>ca9</BiopaxRef>
-
     <Graphics CenterX="1723.3166666666666" CenterY="337.31666666666666" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933" />
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     <Graphics CenterX="1723.3166666666666" CenterY="337.31666666666666" Width="70.7" Height="21.333333333333346" ZOrder="33006" FontSize="10" Valign="Middle" Color="009933"/>
-
     <Xref Database="HMDB" ID="HMDB0000244" />
+
     <Xref Database="HMDB" ID="HMDB0000244"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="O2" GraphId="ff48f" Type="Metabolite">
   <DataNode TextLabel="O2" GraphId="ff48f" Type="Metabolite">
     <Comment>Superoxide</Comment>
     <Comment>Superoxide</Comment>
-
     <Graphics CenterX="1017.0" CenterY="600.0" Width="48.0" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1017.0" CenterY="600.0" Width="48.0" Height="18.0" ZOrder="33014" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0002168" />
+
     <Xref Database="HMDB" ID="HMDB0002168"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="a0e9a" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="a0e9a" Type="Metabolite">
Line 1,346: Line 1,346:
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
     <BiopaxRef>e4d</BiopaxRef>
-
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+
     <Graphics CenterX="1757.0" CenterY="448.5" Width="122.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0001185" />
+
     <Xref Database="HMDB" ID="HMDB0001185"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="a47a5" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="a47a5" Type="Metabolite">
Line 1,353: Line 1,353:
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
     <BiopaxRef>b2a</BiopaxRef>
-
     <Graphics CenterX="1935.0" CenterY="522.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1935.0" CenterY="522.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000696" />
+
     <Xref Database="HMDB" ID="HMDB0000696"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="bbd30" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="bbd30" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
-
     <Graphics CenterX="1442.5" CenterY="2277.5" Width="125.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1442.5" CenterY="2277.5" Width="125.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000939" />
+
     <Xref Database="HMDB" ID="HMDB0000939"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Methionine" GraphId="d8487" Type="Metabolite">
   <DataNode TextLabel="Methionine" GraphId="d8487" Type="Metabolite">
     <BiopaxRef>aa7</BiopaxRef>
     <BiopaxRef>aa7</BiopaxRef>
-
     <Graphics CenterX="1922.0" CenterY="2288.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="1922.0" CenterY="2288.5" Width="72.0" Height="30.0" ZOrder="33022" FontSize="10" Valign="Middle"/>
-
     <Xref Database="HMDB" ID="HMDB0000696" />
+
     <Xref Database="HMDB" ID="HMDB0000696"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="de0ee" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylmethionine" GraphId="de0ee" Type="Metabolite">
Line 1,371: Line 1,371:
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>a7c</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
     <BiopaxRef>b54</BiopaxRef>
-
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     <Xref Database="HMDB" ID="HMDB0001185" />
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     <Xref Database="HMDB" ID="HMDB0001185"/>
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   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="f12e8" Type="Metabolite">
   <DataNode TextLabel=" S-Adenosylhomocysteine" GraphId="f12e8" Type="Metabolite">
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>a2c</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
     <BiopaxRef>d82</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0000939"/>
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   <DataNode TextLabel="ADP" GraphId="d0d40" Type="Metabolite">
   <DataNode TextLabel="ADP" GraphId="d0d40" Type="Metabolite">
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     <Comment>Adenosine diphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB0001341"/>
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   <DataNode TextLabel="ONOO/ONOOH" GraphId="a23e3" Type="Metabolite">
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     <Comment>Peroxynitrite</Comment>
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     <Xref Database="HMDB" ID="HMDB0002179"/>
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   <DataNode TextLabel="Nitrotyrosine" GraphId="b950b" Type="Metabolite">
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   <DataNode TextLabel="Nitrotyrosine" GraphId="d35d3" Type="Metabolite">
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   <DataNode TextLabel="Tetrahydrobiopterin" GraphId="dd14d" Type="Metabolite">
Line 1,404: Line 1,404:
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     <Xref Database="HMDB" ID="HMDB0000027"/>
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   <DataNode TextLabel="ATP" GraphId="a1aad" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="a1aad" Type="Metabolite">
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     <Comment>Adenosine triphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB0000538"/>
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   <DataNode TextLabel="ATP" GraphId="de676" Type="Metabolite">
   <DataNode TextLabel="ATP" GraphId="de676" Type="Metabolite">
     <Comment>Adenosine triphosphate</Comment>
     <Comment>Adenosine triphosphate</Comment>
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     <Xref Database="HMDB" ID="HMDB0000538"/>
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   <DataNode TextLabel="Glucose" GraphId="bbc0b" Type="Metabolite">
   <DataNode TextLabel="Glucose" GraphId="bbc0b" Type="Metabolite">
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
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   <DataNode TextLabel="Glucose" GraphId="bc2dc" Type="Metabolite">
     <BiopaxRef>b59</BiopaxRef>
     <BiopaxRef>b59</BiopaxRef>
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     <Xref Database="HMDB" ID="HMDB0000122"/>
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   <DataNode TextLabel="Fructosamine" GraphId="cb21d" Type="Metabolite">
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   <DataNode TextLabel="Iron" GraphId="a6473" Type="Metabolite">
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     <Xref Database="HMDB" ID="HMDB0000692"/>
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     <Xref Database="HMDB" ID="HMDB0000692"/>
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Line 1,454: Line 1,454:
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     <Xref Database="Entrez Gene" ID="80308" />
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     <Xref Database="Entrez Gene" ID="80308"/>
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     <Xref Database="Ensembl" ID="ENSG00000171560"/>
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     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="a9e4a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="a9f6c">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="aabd6">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="aad44">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="abefe">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="ad82b">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="adba7">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="ae60e">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="af294">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="af7a6">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b2a6d">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b2ae1">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="b318a">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="bd2d2">
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     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="bf21a">
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     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c172a">
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     <Comment>From intracellular part to the plasma</Comment>
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c5e56">
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     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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       <Point X="1782.0" Y="2591.15" GraphRef="bc2dc" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/>
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   <Interaction GraphId="c625f">
   <Interaction GraphId="c625f">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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   <Interaction GraphId="c8299">
   <Interaction GraphId="c8299">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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       <Point X="1971.0" Y="522.5" GraphRef="a47a5" RelX="1.0" RelY="0.0"/>
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       <Point X="1958.0" Y="2288.5" GraphRef="d8487" RelX="1.0" RelY="0.0" ArrowHead="Arrow"/>
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     <Xref Database="" ID=""/>
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   <Interaction GraphId="cac4e">
   <Interaction GraphId="cac4e">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
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     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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       <Point X="1222.6499999999999" Y="1213.5" GraphRef="ba6d9" RelX="-0.5" RelY="1.0"/>
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       <Point X="1102.325" Y="1229.0" />
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       <Point X="1102.325" Y="1229.0"/>
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       <Point X="982.0" Y="1912.575" />
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       <Point X="982.0" Y="1912.575"/>
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       <Point X="1101.4833333333331" Y="2596.15" GraphRef="cd348" RelX="-1.0" RelY="0.0" ArrowHead="Arrow"/>
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   <Interaction GraphId="cd7b3">
   <Interaction GraphId="cd7b3">
     <Comment>From intracellular part to the plasma</Comment>
     <Comment>From intracellular part to the plasma</Comment>
     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
     <Graphics ConnectorType="Elbow" ZOrder="12534" LineThickness="1.0" Color="ff0070">
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